Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | GNAS complex locus | Starlite/ChEMBL | No references |
Rattus norvegicus | Inositol monophosphatase 1 | Starlite/ChEMBL | No references |
Mus musculus | RAR-related orphan receptor gamma | Starlite/ChEMBL | No references |
Influenza A virus | Nonstructural protein 1 | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | matrixin family protein | 0.0449 | 0.5849 | 0.909 |
Trichomonas vaginalis | inositol monophosphatase, putative | 0.0045 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0203 | 0.2283 | 0.3548 |
Schistosoma mansoni | hypothetical protein | 0.0287 | 0.3506 | 1 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0045 | 0 | 0.5 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.0154 | 0.0154 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.0154 | 0.0154 |
Brugia malayi | Matrixin family protein | 0.0203 | 0.2283 | 0.3548 |
Brugia malayi | Matrixin family protein | 0.0203 | 0.2283 | 0.3548 |
Schistosoma mansoni | matrix metallopeptidase-9 (M10 family) | 0.0137 | 0.1342 | 0.3827 |
Loa Loa (eye worm) | hypothetical protein | 0.0203 | 0.2283 | 0.3548 |
Leishmania major | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0045 | 0 | 0.5 |
Onchocerca volvulus | 0.0287 | 0.3506 | 0.3431 | |
Toxoplasma gondii | inositol(myo)-1(or 4)-monophosphatase 2, putative | 0.0045 | 0 | 0.5 |
Loa Loa (eye worm) | matrix metalloproteinase | 0.0203 | 0.2283 | 0.3548 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0055 | 0.0154 | 0.0239 |
Onchocerca volvulus | Matrix metalloproteinase homolog | 0.0449 | 0.5849 | 1 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0045 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0247 | 0.2921 | 0.454 |
Schistosoma mansoni | matrix metallopeptidase-7 (M10 family) | 0.0203 | 0.2283 | 0.6511 |
Mycobacterium tuberculosis | Probable peptidoglycan hydrolase | 0.0247 | 0.2921 | 0.5 |
Loa Loa (eye worm) | matrixin family protein | 0.049 | 0.6434 | 1 |
Brugia malayi | Matrixin family protein | 0.0203 | 0.2283 | 0.3548 |
Brugia malayi | Matrixin family protein | 0.049 | 0.6434 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.0154 | 0.0438 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.0154 | 0.0154 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0045 | 0 | 0.5 |
Trypanosoma brucei | inositol-1(or 4)-monophosphatase 1, putative | 0.0045 | 0 | 0.5 |
Brugia malayi | Hemopexin family protein | 0.0287 | 0.3506 | 0.545 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.0154 | 0.0438 |
Wolbachia endosymbiont of Brugia malayi | fructose-1,6-bisphosphatase | 0.0045 | 0 | 0.5 |
Entamoeba histolytica | myo-inositol monophosphatase, putative | 0.0045 | 0 | 0.5 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0055 | 0.0154 | 0.0239 |
Brugia malayi | Matrix metalloprotease, N-terminal domain containing protein | 0.0247 | 0.2921 | 0.454 |
Mycobacterium leprae | PROBABLE HYDROLASE | 0.0247 | 0.2921 | 0.5 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.0154 | 0.0154 |
Mycobacterium ulcerans | hydrolase | 0.0247 | 0.2921 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0203 | 0.2283 | 0.3548 |
Brugia malayi | Matrixin family protein | 0.0203 | 0.2283 | 0.3548 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.0154 | 0.0438 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0045 | 0 | 0.5 |
Onchocerca volvulus | Matrilysin homolog | 0.0449 | 0.5849 | 1 |
Echinococcus multilocularis | matrix metallopeptidase 7 (M10 family) | 0.0736 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 5.0119 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Influenza NS1 Protein Function. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 5.6234 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 7.3753 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | = 12.5893 um | PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 12.5893 um | PUBCHEM_BIOASSAY: qHTS Assay for Identifying the Cell-Membrane Permeable IMPase Inhibitors: Potentiation with Lithium. (Class of assay: confirmatory) [Related pubchem assays: 901 ] | ChEMBL. | No reference |
Potency (functional) | = 28.1838 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] | ChEMBL. | No reference |
Potency (functional) | 70.7946 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.