Detailed information for compound 1392187

Basic information

Technical information
  • TDR Targets ID: 1392187
  • Name: 1-(2-hydroxyethyl)-N-[(3-nitrophenyl)methylid eneamino]pyridin-1-ium-4-carboxamide chloride
  • MW: 350.757 | Formula: C15H15ClN4O4
  • H donors: 2 H acceptors: 4 LogP: 1.77 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: OCC[n+]1ccc(cc1)C(=O)NN=Cc1cccc(c1)[N+](=O)[O-].[Cl-]
  • InChi: 1S/C15H14N4O4.ClH/c20-9-8-18-6-4-13(5-7-18)15(21)17-16-11-12-2-1-3-14(10-12)19(22)23;/h1-7,10-11,20H,8-9H2;1H
  • InChiKey: ULTGXAYLQRCJQL-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1-(2-hydroxyethyl)-N-[(3-nitrophenyl)methyleneamino]pyridin-1-ium-4-carboxamide chloride
  • 1-(2-hydroxyethyl)-N-[(3-nitrophenyl)methyleneamino]-4-pyridin-1-iumcarboxamide chloride
  • 1-(2-hydroxyethyl)-N-[(3-nitrobenzylidene)amino]pyridin-1-ium-4-carboxamide chloride
  • 1-(2-hydroxyethyl)-4-{[2-(3-nitrobenzylidene)hydrazino]carbonyl}pyridinium chloride
  • MLS001164363
  • BIM-0022446.P001
  • SMR000496569

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens karyopherin (importin) beta 1 No references
Homo sapiens RAN, member RAS oncogene family No references
Homo sapiens snurportin 1 No references
Giardia intestinalis Putative fructose-1,6-bisphosphate aldolase Starlite/ChEMBL No references
Homo sapiens muscleblind-like splicing regulator 1 Starlite/ChEMBL No references
Homo sapiens RAD52 homolog (S. cerevisiae) Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Entamoeba histolytica DNA repair and recombination protein RAD52, putative Get druggable targets OG5_130806 All targets in OG5_130806
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Leishmania mexicana GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium knowlesi GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Theileria parva GTP-binding nuclear protein ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Giardia lamblia DNA repair protein RAD52 Get druggable targets OG5_130806 All targets in OG5_130806
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Cryptosporidium hominis GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Candida albicans similar to S. cerevisiae RAD52 (YML032C) dsDNA break repair annealing factor Get druggable targets OG5_130806 All targets in OG5_130806
Plasmodium yoelii importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania braziliensis importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Brugia malayi GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Trichomonas vaginalis importin beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni ran Get druggable targets OG5_127514 All targets in OG5_127514
Cryptosporidium hominis importin-beta2 Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum Snurportin-1, putative Get druggable targets OG5_131808 All targets in OG5_131808
Schistosoma japonicum ko:K07936 GTP-binding nuclear protein Ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium vivax importin-beta 2, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania major GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma mansoni importin beta-1 Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni hypothetical protein Get druggable targets OG5_131808 All targets in OG5_131808
Candida albicans Ran, Ras family GTP-binding protein Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus multilocularis muscleblind protein 1 Get druggable targets OG5_132352 All targets in OG5_132352
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132352 All targets in OG5_132352
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus granulosus muscleblind protein Get druggable targets OG5_132352 All targets in OG5_132352
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Babesia bovis GTP-binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania infantum GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania infantum importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma mansoni ran Get druggable targets OG5_127514 All targets in OG5_127514
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Leishmania mexicana importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus multilocularis importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus multilocularis muscleblind protein Get druggable targets OG5_132352 All targets in OG5_132352
Trypanosoma brucei gambiense GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Treponema pallidum fructose-bisphosphate aldolase Get druggable targets OG5_129214 All targets in OG5_129214
Echinococcus granulosus importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania major importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Neospora caninum hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Entamoeba histolytica hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Candida albicans similar to S. cerevisiae RAD52 (YML032C) dsDNA break repair annealing factor Get druggable targets OG5_130806 All targets in OG5_130806
Echinococcus granulosus snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma congolense GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium berghei importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus granulosus GTP binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus multilocularis GTP binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma cruzi importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium berghei GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Giardia lamblia Fructose-bisphosphate aldolase Get druggable targets OG5_129214 All targets in OG5_129214
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Plasmodium falciparum importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Toxoplasma gondii HEAT repeat-containing protein Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Candida albicans Ran, Ras family GTP-binding protein Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium knowlesi importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Babesia bovis importin beta subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Brugia malayi RNA, U transporter 1 Get druggable targets OG5_131808 All targets in OG5_131808
Schistosoma japonicum Importin subunit beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Neospora caninum GTP-binding nuclear protein Ran, related Get druggable targets OG5_127514 All targets in OG5_127514
Cryptosporidium parvum importin/karyopherin Get druggable targets OG5_127843 All targets in OG5_127843
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Cryptosporidium parvum GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Entamoeba histolytica Ran family GTPase Get druggable targets OG5_127514 All targets in OG5_127514
Brugia malayi Importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania donovani GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma congolense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) nucleolar RNA-associated protein alpha Get druggable targets OG5_131808 All targets in OG5_131808
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum Importin subunit beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania donovani importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium yoelii GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Theileria parva importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Giardia lamblia GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Brugia malayi Muscleblind-like protein Get druggable targets OG5_132352 All targets in OG5_132352
Trypanosoma brucei gambiense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus multilocularis snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Leishmania braziliensis GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132352 All targets in OG5_132352
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Candida albicans fructose-bisphosphate aldolase Putative fructose-1,6-bisphosphate aldolase   323 aa 358 aa 22.6 %
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba Putative fructose-1,6-bisphosphate aldolase   323 aa 361 aa 25.5 %
Candida albicans fructose-bisphosphate aldolase Putative fructose-1,6-bisphosphate aldolase   323 aa 358 aa 22.6 %
Mycobacterium ulcerans fructose-bisphosphate aldolase Putative fructose-1,6-bisphosphate aldolase   323 aa 361 aa 26.9 %
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba Putative fructose-1,6-bisphosphate aldolase   323 aa 361 aa 25.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi hypothetical protein, conserved 0.0116 0.0535 0.5
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0116 0.0535 1
Loa Loa (eye worm) hypothetical protein 0.1443 0.9236 0.9236
Echinococcus granulosus high affinity cgmp specific 3' 5' cyclic 0.0116 0.0535 0.2423
Schistosoma mansoni camp-specific cyclic nucleotide phosphodiesterase 0.1559 1 1
Entamoeba histolytica DNA repair and recombination protein RAD52, putative 0.042 0.2526 1
Leishmania major cAMP phosphodiesterase A, putative;with=GeneDB:LinJ18_V3.1100 0.0116 0.0535 0.5
Brugia malayi Muscleblind-like protein 0.018 0.0955 0.0955
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0116 0.0535 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.2087 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.2087 1
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0116 0.0535 1
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0372 0.221 0.221
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0116 0.0535 1
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0116 0.0535 0.2423
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0116 0.0535 1
Echinococcus multilocularis cAMP and cAMP inhibited cGMP 3',5' cyclic 0.0116 0.0535 0.2423
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0116 0.0535 1
Plasmodium vivax phosphodiesterase gamma, putative 0.0116 0.0535 1
Trypanosoma brucei cAMP-specific phosphodiesterase, putative 0.0116 0.0535 1
Leishmania major hypothetical protein, conserved 0.0116 0.0535 0.5
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0116 0.0535 0.0535
Loa Loa (eye worm) hypothetical protein 0.1443 0.9236 0.9236
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase 0.0116 0.0535 0.2423
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0116 0.0535 0.0535
Trypanosoma cruzi cyclic nucleotide phosphodiesterase 0.0116 0.0535 0.5
Schistosoma mansoni cgmp-dependent 35-cyclic phosphodiesterase 0.0116 0.0535 0.0535
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0353 0.2087 0.7774
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0116 0.0535 0.2423
Trypanosoma brucei cAMP phosphodiesterase A, putative 0.0116 0.0535 1
Loa Loa (eye worm) hypothetical protein 0.1559 1 1
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0116 0.0535 1
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0172 0.0903 0.5
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0116 0.0535 0.5
Echinococcus multilocularis high affinity cAMP specific 3',5' cyclic 0.0116 0.0535 0.2423
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0116 0.0535 0.2423
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0116 0.0535 0.5
Echinococcus granulosus cAMP and cAMP inhibited cGMP 3'5' cyclic 0.0116 0.0535 0.2423
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.2087 1
Trypanosoma brucei hypothetical protein, conserved 0.0116 0.0535 1
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0116 0.0535 0.5
Leishmania major hypothetical protein, conserved 0.0116 0.0535 0.5
Leishmania major cAMP-specific phosphodiesterase, putative 0.0116 0.0535 0.5
Plasmodium vivax cyclic nucleotide phosphodiesterase, putative 0.0116 0.0535 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.2087 1
Loa Loa (eye worm) hypothetical protein 0.018 0.0955 0.0955
Echinococcus granulosus snurportin 1 0.0372 0.221 1
Echinococcus multilocularis high affinity cgmp specific 3' 5' cyclic 0.0116 0.0535 0.2423
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0116 0.0535 0.0535
Giardia lamblia DNA repair protein RAD52 0.042 0.2526 1
Echinococcus multilocularis muscleblind protein 0.018 0.0955 0.4321
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0116 0.0535 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0116 0.0535 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.2087 1
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0116 0.0535 0.2423
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0116 0.0535 0.2423
Loa Loa (eye worm) PDE1B protein 0.0116 0.0535 0.0535
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0116 0.0535 1
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0116 0.0535 0.5
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0116 0.0535 1
Plasmodium falciparum phosphodiesterase delta, putative 0.0116 0.0535 1
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0172 0.0903 0.5
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0116 0.0535 1
Loa Loa (eye worm) hypothetical protein 0.1443 0.9236 0.9236
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0116 0.0535 0.0535
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0116 0.0535 0.0535
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0116 0.0535 1
Loa Loa (eye worm) hypothetical protein 0.0116 0.0535 0.0535
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0116 0.0535 1
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0116 0.0535 0.0535
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0116 0.0535 0.5
Giardia lamblia Fructose-bisphosphate aldolase 0.0353 0.2087 0.7796
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.2087 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0116 0.0535 1
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0116 0.0535 0.2423
Schistosoma mansoni calcium/calmodulin-dependent 35-cyclic nucleotide phosphodiesterase 0.0116 0.0535 0.0535
Trypanosoma cruzi hypothetical protein, conserved 0.0116 0.0535 0.5
Treponema pallidum fructose-bisphosphate aldolase 0.0353 0.2087 0.5
Echinococcus multilocularis snurportin 1 0.0372 0.221 1
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0116 0.0535 0.2423
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0116 0.0535 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0116 0.0535 1
Echinococcus granulosus high affinity cAMP specific 3'5' cyclic 0.0116 0.0535 0.2423
Trypanosoma cruzi hypothetical protein, conserved 0.0116 0.0535 0.5
Echinococcus granulosus muscleblind protein 0.018 0.0955 0.4321
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0353 0.2087 0.7774
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.2087 1
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase 0.0116 0.0535 0.2423
Trypanosoma cruzi cAMP-specific phosphodiesterase, putative 0.0116 0.0535 0.5
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0116 0.0535 1
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0116 0.0535 0.0535
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0116 0.0535 1
Loa Loa (eye worm) calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase 0.1559 1 1
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0116 0.0535 0.0535
Loa Loa (eye worm) hypothetical protein 0.0116 0.0535 0.0535
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0116 0.0535 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0116 0.0535 1
Echinococcus multilocularis muscleblind protein 1 0.018 0.0955 0.4321
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0116 0.0535 1
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0116 0.0535 0.0535
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0116 0.0535 0.5
Loa Loa (eye worm) hypothetical protein 0.0116 0.0535 0.0535
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0116 0.0535 1
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase 0.0116 0.0535 0.0535
Trypanosoma cruzi hypothetical protein, conserved 0.0116 0.0535 0.5
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0116 0.0535 1
Loa Loa (eye worm) hypothetical protein 0.018 0.0955 0.0955
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.2087 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0116 0.0535 1
Brugia malayi RNA, U transporter 1 0.0099 0.0421 0.0421
Brugia malayi Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative 0.0116 0.0535 0.0535
Trypanosoma cruzi hypothetical protein, conserved 0.0116 0.0535 0.5
Trypanosoma cruzi hypothetical protein, conserved 0.0116 0.0535 0.5
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0172 0.0903 0.5
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0116 0.0535 1
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0116 0.0535 0.2423
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0116 0.0535 0.0535
Brugia malayi Probable 3',5'-cyclic phosphodiesterase T04D3.3, putative 0.0116 0.0535 0.0535
Schistosoma mansoni hypothetical protein 0.0372 0.221 0.221
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0116 0.0535 1
Plasmodium falciparum phosphodiesterase gamma, putative 0.0116 0.0535 1
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0116 0.0535 1

Activities

Activity type Activity value Assay description Source Reference
AC50 (functional) = 14.1 uM PubChem BioAssay. FRET-based HTS for detection of RAD52 Inhibitors Measured in Biochemical System Using Plate Reader - 7018-01_Inhibitor_Dose_CherryPick_Activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 8.2753 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 9.285 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (binding) 12.5893 uM PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 12.9953 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RanGTP induced Rango (Ran-regulated importin-beta cargo) - Importin beta complex dissociation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540262] ChEMBL. No reference
Potency (functional) = 15.8489 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Fructose-1,6-bisphosphate Aldolase from Giardia Lamblia. (Class of assay: confirmatory) [Related pubchem assays: 2472, 2464 ] ChEMBL. No reference
Potency (functional) 50.1187 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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