Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | chromobox homolog 1 | Starlite/ChEMBL | No references |
Homo sapiens | bromodomain adjacent to zinc finger domain, 2B | Starlite/ChEMBL | No references |
Homo sapiens | glucagon-like peptide 1 receptor | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Loa Loa (eye worm) | pigment dispersing factor receptor c | glucagon-like peptide 1 receptor | 463 aa | 388 aa | 25.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Heterochromatin protein 1 | 0.0084 | 0.9039 | 0.8936 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.5463 | 0.5833 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0041 | 0.2617 | 0.183 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.4163 | 0.4395 |
Echinococcus multilocularis | chromobox protein 1 | 0.0084 | 0.9039 | 1 |
Trichomonas vaginalis | chromobox protein, putative | 0.0084 | 0.9039 | 1 |
Schistosoma mansoni | bromodomain containing protein | 0.0076 | 0.7886 | 0.8724 |
Echinococcus granulosus | chromobox protein 1 | 0.0084 | 0.9039 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.3818 | 0.4014 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0047 | 0.3514 | 0.2714 |
Loa Loa (eye worm) | hypothetical protein | 0.0047 | 0.3514 | 0.3678 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0043 | 0.2951 | 0.3265 |
Trichomonas vaginalis | chromobox protein, putative | 0.0084 | 0.9039 | 1 |
Echinococcus multilocularis | fetal alzheimer antigen, falz | 0.0027 | 0.0535 | 0.0592 |
Schistosoma mansoni | chromobox protein | 0.0084 | 0.9039 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0025 | 0.0191 | 0.0211 |
Onchocerca volvulus | Heterochromatin protein 1 homolog | 0.0047 | 0.3514 | 0.7399 |
Echinococcus granulosus | chromobox protein 1 | 0.0084 | 0.9039 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.006 | 0.5463 | 0.5833 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0027 | 0.0535 | 0.0592 |
Trichomonas vaginalis | chromobox protein, putative | 0.0051 | 0.405 | 0.3419 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.006 | 0.5463 | 0.4979 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0047 | 0.3514 | 0.2714 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.2617 | 0.2684 |
Onchocerca volvulus | Heterochromatin protein 1 homolog | 0.0051 | 0.405 | 1 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0072 | 0.724 | 0.801 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.006 | 0.5463 | 0.4979 |
Echinococcus multilocularis | chromobox protein 1 | 0.0084 | 0.9039 | 1 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0043 | 0.2951 | 0.3265 |
Schistosoma mansoni | chromobox protein | 0.0084 | 0.9039 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0085 | 0.9228 | 1 |
Trichomonas vaginalis | chromobox protein, putative | 0.0051 | 0.405 | 0.3419 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.3391 | 0.3541 |
Echinococcus granulosus | fetal alzheimer antigen falz | 0.0027 | 0.0535 | 0.0592 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.1992 | 0.1993 |
Schistosoma mansoni | hypothetical protein | 0.0041 | 0.2617 | 0.2895 |
Brugia malayi | Bromodomain containing protein | 0.0046 | 0.3378 | 0.2673 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0072 | 0.724 | 0.801 |
Loa Loa (eye worm) | heterochromatin protein 1 | 0.0084 | 0.9039 | 0.979 |
Brugia malayi | chromobox protein homolog 3 | 0.0047 | 0.3514 | 0.2824 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 10 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] | ChEMBL. | No reference |
Potency (functional) | 12.5893 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 14.1254 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Potency (functional) | = 25.1189 um | PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of L3MBTL1. (Class of assay: confirmatory) [Related pubchem assays: 485292 (Probe Development Summary for Inhibitors of L3MBTL1)] | ChEMBL. | No reference |
Potency (functional) | 25.1189 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] | ChEMBL. | No reference |
Potency (functional) | 25.1189 uM | PubChem BioAssay. qHTS Assay for Activators of ClpP. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 28.1838 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.