Detailed information for compound 1408682

Basic information

Technical information
  • TDR Targets ID: 1408682
  • Name: N-(2,5-dimethoxyphenyl)-1-[(2-oxo-1H-quinolin -6-yl)sulfonyl]piperidine-3-carboxamide
  • MW: 471.526 | Formula: C23H25N3O6S
  • H donors: 2 H acceptors: 4 LogP: 1.75 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1NC(=O)C1CCCN(C1)S(=O)(=O)c1ccc2c(c1)ccc(=O)[nH]2)OC
  • InChi: 1S/C23H25N3O6S/c1-31-17-6-9-21(32-2)20(13-17)25-23(28)16-4-3-11-26(14-16)33(29,30)18-7-8-19-15(12-18)5-10-22(27)24-19/h5-10,12-13,16H,3-4,11,14H2,1-2H3,(H,24,27)(H,25,28)
  • InChiKey: ZXVGKADEAJUOPK-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(2,5-dimethoxyphenyl)-1-[(2-oxo-1H-quinolin-6-yl)sulfonyl]-3-piperidinecarboxamide
  • N-(2,5-dimethoxyphenyl)-1-[(2-keto-1H-quinolin-6-yl)sulfonyl]nipecotamide
  • E589-5210
  • NCGC00123288-01

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens microtubule-associated protein tau Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum ko:K04380 microtubule-associated protein tau, putative Get druggable targets OG5_133504 All targets in OG5_133504
Echinococcus multilocularis microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Schistosoma mansoni microtubule-associated protein tau Get druggable targets OG5_133504 All targets in OG5_133504
Echinococcus granulosus microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0266 0.2775 0.5553
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0251 0.2582 1
Entamoeba histolytica cysteine proteinase, putative 0.0205 0.1997 1
Entamoeba histolytica calpain large subunit domain III containing protein 0.0113 0.082 0.4104
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0161 0.1437 0.5568
Loa Loa (eye worm) hypothetical protein 0.0064 0.0195 0.0391
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0169 0.1539 0.1539
Trypanosoma brucei serine peptidase, Clan SC, Family S9B 0.0071 0.029 0.1122
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0205 0.1997 0.6187
Schistosoma mansoni family S28 unassigned peptidase (S28 family) 0.0384 0.4276 0.4276
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0441 0.4998 1
Echinococcus multilocularis expressed protein 0.0364 0.4021 0.3842
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0112 0.0804 0.0804
Brugia malayi calpain family protein 1 0.0428 0.4831 0.9666
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0161 0.1437 0.5568
Brugia malayi Cathepsin L-like cysteine proteinase 0.0141 0.1184 0.2368
Onchocerca volvulus 0.0205 0.1997 0.4014
Onchocerca volvulus 0.0205 0.1997 0.4014
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0205 0.1997 0.6187
Onchocerca volvulus 0.0266 0.2775 0.7802
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0141 0.1184 0.3668
Leishmania major cathepsin L-like protease 0.0251 0.2582 1
Onchocerca volvulus 0.0141 0.1184 0.0058
Trypanosoma brucei cysteine peptidase C (CPC) 0.0169 0.1539 0.5963
Schistosoma mansoni hypothetical protein 0.0302 0.3227 0.3227
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0441 0.4998 0.4998
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0205 0.1997 1
Schistosoma mansoni calpain (C02 family) 0.0161 0.1437 0.1437
Echinococcus granulosus cathepsin L cysteine protease 0.0112 0.0804 0.053
Plasmodium falciparum cysteine proteinase falcipain 1 0.0112 0.0804 0.4027
Entamoeba histolytica cysteine proteinase, putative 0.0141 0.1184 0.5927
Schistosoma mansoni Mername-AA248 (C02 family) 0.0161 0.1437 0.1437
Trypanosoma cruzi cruzipain precursor, putative 0.0064 0.0195 0.0391
Mycobacterium tuberculosis Long conserved protein 0.0302 0.3227 1
Loa Loa (eye worm) hypothetical protein 0.0315 0.3393 0.679
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0112 0.0804 0.2492
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0205 0.1997 0.6187
Echinococcus granulosus expressed protein 0.0364 0.4021 0.3842
Entamoeba histolytica cysteine protease, putative 0.0112 0.0804 0.4027
Entamoeba histolytica cysteine proteinase, putative 0.0112 0.0804 0.4027
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0205 0.1997 0.6187
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0205 0.1997 0.6187
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0205 0.1997 0.1758
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0454 0.5161 0.5161
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0205 0.1997 0.6187
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0205 0.1997 0.6187
Entamoeba histolytica cysteine protease, putative 0.0112 0.0804 0.4027
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0064 0.0195 0.0391
Trypanosoma brucei calpain-like protein, putative 0.0161 0.1437 0.5568
Schistosoma mansoni subfamily S9B unassigned peptidase (S09 family) 0.0186 0.1747 0.1747
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0205 0.1997 0.6187
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0205 0.1997 0.6187
Echinococcus granulosus cathepsin b 0.0441 0.4998 0.4849
Echinococcus granulosus calpain 0.0161 0.1437 0.1182
Plasmodium vivax vivapain-2 0.0205 0.1997 1
Echinococcus multilocularis cysteine protease 0.0205 0.1997 0.1758
Entamoeba histolytica cysteine protease, putative 0.0112 0.0804 0.4027
Onchocerca volvulus 0.0205 0.1997 0.4014
Echinococcus granulosus calpain A 0.0161 0.1437 0.1182
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0251 0.2582 1
Brugia malayi Papain family cysteine protease containing protein 0.0112 0.0804 0.1609
Brugia malayi cathepsin B-like cysteine proteinase 0.0441 0.4998 1
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0205 0.1997 1
Plasmodium vivax vivapain-1 0.0112 0.0804 0.3379
Trypanosoma cruzi oligopeptidase b 0.0064 0.0199 0.0397
Mycobacterium ulcerans transglutaminase family protein 0.0302 0.3227 1
Trypanosoma cruzi cysteine peptidase, putative 0.0112 0.0804 0.1609
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.014 0.1172 0.1172
Trypanosoma cruzi serine peptidase, clan SC, family S9A-like protein, putative 0.0064 0.0199 0.0397
Mycobacterium ulcerans hypothetical protein 0.0302 0.3227 1
Echinococcus multilocularis dipeptidyl aminopeptidaseprotein 0.0186 0.1747 0.1501
Loa Loa (eye worm) hypothetical protein 0.0141 0.1184 0.2368
Echinococcus multilocularis calpain A 0.0454 0.5167 0.5023
Schistosoma mansoni cathepsin F (C01 family) 0.0205 0.1997 0.1997
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0161 0.1437 0.2876
Loa Loa (eye worm) calpain family protein 1 0.0315 0.3393 0.679
Trypanosoma cruzi cysteine peptidase, putative 0.0251 0.2582 0.5165
Echinococcus multilocularis cathepsin b 0.0441 0.4998 0.4849
Leishmania major cysteine peptidase A (CPA) 0.0205 0.1997 0.7735
Trypanosoma cruzi cysteine proteinase, putative 0.0112 0.0804 0.1609
Loa Loa (eye worm) hypothetical protein 0.0428 0.4831 0.9666
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0205 0.1997 0.6187
Loa Loa (eye worm) hypothetical protein 0.0441 0.4998 1
Loa Loa (eye worm) hypothetical protein 0.0141 0.1184 0.2368
Loa Loa (eye worm) calpain 0.0161 0.1437 0.2876
Echinococcus granulosus prolyl endopeptidase 0.014 0.1172 0.0908
Echinococcus granulosus calpain 7 C02 family 0.0161 0.1437 0.1182
Trypanosoma cruzi oligopeptidase B-like protein, putative 0.0064 0.0199 0.0397
Loa Loa (eye worm) cysteine protease 0.0205 0.1997 0.3996
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0205 0.1997 0.6187
Brugia malayi Cathepsin L-like precursor 0.0205 0.1997 0.3996
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0205 0.1997 0.6187
Loa Loa (eye worm) ctsf protein 0.0205 0.1997 0.3996
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0205 0.1997 0.6187
Trypanosoma brucei kinesin, putative 0.0113 0.082 0.3175
Loa Loa (eye worm) fibroinase 0.0205 0.1997 0.3996
Trypanosoma cruzi prolyl endopeptidase 0.014 0.1172 0.2344
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0161 0.1437 0.2876
Schistosoma mansoni cathepsin s 0.0064 0.0195 0.0195
Echinococcus multilocularis prolyl endopeptidase 0.014 0.1172 0.0908
Leishmania major cathepsin L-like protease 0.0205 0.1997 0.7735
Echinococcus granulosus cysteine protease 0.0112 0.0804 0.053
Brugia malayi Papain family cysteine protease containing protein 0.0205 0.1997 0.3996
Loa Loa (eye worm) calpain family protein 1 0.0428 0.4831 0.9666
Entamoeba histolytica cysteine proteinase 2 0.0112 0.0804 0.4027
Toxoplasma gondii prolyl endopeptidase 0.014 0.1172 0.5867
Leishmania major cathepsin L-like protease 0.0251 0.2582 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0205 0.1997 0.6187
Brugia malayi cathepsin L-like precursor 0.0141 0.1184 0.2368
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0441 0.4998 0.4998
Loa Loa (eye worm) hypothetical protein 0.0141 0.1184 0.2368
Entamoeba histolytica cysteine protease, putative 0.0112 0.0804 0.4027
Echinococcus multilocularis calpain family protein 1, d 0.0315 0.3393 0.3196
Loa Loa (eye worm) hypothetical protein 0.0205 0.1997 0.3996
Echinococcus granulosus cathepsin l1 0.0205 0.1997 0.1758
Echinococcus multilocularis Lysosomal Pro X carboxypeptidase 0.0384 0.4276 0.4106
Brugia malayi calpain 5 0.0113 0.082 0.164
Echinococcus multilocularis calpain 5 0.0161 0.1437 0.1182
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0251 0.2582 1
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0112 0.0804 0.0804
Trypanosoma cruzi calpain cysteine peptidase, putative 0.0161 0.1437 0.2876
Plasmodium vivax calpain, putative 0.0161 0.1437 0.6895
Trypanosoma cruzi cruzipain precursor, putative 0.0251 0.2582 0.5165
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0161 0.1437 0.5568
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0161 0.1437 0.2876
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0112 0.0804 0.1609
Giardia lamblia Transglutaminase/protease, putative 0.0302 0.3227 1
Trypanosoma cruzi kinesin, putative 0.0113 0.082 0.164
Trypanosoma cruzi cysteine proteinase, putative 0.0112 0.0804 0.1609
Plasmodium vivax unspecified product 0.0112 0.0804 0.3379
Echinococcus granulosus cathepsin l1 0.0141 0.1184 0.0921
Trypanosoma cruzi cysteine peptidase, putative 0.0064 0.0195 0.0391
Echinococcus granulosus Lysosomal Pro X carboxypeptidase 0.0384 0.4276 0.4106
Entamoeba histolytica cysteine protease, putative 0.0205 0.1997 1
Brugia malayi calpain family protein 1 0.0428 0.4831 0.9666
Trypanosoma cruzi dipeptidyl-peptidase 8-like serine peptidase 0.0071 0.029 0.058
Trypanosoma brucei calpain-like protein, putative 0.0161 0.1437 0.5568
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0205 0.1997 0.6187
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0251 0.2582 1
Echinococcus granulosus Transglutaminase 0.0302 0.3227 0.3025
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0205 0.1997 0.3996
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0205 0.1997 0.6187
Toxoplasma gondii dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein 0.0071 0.029 0.1451
Leishmania major prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative 0.014 0.1172 0.4538
Echinococcus multilocularis family C2 unassigned peptidase (C02 family) 0.0454 0.5161 0.5017
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0441 0.4998 0.4998
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0251 0.2582 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0205 0.1997 0.6187
Brugia malayi Cathepsin L-like precursor 0.0205 0.1997 0.3996
Loa Loa (eye worm) hypothetical protein 0.0064 0.0195 0.0391
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0205 0.1997 0.1758
Echinococcus granulosus cathepsin b 0.0441 0.4998 0.4849
Entamoeba histolytica cysteine protease, putative 0.0112 0.0804 0.4027
Schistosoma mansoni calpain C (C02 family) 0.0161 0.1437 0.1437
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0205 0.1997 0.6187
Echinococcus multilocularis cathepsin b 0.0441 0.4998 0.4849
Leishmania major dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B 0.0071 0.029 0.1122
Trypanosoma cruzi serine peptidase, Clan SC, Family S9B 0.0071 0.029 0.058
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0169 0.1539 0.477
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0205 0.1997 0.6187
Leishmania major cathepsin L-like protease 0.0205 0.1997 0.7735
Brugia malayi prolyl oligopeptidase family protein 0.0186 0.1747 0.3496
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0205 0.1997 0.6187
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0161 0.1437 0.2876
Entamoeba histolytica protein kinase, putative 0.0113 0.082 0.4104
Leishmania major oligopeptidase B-like protein,serine peptidase, clan SC, family S9A-like protein 0.0064 0.0199 0.0769
Entamoeba histolytica cysteine protease, putative 0.0112 0.0804 0.4027
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0112 0.0804 0.0804
Echinococcus granulosus family C2 unassigned peptidase C02 family 0.0454 0.5161 0.5017
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0251 0.2582 1
Trypanosoma cruzi major cysteine proteinase, putative 0.0094 0.0576 0.1152
Echinococcus granulosus cathepsin L cysteine proteinase 0.0205 0.1997 0.1758
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0064 0.0195 0.0391
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0161 0.1437 0.2876
Trypanosoma cruzi cysteine protease, putative 0.0112 0.0804 0.1609
Mycobacterium leprae Conserved hypothetical protein 0.0302 0.3227 1
Mycobacterium tuberculosis Conserved hypothetical protein 0.0302 0.3227 1
Brugia malayi prolyl oligopeptidase family protein 0.014 0.1172 0.2344
Loa Loa (eye worm) hypothetical protein 0.0064 0.0195 0.0391
Loa Loa (eye worm) cathepsin B 0.0169 0.1539 0.308
Onchocerca volvulus 0.0205 0.1997 0.4014
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0112 0.0804 0.3115
Schistosoma mansoni cathepsin F (C01 family) 0.0205 0.1997 0.1997
Entamoeba histolytica cysteine proteinase, putative 0.0112 0.0804 0.4027
Leishmania major cathepsin L-like protease 0.0251 0.2582 1
Leishmania major kinesin, putative 0.0113 0.082 0.3175
Brugia malayi Cathepsin L-like precursor 0.0205 0.1997 0.3996
Trypanosoma brucei calpain-like protein, putative 0.0161 0.1437 0.5568
Onchocerca volvulus 0.0302 0.3227 1
Brugia malayi Thioredoxin family protein 0.0302 0.3227 0.6458
Brugia malayi calpain 7 0.0161 0.1437 0.2876
Onchocerca volvulus Dipeptidyl peptidase family member 1 homolog 0.0186 0.1747 0.2799
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0161 0.1437 0.2876
Onchocerca volvulus Cathepsin L homolog 0.0205 0.1997 0.4014
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0161 0.1437 0.2876
Echinococcus granulosus dipeptidyl aminopeptidaseprotein 0.0186 0.1747 0.1501
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0251 0.2582 1
Mycobacterium tuberculosis Probable protease II PtrBa [first part] (oligopeptidase B) 0.0113 0.0828 0.2079
Echinococcus granulosus calpain A 0.0454 0.5167 0.5023
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0112 0.0804 0.3115
Trypanosoma cruzi kinesin, putative 0.0113 0.082 0.164
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0251 0.2582 1
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0205 0.1997 0.3996
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0454 0.5161 0.5161
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0161 0.1437 0.2876
Trypanosoma brucei calpain-like protein, putative 0.0161 0.1437 0.5568
Onchocerca volvulus 0.0205 0.1997 0.4014
Mycobacterium tuberculosis Conserved protein 0.0302 0.3227 1
Entamoeba histolytica cysteine protease, putative 0.0112 0.0804 0.4027
Trichomonas vaginalis peptide N-glycanase, putative 0.0302 0.3227 1
Entamoeba histolytica cysteine proteinase 1, putative 0.0112 0.0804 0.4027
Entamoeba histolytica cysteine protease, putative 0.0112 0.0804 0.4027
Trypanosoma brucei prolyl oligopeptidase, putative 0.0064 0.0199 0.0769
Plasmodium falciparum cysteine proteinase falcipain 3 0.0205 0.1997 1
Trypanosoma brucei antigen, putative 0.0161 0.1437 0.5568
Loa Loa (eye worm) hypothetical protein 0.014 0.1172 0.2344
Echinococcus multilocularis calpain 0.0161 0.1437 0.1182
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0141 0.1184 0.3668
Echinococcus multilocularis cathepsin L cysteine protease 0.0205 0.1997 0.1758
Entamoeba histolytica cysteine protease, putative 0.0112 0.0804 0.4027
Entamoeba histolytica cysteine protease, putative 0.0112 0.0804 0.4027
Plasmodium vivax vivapain-2 0.0205 0.1997 1
Brugia malayi Cathepsin L-like precursor 0.0205 0.1997 0.3996
Brugia malayi Cathepsin L-like precursor 0.0064 0.0195 0.0391
Brugia malayi prolyl oligopeptidase family protein 0.0071 0.029 0.058
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0112 0.0804 0.2492
Mycobacterium tuberculosis Hypothetical protein 0.0302 0.3227 1
Brugia malayi Cathepsin L-like precursor 0.0141 0.1184 0.2368
Brugia malayi Cathepsin L-like precursor 0.0205 0.1997 0.3996
Onchocerca volvulus Cathepsin L homolog 0.0205 0.1997 0.4014
Schistosoma mansoni calpain-7 (C02 family) 0.0161 0.1437 0.1437
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0205 0.1997 0.6187
Echinococcus granulosus cathepsin l cysteine peptidase 0.0205 0.1997 0.1758
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0169 0.1539 0.5963
Mycobacterium ulcerans putative transglutaminase-like protein 0.0302 0.3227 1
Leishmania major oligopeptidase b 0.0064 0.0199 0.0769
Echinococcus multilocularis cathepsin L 0.0112 0.0804 0.053
Trypanosoma cruzi cysteine peptidase, putative 0.0251 0.2582 0.5165
Entamoeba histolytica cysteine protease, putative 0.0112 0.0804 0.4027
Trypanosoma brucei serine peptidase, clan SC, family S9A-like protein 0.0064 0.0199 0.0769
Leishmania major cathepsin L-like protease 0.0205 0.1997 0.7735
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0251 0.2582 1
Echinococcus multilocularis Transglutaminase 0.0302 0.3227 0.3025
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0205 0.1997 0.6187
Giardia lamblia Hypothetical protein 0.0302 0.3227 1
Loa Loa (eye worm) calpain 5 0.0113 0.082 0.164
Echinococcus granulosus cathepsin L 0.0112 0.0804 0.053
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0441 0.4998 0.4998
Entamoeba histolytica cysteine protease, putative 0.0112 0.0804 0.4027
Mycobacterium ulcerans hypothetical protein 0.0302 0.3227 1
Brugia malayi Papain family cysteine protease containing protein 0.0112 0.0804 0.1609
Trypanosoma brucei oligopeptidase b 0.0064 0.0199 0.0769
Entamoeba histolytica cysteine proteinase, putative 0.0205 0.1997 1
Schistosoma mansoni cathepsin F (C01 family) 0.0141 0.1184 0.1184
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0161 0.1437 0.5568
Echinococcus multilocularis cysteine protease 0.0205 0.1997 0.1758
Onchocerca volvulus 0.0205 0.1997 0.4014
Trypanosoma cruzi cysteine peptidase, putative 0.0205 0.1997 0.3996
Onchocerca volvulus Cathepsin F homolog 0.0205 0.1997 0.4014
Echinococcus multilocularis cathepsin L cysteine protease 0.0205 0.1997 0.1758
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0205 0.1997 0.6187
Trypanosoma cruzi cysteine peptidase, putative 0.0251 0.2582 0.5165
Trypanosoma brucei prolyl endopeptidase 0.014 0.1172 0.4538
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0251 0.2582 1
Entamoeba histolytica cysteine proteinase, putative 0.0112 0.0804 0.4027
Loa Loa (eye worm) prolyl oligopeptidase 0.0186 0.1747 0.3496
Brugia malayi cathepsin F-like cysteine proteinase 0.0064 0.0195 0.0391
Loa Loa (eye worm) hypothetical protein 0.0379 0.4213 0.843
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0251 0.2582 1
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0428 0.4831 0.4831
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0205 0.1997 0.6187
Leishmania major cathepsin L-like protease 0.0205 0.1997 0.7735
Schistosoma mansoni calpain-7 (C02 family) 0.0161 0.1437 0.1437
Echinococcus multilocularis calpain 7 (C02 family) 0.0161 0.1437 0.1182
Brugia malayi Cathepsin L-like precursor 0.0205 0.1997 0.3996
Mycobacterium tuberculosis Conserved hypothetical protein 0.0302 0.3227 1
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0169 0.1539 0.308
Leishmania major cathepsin L-like protease 0.0205 0.1997 0.7735
Trypanosoma cruzi oligopeptidase b 0.0064 0.0199 0.0397
Brugia malayi Cathepsin L-like precursor 0.0141 0.1184 0.2368
Plasmodium vivax vivapain-3 0.0112 0.0804 0.3379
Entamoeba histolytica cysteine proteinase, putative 0.0112 0.0804 0.4027
Echinococcus granulosus calpain 5 0.0161 0.1437 0.1182
Mycobacterium leprae Conserved hypothetical protein 0.0302 0.3227 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0205 0.1997 0.6187
Echinococcus multilocularis hypothetical protein 0.0161 0.1437 0.1182
Toxoplasma gondii cathepsin B 0.0169 0.1539 0.7709
Trypanosoma brucei Dipeptidyl-peptidase 8-like, putative 0.0071 0.029 0.1122
Toxoplasma gondii cathepsin CPL 0.0205 0.1997 1
Schistosoma mansoni dipeptidyl-peptidase 9 (S09 family) 0.0071 0.029 0.029
Entamoeba histolytica cysteine protease, putative 0.0112 0.0804 0.4027
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0187 0.1768 0.3538
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0161 0.1437 0.2876
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.014 0.1172 0.1172
Leishmania major calpain, putative,cysteine peptidase, Clan CA, family C2, putative 0.0161 0.1437 0.5568
Onchocerca volvulus 0.0205 0.1997 0.4014

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 19.9526 um PUBCHEM_BIOASSAY: Counterscreen qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. This assay monitors tau fibrillation by fluorescence polarization (FP) of Alexa 594-labeled K18 P301L, which does not fibrillize readily but incorporates into growing filaments of unlabeled tau. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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