Detailed information for compound 1369048

Basic information

Technical information
  • TDR Targets ID: 1369048
  • Name: 5-[(2-fluorophenyl)methyl]-3-[2-(2-methylpipe ridin-1-yl)-2-oxoethyl]pyridazino[4,5-b]indol -4-one
  • MW: 432.49 | Formula: C25H25FN4O2
  • H donors: 0 H acceptors: 2 LogP: 3.8 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC1CCCCN1C(=O)Cn1ncc2c(c1=O)n(Cc1ccccc1F)c1c2cccc1
  • InChi: 1S/C25H25FN4O2/c1-17-8-6-7-13-28(17)23(31)16-30-25(32)24-20(14-27-30)19-10-3-5-12-22(19)29(24)15-18-9-2-4-11-21(18)26/h2-5,9-12,14,17H,6-8,13,15-16H2,1H3
  • InChiKey: XXGUMFHEAQNEPS-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 5-[(2-fluorophenyl)methyl]-3-[2-(2-methyl-1-piperidyl)-2-oxo-ethyl]pyridazino[4,5-b]indol-4-one
  • 5-[(2-fluorophenyl)methyl]-3-[2-(2-methyl-1-piperidinyl)-2-oxoethyl]-4-pyridazino[4,5-b]indolone
  • 5-(2-fluorobenzyl)-3-[2-keto-2-(2-methyl-1-piperidyl)ethyl]pyridazino[4,5-b]indol-4-one
  • 5-[(2-fluorophenyl)methyl]-3-[2-(2-methylpiperidin-1-yl)-2-oxo-ethyl]pyridazino[4,5-b]indol-4-one
  • C880-2365
  • NCGC00114040-01

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens polymerase (DNA directed) iota Starlite/ChEMBL No references
Homo sapiens SMAD family member 2 Starlite/ChEMBL No references
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Homo sapiens tumor protein p53 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) transcription factor SMAD2 Get druggable targets OG5_131716 All targets in OG5_131716
Echinococcus granulosus tumor protein p63 Get druggable targets OG5_140038 All targets in OG5_140038
Loa Loa (eye worm) MH2 domain-containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Brugia malayi MH2 domain containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Echinococcus multilocularis tumor protein p63 Get druggable targets OG5_140038 All targets in OG5_140038
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi MH2 domain containing protein SMAD family member 2 467 aa 405 aa 31.6 %
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Onchocerca volvulus 0.0316 0.0347 0.0508
Loa Loa (eye worm) hypothetical protein 0.0316 0.0347 0.0347
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.1571 0.1837 0.3051
Leishmania major hypothetical protein, conserved 0.1571 0.1837 1
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0316 0.0347 0.0347
Trypanosoma cruzi tyrosine specific protein phosphatase, putative 0.0316 0.0347 0.1889
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0316 0.0347 0.0347
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.845 1 1
Brugia malayi hypothetical protein 0.0316 0.0347 0.0347
Loa Loa (eye worm) hypothetical protein 0.0316 0.0347 0.0347
Trypanosoma cruzi hypothetical protein, conserved 0.1571 0.1837 1
Onchocerca volvulus 0.0316 0.0347 0.0508
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0316 0.0347 0.0347
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.1571 0.1837 0.3051
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0316 0.0347 0.0347
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0316 0.0347 0.0347
Onchocerca volvulus 0.0316 0.0347 0.0508
Onchocerca volvulus 4.1 G protein, putative homolog 0.0316 0.0347 0.0508
Loa Loa (eye worm) protein-tyrosine-phosphatase 0.0316 0.0347 0.0347
Loa Loa (eye worm) dual specificity protein phosphatase CDC14B 0.0316 0.0347 0.0347
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0316 0.0347 0.0347
Onchocerca volvulus 0.0316 0.0347 0.0508
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0316 0.0347 0.0347
Giardia lamblia Protein tyrosine phosphatase 0.0316 0.0347 0.0576
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0316 0.0347 0.0347
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0316 0.0347 0.0347
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0316 0.0347 0.0347
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.5097 0.602 1
Loa Loa (eye worm) hypothetical protein 0.0316 0.0347 0.0347
Echinococcus multilocularis 0.0316 0.0347 0.0347
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0316 0.0347 0.0347
Schistosoma mansoni protein-tyrosine phosphatase n9 0.0316 0.0347 0.0347
Brugia malayi MH2 domain containing protein 0.0144 0.0143 0.0143
Onchocerca volvulus 0.0316 0.0347 0.0508
Onchocerca volvulus 0.0316 0.0347 0.0508
Trypanosoma brucei protein tyrosine phosphatase 1 0.0316 0.0347 0.1889
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0316 0.0347 0.0347
Loa Loa (eye worm) hypothetical protein 0.0316 0.0347 0.0347
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0316 0.0347 0.0347
Schistosoma mansoni receptor protein tyrosine phosphatase r (pcptp1) 0.0316 0.0347 0.0347
Onchocerca volvulus 0.0316 0.0347 0.0508
Loa Loa (eye worm) protein tyrosine phosphatase 0.0316 0.0347 0.0347
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0316 0.0347 0.0347
Loa Loa (eye worm) hypothetical protein 0.0316 0.0347 0.0347
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0316 0.0347 0.0347
Onchocerca volvulus 0.0316 0.0347 0.0508
Brugia malayi protein-tyrosine phosphatase Lar-like precursor, putative 0.0316 0.0347 0.0347
Echinococcus multilocularis receptor type tyrosine protein phosphatase zeta 0.0316 0.0347 0.0347
Loa Loa (eye worm) hypothetical protein 0.0316 0.0347 0.0347
Trypanosoma cruzi hypothetical protein, conserved 0.1571 0.1837 1
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.845 1 1
Onchocerca volvulus 0.0316 0.0347 0.0508
Loa Loa (eye worm) hypothetical protein 0.0316 0.0347 0.0347
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0316 0.0347 0.0347
Onchocerca volvulus 0.0316 0.0347 0.0508
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0316 0.0347 0.0347
Entamoeba histolytica protein tyrosine phosphatase, putative 0.0316 0.0347 0.0576
Schistosoma mansoni rgs-gaip interacting protein gipc 0.0316 0.0347 0.0347
Onchocerca volvulus 0.0316 0.0347 0.0508
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.0316 0.0347 0.0347
Loa Loa (eye worm) protein-tyrosine phosphatase 1 0.0316 0.0347 0.0347
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.5097 0.602 1
Loa Loa (eye worm) hypothetical protein 0.0316 0.0347 0.0347
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0316 0.0347 0.0347
Entamoeba histolytica protein tyrosine phosphatase, putative 0.5097 0.602 1
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0316 0.0347 0.0347
Brugia malayi hypothetical protein 0.0316 0.0347 0.0347
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0316 0.0347 0.0347
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.5097 0.602 1
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0316 0.0347 0.0347
Schistosoma mansoni hypothetical protein 0.0041 0.0021 0.0021
Brugia malayi Protein-tyrosine phosphatase 0.0316 0.0347 0.0347
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0316 0.0347 0.0347
Schistosoma mansoni protein tyrosine phosphatase non-receptor type nt1 0.845 1 1
Onchocerca volvulus 0.5097 0.602 1
Loa Loa (eye worm) protein-tyrosine phosphatase 0.845 1 1
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0316 0.0347 0.0347
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0316 0.0347 0.0347
Loa Loa (eye worm) hypothetical protein 0.0041 0.0021 0.0021
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0316 0.0347 0.0347
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0316 0.0347 0.0347
Loa Loa (eye worm) hypothetical protein 0.0316 0.0347 0.0347
Schistosoma mansoni protein tyrosine phosphatase 0.0316 0.0347 0.0347
Loa Loa (eye worm) transcription factor SMAD2 0.0144 0.0143 0.0143
Echinococcus multilocularis receptor type tyrosine protein phosphatase H 0.0316 0.0347 0.0347
Loa Loa (eye worm) MH2 domain-containing protein 0.0144 0.0143 0.0143
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0316 0.0347 0.0347
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0316 0.0347 0.0347
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0316 0.0347 0.0347
Loa Loa (eye worm) hypothetical protein 0.0316 0.0347 0.0347
Schistosoma mansoni non-receptor protein-tyrosine phosphatase 0.0316 0.0347 0.0347
Echinococcus multilocularis tumor protein p63 0.0408 0.0457 0.0457
Mycobacterium tuberculosis Phosphotyrosine protein phosphatase PtpA (protein-tyrosine-phosphatase) (PTPase) (LMW phosphatase) 0.3526 0.4156 1
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0316 0.0347 0.0347
Schistosoma mansoni cellular tumor antigen P53 0.006 0.0043 0.0043
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0316 0.0347 0.0347
Loa Loa (eye worm) hypothetical protein 0.0316 0.0347 0.0347
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.5097 0.602 1
Schistosoma mansoni protein tyrosine phosphatase 0.0316 0.0347 0.0347
Loa Loa (eye worm) hypothetical protein 0.0316 0.0347 0.0347
Onchocerca volvulus 0.0316 0.0347 0.0508
Trypanosoma brucei low molecular weight protein tyrosine phosphatase, putative 0.1571 0.1837 1
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.0316 0.0347 0.0347
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0316 0.0347 0.0347
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0316 0.0347 0.0347
Onchocerca volvulus 0.0316 0.0347 0.0508
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0316 0.0347 0.0347
Loa Loa (eye worm) fibronectin type III domain-containing protein 0.0316 0.0347 0.0347
Onchocerca volvulus 0.0316 0.0347 0.0508
Echinococcus granulosus Receptor type tyrosine protein phosphatase O 0.0316 0.0347 0.0347
Brugia malayi hypothetical protein 0.0316 0.0347 0.0347
Echinococcus multilocularis receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type 0.0316 0.0347 0.0347
Trypanosoma cruzi tyrosine specific protein phosphatase, putative 0.0316 0.0347 0.1889
Loa Loa (eye worm) hypothetical protein 0.0316 0.0347 0.0347
Brugia malayi Protein-tyrosine phosphatase 0.0316 0.0347 0.0347
Echinococcus multilocularis receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type 0.0316 0.0347 0.0347
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0316 0.0347 0.0347
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.5097 0.602 1
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0316 0.0347 0.0347
Brugia malayi Dual specificity protein phosphatase CDC14B 0.0316 0.0347 0.0347
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0316 0.0347 0.0347
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0316 0.0347 0.0347
Schistosoma mansoni receptor protein tyrosine phosphatase 0.0316 0.0347 0.0347
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0316 0.0347 0.0347
Loa Loa (eye worm) hypothetical protein 0.0316 0.0347 0.0347
Echinococcus multilocularis hypothetical protein 0.0316 0.0347 0.0347
Schistosoma mansoni receptor protein tyrosine phosphatase n (ia2) 0.0316 0.0347 0.0347
Loa Loa (eye worm) hypothetical protein 0.0316 0.0347 0.0347
Entamoeba histolytica protein tyrosine phosphatase, putative 0.5097 0.602 1
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0316 0.0347 0.0347
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0316 0.0347 0.0347
Onchocerca volvulus 0.0316 0.0347 0.0508
Loa Loa (eye worm) hypothetical protein 0.0316 0.0347 0.0347
Echinococcus granulosus receptor type tyrosine protein phosphatase zeta 0.0316 0.0347 0.0347
Onchocerca volvulus 0.0316 0.0347 0.0508
Loa Loa (eye worm) hypothetical protein 0.0316 0.0347 0.0347
Echinococcus multilocularis receptor type tyrosine protein phosphatase zeta 0.0316 0.0347 0.0347
Loa Loa (eye worm) phosphotyrosine protein phosphatase 0.5097 0.602 0.602
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0316 0.0347 0.0347
Echinococcus granulosus tumor protein p63 0.0408 0.0457 0.0457
Mycobacterium ulcerans phosphotyrosine protein phosphatase PtpA 0.5097 0.602 1
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.0316 0.0347 0.0347
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0316 0.0347 0.0347
Schistosoma mansoni protein tyrosine phosphatase n11 (shp2) 0.0316 0.0347 0.0347
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0316 0.0347 0.0347
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0316 0.0347 0.0347
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.0021 0.0021
Brugia malayi hypothetical protein 0.0316 0.0347 0.0347
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.0044 0.0044
Trichomonas vaginalis pten, drome, putative 0.0316 0.0347 0.0576
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0316 0.0347 0.0347
Loa Loa (eye worm) hypothetical protein 0.0316 0.0347 0.0347
Onchocerca volvulus 0.0316 0.0347 0.0508
Echinococcus granulosus Receptor type tyrosine protein phosphatase O 0.0316 0.0347 0.0347
Leishmania major tyrosine specific protein phosphatase, putative 0.0316 0.0347 0.1889
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0316 0.0347 0.0347
Schistosoma mansoni protein-tyrosine phosphatase non-receptor type nt5 0.0316 0.0347 0.0347
Loa Loa (eye worm) hypothetical protein 0.006 0.0044 0.0044
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0316 0.0347 0.0347
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0316 0.0347 0.0347
Schistosoma mansoni protein tyrosine phosphatase 0.0316 0.0347 0.0347
Onchocerca volvulus 0.0316 0.0347 0.0508
Onchocerca volvulus 0.0316 0.0347 0.0508
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0316 0.0347 0.0347
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0316 0.0347 0.0347
Echinococcus granulosus protein tyrosine phosphatase n9 0.0316 0.0347 0.0347
Loa Loa (eye worm) hypothetical protein 0.0316 0.0347 0.0347
Loa Loa (eye worm) hypothetical protein 0.0316 0.0347 0.0347
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0316 0.0347 0.0347
Echinococcus multilocularis receptor type tyrosine protein phosphatase F 0.0316 0.0347 0.0347
Echinococcus granulosus receptor type tyrosine protein phosphatase zeta 0.0316 0.0347 0.0347
Loa Loa (eye worm) hypothetical protein 0.0316 0.0347 0.0347
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.0044 0.0044
Entamoeba histolytica Pten 3-phosphoinositide phosphatase, putative 0.0316 0.0347 0.0576
Giardia lamblia Low molecular weight protein-tyrosine-phosphatase 0.5097 0.602 1
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0316 0.0347 0.0347
Loa Loa (eye worm) hypothetical protein 0.0316 0.0347 0.0347
Schistosoma mansoni receptor protein tyrosine phosphatase n (ia2) 0.0316 0.0347 0.0347
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0316 0.0347 0.0347
Onchocerca volvulus 0.0316 0.0347 0.0508
Brugia malayi Protein-tyrosine phosphatase 1 0.0316 0.0347 0.0347
Loa Loa (eye worm) hypothetical protein 0.0316 0.0347 0.0347
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0316 0.0347 0.0347
Loa Loa (eye worm) hypothetical protein 0.0316 0.0347 0.0347
Loa Loa (eye worm) hypothetical protein 0.0316 0.0347 0.0347
Onchocerca volvulus 0.0316 0.0347 0.0508
Loa Loa (eye worm) hypothetical protein 0.006 0.0043 0.0043
Onchocerca volvulus 0.0316 0.0347 0.0508
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0316 0.0347 0.0347
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0316 0.0347 0.0347
Echinococcus multilocularis protein tyrosine phosphatase n9 0.0316 0.0347 0.0347
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0316 0.0347 0.0347
Leishmania major protein-tyrosine phosphatase 1-like protein 0.0316 0.0347 0.1889
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0316 0.0347 0.0347
Entamoeba histolytica protein tyrosine phosphatase, putative 0.0316 0.0347 0.0576
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.0044 0.0044
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0316 0.0347 0.0347
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.5097 0.602 1
Brugia malayi Low molecular weight phosphotyrosine protein phosphatase containing protein 0.5097 0.602 0.602
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0316 0.0347 0.0347
Onchocerca volvulus 0.0316 0.0347 0.0508
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.0316 0.0347 0.0347
Brugia malayi hypothetical protein 0.0316 0.0347 0.0347
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0316 0.0347 0.0347
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0316 0.0347 0.0347
Trypanosoma cruzi tyrosine specific protein phosphatase, putative 0.0316 0.0347 0.1889
Schistosoma mansoni pcd6 interacting protein-related 0.0316 0.0347 0.0347
Loa Loa (eye worm) hypothetical protein 0.0316 0.0347 0.0347
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0316 0.0347 0.0347

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 0.005 um PUBCHEM_BIOASSAY: qHTS Screen for Compounds that Selectively Target Cancer Cells with p53 Mutations: Cytotoxicity of p53 Null Cells at the Nonpermissive Temperature. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 0.8913 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference
Potency (functional) 3.9811 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 11.2202 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) 29.0929 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) 31.6228 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: qHTS Assay for Substrates of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] ChEMBL. No reference
Potency (functional) = 112.2018 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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