Detailed information for compound 1370819

Basic information

Technical information
  • TDR Targets ID: 1370819
  • Name: N-(6-pyrrolidin-1-ylsulfonyl-1,3-benzothiazol -2-yl)thiophene-2-carboxamide
  • MW: 393.504 | Formula: C16H15N3O3S3
  • H donors: 1 H acceptors: 4 LogP: 3.2 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(c1cccs1)Nc1nc2c(s1)cc(cc2)S(=O)(=O)N1CCCC1
  • InChi: 1S/C16H15N3O3S3/c20-15(13-4-3-9-23-13)18-16-17-12-6-5-11(10-14(12)24-16)25(21,22)19-7-1-2-8-19/h3-6,9-10H,1-2,7-8H2,(H,17,18,20)
  • InChiKey: OMJZKOGUNJVWPO-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • N-(6-1-pyrrolidinylsulfonyl-1,3-benzothiazol-2-yl)-2-thiophenecarboxamide
  • MLS000051474
  • N-[6-(1-pyrrolidinylsulfonyl)-1,3-benzothiazol-2-yl]-2-thiophenecarboxamide
  • SMR000079850
  • ZINC00937596

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens lysine (K)-specific methyltransferase 2A Starlite/ChEMBL No references
Homo sapiens multiple endocrine neoplasia I No references
Homo sapiens parathyroid hormone 1 receptor Starlite/ChEMBL No references
Homo sapiens lamin A/C Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Neospora caninum Multidomain chromatinic protein with the following architecture: 3x PHD-bromo-3xPHD-SET domain and associated cysteine cluster a Get druggable targets OG5_130642 All targets in OG5_130642
Schistosoma japonicum Lamin-C, putative Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum ko:K04588 secretin receptor, putative Get druggable targets OG5_139196 All targets in OG5_139196
Echinococcus multilocularis musashi Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) intermediate filament tail domain-containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni hypothetical protein Get druggable targets OG5_133913 All targets in OG5_133913
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum Menin, putative Get druggable targets OG5_133913 All targets in OG5_133913
Echinococcus granulosus cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni mixed-lineage leukemia protein mll Get druggable targets OG5_130642 All targets in OG5_130642
Echinococcus multilocularis lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi Intermediate filament tail domain containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus dnaJ subfamily B Get druggable targets OG5_133913 All targets in OG5_133913
Echinococcus granulosus lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis lamin Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum ko:K07611 lamin, putative Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Toxoplasma gondii histone lysine methyltransferase SET1 Get druggable targets OG5_130642 All targets in OG5_130642
Echinococcus multilocularis dnaJ subfamily B Get druggable targets OG5_133913 All targets in OG5_133913
Schistosoma japonicum ko:K09188 myeloid/lymphoid or mixed-lineage leukemia protein 3, putative Get druggable targets OG5_130642 All targets in OG5_130642
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni intermediate filament proteins Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus lamin Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum Intermediate filament protein ifa-1, putative Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis TWiK family of potassium channels protein 7 0.0023 0.0313 0.0298
Brugia malayi Intermediate filament tail domain containing protein 0.0033 0.0508 0.4429
Giardia lamblia Hypothetical protein 0.0023 0.0313 0.5
Loa Loa (eye worm) hypothetical protein 0.0023 0.0313 0.0267
Plasmodium falciparum potassium channel 0.0023 0.0313 0.5
Loa Loa (eye worm) potassium voltage-gated channel subfamily Q member 5 0.0023 0.0313 0.0267
Schistosoma mansoni hypothetical protein 0.0019 0.023 0.0215
Schistosoma mansoni twik family of potassium channels-related 0.0023 0.0313 0.0298
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.0685 0.616
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 28 0.0023 0.0313 0.2515
Trypanosoma cruzi ion transport protein, putative 0.0023 0.0313 0.5
Schistosoma mansoni hypothetical protein 0.0473 0.9573 0.9572
Loa Loa (eye worm) hypothetical protein 0.0023 0.0313 0.0267
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0011 0.0059 0.0044
Schistosoma mansoni calcium-activated potassium channel 0.0023 0.0313 0.0298
Echinococcus granulosus lamin 0.0033 0.0508 0.0493
Schistosoma mansoni twik family of potassium channels-related 0.0023 0.0313 0.0298
Loa Loa (eye worm) S-phase kinase-associated protein 1A 0.0023 0.0313 0.0267
Loa Loa (eye worm) hypothetical protein 0.0023 0.0313 0.0267
Schistosoma mansoni twik family of potassium channels-related 0.0023 0.0313 0.0298
Mycobacterium ulcerans transmembrane cation transporter 0.0023 0.0313 0.5
Loa Loa (eye worm) hypothetical protein 0.0023 0.0313 0.0267
Loa Loa (eye worm) TWK-7 protein 0.0023 0.0313 0.0267
Loa Loa (eye worm) hypothetical protein 0.0023 0.0313 0.0267
Leishmania major potassium channel subunit-like protein 0.0023 0.0313 0.5
Brugia malayi cytoplasmic intermediate filament protein 0.0017 0.0197 0.1381
Brugia malayi Twik (KCNK-like) family of potasium channels, alpha subunit 40 0.0023 0.0313 0.2515
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 13 0.0023 0.0313 0.2515
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0023 0.0313 1
Echinococcus granulosus calcium activated potassium channel variant 0.0023 0.0313 0.0298
Loa Loa (eye worm) hypothetical protein 0.006 0.1077 0.107
Trypanosoma cruzi calcium/potassium channel (CAKC), putative 0.0023 0.0313 0.5
Brugia malayi Latrophilin receptor protein 2 0.0019 0.023 0.1704
Schistosoma mansoni lamin 0.0033 0.0508 0.0493
Loa Loa (eye worm) hypothetical protein 0.0023 0.0313 0.0267
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0019 0.023 0.0215
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0017 0.0197 0.0145
Echinococcus multilocularis lamin dm0 0.0033 0.0508 0.0493
Mycobacterium ulcerans ion transport protein 0.0023 0.0313 0.5
Echinococcus granulosus twik family of potassium channels 0.0023 0.0313 0.0298
Trypanosoma cruzi hypothetical protein, conserved 0.0023 0.0313 0.5
Echinococcus multilocularis twik family of potassium channels 0.0023 0.0313 0.0298
Plasmodium vivax potassium channel, putative 0.0023 0.0313 0.5
Entamoeba histolytica calcium-gated potassium channel protein, putative 0.0023 0.0313 0.5
Schistosoma mansoni twik family of potassium channels-related 0.0023 0.0313 0.0298
Trypanosoma brucei calcium/potassium channel (CAKC), putative 0.0023 0.0313 0.5
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0011 0.0059 0.0044
Echinococcus multilocularis potassium channel subfamily K 8 0.0023 0.0313 0.0298
Loa Loa (eye worm) hypothetical protein 0.0015 0.0149 0.0095
Leishmania major calcium/potassium channel (CAKC), putative 0.0023 0.0313 0.5
Loa Loa (eye worm) hypothetical protein 0.0023 0.0313 0.0267
Schistosoma mansoni twik family of potassium channels-related 0.0023 0.0313 0.0298
Loa Loa (eye worm) intermediate filament protein 0.0033 0.0508 0.0472
Loa Loa (eye worm) hypothetical protein 0.0023 0.0313 0.0267
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.1077 1
Schistosoma mansoni cpg binding protein 0.0035 0.0552 0.0537
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 35 0.0023 0.0313 0.2515
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 38. C. elegans sup-9 ortholog 0.0023 0.0313 0.2515
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0016 0.0162 0.0146
Loa Loa (eye worm) hypothetical protein 0.0023 0.0313 0.0267
Echinococcus multilocularis potassium channel subfamily K 0.0023 0.0313 0.0298
Loa Loa (eye worm) hypothetical protein 0.0023 0.0313 0.0267
Toxoplasma gondii histone lysine methyltransferase SET1 0.0066 0.119 1
Loa Loa (eye worm) hypothetical protein 0.0023 0.0313 0.0267
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 24 0.0023 0.0313 0.2515
Loa Loa (eye worm) hypothetical protein 0.0023 0.0313 0.0267
Schistosoma mansoni twik family of potassium channels-related 0.0023 0.0313 0.0298
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.1077 0.107
Loa Loa (eye worm) hypothetical protein 0.0016 0.0162 0.0108
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0019 0.023 0.0215
Echinococcus granulosus intermediate filament protein 0.0033 0.0508 0.0493
Loa Loa (eye worm) hypothetical protein 0.0023 0.0313 0.0267
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 7 0.0023 0.0313 0.2515
Echinococcus granulosus potassium channel subfamily K 0.0023 0.0313 0.0298
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0074 0.1352 0.1338
Plasmodium vivax potassium channel, putative 0.0023 0.0313 0.5
Leishmania major ion transport protein-like protein 0.0023 0.0313 0.5
Trypanosoma cruzi ion transport protein, putative 0.0023 0.0313 0.5
Schistosoma mansoni hypothetical protein 0.0023 0.0313 0.0298
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 19. C. elegans unc-58 ortholog 0.0023 0.0313 0.2515
Schistosoma mansoni intermediate filament proteins 0.0033 0.0508 0.0493
Trypanosoma brucei calcium-activated potassium channel, putative 0.0023 0.0313 0.5
Trypanosoma cruzi calcium/potassium channel (CAKC), putative 0.0023 0.0313 0.5
Loa Loa (eye worm) hypothetical protein 0.0023 0.0313 0.0267
Loa Loa (eye worm) hypothetical protein 0.0023 0.0313 0.0267
Loa Loa (eye worm) CXXC zinc finger family protein 0.0035 0.0552 0.0518
Echinococcus multilocularis potassium channel subfamily K 8 0.0023 0.0313 0.0298
Leishmania major hypothetical protein, conserved 0.0023 0.0313 0.5
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0019 0.023 0.0215
Echinococcus granulosus TWiK family of potassium channels protein 7 0.0023 0.0313 0.0298
Loa Loa (eye worm) hypothetical protein 0.0023 0.0313 0.0267
Schistosoma mansoni cpg binding protein 0.0037 0.0593 0.0578
Echinococcus multilocularis calcium activated potassium channel variant 0.0023 0.0313 0.0298
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0023 0.0313 1
Echinococcus granulosus potassium channel subfamily K 8 0.0023 0.0313 0.0298
Plasmodium falciparum potassium channel 0.0023 0.0313 0.5
Loa Loa (eye worm) hypothetical protein 0.0213 0.4218 0.4372
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0033 0.0508 0.0472
Loa Loa (eye worm) hypothetical protein 0.0041 0.0685 0.0658
Loa Loa (eye worm) latrophilin receptor protein 2 0.0019 0.023 0.018
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0023 0.0313 1
Echinococcus granulosus GPCR family 2 0.0019 0.023 0.0215
Schistosoma mansoni hypothetical protein 0.0019 0.023 0.0215
Brugia malayi CXXC zinc finger family protein 0.0035 0.0552 0.4856
Loa Loa (eye worm) large conductance calcium-activated potassium channel alpha subunit ai 0.0023 0.0313 0.0267
Loa Loa (eye worm) hypothetical protein 0.0019 0.023 0.018
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 39B 0.0023 0.0313 0.2515
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 5 0.0023 0.0313 0.2515
Schistosoma mansoni calcium-activated potassium channel 0.045 0.9098 0.9097
Echinococcus multilocularis dnaJ subfamily B 0.0494 1 1
Loa Loa (eye worm) TWK-28 protein 0.0023 0.0313 0.0267
Schistosoma mansoni hypothetical protein 0.0019 0.023 0.0215
Echinococcus granulosus small conductance calcium activated potassium 0.0473 0.9573 0.9572
Schistosoma mansoni twik family of potassium channels-related 0.0023 0.0313 0.0298
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 39A 0.0023 0.0313 0.2515
Echinococcus granulosus potassium channel subfamily K 8 0.0023 0.0313 0.0298
Brugia malayi hypothetical protein 0.0023 0.0313 0.2515
Loa Loa (eye worm) hypothetical protein 0.0237 0.4719 0.4898
Brugia malayi hypothetical protein 0.0023 0.0313 0.2515
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.1077 1
Schistosoma mansoni hypothetical protein 0.0019 0.023 0.0215
Echinococcus multilocularis lamin 0.0033 0.0508 0.0493
Loa Loa (eye worm) hypothetical protein 0.0473 0.9573 1
Loa Loa (eye worm) hypothetical protein 0.0023 0.0313 0.0267
Loa Loa (eye worm) hypothetical protein 0.0023 0.0313 0.0267
Trypanosoma cruzi calcium-activated potassium channel, putative 0.0023 0.0313 0.5
Loa Loa (eye worm) hypothetical protein 0.0023 0.0313 0.0267
Loa Loa (eye worm) hypothetical protein 0.0023 0.0313 0.0267
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0019 0.023 0.0215
Schistosoma mansoni lamin 0.0033 0.0508 0.0493
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0019 0.023 0.1704
Loa Loa (eye worm) hypothetical protein 0.0023 0.0313 0.0267
Echinococcus multilocularis small conductance calcium activated potassium 0.0473 0.9573 0.9572
Echinococcus multilocularis musashi 0.0033 0.0508 0.0493
Loa Loa (eye worm) hypothetical protein 0.0023 0.0313 0.0267
Onchocerca volvulus 0.0035 0.0552 1
Loa Loa (eye worm) hypothetical protein 0.0032 0.0496 0.0459
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 32 0.0023 0.0313 0.2515
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 12 0.0023 0.0313 0.2515
Brugia malayi intermediate filament protein 0.0033 0.0508 0.4429
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0016 0.0162 0.0146
Loa Loa (eye worm) hypothetical protein 0.0023 0.0313 0.0267
Loa Loa (eye worm) hypothetical protein 0.0033 0.0508 0.0472
Mycobacterium tuberculosis Possible transmembrane cation transporter 0.0023 0.0313 0.5
Echinococcus multilocularis twik family of potassium channels 0.0023 0.0313 0.0298
Loa Loa (eye worm) hypothetical protein 0.0023 0.0313 0.0267
Echinococcus multilocularis Two pore potassium channel protein sup 9 0.0023 0.0313 0.0298
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 21 0.0023 0.0313 0.2515
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0023 0.0313 1
Echinococcus granulosus twik family of potassium channels 0.0023 0.0313 0.0298
Trypanosoma cruzi hypothetical protein, conserved 0.0023 0.0313 0.5
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 17 0.0023 0.0313 0.2515
Onchocerca volvulus 0.0033 0.0508 0.8178
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 45 0.0023 0.0313 0.2515
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 30. 0.0023 0.0313 0.2515
Schistosoma mansoni calcium-activated potassium channel 0.0473 0.9573 0.9572
Schistosoma mansoni calcium-activated potassium channel 0.0023 0.0313 0.0298
Echinococcus granulosus Two pore potassium channel protein sup 9 0.0023 0.0313 0.0298
Loa Loa (eye worm) hypothetical protein 0.0015 0.0149 0.0095
Trypanosoma cruzi calcium-activated potassium channel, putative 0.0023 0.0313 0.5
Loa Loa (eye worm) hypothetical protein 0.0023 0.0313 0.0267
Loa Loa (eye worm) hypothetical protein 0.0023 0.0313 0.0267
Loa Loa (eye worm) hypothetical protein 0.0023 0.0313 0.0267
Loa Loa (eye worm) hypothetical protein 0.0023 0.0313 0.0267
Loa Loa (eye worm) hypothetical protein 0.0023 0.0313 0.0267
Loa Loa (eye worm) uncoordinated protein 58 0.0023 0.0313 0.0267
Loa Loa (eye worm) hypothetical protein 0.0023 0.0313 0.0267
Echinococcus granulosus cpg binding protein 0.0037 0.0593 0.0578
Echinococcus multilocularis GPCR, family 2 0.0019 0.023 0.0215
Loa Loa (eye worm) hypothetical protein 0.0023 0.0313 0.0267
Leishmania major hypothetical protein, conserved 0.0023 0.0313 0.5
Schistosoma mansoni hypothetical protein 0.0041 0.0685 0.067
Loa Loa (eye worm) hypothetical protein 0.0023 0.0313 0.0267
Schistosoma mansoni twik family of potassium channels-related 0.0023 0.0313 0.0298
Schistosoma mansoni hypothetical protein 0.0494 1 1
Onchocerca volvulus 0.0033 0.0508 0.8178
Loa Loa (eye worm) hypothetical protein 0.0023 0.0313 0.0267
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0023 0.0313 1
Echinococcus granulosus lamin dm0 0.0033 0.0508 0.0493
Echinococcus multilocularis cpg binding protein 0.0037 0.0593 0.0578
Schistosoma mansoni cpg binding protein 0.0037 0.0593 0.0578

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 11.2202 um PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 12.5893 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 12.5893 uM PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of 15-hLO (15-human lipoxygenase). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor: Activators of Intracellular cAMP Concentrations in Parental HEK 293. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 26.8545 uM PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] ChEMBL. No reference
Potency (functional) = 28.1838 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) 29.0929 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Leishmania Mexicana Pyruvate Kinase (LmPK). (Class of assay: confirmatory) [Related pubchem assays: 1379 ] ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Activators of Leishmania Mexicana Pyruvate Kinase (LmPK). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) 35.4813 uM PubChem BioAssay. qHTS Assay to Identify Small Molecule Activators of BRCA1 Expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HSD17B4, hydroxysteroid (17-beta) dehydrogenase 4. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HADH2 (Hydroxyacyl-Coenzyme A Dehydrogenase, Type II). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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