Detailed information for compound 1371294

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 488.416 | Formula: C23H19F3N4O5
  • H donors: 2 H acceptors: 2 LogP: 4.02 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(c1cc2n(n1)C(CC(N2)c1ccc2c(c1)OCO2)C(F)(F)F)NCc1ccc2c(c1)OCO2
  • InChi: 1S/C23H19F3N4O5/c24-23(25,26)20-7-14(13-2-4-17-19(6-13)35-11-33-17)28-21-8-15(29-30(20)21)22(31)27-9-12-1-3-16-18(5-12)34-10-32-16/h1-6,8,14,20,28H,7,9-11H2,(H,27,31)
  • InChiKey: FSNGQUKXWUDMST-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens tumor protein p53 Starlite/ChEMBL No references
Homo sapiens nuclear factor, erythroid 2-like 2 Starlite/ChEMBL No references
Homo sapiens ubiquitin specific peptidase 2 Starlite/ChEMBL No references
Mus musculus RAR-related orphan receptor gamma Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) Get druggable targets OG5_127431 All targets in OG5_127431
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127431 All targets in OG5_127431
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase Get druggable targets OG5_127431 All targets in OG5_127431
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus multilocularis ubiquitin specific protease 41 Get druggable targets OG5_127431 All targets in OG5_127431
Trypanosoma brucei gambiense ubiquitin carboxyl-terminal hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_127431 All targets in OG5_127431
Leishmania infantum ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma japonicum IPR001394,Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2,domain-containing Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus granulosus ubiquitin specific protease 41 Get druggable targets OG5_127431 All targets in OG5_127431
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma japonicum Ubiquitin carboxyl-terminal hydrolase 8, putative Get druggable targets OG5_127431 All targets in OG5_127431
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 Get druggable targets OG5_127431 All targets in OG5_127431
Leishmania braziliensis ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Leishmania donovani ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 Get druggable targets OG5_127431 All targets in OG5_127431
Candida albicans ubiquitin-specific protease Get druggable targets OG5_127431 All targets in OG5_127431
Cryptosporidium parvum ubiquitin C-terminal hydrolase of the cysteine proteinase fold Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus granulosus tumor protein p63 Get druggable targets OG5_140038 All targets in OG5_140038
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase Get druggable targets OG5_127431 All targets in OG5_127431
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein Get druggable targets OG5_127431 All targets in OG5_127431
Cryptosporidium hominis ubiquitin specific protease 66 Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma japonicum ko:K01072 ubiquitin thiolesterase [EC3.1.2.15], putative Get druggable targets OG5_127431 All targets in OG5_127431
Trypanosoma congolense ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma japonicum IPR015063,Domain of unknown function DUF1873,domain-containing Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma japonicum hypothetical protein Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma japonicum expressed protein Get druggable targets OG5_127431 All targets in OG5_127431
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus multilocularis tumor protein p63 Get druggable targets OG5_140038 All targets in OG5_140038
Schistosoma japonicum Ubiquitin carboxyl-terminal hydrolase 8, putative Get druggable targets OG5_127431 All targets in OG5_127431
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Leishmania mexicana ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Plasmodium falciparum ubiquitin specific protease, putative ubiquitin specific peptidase 2 362 aa 378 aa 25.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.007 0.0054
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0007 0.0024 0.0008
Echinococcus multilocularis dnaJ subfamily B 0.0383 0.3167 0.3156
Schistosoma mansoni retinoic acid receptor RXR 0.0012 0.007 0.007
Echinococcus granulosus ecdysone induced protein 78C 0.0012 0.007 0.0054
Schistosoma mansoni nuclear hormone receptor 0.0006 0.0016 0.0016
Loa Loa (eye worm) hypothetical protein 0.0006 0.0022 0.0006
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0012 0.007 0.0054
Brugia malayi hypothetical protein 0.0006 0.0022 0.0006
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0045 0.0341 0.5
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0012 0.007 0.0054
Schistosoma mansoni cpg binding protein 0.0027 0.0192 0.0192
Loa Loa (eye worm) hypothetical protein 0.0012 0.007 0.0054
Echinococcus granulosus ubiquitin specific protease 41 0.0045 0.0341 0.0326
Brugia malayi Nuclear hormone receptor-like 1 0.0006 0.0022 0.0006
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0012 0.007 0.0054
Schistosoma mansoni nuclear hormone receptor 0.0012 0.007 0.007
Loa Loa (eye worm) hypothetical protein 0.0012 0.007 0.0054
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0363 0.3004 1
Brugia malayi F/Y-rich N-terminus family protein 0.0008 0.0036 0.0021
Schistosoma mansoni hypothetical protein 0.0043 0.0331 0.0331
Schistosoma mansoni steroid hormone receptor ad4bp 0.0012 0.007 0.007
Schistosoma mansoni thyroid hormone receptor 0.0012 0.007 0.007
Echinococcus multilocularis ubiquitin specific protease 41 0.0045 0.0341 0.0326
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0012 0.007 0.0054
Loa Loa (eye worm) STE/STE11/ASK protein kinase 0.0363 0.3004 0.2997
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0045 0.0341 1
Loa Loa (eye worm) histone methyltransferase 0.0008 0.0037 0.0021
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0012 0.007 0.007
Echinococcus multilocularis thyroid hormone receptor alpha 0.0012 0.007 0.0054
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0012 0.007 0.1195
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0363 0.3004 1
Brugia malayi ecdysteroid receptor 0.0012 0.007 0.0054
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0012 0.007 0.0054
Schistosoma mansoni RAR-like nuclear receptor 0.0012 0.007 0.007
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0006 0.0022 0.0006
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0012 0.007 0.0054
Schistosoma mansoni zinc finger protein 0.0006 0.0016 0.0016
Brugia malayi nuclear hormone receptor 0.0012 0.007 0.0054
Onchocerca volvulus 0.0012 0.007 0.1195
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0045 0.0341 0.5
Onchocerca volvulus Bile acid receptor homolog 0.0012 0.007 0.1195
Schistosoma mansoni nuclear receptor 0.0006 0.0016 0.0016
Echinococcus granulosus mixed lineage leukemia protein mll 0.0007 0.0024 0.0008
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.007 0.0054
Brugia malayi hypothetical protein 0.0006 0.0022 0.0006
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0012 0.007 0.007
Loa Loa (eye worm) hypothetical protein 0.0006 0.0022 0.0006
Loa Loa (eye worm) hypothetical protein 0.0012 0.007 0.0054
Loa Loa (eye worm) hypothetical protein 0.0012 0.007 0.0054
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.007 0.0054
Loa Loa (eye worm) CXXC zinc finger family protein 0.0027 0.0192 0.0177
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0006 0.0022 0.0006
Loa Loa (eye worm) hypothetical protein 0.0361 0.2989 0.2982
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0012 0.007 0.0054
Loa Loa (eye worm) hypothetical protein 0.0045 0.0341 0.0326
Loa Loa (eye worm) hypothetical protein 0.0152 0.1238 0.1226
Brugia malayi Nuclear hormone receptor-like 1 0.0012 0.007 0.0054
Schistosoma mansoni coup transcription factor 0.0012 0.007 0.007
Echinococcus granulosus tumor protein p63 0.0408 0.3379 0.3369
Onchocerca volvulus 0.0027 0.0192 0.3912
Loa Loa (eye worm) hypothetical protein 0.0006 0.0022 0.0006
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0045 0.0341 1
Loa Loa (eye worm) hypothetical protein 0.0006 0.0022 0.0006
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0012 0.007 0.0054
Schistosoma mansoni nuclear receptor nhr-48 0.0006 0.0016 0.0016
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.007 0.0054
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0012 0.007 0.0054
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.007 0.0054
Echinococcus granulosus cpg binding protein 0.0028 0.0205 0.019
Loa Loa (eye worm) hypothetical protein 0.0012 0.007 0.0054
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0045 0.0341 0.0326
Schistosoma mansoni nuclear receptor 0.0006 0.0016 0.0016
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.007 0.0054
Brugia malayi Steroid receptor seven-up type 2 0.0012 0.007 0.0054
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0012 0.007 0.0054
Schistosoma mansoni nuclear hormone receptor 0.0006 0.0016 0.0016
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0012 0.007 0.0054
Echinococcus multilocularis cpg binding protein 0.0028 0.0205 0.019
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0012 0.007 0.0054
Toxoplasma gondii histone lysine methyltransferase SET1 0.0051 0.0393 0.5
Schistosoma mansoni cpg binding protein 0.0028 0.0205 0.0205
Onchocerca volvulus 0.006 0.0467 1
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0006 0.0016 0.0016
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0012 0.007 0.0054
Brugia malayi nuclear receptor RXR 0.0006 0.0022 0.0006
Schistosoma mansoni protein kinase 0.12 1 1
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0045 0.0341 0.5
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.007 0.0054
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0057 0.0444 0.0444
Loa Loa (eye worm) hypothetical protein 0.006 0.0467 0.0453
Schistosoma mansoni transcription factor LCR-F1 0.0043 0.0331 0.0331
Loa Loa (eye worm) hypothetical protein 0.0006 0.0022 0.0006
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0006 0.0022 0.0006
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0008 0.0037 0.0021
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0759 0.6311 0.6305
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0006 0.0016 0.0016
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0006 0.0022 0.0022
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0012 0.007 0.007
Brugia malayi nuclear receptor NHR-88 0.0012 0.007 0.0054
Brugia malayi photoreceptor-specific nuclear receptor 0.0012 0.007 0.0054
Loa Loa (eye worm) hypothetical protein 0.0012 0.007 0.0054
Loa Loa (eye worm) steroid hormone receptor 0.0012 0.007 0.0054
Echinococcus multilocularis ecdysone induced protein 78C 0.0012 0.007 0.0054
Loa Loa (eye worm) hypothetical protein 0.0012 0.007 0.0054
Brugia malayi steroid hormone receptor 0.0012 0.007 0.0054
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0007 0.0024 0.0024
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0012 0.007 0.007
Echinococcus granulosus FTZ F1 alpha 0.0012 0.007 0.0054
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0045 0.0341 0.0326
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0012 0.007 0.0054
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0012 0.007 0.0054
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.0341 1
Echinococcus multilocularis FTZ F1 alpha 0.0012 0.007 0.0054
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0043 0.0331 0.0316
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0012 0.007 0.0054
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0012 0.007 0.0054
Loa Loa (eye worm) hypothetical protein 0.1198 0.9985 1
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0045 0.0341 0.0326
Brugia malayi hypothetical protein 0.0043 0.0331 0.0316
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.007 0.0054
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0012 0.007 0.007
Onchocerca volvulus Protein ultraspiracle homolog 0.0012 0.007 0.1195
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0012 0.007 0.0054
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0045 0.0341 1
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0012 0.007 0.0054
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.12 1 1
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0045 0.0341 0.0341
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0012 0.007 0.0054
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0045 0.0341 0.0326
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0043 0.0331 0.0316
Echinococcus multilocularis tumor protein p63 0.0408 0.3379 0.3369
Schistosoma mansoni protein kinase 0.12 1 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0012 0.007 0.0054
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.12 1 1
Brugia malayi Nuclear hormone receptor-like 1 0.0006 0.0022 0.0006
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0012 0.007 0.0054
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0007 0.0024 0.0008
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0012 0.007 0.0054
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0012 0.007 0.007
Echinococcus granulosus dnaJ subfamily B 0.0383 0.3167 0.3156
Brugia malayi Probable ATP-dependent helicase DHX35 0.0152 0.1238 0.1224
Brugia malayi CXXC zinc finger family protein 0.0027 0.0192 0.0177
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0045 0.0341 0.0341
Schistosoma mansoni thyroid hormone receptor 0.0012 0.007 0.007
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.007 0.0054
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0008 0.0037 0.0021
Schistosoma mansoni peptidase 0.0005 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.0012 0.007 0.0054
Schistosoma mansoni cellular tumor antigen P53 0.006 0.0467 0.0467
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.007 0.0054
Schistosoma mansoni cpg binding protein 0.0028 0.0205 0.0205
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0007 0.0024 0.0008
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0006 0.0022 0.0022
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0045 0.0341 0.0326
Schistosoma mansoni hypothetical protein 0.0383 0.3167 0.3167
Loa Loa (eye worm) DEAH box polypeptide 35 0.0152 0.1238 0.1226

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 1.1689 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 2.31 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) = 3.5481 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 10 uM PUBCHEM_BIOASSAY: qHTS assay for re-activators of p53 using a Luc reporter. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504709] ChEMBL. No reference
Potency (functional) 11.5821 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) = 12.5893 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Ubiquitin-specific Protease USP2a. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 22.3872 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (without detergent). (Class of assay: confirmatory) [Related pubchem assays: 2158 (Confirmation qHTS Assay for Inhibitors of Cruzain), 2249 (Probe Development Summary of Promiscuous Inhibitors (Artifacts) of Cruzain), 2161 (qHTS Assay for Inhibitors of Papain: Counterscreen for Cruzain Assay), 1478 (qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (with detergent))] ChEMBL. No reference
Potency (functional) 56.2341 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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