Detailed information for compound 1376876

Basic information

Technical information
  • TDR Targets ID: 1376876
  • Name: N-(3-chloro-4-fluorophenyl)-2-[4-(1,3,4-oxadi azol-2-yl)phenoxy]acetamide
  • MW: 347.728 | Formula: C16H11ClFN3O3
  • H donors: 1 H acceptors: 3 LogP: 3.02 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(Nc1ccc(c(c1)Cl)F)COc1ccc(cc1)c1nnco1
  • InChi: 1S/C16H11ClFN3O3/c17-13-7-11(3-6-14(13)18)20-15(22)8-23-12-4-1-10(2-5-12)16-21-19-9-24-16/h1-7,9H,8H2,(H,20,22)
  • InChiKey: WDHHDWDNJKAGEW-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(3-chloro-4-fluoro-phenyl)-2-[4-(1,3,4-oxadiazol-2-yl)phenoxy]acetamide
  • N-(3-chloro-4-fluoro-phenyl)-2-[4-(1,3,4-oxadiazol-2-yl)phenoxy]ethanamide
  • T5334557
  • ZINC03533885

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Trypanosoma brucei gambiense ATP-dependent phosphofructokinase,6-phospho-1-fructokinase No references
Homo sapiens GNAS complex locus Starlite/ChEMBL No references
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal Starlite/ChEMBL No references
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Candida albicans phosphofructokinase alpha subunit that can functionally substitute for S. cerevisiae PFK1 (YGR240C) Get druggable targets OG5_126758 All targets in OG5_126758
Trypanosoma congolense ATP-dependent 6-phosphofructokinase, glycosomal Get druggable targets OG5_126758 All targets in OG5_126758
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase Get druggable targets OG5_126758 All targets in OG5_126758
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) phosphofructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Brugia malayi phosphofructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Trichomonas vaginalis phosphofructokinase, putative Get druggable targets OG5_126758 All targets in OG5_126758
Brugia malayi 6-phosphofructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Entamoeba histolytica phosphofructokinase, putative Get druggable targets OG5_126758 All targets in OG5_126758
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis 6 phosphofructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Leishmania infantum ATP-dependent phosphofructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Brugia malayi 6-phosphofructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Entamoeba histolytica phosphofructokinase, putative Get druggable targets OG5_126758 All targets in OG5_126758
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) Get druggable targets OG5_126758 All targets in OG5_126758
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal Get druggable targets OG5_126758 All targets in OG5_126758
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Mycobacterium ulcerans 6-phosphofructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Leishmania mexicana 6-phospho-1-fructokinase, putative Get druggable targets OG5_126758 All targets in OG5_126758
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni 6-phosphofructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Candida albicans phosphofructokinase beta-subunit that can functionally substitute for S. cerevisiae PFK2 (YMR205C) Get druggable targets OG5_126758 All targets in OG5_126758
Schistosoma mansoni 6-phosphofructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Trichomonas vaginalis phosphofructokinase, putative Get druggable targets OG5_126758 All targets in OG5_126758
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Candida albicans hypothetical protein Get druggable targets OG5_126758 All targets in OG5_126758
Entamoeba histolytica phosphofructokinase, putative Get druggable targets OG5_126758 All targets in OG5_126758
Loa Loa (eye worm) 6-phosphofructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Trypanosoma brucei gambiense ATP-dependent phosphofructokinase,6-phospho-1-fructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Leishmania donovani ATP-dependent 6-phosphofructokinase, glycosomal Get druggable targets OG5_126758 All targets in OG5_126758
Leishmania braziliensis ATP-dependent phosphofructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal Get druggable targets OG5_126758 All targets in OG5_126758
Candida albicans phosphofructokinase beta-subunit that can functionally substitute for S. cerevisiae PFK2 (YMR205C) Get druggable targets OG5_126758 All targets in OG5_126758
Echinococcus granulosus 6 phosphofructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Candida albicans phosphofructokinase alpha subunit that can functionally substitute for S. cerevisiae PFK1 (YGR240C) Get druggable targets OG5_126758 All targets in OG5_126758
Loa Loa (eye worm) 6-phosphofructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Trichomonas vaginalis phosphofructokinase, putative Get druggable targets OG5_126758 All targets in OG5_126758
Schistosoma japonicum ko:K00850 6-phosphofructokinase [EC2.7.1.11], putative Get druggable targets OG5_126758 All targets in OG5_126758
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) Get druggable targets OG5_126758 All targets in OG5_126758
Trichomonas vaginalis phosphofructokinase, putative Get druggable targets OG5_126758 All targets in OG5_126758
Leishmania major ATP-dependent phosphofructokinase Get druggable targets OG5_126758 All targets in OG5_126758
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0035 0.0466 0.5
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.0971 0.2109
Onchocerca volvulus 0.0015 0.0044 0.0129
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0015 0.0044 0.0099
Loa Loa (eye worm) hypothetical protein 0.0015 0.0044 0.0099
Loa Loa (eye worm) follicle stimulating hormone receptor 0.023 0.4438 1
Onchocerca volvulus 0.0079 0.1354 0.398
Echinococcus multilocularis protein tyrosine phosphatase n9 0.0015 0.0044 0.0044
Loa Loa (eye worm) hypothetical protein 0.0074 0.1257 0.2833
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0131 0.2419 1
Schistosoma mansoni protein tyrosine phosphatase 0.0019 0.0141 0.0409
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0019 0.0141 0.0409
Loa Loa (eye worm) hypothetical protein 0.0015 0.0044 0.0099
Echinococcus multilocularis receptor type tyrosine protein phosphatase H 0.0015 0.0044 0.0044
Schistosoma mansoni hypothetical protein 0.0019 0.0132 0.0371
Loa Loa (eye worm) fibronectin type III domain-containing protein 0.0019 0.0141 0.0318
Trichomonas vaginalis phosphofructokinase, putative 0.0035 0.0466 0.1928
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0035 0.0466 0.5
Onchocerca volvulus 0.0015 0.0044 0.0129
Trypanosoma cruzi tyrosine specific protein phosphatase, putative 0.0015 0.0044 0.0181
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0057 0.0906 0.1963
Entamoeba histolytica phosphofructokinase, putative 0.0131 0.2419 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.0044 0.0099
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0015 0.0044 0.0044
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0035 0.0466 0.1779
Schistosoma mansoni 6-phosphofructokinase 0.0131 0.2419 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.0044 0.0099
Echinococcus multilocularis receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type 0.0019 0.0141 0.0142
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.087 0.0878
Echinococcus multilocularis GPCR, family 2 0.0019 0.0132 0.0133
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0131 0.2419 1
Echinococcus granulosus single minded 2 0.0036 0.0474 0.0474
Brugia malayi Cytochrome P450 family protein 0.0049 0.0732 0.1567
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0015 0.0044 0.0044
Loa Loa (eye worm) hypothetical protein 0.0015 0.0044 0.0099
Onchocerca volvulus 0.0015 0.0044 0.0129
Loa Loa (eye worm) hypothetical protein 0.006 0.0971 0.2187
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0015 0.0044 0.0044
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0057 0.0906 0.2226
Onchocerca volvulus 0.0015 0.0044 0.0129
Loa Loa (eye worm) hypoxia-induced factor 1 0.015 0.2795 0.6299
Onchocerca volvulus 0.0015 0.0044 0.0129
Leishmania major protein-tyrosine phosphatase 1-like protein 0.0015 0.0044 0.0181
Loa Loa (eye worm) protein-tyrosine phosphatase 1 0.0015 0.0044 0.0099
Echinococcus multilocularis 0.0015 0.0044 0.0044
Loa Loa (eye worm) hypothetical protein 0.0015 0.0044 0.0099
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0019 0.0132 0.0132
Onchocerca volvulus 0.0015 0.0044 0.0129
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0015 0.0044 0.0099
Loa Loa (eye worm) hypothetical protein 0.0074 0.1257 0.2833
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0035 0.0466 1
Loa Loa (eye worm) 6-phosphofructokinase 0.0131 0.2419 0.545
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0015 0.0044 0.0044
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0015 0.0044 0.0099
Loa Loa (eye worm) hypothetical protein 0.0015 0.0044 0.0099
Schistosoma mansoni 6-phosphofructokinase 0.0131 0.2419 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.0019 0.0132 0.0297
Loa Loa (eye worm) protein tyrosine phosphatase 0.0015 0.0044 0.0099
Loa Loa (eye worm) hypothetical protein 0.0019 0.0132 0.0297
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0015 0.0044 0.0044
Brugia malayi Latrophilin receptor protein 2 0.0019 0.0132 0.02
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0015 0.0044 0.0099
Echinococcus multilocularis receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type 0.0498 0.9903 1
Trichomonas vaginalis phosphofructokinase, putative 0.0131 0.2419 1
Brugia malayi PAS domain containing protein 0.0048 0.073 0.1561
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0015 0.0044 0.0099
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0019 0.0141 0.0141
Loa Loa (eye worm) hypothetical protein 0.0015 0.0044 0.0099
Brugia malayi Protein-tyrosine phosphatase 0.0094 0.1655 0.3665
Loa Loa (eye worm) hypothetical protein 0.0015 0.0044 0.0099
Schistosoma mansoni receptor protein tyrosine phosphatase 0.0019 0.0141 0.0409
Leishmania major ATP-dependent phosphofructokinase 0.0131 0.2419 1
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0057 0.0906 0.3632
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0019 0.0132 0.02
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0057 0.0906 0.0906
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0015 0.0044 0.0099
Onchocerca volvulus 0.0015 0.0044 0.0129
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0019 0.0141 0.0409
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.087 0.1879
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0015 0.0044 0.0044
Schistosoma mansoni hypothetical protein 0.0019 0.0132 0.0371
Onchocerca volvulus 0.0015 0.0044 0.0129
Onchocerca volvulus 0.0015 0.0044 0.0129
Entamoeba histolytica phosphofructokinase, putative 0.0131 0.2419 1
Toxoplasma gondii 6-phosphofructokinase 0.0035 0.0466 0.5
Loa Loa (eye worm) hypothetical protein 0.0089 0.1557 0.3509
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0035 0.0466 0.5
Echinococcus granulosus receptor type tyrosine protein phosphatase zeta 0.0019 0.0141 0.0141
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0015 0.0044 0.0099
Trichomonas vaginalis pten, drome, putative 0.0015 0.0044 0.0181
Loa Loa (eye worm) hypothetical protein 0.0015 0.0044 0.0099
Loa Loa (eye worm) hypothetical protein 0.0015 0.0044 0.0099
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0015 0.0044 0.0044
Onchocerca volvulus 0.0015 0.0044 0.0129
Schistosoma mansoni aryl hydrocarbon receptor 0.0048 0.073 0.2888
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0035 0.0466 1
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0015 0.0044 0.0044
Loa Loa (eye worm) hypothetical protein 0.0015 0.0044 0.0099
Echinococcus multilocularis hypothetical protein 0.0015 0.0044 0.0044
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.018 0.3403 1
Loa Loa (eye worm) hypothetical protein 0.0162 0.3052 0.6876
Loa Loa (eye worm) hypothetical protein 0.0015 0.0044 0.0099
Onchocerca volvulus 0.0015 0.0044 0.0129
Loa Loa (eye worm) hypothetical protein 0.0015 0.0044 0.0099
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0015 0.0044 0.0099
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0131 0.2419 1
Echinococcus multilocularis transfer RNA-Lys 0.0036 0.0474 0.0478
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.087 0.0878
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.087 0.1959
Loa Loa (eye worm) hypothetical protein 0.0041 0.0582 0.1312
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0057 0.0906 0.2226
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.0015 0.0044 0.0044
Echinococcus granulosus receptor type tyrosine protein phosphatase zeta 0.0015 0.0044 0.0044
Brugia malayi bHLH-PAS transcription factor 0.0036 0.0474 0.0978
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0015 0.0044 0.0044
Trypanosoma cruzi tyrosine specific protein phosphatase, putative 0.0015 0.0044 0.0181
Loa Loa (eye worm) hypothetical protein 0.018 0.3403 0.7667
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0015 0.0044 0.0044
Onchocerca volvulus 0.0015 0.0044 0.0129
Brugia malayi follicle stimulating hormone receptor 0.023 0.4438 1
Echinococcus multilocularis 6 phosphofructokinase 0.0131 0.2419 0.2443
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0015 0.0044 0.0099
Plasmodium vivax 6-phosphofructokinase, putative 0.0035 0.0466 0.5
Brugia malayi 6-phosphofructokinase 0.0131 0.2419 0.5405
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0015 0.0044 0.0099
Trichomonas vaginalis phosphofructokinase, putative 0.0035 0.0466 0.1928
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.087 0.3476
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.087 0.3476
Onchocerca volvulus 0.0036 0.0474 0.1392
Leishmania major tyrosine specific protein phosphatase, putative 0.0015 0.0044 0.0181
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.0971 0.2187
Loa Loa (eye worm) hypothetical protein 0.0015 0.0044 0.0099
Loa Loa (eye worm) dual specificity protein phosphatase CDC14B 0.0015 0.0044 0.0099
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0019 0.0141 0.0142
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0057 0.0906 0.0915
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.0015 0.0044 0.0044
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0015 0.0044 0.0044
Loa Loa (eye worm) hypothetical protein 0.0015 0.0044 0.0099
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0035 0.0466 0.1928
Plasmodium vivax 6-phosphofructokinase, putative 0.0035 0.0466 0.5
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0015 0.0044 0.0044
Trichomonas vaginalis phosphofructokinase, putative 0.0131 0.2419 1
Loa Loa (eye worm) cytochrome P450 family protein 0.0049 0.0732 0.165
Brugia malayi hypoxia-induced factor 1 0.015 0.2795 0.6262
Echinococcus granulosus protein tyrosine phosphatase n9 0.0015 0.0044 0.0044
Onchocerca volvulus 4.1 G protein, putative homolog 0.0015 0.0044 0.0129
Brugia malayi hypothetical protein 0.0162 0.3052 0.6845
Loa Loa (eye worm) hypothetical protein 0.0015 0.0044 0.0099
Loa Loa (eye worm) hypothetical protein 0.0015 0.0044 0.0099
Loa Loa (eye worm) hypothetical protein 0.0074 0.1257 0.2833
Onchocerca volvulus 0.0015 0.0044 0.0129
Brugia malayi N-terminal motif family protein 0.018 0.3403 0.7644
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0131 0.2419 1
Onchocerca volvulus 0.0015 0.0044 0.0129
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0015 0.0044 0.0099
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0019 0.0132 0.0132
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0057 0.0906 0.3747
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0015 0.0044 0.0044
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0015 0.0044 0.0044
Loa Loa (eye worm) hypothetical protein 0.0015 0.0044 0.0099
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.087 0.3476
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0019 0.0141 0.0409
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0015 0.0044 0.0099
Entamoeba histolytica phosphofructokinase, putative 0.0131 0.2419 1
Leishmania major protein kinase, putative 0.0016 0.0079 0.0327
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0015 0.0044 0.0099
Loa Loa (eye worm) hypothetical protein 0.0015 0.0044 0.0099
Echinococcus granulosus GPCR family 2 0.0019 0.0132 0.0132
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.0019 0.0141 0.0142
Onchocerca volvulus 0.0015 0.0044 0.0129
Echinococcus multilocularis receptor type tyrosine protein phosphatase F 0.0019 0.0141 0.0142
Loa Loa (eye worm) hypothetical protein 0.0015 0.0044 0.0099
Echinococcus multilocularis receptor type tyrosine protein phosphatase zeta 0.0015 0.0044 0.0044
Brugia malayi phosphofructokinase 0.0131 0.2419 0.5405
Mycobacterium ulcerans 6-phosphofructokinase 0.0131 0.2419 1
Echinococcus multilocularis receptor type tyrosine protein phosphatase zeta 0.0019 0.0141 0.0142
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0019 0.0141 0.0142
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0019 0.0141 0.0141
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0498 0.9903 0.9903
Loa Loa (eye worm) phosphofructokinase 0.0131 0.2419 0.545
Onchocerca volvulus 0.0015 0.0044 0.0129
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0053 0.0828 0.1866
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.0582 0.1226
Loa Loa (eye worm) hypothetical protein 0.0015 0.0044 0.0099
Echinococcus granulosus 6 phosphofructokinase 0.0131 0.2419 0.2419
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0015 0.0044 0.0044
Trypanosoma cruzi tyrosine specific protein phosphatase, putative 0.0015 0.0044 0.0181
Loa Loa (eye worm) hypothetical protein 0.0015 0.0044 0.0099
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0019 0.0132 0.0133
Onchocerca volvulus 0.0015 0.0044 0.0129
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.087 0.087
Onchocerca volvulus 0.0015 0.0044 0.0129
Trichomonas vaginalis phosphofructokinase, putative 0.0131 0.2419 1
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0019 0.0132 0.0133
Echinococcus granulosus Receptor type tyrosine protein phosphatase O 0.0015 0.0044 0.0044
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0131 0.2419 1
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0015 0.0044 0.0044
Trichomonas vaginalis phosphofructokinase, putative 0.0035 0.0466 0.1928
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0035 0.0466 1
Onchocerca volvulus 0.0015 0.0044 0.0129
Schistosoma mansoni hypothetical protein 0.0019 0.0132 0.0371
Loa Loa (eye worm) hypothetical protein 0.0015 0.0044 0.0099
Trichomonas vaginalis phosphofructokinase, putative 0.0035 0.0466 0.1928
Toxoplasma gondii phosphofructokinase PFKII 0.0035 0.0466 0.5
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0015 0.0044 0.0044
Loa Loa (eye worm) hypothetical protein 0.0015 0.0044 0.0099
Onchocerca volvulus 0.0015 0.0044 0.0129
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0015 0.0044 0.0099
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0019 0.0141 0.0409
Loa Loa (eye worm) 6-phosphofructokinase 0.0131 0.2419 0.545
Onchocerca volvulus 0.0015 0.0044 0.0129
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.087 0.087
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0015 0.0044 0.0044
Brugia malayi 6-phosphofructokinase 0.0131 0.2419 0.5405
Schistosoma mansoni hypothetical protein 0.0019 0.0132 0.0371
Onchocerca volvulus 0.0015 0.0044 0.0129
Trichomonas vaginalis phosphofructokinase, putative 0.0131 0.2419 1
Schistosoma mansoni hypothetical protein 0.0041 0.0582 0.2268
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.0971 0.2109
Loa Loa (eye worm) protein-tyrosine-phosphatase 0.0015 0.0044 0.0099
Onchocerca volvulus 0.0015 0.0044 0.0129
Trichomonas vaginalis phosphofructokinase, putative 0.0035 0.0466 0.1928
Echinococcus granulosus Receptor type tyrosine protein phosphatase O 0.0015 0.0044 0.0044
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.0015 0.0044 0.0044
Schistosoma mansoni single-minded 0.0048 0.073 0.2888
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0015 0.0044 0.0044
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0015 0.0044 0.0099
Trichomonas vaginalis phosphofructokinase, putative 0.0035 0.0466 0.1928

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 2.8184 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 11.2202 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 15.1014 uM PUBCHEM_BIOASSAY: qHTS Assay to Find Inhibitors of T. brucei phosphofructokinase. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488768, AID492961] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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