TDR Targets

Basic information

Technical information

TDR Targets ID: 1371183
Name: ethyl 4-[[8-[(1-tert-butyltetrazol-5-yl)methy l]-8-azabicyclo[3.2.1]octan-3-yl]carbamoylami no]benzoate
MW: 455.553 | Formula: C23H33N7O3
H donors: 2 H acceptors: 5 LogP: 2.42 Rotable bonds: 10
Rule of 5 violations (Lipinski): 1
SMILES: CCOC(=O)c1ccc(cc1)NC(=O)NC1CC2CCC(C1)N2Cc1nnnn1C(C)(C)C
InChi: 1S/C23H33N7O3/c1-5-33-21(31)15-6-8-16(9-7-15)24-22(32)25-17-12-18-10-11-19(13-17)29(18)14-20-26-27-28-30(20)23(2,3)4/h6-9,17-19H,5,10-14H2,1-4H3,(H2,24,25,32)
InChiKey: FOODIZRFHBFNPF-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

4-[[[[8-[(1-tert-butyl-5-tetrazolyl)methyl]-8-azabicyclo[3.2.1]octan-3-yl]amino]-oxomethyl]amino]benzoic acid ethyl ester
4-[[8-[(1-tert-butyltetrazol-5-yl)methyl]-8-azabicyclo[3.2.1]octan-3-yl]carbamoylamino]benzoic acid ethyl ester
ethyl 4-[[8-[(1-tert-butyl-1,2,3,4-tetrazol-5-yl)methyl]-8-azabicyclo[3.2.1]octan-3-yl]carbamoylamino]benzoate
ASN 06448343
4-{3-[8-(1-tert-Butyl-1H-tetrazol-5-ylmethyl)-8-aza-bicyclo[3.2.1]oct-3-yl]-ureido}-benzoic acid ethyl ester
MLS000034314
SMR000006689

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	aldehyde dehydrogenase 1 family, member A1	Starlite/ChEMBL	No references
Homo sapiens	glycoprotein hormones, alpha polypeptide	Starlite/ChEMBL	No references
Escherichia coli	penicillin-binding protein	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Schistosoma japonicum	Aldehyde dehydrogenase X, mitochondrial precursor, putative	Get druggable targets OG5_126638	All targets in OG5_126638
Candida albicans	Mitochondrial aldehyde dehydrogenase	Get druggable targets OG5_126638	All targets in OG5_126638
Schistosoma mansoni	aldehyde dehydrogenase	Get druggable targets OG5_126638	All targets in OG5_126638
Schistosoma japonicum	Retinal dehydrogenase 1, putative	Get druggable targets OG5_126638	All targets in OG5_126638
Candida albicans	aldehyde dehydrogenase	Get druggable targets OG5_126638	All targets in OG5_126638
Mycobacterium ulcerans	aldehyde dehydrogenase	Get druggable targets OG5_126638	All targets in OG5_126638
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	Get druggable targets OG5_126638	All targets in OG5_126638
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	Get druggable targets OG5_126638	All targets in OG5_126638
Candida albicans	aldehyde dehydrogenase	Get druggable targets OG5_126638	All targets in OG5_126638
Mycobacterium tuberculosis	Possible penicillin-binding protein	Get druggable targets OG5_149948	All targets in OG5_149948
Mycobacterium ulcerans	aldehyde dehydrogenase	Get druggable targets OG5_126638	All targets in OG5_126638
Schistosoma japonicum	Aldehyde dehydrogenase, mitochondrial precursor, putative	Get druggable targets OG5_126638	All targets in OG5_126638
Leishmania infantum	aldehyde dehydrogenase, mitochondrial precursor	Get druggable targets OG5_126638	All targets in OG5_126638
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	Get druggable targets OG5_126638	All targets in OG5_126638
Mycobacterium ulcerans	aldehyde dehydrogenase	Get druggable targets OG5_126638	All targets in OG5_126638
Schistosoma mansoni	aldehyde dehydrogenase	Get druggable targets OG5_126638	All targets in OG5_126638
Schistosoma japonicum	ko:K00128 aldehyde dehydrogenase (NAD+) [EC1.2.1.3], putative	Get druggable targets OG5_126638	All targets in OG5_126638
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	Get druggable targets OG5_126638	All targets in OG5_126638
Leishmania braziliensis	aldehyde dehydrogenase, mitochondrial precursor	Get druggable targets OG5_126638	All targets in OG5_126638
Neospora caninum	hypothetical protein	Get druggable targets OG5_126638	All targets in OG5_126638
Toxoplasma gondii	aldehyde dehydrogenase	Get druggable targets OG5_126638	All targets in OG5_126638
Candida albicans	Mitochondrial aldehyde dehydrogenase	Get druggable targets OG5_126638	All targets in OG5_126638
Leishmania donovani	aldehyde dehydrogenase, mitochondrial precursor	Get druggable targets OG5_126638	All targets in OG5_126638
Leishmania mexicana	aldehyde dehydrogenase, mitochondrial precursor	Get druggable targets OG5_126638	All targets in OG5_126638

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Toxoplasma gondii	intraflagellar transport protein 172, putative	glycoprotein hormones, alpha polypeptide	116 aa	94 aa	26.6 %
Mycobacterium tuberculosis	Succinate-semialdehyde dehydrogenase [NADP+] dependent (SSDH) GabD1	aldehyde dehydrogenase 1 family, member A1	501 aa	456 aa	33.3 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	aminopeptidase N	0.0108	0.0171	0.0311
Loa Loa (eye worm)	hypothetical protein	0.0217	0.0625	0.1193
Echinococcus granulosus	neuropeptide receptor	0.012	0.0221	0.0429
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.012	0.0221	0.0399
Echinococcus granulosus	lysine specific histone demethylase 1A	0.0415	0.1455	0.2823
Schistosoma mansoni	amine GPCR	0.012	0.0221	0.021
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0073	0.0024	0.0046
Echinococcus multilocularis	orexin receptor type 2	0.012	0.0221	0.0549
Trypanosoma cruzi	Aminopeptidase M1, putative	0.0108	0.0171	1
Echinococcus multilocularis	somatostatin receptor	0.012	0.0221	0.0549
Echinococcus multilocularis	rhodopsin orphan GPCR	0.012	0.0221	0.0549
Mycobacterium leprae	probable zinc metalloprotease	0.0294	0.0946	1
Echinococcus multilocularis	aminopeptidase N	0.0369	0.1259	0.3125
Brugia malayi	Peptidase family M1 containing protein	0.0369	0.1259	0.2421
Loa Loa (eye worm)	hypothetical protein	0.012	0.0221	0.0408
Brugia malayi	hypothetical protein	0.012	0.0221	0.0399
Echinococcus multilocularis	neuropeptide receptor	0.012	0.0221	0.0549
Loa Loa (eye worm)	hypothetical protein	0.012	0.0221	0.0408
Schistosoma mansoni	family M13 unassigned peptidase (M13 family)	0.0077	0.0038	0.0026
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.0108	0.0171	0.0424
Echinococcus granulosus	rhodopsin orphan GPCR	0.012	0.0221	0.0429
Brugia malayi	hypothetical protein	0.012	0.0221	0.0399
Schistosoma mansoni	endothelin-converting enzyme-like 1 (damage-induced neuronal endopeptidase)	0.0071	0.0016	0.0005
Echinococcus granulosus	allatostatin A receptor	0.012	0.0221	0.0429
Brugia malayi	G-protein coupled receptor	0.012	0.0221	0.0399
Trichomonas vaginalis	conserved hypothetical protein	0.0268	0.084	0.231
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.012	0.0221	0.0549
Echinococcus granulosus	tm gpcr rhodopsin	0.0622	0.2322	0.4507
Schistosoma mansoni	amine GPCR	0.012	0.0221	0.021
Brugia malayi	hypothetical protein	0.012	0.0221	0.0399
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.012	0.0221	0.0549
Schistosoma mansoni	histamine h1 receptor	0.012	0.0221	0.021
Schistosoma mansoni	subfamily S8B unassigned peptidase (S08 family)	0.1299	0.5153	0.5147
Echinococcus granulosus	neuropeptide Y receptor	0.012	0.0221	0.0429
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.012	0.0221	0.0549
Schistosoma mansoni	subfamily S8B non-peptidase homologue (S08 family)	0.0328	0.1088	0.1078
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0349	0.1176	0.2258
Loa Loa (eye worm)	hypothetical protein	0.026	0.0805	0.1544
Schistosoma mansoni	biogenic amine (5HT) receptor	0.012	0.0221	0.021
Loa Loa (eye worm)	hypothetical protein	0.012	0.0221	0.0408
Onchocerca volvulus		0.012	0.0221	0.0351
Trichomonas vaginalis	conserved hypothetical protein	0.0268	0.084	0.231
Trypanosoma brucei	Aminopeptidase M1, putative	0.0108	0.0171	1
Onchocerca volvulus		0.012	0.0221	0.0351
Brugia malayi	hypothetical protein	0.012	0.0221	0.0399
Trypanosoma brucei	Aminopeptidase M1, putative	0.0108	0.0171	1
Echinococcus granulosus	neuropeptide receptor	0.012	0.0221	0.0429
Trichomonas vaginalis	leucine-rich repeat protein, BspA family	0.0268	0.084	0.231
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.012	0.0221	0.0429
Echinococcus granulosus	tachykinin peptides receptor 99D	0.012	0.0221	0.0429
Trichomonas vaginalis	conserved hypothetical protein	0.0268	0.084	0.231
Echinococcus granulosus	g protein coupled receptor	0.012	0.0221	0.0429
Echinococcus granulosus	furin	0.1299	0.5153	1
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.012	0.0221	0.021
Echinococcus granulosus	aminopeptidase N	0.0369	0.1259	0.2444
Loa Loa (eye worm)	hypothetical protein	0.012	0.0221	0.0408
Schistosoma mansoni	family M13 non-peptidase homologue (M13 family)	0.0071	0.0016	0.0005
Loa Loa (eye worm)	hypothetical protein	0.012	0.0221	0.0408
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.012	0.0221	0.021
Giardia lamblia	High cysteine membrane protein Group 2	0.0472	0.1694	1
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.012	0.0221	0.0549
Echinococcus granulosus	G protein coupled receptor 139	0.012	0.0221	0.0429
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.012	0.0221	0.0549
Onchocerca volvulus		0.012	0.0221	0.0351
Brugia malayi	neuroendocrine convertase 1 precursor	0.0826	0.3175	0.615
Loa Loa (eye worm)	peptidase family M13 containing protein	0.0217	0.0625	0.1193
Brugia malayi	Dopamine receptor protein 2	0.012	0.0221	0.0399
Trichomonas vaginalis	conserved hypothetical protein	0.0268	0.084	0.231
Loa Loa (eye worm)	hypothetical protein	0.1299	0.5153	1
Schistosoma mansoni	family A2 unassigned peptidase (A02 family)	0.0447	0.1587	0.1577
Onchocerca volvulus		0.012	0.0221	0.0351
Brugia malayi	follicle stimulating hormone receptor	0.012	0.0221	0.0399
Loa Loa (eye worm)	hypothetical protein	0.012	0.0221	0.0408
Echinococcus granulosus	puromycin sensitive aminopeptidase	0.0108	0.0171	0.0332
Echinococcus granulosus	neuropeptide s receptor	0.0567	0.2089	0.4054
Echinococcus granulosus	puromycin sensitive aminopeptidase	0.0108	0.0171	0.0332
Loa Loa (eye worm)	hypothetical protein	0.012	0.0221	0.0408
Schistosoma mansoni	cytosol alanyl aminopeptidase (M01 family)	0.0108	0.0171	0.016
Mycobacterium ulcerans	dehydrogenase	0.0084	0.007	0.0501
Echinococcus multilocularis	fmrfamide receptor	0.012	0.0221	0.0549
Leishmania major	aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1	0.0108	0.0171	1
Brugia malayi	neuropeptide F receptor	0.012	0.0221	0.0399
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.012	0.0221	0.0549
Loa Loa (eye worm)	hypothetical protein	0.012	0.0221	0.0408
Leishmania major	UDP-galactopyranose mutase	0.0084	0.007	0.314
Plasmodium vivax	hypothetical protein, conserved	0.0084	0.007	0.1734
Loa Loa (eye worm)	hypothetical protein	0.012	0.0221	0.0408
Loa Loa (eye worm)	hypothetical protein	0.012	0.0221	0.0408
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.012	0.0221	0.0399
Onchocerca volvulus		0.012	0.0221	0.0351
Loa Loa (eye worm)	hypothetical protein	0.012	0.0221	0.0408
Echinococcus multilocularis	fmrfamide receptor	0.012	0.0221	0.0549
Toxoplasma gondii	histone lysine-specific demethylase LSD1/BHC110/KDMA1A	0.0084	0.007	0.0741
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0278	0.088	0.9285
Schistosoma mansoni	hypothetical protein	0.0077	0.0038	0.0026
Loa Loa (eye worm)	hypothetical protein	0.012	0.0221	0.0408
Toxoplasma gondii	aldehyde dehydrogenase	0.0073	0.0024	0.0252
Schistosoma mansoni	tyrosine kinase	0.0136	0.0285	0.0274
Loa Loa (eye worm)	hypothetical protein	0.0222	0.0646	0.1235
Brugia malayi	Dopamine receptor	0.012	0.0221	0.0399
Echinococcus granulosus	lysine specific histone demethylase 1A	0.0084	0.007	0.0136
Schistosoma mansoni	biogenic amine (5HT) receptor	0.012	0.0221	0.021
Echinococcus multilocularis	Peptidase M1, membrane alanine aminopeptidase, N terminal	0.0108	0.0171	0.0424
Loa Loa (eye worm)	hypothetical protein	0.012	0.0221	0.0408
Schistosoma mansoni	amine oxidase	0.0084	0.007	0.0059
Schistosoma mansoni	adenoreceptor	0.012	0.0221	0.021
Schistosoma mansoni	neuropeptide f receptor 76f	0.012	0.0221	0.021
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.012	0.0221	0.0408
Loa Loa (eye worm)	TK/EGFR protein kinase	0.0136	0.0285	0.0533
Echinococcus granulosus	rhodopsin orphan GPCR	0.012	0.0221	0.0429
Brugia malayi	putative neuropeptide receptor NPR1	0.012	0.0221	0.0399
Loa Loa (eye worm)	G-protein coupled receptor	0.012	0.0221	0.0408
Mycobacterium tuberculosis	Probable zinc metalloprotease Zmp1	0.0294	0.0946	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.012	0.0221	0.0549
Echinococcus multilocularis	g protein coupled receptor	0.012	0.0221	0.0549
Echinococcus granulosus	puromycin sensitive aminopeptidase	0.0108	0.0171	0.0332
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0328	0.1088	0.3168
Brugia malayi	GnHR receptor homolog	0.012	0.0221	0.0399
Onchocerca volvulus		0.012	0.0221	0.0351
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0328	0.1088	0.3168
Loa Loa (eye worm)	hypothetical protein	0.012	0.0221	0.0408
Loa Loa (eye worm)	hypothetical protein	0.045	0.1602	0.3093
Schistosoma mansoni	hypothetical protein	0.0077	0.0038	0.0026
Schistosoma mansoni	endothelin-converting enzyme-related	0.0071	0.0016	0.0005
Plasmodium vivax	protoporphyrinogen oxidase, putative	0.0084	0.007	0.1734
Loa Loa (eye worm)	hypothetical protein	0.012	0.0221	0.0408
Loa Loa (eye worm)	peptidase family M13 containing protein	0.0217	0.0625	0.1193
Brugia malayi	amine oxidase, flavin-containing family protein	0.0119	0.0217	0.0391
Brugia malayi	G-protein coupled receptor	0.012	0.0221	0.0399
Echinococcus multilocularis	neuropeptides capa receptor	0.012	0.0221	0.0549
Onchocerca volvulus		0.045	0.1602	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.012	0.0221	0.021
Brugia malayi	RE15519p	0.012	0.0221	0.0399
Echinococcus multilocularis	neuropeptide Y receptor	0.012	0.0221	0.0549
Onchocerca volvulus		0.012	0.0221	0.0351
Trichomonas vaginalis	conserved hypothetical protein	0.0268	0.084	0.231
Mycobacterium ulcerans	flavin-containing monoamine oxidase AofH	0.0084	0.007	0.0501
Brugia malayi	Dopamine receptor protein 1	0.012	0.0221	0.0399
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.012	0.0221	0.0351
Loa Loa (eye worm)	hypothetical protein	0.0222	0.0646	0.1235
Loa Loa (eye worm)	hypothetical protein	0.0222	0.0646	0.1235
Loa Loa (eye worm)	hypothetical protein	0.0145	0.0326	0.0611
Echinococcus multilocularis	neuropeptide receptor	0.012	0.0221	0.0549
Loa Loa (eye worm)	hypothetical protein	0.0217	0.0625	0.1193
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.012	0.0221	0.021
Echinococcus granulosus	7tm_1 domain containing protein	0.012	0.0221	0.0429
Echinococcus granulosus	proprotein convertase subtilisin:kexin type 5	0.08	0.3065	0.5949
Echinococcus multilocularis	rhodopsin orphan GPCR	0.012	0.0221	0.0549
Echinococcus granulosus	rhodopsin orphan GPCR	0.012	0.0221	0.0429
Mycobacterium ulcerans	flavin-containing monoamine oxidase AofH	0.0084	0.007	0.0501
Mycobacterium ulcerans	aminopeptidase N PepN	0.0108	0.0171	0.1597
Schistosoma mansoni	neuropeptide F-like receptor	0.012	0.0221	0.021
Schistosoma mansoni	family M13 unassigned peptidase (M13 family)	0.0294	0.0946	0.0935
Trichomonas vaginalis	conserved hypothetical protein	0.0268	0.084	0.231
Schistosoma mansoni	hypothetical protein	0.012	0.0221	0.021
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.012	0.0221	0.0399
Loa Loa (eye worm)	hypothetical protein	0.0217	0.0625	0.1193
Schistosoma mansoni	myosin xvIII	0.012	0.0221	0.021
Trichomonas vaginalis	hypothetical protein	0.0268	0.084	0.231
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.012	0.0221	0.0429
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.012	0.0221	0.0549
Loa Loa (eye worm)	hypothetical protein	0.012	0.0221	0.0408
Echinococcus multilocularis	rhodopsin orphan GPCR	0.012	0.0221	0.0549
Brugia malayi	endoprotease bli-4 precursor	0.1299	0.5153	1
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.012	0.0221	0.021
Schistosoma mansoni	family M13 unassigned peptidase (M13 family)	0.0071	0.0016	0.0005
Loa Loa (eye worm)	hypothetical protein	0.012	0.0221	0.0408
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.012	0.0221	0.0549
Echinococcus multilocularis	G protein coupled receptor 139	0.012	0.0221	0.0549
Echinococcus granulosus	g protein coupled receptor	0.012	0.0221	0.0429
Schistosoma mansoni	opsin-like receptor	0.012	0.0221	0.021
Echinococcus granulosus	somatostatin receptor	0.012	0.0221	0.0429
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.012	0.0221	0.0549
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.012	0.0221	0.0429
Mycobacterium ulcerans	protoporphyrinogen oxidase	0.0084	0.007	0.0501
Echinococcus multilocularis	serotonin receptor	0.012	0.0221	0.0549
Schistosoma mansoni	family M13 non-peptidase homologue (M13 family)	0.0148	0.0337	0.0326
Loa Loa (eye worm)	hypothetical protein	0.012	0.0221	0.0408
Brugia malayi	hypothetical protein	0.0108	0.0171	0.0301
Brugia malayi	Serotonin receptor	0.012	0.0221	0.0399
Schistosoma mansoni	opsin-like receptor	0.012	0.0221	0.021
Loa Loa (eye worm)	hypothetical protein	0.012	0.0221	0.0408
Schistosoma mansoni	hypothetical protein	0.012	0.0221	0.021
Schistosoma mansoni	growth hormone secretagogue receptor	0.012	0.0221	0.021
Echinococcus granulosus	g-protein coupled receptor	0.012	0.0221	0.0429
Brugia malayi	proprotein convertase 2	0.0826	0.3175	0.615
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.012	0.0221	0.021
Echinococcus granulosus	puromycin sensitive aminopeptidase	0.0108	0.0171	0.0332
Loa Loa (eye worm)	hypothetical protein	0.0499	0.1804	0.3487
Toxoplasma gondii	peptidase family M13 protein	0.0294	0.0946	1
Schistosoma mansoni	hypothetical protein	0.0101	0.0141	0.013
Loa Loa (eye worm)	hypothetical protein	0.012	0.0221	0.0408
Schistosoma mansoni	serine-type protease inhibitor	0.1312	0.5207	0.5201
Onchocerca volvulus		0.012	0.0221	0.0351
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.012	0.0221	0.0549
Loa Loa (eye worm)	hypothetical protein	0.012	0.0221	0.0408
Mycobacterium tuberculosis	Possible oxidoreductase	0.0084	0.007	0.0501
Brugia malayi	SWIRM domain containing protein	0.045	0.1602	0.3087
Schistosoma mansoni	neuropeptide receptor	0.012	0.0221	0.021
Echinococcus multilocularis	neuroendocrine convertase 2	0.0826	0.3175	0.7879
Brugia malayi	hypothetical protein	0.0084	0.007	0.0105
Schistosoma mansoni	alpha-1 adrenergic receptor	0.012	0.0221	0.021
Brugia malayi	hypothetical protein	0.012	0.0221	0.0399
Schistosoma mansoni	amine GPCR	0.012	0.0221	0.021
Echinococcus multilocularis	neuropeptide Y receptor	0.012	0.0221	0.0549
Schistosoma mansoni	Lysine-specific histone demethylase 1	0.0415	0.1455	0.1445
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.012	0.0221	0.0399
Onchocerca volvulus		0.012	0.0221	0.0351
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.012	0.0221	0.021
Loa Loa (eye worm)	zinc metallopeptidase 4	0.0071	0.0016	0.0009
Schistosoma mansoni	neuropeptide receptor	0.012	0.0221	0.021
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.012	0.0221	0.0408
Echinococcus multilocularis		0.0084	0.007	0.0174
Echinococcus multilocularis	neuropeptide receptor A26	0.0567	0.2089	0.5183
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.0108	0.0171	0.0424
Echinococcus granulosus	biogenic amine 5HT receptor	0.012	0.0221	0.0429
Trichomonas vaginalis	neuroendocrine convertase 2 precursor, putative	0.0268	0.084	0.231
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.012	0.0221	0.021
Loa Loa (eye worm)	hypothetical protein	0.0222	0.0646	0.1235
Loa Loa (eye worm)	hypothetical protein	0.0084	0.007	0.0114
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.0108	0.0171	0.0424
Loa Loa (eye worm)	hypothetical protein	0.0222	0.0646	0.1235
Leishmania major	aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1	0.0108	0.0171	1
Onchocerca volvulus	CoRest homolog	0.0169	0.0424	0.1769
Schistosoma mansoni	family M13 unassigned peptidase (M13 family)	0.0148	0.0337	0.0326
Brugia malayi	Myb-like DNA-binding domain containing protein	0.0164	0.0404	0.0755
Loa Loa (eye worm)	hypothetical protein	0.0415	0.1455	0.2807
Loa Loa (eye worm)	hypothetical protein	0.0294	0.0946	0.1817
Trichomonas vaginalis	proprotein convertase subtilisin/kexin type, putative	0.0268	0.084	0.231
Plasmodium falciparum	dipeptidyl aminopeptidase 3	0.0164	0.0404	1
Brugia malayi	Furin-like cysteine rich region family protein	0.0136	0.0285	0.0524
Echinococcus granulosus	rhodopsin orphan GPCR	0.012	0.0221	0.0429
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.007	0.0011	0.0028
Onchocerca volvulus		0.012	0.0221	0.0351
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.012	0.0221	0.021
Toxoplasma gondii	histone lysine-specific demethylase	0.0084	0.007	0.0741
Brugia malayi	ORL1-like opioid receptor	0.012	0.0221	0.0399
Toxoplasma gondii	cathepsin CPC2	0.0164	0.0404	0.4273
Echinococcus granulosus	sex peptide receptor	0.012	0.0221	0.0429
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.012	0.0221	0.021
Loa Loa (eye worm)	proprotein convertase 2	0.0328	0.1088	0.2094
Loa Loa (eye worm)	endoprotease bli-4	0.1299	0.5153	1
Schistosoma mansoni	neuropeptide receptor	0.012	0.0221	0.021
Brugia malayi	hypothetical protein	0.012	0.0221	0.0399
Echinococcus multilocularis	neuropeptide s receptor	0.0567	0.2089	0.5183
Brugia malayi	hypothetical protein	0.012	0.0221	0.0399
Echinococcus granulosus	g protein coupled receptor	0.012	0.0221	0.0429
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0622	0.2322	0.5762
Echinococcus granulosus	neuropeptides capa receptor	0.012	0.0221	0.0429
Loa Loa (eye worm)	melatonin receptor type 1A	0.012	0.0221	0.0408
Echinococcus granulosus	Furin 1	0.0328	0.1088	0.2111
Echinococcus multilocularis	rhodopsin orphan GPCR	0.012	0.0221	0.0549
Echinococcus granulosus	neuropeptide Y receptor	0.012	0.0221	0.0429
Loa Loa (eye worm)	hypothetical protein	0.012	0.0221	0.0408
Onchocerca volvulus		0.0145	0.0326	0.1081
Schistosoma mansoni	hypothetical protein	0.0077	0.0038	0.0026
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.012	0.0221	0.021
Echinococcus granulosus	rhodopsin orphan GPCR	0.012	0.0221	0.0429
Onchocerca volvulus		0.012	0.0221	0.0351
Trypanosoma cruzi	aminopeptidase, putative	0.0108	0.0171	1
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.0108	0.0171	0.0424
Brugia malayi	G protein-coupled receptor F59B2.13	0.012	0.0221	0.0399
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.012	0.0221	0.0408
Schistosoma mansoni	hypothetical protein	0.0077	0.0038	0.0026
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.08	0.3065	1
Schistosoma mansoni	hypothetical protein	0.0268	0.084	0.0829
Schistosoma mansoni	hypothetical protein	0.012	0.0221	0.021
Loa Loa (eye worm)	hypothetical protein	0.012	0.0221	0.0408
Loa Loa (eye worm)	hypothetical protein	0.012	0.0221	0.0408
Trypanosoma cruzi	UDP-galactopyranose mutase	0.0084	0.007	0.3677
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0073	0.0024	0.0059
Loa Loa (eye worm)	hypothetical protein	0.0169	0.0424	0.0803
Trypanosoma brucei	metallo-peptidase, Clan MA(E) Family M1	0.0108	0.0171	1
Brugia malayi	Peptidase family M13 containing protein	0.0294	0.0946	0.1809
Echinococcus multilocularis	serotonin receptor	0.012	0.0221	0.0549
Schistosoma mansoni	Protoporphyrinogen oxidase chloroplast/mitochondrial precursor	0.0084	0.007	0.0059
Plasmodium falciparum	protoporphyrinogen oxidase	0.0084	0.007	0.1734
Schistosoma mansoni	amine GPCR	0.012	0.0221	0.021
Echinococcus multilocularis	proprotein convertase subtilisin:kexin type 5	0.08	0.3065	0.7606
Trichomonas vaginalis	conserved hypothetical protein	0.0268	0.084	0.231
Loa Loa (eye worm)	hypothetical protein	0.0294	0.0946	0.1817
Plasmodium falciparum	conserved Plasmodium protein, unknown function	0.0084	0.007	0.1734
Echinococcus granulosus	tm gpcr rhodopsin	0.012	0.0221	0.0429
Mycobacterium ulcerans	oxidoreductase	0.0084	0.007	0.0501
Echinococcus multilocularis	sex peptide receptor	0.012	0.0221	0.0549
Echinococcus multilocularis	dro:myosuppressin receptor	0.012	0.0221	0.0549
Brugia malayi	Melatonin receptor type 1A	0.012	0.0221	0.0399
Trichomonas vaginalis	conserved hypothetical protein	0.0268	0.084	0.231
Loa Loa (eye worm)	hypothetical protein	0.012	0.0221	0.0408
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.012	0.0221	0.021
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.012	0.0221	0.0549
Echinococcus multilocularis	rhodopsin orphan GPCR	0.012	0.0221	0.0549
Schistosoma mansoni	opsin-like receptor	0.012	0.0221	0.021
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.012	0.0221	0.021
Loa Loa (eye worm)	hypothetical protein	0.012	0.0221	0.0408
Onchocerca volvulus		0.0369	0.1259	0.7608
Loa Loa (eye worm)	hypothetical protein	0.012	0.0221	0.0408
Schistosoma mansoni	neuropeptide receptor	0.012	0.0221	0.021
Echinococcus granulosus	hypothetical protein	0.012	0.0221	0.0429
Echinococcus multilocularis		0.103	0.403	1
Echinococcus granulosus	neuropeptide receptor A26	0.0567	0.2089	0.4054
Echinococcus granulosus	endothelin converting enzyme 1	0.0294	0.0946	0.1835
Echinococcus granulosus	rhodopsin orphan GPCR	0.012	0.0221	0.0429
Echinococcus granulosus	neuropeptide FF receptor 2	0.0349	0.1176	0.2283
Loa Loa (eye worm)	hypothetical protein	0.012	0.0221	0.0408
Echinococcus granulosus	fmrfamide receptor	0.012	0.0221	0.0429
Loa Loa (eye worm)	neuropeptide F receptor	0.012	0.0221	0.0408
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0328	0.1088	0.3168
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.012	0.0221	0.0429
Loa Loa (eye worm)	peptidase family M1 containing protein	0.0298	0.0965	0.1855
Schistosoma mansoni	hypothetical protein	0.0077	0.0038	0.0026
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0328	0.1088	0.3168
Brugia malayi	celfurPC protein	0.103	0.403	0.7814
Schistosoma mansoni	serine-type protease inhibitor	0.1312	0.5207	0.5201
Schistosoma mansoni	biogenic amine receptor	0.012	0.0221	0.021
Chlamydia trachomatis	protoporphyrinogen oxidase	0.0084	0.007	0.5
Echinococcus granulosus	neuroendocrine convertase 2	0.0826	0.3175	0.6162
Schistosoma mansoni	Nep2 peptidase (M13 family)	0.0148	0.0337	0.0326
Echinococcus granulosus	neuropeptides capa receptor	0.012	0.0221	0.0429
Mycobacterium ulcerans	zinc metalloprotease	0.0294	0.0946	1
Onchocerca volvulus		0.012	0.0221	0.0351
Schistosoma mansoni	family M13 unassigned peptidase (M13 family)	0.0071	0.0016	0.0005
Schistosoma mansoni	biogenic amine receptor	0.012	0.0221	0.021
Echinococcus granulosus	rhodopsin orphan GPCR	0.012	0.0221	0.0429
Brugia malayi	hypothetical protein	0.012	0.0221	0.0399
Echinococcus multilocularis	allatostatin A receptor	0.012	0.0221	0.0549
Loa Loa (eye worm)	hypothetical protein	0.0415	0.1455	0.2807
Schistosoma mansoni	aminopeptidase PILS (M01 family)	0.0108	0.0171	0.016
Loa Loa (eye worm)	hypothetical protein	0.012	0.0221	0.0408
Brugia malayi	larval opioid receptor	0.012	0.0221	0.0399
Loa Loa (eye worm)	hypothetical protein	0.0164	0.0404	0.0764
Loa Loa (eye worm)	TYRA-2 protein	0.012	0.0221	0.0408
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.012	0.0221	0.0549
Echinococcus multilocularis	g-protein coupled receptor	0.012	0.0221	0.0549
Echinococcus multilocularis	neuropeptides capa receptor	0.012	0.0221	0.0549
Echinococcus multilocularis	protoporphyrinogen oxidase	0.0084	0.007	0.0174
Onchocerca volvulus	Neuropeptide F receptor homolog	0.012	0.0221	0.0351
Trichomonas vaginalis	conserved hypothetical protein	0.0268	0.084	0.231
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.08	0.3065	1
Loa Loa (eye worm)	hypothetical protein	0.0222	0.0646	0.1235
Loa Loa (eye worm)	hypothetical protein	0.012	0.0221	0.0408
Schistosoma mansoni	hypothetical protein	0.012	0.0221	0.021
Trypanosoma cruzi	UDP-galactopyranose mutase	0.0084	0.007	0.3677
Brugia malayi	hypothetical protein	0.012	0.0221	0.0399
Echinococcus multilocularis	rhodopsin orphan GPCR	0.012	0.0221	0.0549
Echinococcus granulosus	alpha 1A adrenergic receptor	0.012	0.0221	0.0429
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.012	0.0221	0.0429
Echinococcus multilocularis	endothelin converting enzyme 1	0.0294	0.0946	0.2346
Loa Loa (eye worm)	hypothetical protein	0.0084	0.007	0.0114
Schistosoma mansoni	biogenic amine receptor	0.012	0.0221	0.021
Loa Loa (eye worm)	hypothetical protein	0.033	0.11	0.2117
Onchocerca volvulus		0.012	0.0221	0.0351
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.012	0.0221	0.021
Trypanosoma cruzi	metallo-peptidase, clan MA(E), family M1, putative	0.0108	0.0171	1
Loa Loa (eye worm)	hypothetical protein	0.012	0.0221	0.0408
Echinococcus multilocularis	g protein coupled receptor	0.012	0.0221	0.0549
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.012	0.0221	0.021
Schistosoma mansoni	aldehyde dehydrogenase	0.0073	0.0024	0.0013
Plasmodium vivax	dipeptidyl aminopeptidase 3, putative	0.0164	0.0404	1
Plasmodium vivax	lysine-specific histone demethylase 1, putative	0.0084	0.007	0.1734
Schistosoma mansoni	aldehyde dehydrogenase	0.0073	0.0024	0.0013
Echinococcus granulosus	orexin receptor type 2	0.012	0.0221	0.0429
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0084	0.007	0.0501
Schistosoma mansoni	hypothetical protein	0.0077	0.0038	0.0026
Loa Loa (eye worm)	hypothetical protein	0.012	0.0221	0.0408
Loa Loa (eye worm)	hypothetical protein	0.012	0.0221	0.0408
Brugia malayi	Peptidase family M1 containing protein	0.0108	0.0171	0.0301
Echinococcus granulosus	dro:myosuppressin receptor	0.012	0.0221	0.0429
Schistosoma mansoni	neprilysin	0.0077	0.0038	0.0026
Loa Loa (eye worm)	hypothetical protein	0.012	0.0221	0.0408
Echinococcus granulosus	serotonin receptor	0.012	0.0221	0.0429
Loa Loa (eye worm)	neuropeptide F receptor	0.012	0.0221	0.0408
Schistosoma mansoni	family M13 unassigned peptidase (M13 family)	0.0148	0.0337	0.0326
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.012	0.0221	0.021
Echinococcus granulosus	epidermal growth factor receptor	0.0136	0.0285	0.0553
Loa Loa (eye worm)	hypothetical protein	0.012	0.0221	0.0408
Schistosoma mansoni	amine oxidase	0.0084	0.007	0.0059
Mycobacterium ulcerans	monoamine oxidase	0.0084	0.007	0.0501
Onchocerca volvulus		0.012	0.0221	0.0351
Loa Loa (eye worm)	hypothetical protein	0.0217	0.0625	0.1193
Entamoeba histolytica	aminopeptidase, putative	0.0108	0.0171	0.5
Schistosoma mansoni	neprilysin-2 (M13 family)	0.0148	0.0337	0.0326
Brugia malayi	AKH receptor	0.012	0.0221	0.0399
Loa Loa (eye worm)	hypothetical protein	0.012	0.0221	0.0408
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.012	0.0221	0.0549
Trichomonas vaginalis	conserved hypothetical protein	0.0268	0.084	0.231
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.012	0.0221	0.0408
Echinococcus multilocularis	rhodopsin orphan GPCR	0.012	0.0221	0.0549
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.012	0.0221	0.021
Echinococcus granulosus	biogenic amine 5HT receptor	0.012	0.0221	0.0429
Echinococcus multilocularis	G-protein coupled receptor, putative	0.012	0.0221	0.0549
Echinococcus multilocularis	g protein coupled receptor	0.012	0.0221	0.0549
Schistosoma mansoni	furin-1 (S08 family)	0.0558	0.2052	0.2043
Loa Loa (eye worm)	hypothetical protein	0.0119	0.0217	0.04
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0349	0.1176	0.2919
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0328	0.1088	0.3168
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.012	0.0221	0.0429
Echinococcus multilocularis	epidermal growth factor receptor	0.0136	0.0285	0.0708
Echinococcus multilocularis	Furin 1	0.0328	0.1088	0.2699
Onchocerca volvulus		0.012	0.0221	0.0351
Onchocerca volvulus		0.012	0.0221	0.0351
Brugia malayi	Hypothetical zinc metalloproteinase T16A9.4	0.0294	0.0946	0.1809
Schistosoma mansoni	amine GPCR	0.012	0.0221	0.021
Brugia malayi	sulfakinin receptor protein	0.012	0.0221	0.0399
Brugia malayi	hypothetical protein	0.012	0.0221	0.0399
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.012	0.0221	0.0408
Brugia malayi	neuropeptide F receptor	0.012	0.0221	0.0399
Plasmodium vivax	hypothetical protein, conserved	0.0084	0.007	0.1734
Onchocerca volvulus		0.012	0.0221	0.0351
Brugia malayi	putative neuropeptide receptor	0.012	0.0221	0.0399
Loa Loa (eye worm)	hypothetical protein	0.012	0.0221	0.0408
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.012	0.0221	0.021
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.012	0.0221	0.021
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0328	0.1088	0.3168
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.012	0.0221	0.021
Loa Loa (eye worm)	hypothetical protein	0.012	0.0221	0.0408
Echinococcus granulosus	7TM GPCR rhodopsin	0.012	0.0221	0.0429
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.0108	0.0171	0.0424
Brugia malayi	G protein-coupled receptor	0.012	0.0221	0.0399
Echinococcus granulosus	tm gpcr rhodopsin	0.012	0.0221	0.0429
Loa Loa (eye worm)	G-protein coupled receptor	0.012	0.0221	0.0408
Brugia malayi	Serotonin receptor	0.012	0.0221	0.0399
Loa Loa (eye worm)	hypothetical protein	0.012	0.0221	0.0408
Echinococcus multilocularis	lysine specific histone demethylase 1A	0.0415	0.1455	0.361
Schistosoma mansoni	neuropeptide F-like receptor	0.012	0.0221	0.021
Loa Loa (eye worm)	hypothetical protein	0.012	0.0221	0.0408
Loa Loa (eye worm)	hypothetical protein	0.012	0.0221	0.0408
Loa Loa (eye worm)	hypothetical protein	0.012	0.0221	0.0408
Loa Loa (eye worm)	hypothetical protein	0.0349	0.1176	0.2266
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.012	0.0221	0.021
Echinococcus granulosus	peptide allatostatin:somatostatin	0.012	0.0221	0.0429
Schistosoma mansoni	family M13 unassigned peptidase (M13 family)	0.0071	0.0016	0.0005
Plasmodium falciparum	lysine-specific histone demethylase 1, putative	0.0084	0.007	0.1734
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.012	0.0221	0.021
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.012	0.0221	0.0399
Loa Loa (eye worm)	hypothetical protein	0.012	0.0221	0.0408
Trichomonas vaginalis	conserved hypothetical protein	0.0268	0.084	0.231
Loa Loa (eye worm)	hypothetical protein	0.012	0.0221	0.0408
Loa Loa (eye worm)	hypothetical protein	0.0294	0.0946	0.1817

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	2.0787 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference
Potency (functional)	= 2.5119 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))]	ChEMBL.	No reference
Potency (functional)	= 5.6234 um	PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))]	ChEMBL.	No reference
Potency (functional)	12.5893 uM	PubChem BioAssay. qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	= 56.2341 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human alpha-Glucosidase as a Potential Chaperone Treatment of Pompe Disease. (Class of assay: confirmatory) [Related pubchem assays: 997 ]	ChEMBL.	No reference
Potency (functional)	= 56.2341 um	PUBCHEM_BIOASSAY: qHTS Assay for Activators of Human alpha-Glucosidase as a Potential Chaperone Treatment of Pompe Disease. (Class of assay: confirmatory) [Related pubchem assays: 1467, 2100, 2112, 1473, 1466 ]	ChEMBL.	No reference
Potency (functional)	79.4328 uM	PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Plasmodium falciparum	ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1499149

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1371183