Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | ataxin 2 | Starlite/ChEMBL | No references |
Homo sapiens | parathyroid hormone 1 receptor | Starlite/ChEMBL | No references |
Homo sapiens | mitogen-activated protein kinase 1 | Starlite/ChEMBL | No references |
Homo sapiens | ATPase family, AAA domain containing 5 | Starlite/ChEMBL | No references |
Homo sapiens | survival of motor neuron 2, centromeric | Starlite/ChEMBL | No references |
Homo sapiens | nucleotide-binding oligomerization domain containing 2 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Trypanosoma brucei | mitogen-activated protein kinase 5 | mitogen-activated protein kinase 1 | 360 aa | 361 aa | 33.2 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0019 | 0.0071 | 0.0078 |
Echinococcus granulosus | FTZ F1 alpha | 0.0009 | 0.0003 | 0.0004 |
Schistosoma mansoni | hypothetical protein | 0.0058 | 0.033 | 0.0364 |
Echinococcus granulosus | mitogen activated protein kinase | 0.0062 | 0.0352 | 0.0388 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0009 | 0.0003 | 0.0004 |
Echinococcus multilocularis | carbonic anhydrase | 0.0585 | 0.3812 | 0.4204 |
Schistosoma mansoni | hypothetical protein | 0.0019 | 0.0071 | 0.0078 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0009 | 0.0003 | 0.0004 |
Brugia malayi | hypothetical protein | 0.003 | 0.0146 | 0.0157 |
Trypanosoma brucei | carbonic anhydrase-like protein | 0.1381 | 0.9069 | 1 |
Onchocerca volvulus | 0.0033 | 0.0166 | 0.4989 | |
Schistosoma mansoni | carbonic anhydrase | 0.0585 | 0.3812 | 0.4204 |
Onchocerca volvulus | Cell death protein 3 homolog | 0.0037 | 0.0192 | 0.5763 |
Leishmania major | carbonic anhydrase-like protein | 0.1381 | 0.9069 | 1 |
Echinococcus multilocularis | cpg binding protein | 0.0035 | 0.0179 | 0.0197 |
Echinococcus granulosus | apoptotic protease activating factor 1 | 0.0037 | 0.0192 | 0.0211 |
Trypanosoma cruzi | mitogen activated protein kinase 2, putative | 0.0062 | 0.0352 | 0.023 |
Echinococcus granulosus | caspase 2 | 0.0037 | 0.0192 | 0.0211 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0019 | 0.0071 | 0.0074 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0009 | 0.0003 | 0.0004 |
Brugia malayi | Putative carbonic anhydrase 5 precursor | 0.1381 | 0.9069 | 1 |
Loa Loa (eye worm) | CXXC zinc finger family protein | 0.0033 | 0.0166 | 0.018 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0585 | 0.3812 | 0.4201 |
Echinococcus multilocularis | GPCR, family 2 | 0.0019 | 0.0071 | 0.0078 |
Schistosoma mansoni | coup transcription factor | 0.0009 | 0.0003 | 0.0004 |
Echinococcus granulosus | Ataxin 2 N terminaldomain containing protein | 0.0014 | 0.0035 | 0.0039 |
Echinococcus multilocularis | carbonic anhydrase II | 0.1381 | 0.9069 | 1 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0009 | 0.0003 | 0.0004 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0019 | 0.0071 | 0.0078 |
Loa Loa (eye worm) | histone methyltransferase | 0.001 | 0.0013 | 0.0011 |
Schistosoma mansoni | nuclear hormone receptor | 0.0009 | 0.0003 | 0.0004 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0019 | 0.0071 | 0.0078 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0585 | 0.3812 | 0.4201 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0009 | 0.0003 | 0.0004 |
Onchocerca volvulus | 0.0037 | 0.0192 | 0.5763 | |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0009 | 0.0003 | 0.0004 |
Toxoplasma gondii | hypothetical protein | 0.0585 | 0.3812 | 1 |
Giardia lamblia | Kinase, CMGC MAPK | 0.0062 | 0.0352 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0192 | 0.0208 |
Plasmodium falciparum | carbonic anhydrase | 0.0585 | 0.3812 | 1 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0058 | 0.033 | 0.036 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0009 | 0.0003 | 0.0004 |
Schistosoma mansoni | cpg binding protein | 0.0035 | 0.0179 | 0.0197 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0009 | 0.0003 | 0.0004 |
Schistosoma mansoni | hypothetical protein | 0.0037 | 0.0192 | 0.0211 |
Brugia malayi | hypothetical protein | 0.002 | 0.0075 | 0.0079 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0146 | 0.0157 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.1381 | 0.9069 | 1 |
Schistosoma mansoni | carbonic anhydrase | 0.1183 | 0.7764 | 0.8562 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.003 | 0.0146 | 0.5 |
Toxoplasma gondii | CMGC kinase, MAPK family (ERK) MAPK-1 | 0.0062 | 0.0352 | 0.056 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0009 | 0.0003 | 0.0004 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0009 | 0.0003 | 0.0004 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0019 | 0.0071 | 0.0074 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0009 | 0.0003 | 0.0004 |
Brugia malayi | Carbonic anhydrase like protein 2 precursor | 0.0585 | 0.3812 | 0.4201 |
Brugia malayi | hypothetical protein | 0.0037 | 0.0192 | 0.0208 |
Onchocerca volvulus | 0.0058 | 0.033 | 1 | |
Echinococcus multilocularis | mitogen activated protein kinase | 0.0062 | 0.0352 | 0.0388 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0071 | 0.0414 | 0.0457 |
Echinococcus granulosus | mitogen activated protein kinase 3 | 0.0062 | 0.0352 | 0.0388 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0009 | 0.0003 | 0.0004 |
Schistosoma mansoni | survival motor neuron protein | 0.0058 | 0.033 | 0.0364 |
Echinococcus granulosus | GPCR family 2 | 0.0019 | 0.0071 | 0.0078 |
Echinococcus multilocularis | mitogen activated protein kinase 3 | 0.0062 | 0.0352 | 0.0388 |
Entamoeba histolytica | carbonic anhydrase, putative | 0.1183 | 0.7764 | 0.5 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0009 | 0.0003 | 0.0004 |
Echinococcus granulosus | carbonic anhydrase | 0.0585 | 0.3812 | 0.4204 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0019 | 0.0071 | 0.0074 |
Schistosoma mansoni | cpg binding protein | 0.0035 | 0.0179 | 0.0197 |
Echinococcus multilocularis | carbonic anhydrase | 0.0585 | 0.3812 | 0.4204 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0009 | 0.0003 | 0.0004 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0009 | 0.0003 | 0.0004 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.006 | 0.0343 | 0.0374 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0217 | 0.0236 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0009 | 0.0003 | 0.0004 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0071 | 0.0074 |
Schistosoma mansoni | hypothetical protein | 0.0019 | 0.0071 | 0.0078 |
Brugia malayi | Cell death protein 3 precursor | 0.0037 | 0.0192 | 0.0208 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0019 | 0.0071 | 0.0078 |
Loa Loa (eye worm) | hypothetical protein | 0.0585 | 0.3812 | 0.4201 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.0585 | 0.3812 | 0.4201 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0041 | 0.0217 | 0.0236 |
Brugia malayi | CXXC zinc finger family protein | 0.0033 | 0.0166 | 0.018 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.001 | 0.0013 | 0.0015 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.006 | 0.0343 | 0.0374 |
Schistosoma mansoni | hypothetical protein | 0.0041 | 0.0217 | 0.0239 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0009 | 0.0003 | 0.0004 |
Echinococcus multilocularis | Ataxin 2, N terminal,domain containing protein | 0.0014 | 0.0035 | 0.0039 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0023 | 0.01 | 0.0107 |
Loa Loa (eye worm) | hypothetical protein | 0.0585 | 0.3812 | 0.4201 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.1381 | 0.9069 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.0009 | 0.0003 | 0.0004 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0009 | 0.0003 | 0.0004 |
Schistosoma mansoni | thyroid hormone receptor | 0.0009 | 0.0003 | 0.0004 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0009 | 0.0003 | 0.0004 |
Brugia malayi | MAP kinase sur-1 | 0.0062 | 0.0352 | 0.0384 |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.001 | 0.0013 | 0.0015 |
Leishmania major | mitogen activated protein kinase, putative,map kinase, putative | 0.0062 | 0.0352 | 0.023 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0062 | 0.0352 | 0.0388 |
Trypanosoma brucei | protein kinase, putative | 0.0062 | 0.0352 | 0.023 |
Trypanosoma cruzi | mitogen activated protein kinase 4, putative | 0.0062 | 0.0352 | 0.023 |
Loa Loa (eye worm) | hypothetical protein | 0.0286 | 0.1832 | 0.2017 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0009 | 0.0003 | 0.0004 |
Mycobacterium tuberculosis | Beta-carbonic anhydrase | 0.101 | 0.6619 | 1 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0585 | 0.3812 | 0.4201 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.0343 | 0.0374 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0286 | 0.1832 | 0.202 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0009 | 0.0003 | 0.0004 |
Trichomonas vaginalis | conserved hypothetical protein | 0.1522 | 1 | 1 |
Leishmania major | mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 | 0.0062 | 0.0352 | 0.023 |
Schistosoma mansoni | hypothetical protein | 0.0585 | 0.3812 | 0.4204 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0009 | 0.0003 | 0.0004 |
Loa Loa (eye worm) | hypothetical protein | 0.0585 | 0.3812 | 0.4201 |
Mycobacterium tuberculosis | Beta-carbonic anhydrase CanB | 0.0672 | 0.4383 | 0.321 |
Echinococcus multilocularis | carbonic anhydrase | 0.0585 | 0.3812 | 0.4204 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.006 | 0.0343 | 0.0374 |
Echinococcus granulosus | cpg binding protein | 0.0035 | 0.0179 | 0.0197 |
Echinococcus multilocularis | atpase aaa+ type core atpase aaa type core | 0.0979 | 0.6416 | 0.7075 |
Toxoplasma gondii | histone lysine methyltransferase SET1 | 0.0063 | 0.0364 | 0.0595 |
Echinococcus multilocularis | apoptotic protease activating factor 1 | 0.0037 | 0.0192 | 0.0211 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0009 | 0.0003 | 0.0004 |
Echinococcus granulosus | carbonic anhydrase | 0.0585 | 0.3812 | 0.4204 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.1381 | 0.9069 | 1 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0009 | 0.0003 | 0.0004 |
Leishmania major | carbonic anhydrase family protein, putative | 0.1183 | 0.7764 | 0.8538 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0585 | 0.3812 | 0.4204 |
Loa Loa (eye worm) | CMGC/MAPK/ERK1 protein kinase | 0.0062 | 0.0352 | 0.0384 |
Schistosoma mansoni | cpg binding protein | 0.0033 | 0.0166 | 0.0183 |
Schistosoma mansoni | hypothetical protein | 0.0019 | 0.0071 | 0.0078 |
Brugia malayi | F/Y-rich N-terminus family protein | 0.001 | 0.0013 | 0.001 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.1381 | 0.9069 | 1 |
Trypanosoma brucei | mitogen activated protein kinase 4, putative | 0.0062 | 0.0352 | 0.023 |
Loa Loa (eye worm) | carbonic anhydrase 3 | 0.1381 | 0.9069 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.1522 | 1 | 1 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0009 | 0.0003 | 0.0004 |
Schistosoma mansoni | hypothetical protein | 0.0019 | 0.0071 | 0.0078 |
Brugia malayi | Cytochrome P450 family protein | 0.0023 | 0.01 | 0.0107 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.1381 | 0.9069 | 1 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0009 | 0.0003 | 0.0004 |
Schistosoma mansoni | hypothetical protein | 0.0014 | 0.0035 | 0.0039 |
Mycobacterium leprae | CARBONIC ANHYDRASE (CARBONATE DEHYDRATASE) (CARBONIC DEHYDRATASE) | 0.1183 | 0.7764 | 0.5 |
Echinococcus multilocularis | caspase 2 | 0.0037 | 0.0192 | 0.0211 |
Echinococcus granulosus | carbonic anhydrase II | 0.1381 | 0.9069 | 1 |
Brugia malayi | hypothetical protein | 0.0286 | 0.1832 | 0.2017 |
Brugia malayi | Carbonic anhydrase like protein 2 precursor | 0.0585 | 0.3812 | 0.4201 |
Schistosoma mansoni | hypothetical protein | 0.0029 | 0.014 | 0.0154 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0062 | 0.0352 | 0.023 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0585 | 0.3812 | 0.4204 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0192 | 0.0208 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0062 | 0.0352 | 0.023 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0286 | 0.1832 | 0.202 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.1381 | 0.9069 | 1 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0585 | 0.3812 | 0.4204 |
Schistosoma mansoni | caspase-7 (C14 family) | 0.0037 | 0.0192 | 0.0211 |
Echinococcus granulosus | carbonic anhydrase | 0.0585 | 0.3812 | 0.4204 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | = 8.89 uM | PUBCHEM_BIOASSAY: uHTS luminescence assay for the identification of compounds that inhibit NOD2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1575, AID1578, AID1579, AID1848, AID1849, AID1852, AID2001, AID2260, AID2264, AID2334, AID2335, AID2337, AID2466, AID2475, AID2485, AID2503, AID2793, AID2798, AID2799] | ChEMBL. | No reference |
EC50 (functional) | > 20 uM | PUBCHEM_BIOASSAY: uHTS luminescence assay for the identification of compounds that inhibit NOD1. uHTS luminescence assay for the identification of compounds that inhibit NOD1, utilizing an NF-kB-mediated luciferase reporter gene activity as a measure of NOD1 modulation (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1566, AID1575, AID1849, AID1852, AID2250, AID2255, AID2260, AID2261, AID2264, AID2333, AID2334, AID2335, AID2337, AID2466, AID2469, AID2475, AID2483, AID2485, AID2503, AID2505, AID2789, AID2792, AID2793, AID2798, AID2799, AID2800, AID2801] | ChEMBL. | No reference |
IC50 (functional) | > 20 uM | PUBCHEM_BIOASSAY: uHTS Fluorescence assay for the identification of cytotoxic compounds among compounds active in NOD1 cell inhibition assay. Cytotoxicity counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1566, AID1575, AID1578, AID1852, AID2001, AID2260, AID2264, AID2334, AID2335, AID2466, AID2469, AID2475, AID2503, AID2793, AID2798, AID2799, AID2800] | ChEMBL. | No reference |
IC50 (functional) | > 20 uM | PUBCHEM_BIOASSAY: uHTS Fluorescence assay for the identification of cytotoxic compounds among compounds active in NOD2 cell inhibition assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1566, AID1579, AID2260, AID2334, AID2335, AID2475, AID2503, AID2799, AID2800] | ChEMBL. | No reference |
IC50 (functional) | > 20 uM | PUBCHEM_BIOASSAY: uHTS luminescence assay for the identification of compounds that inhibit NOD2 in MDP treated cells. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1566, AID1579, AID1849, AID2260, AID2335, AID2469, AID2503, AID2800] | ChEMBL. | No reference |
IC50 (functional) | > 20 uM | PUBCHEM_BIOASSAY: HTS dose response assay for identification of inhibitors of TNFa-specific NF-kB induction. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1566, AID1575, AID1578, AID1579, AID1852, AID2337] | ChEMBL. | No reference |
Potency (functional) | 0.0024 uM | PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 1.0297 uM | PUBCHEM_BIOASSAY: qHTS of small molecules that selectively kill Giardia lamblia: Hit Validation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540272] | ChEMBL. | No reference |
Potency (functional) | 1.1689 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | = 8.9125 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of the ERK Signaling Pathway using a Homogeneous Screening Assay; Stimulation with EGF. (Class of assay: confirmatory) [Related pubchem assays: 995 ] | ChEMBL. | No reference |
Potency (functional) | 10 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] | ChEMBL. | No reference |
Potency (functional) | = 14.1254 um | PUBCHEM_BIOASSAY: qHTS Assay for Enhancers of SMN2 Splice Variant Expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 17.7828 uM | PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 18.3489 uM | PUBCHEM_BIOASSAY: qHTS screen for small molecules that induce genotoxicity in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493106, AID493143] | ChEMBL. | No reference |
Potency (functional) | 23.9341 uM | PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] | ChEMBL. | No reference |
Potency (functional) | 25.1189 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Potency (functional) | 29.0929 uM | PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] | ChEMBL. | No reference |
Potency (functional) | 29.0929 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 29.0929 uM | PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 39.8107 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] | ChEMBL. | No reference |
Potency (functional) | 39.8107 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] | ChEMBL. | No reference |
Potency (functional) | 39.8107 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] | ChEMBL. | No reference |
Potency (functional) | 50.1187 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Giardia lamblia | |||
Homo sapiens | ChEMBL23 | ||
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.