IC50 (functional)
|
= 8 uM
|
Evaluated for the inhibitory concentration required to cause growth inhibition of LOX melanoma cell line using the MTT Cytototoxicity Assay
|
ChEMBL.
|
2391696
|
IC50 (functional)
|
= 8 uM
|
Evaluated for the inhibitory concentration required to cause growth inhibition of LOX melanoma cell line using the MTT Cytototoxicity Assay
|
ChEMBL.
|
2391696
|
IC50 (functional)
|
= 12 uM
|
Evaluated for the inhibitory concentration required to cause growth inhibition of A427Mer- cell line of lung using the MTT Cytotoxicity Assay
|
ChEMBL.
|
2391696
|
IC50 (functional)
|
= 12 uM
|
Evaluated for the inhibitory concentration required to cause growth inhibition of A427Mer- cell line of lung using the MTT Cytotoxicity Assay
|
ChEMBL.
|
2391696
|
IC50 (functional)
|
= 15 uM
|
Evaluated for the inhibitory concentration required to cause growth inhibition of MCF-7 breast cell line using the MTT Cytotoxicity Assay
|
ChEMBL.
|
2391696
|
IC50 (functional)
|
= 15 uM
|
Evaluated for the inhibitory concentration required to cause growth inhibition of WiDR breast cell line using the MTT Cytotoxicity Assay
|
ChEMBL.
|
2391696
|
IC50 (functional)
|
= 15 uM
|
Evaluated for the inhibitory concentration required to cause growth inhibition of SK-MEL-5 melanoma cell line using the MTT Cytototoxicity Assay
|
ChEMBL.
|
2391696
|
IC50 (functional)
|
= 15 uM
|
Evaluated for the inhibitory concentration required to cause growth inhibition of MCF-7 breast cell line using the MTT Cytotoxicity Assay
|
ChEMBL.
|
2391696
|
IC50 (functional)
|
= 15 uM
|
Evaluated for the inhibitory concentration required to cause growth inhibition of WiDR breast cell line using the MTT Cytotoxicity Assay
|
ChEMBL.
|
2391696
|
IC50 (functional)
|
= 15 uM
|
Evaluated for the inhibitory concentration required to cause growth inhibition of SK-MEL-5 melanoma cell line using the MTT Cytototoxicity Assay
|
ChEMBL.
|
2391696
|
IC50 (functional)
|
= 17 uM
|
Evaluated for the inhibitory concentration required to cause growth inhibition of RPMI7951 melanoma cell line using the MTT Cytototoxicity Assay
|
ChEMBL.
|
2391696
|
IC50 (functional)
|
= 17 uM
|
Evaluated for the inhibitory concentration required to cause growth inhibition of RPMI7951 melanoma cell line using the MTT Cytototoxicity Assay
|
ChEMBL.
|
2391696
|
IC50 (functional)
|
= 18 uM
|
Evaluated for the inhibitory concentration required to cause growth inhibition of H522 cell line of lung using the Microculture Tetrazolium (MTT) Cytotoxicity Assay
|
ChEMBL.
|
2391696
|
IC50 (functional)
|
= 18 uM
|
Evaluated for the inhibitory concentration required to cause growth inhibition of U251 cell line of central nervous system (CNS) using the MTT Cytotoxicity Assay
|
ChEMBL.
|
2391696
|
IC50 (functional)
|
= 18 uM
|
Evaluated for the inhibitory concentration required to cause growth inhibition of A498Rem- renal cell line using the MTT Cytototoxicity Assay
|
ChEMBL.
|
2391696
|
IC50 (functional)
|
= 18 uM
|
Evaluated for the inhibitory concentration required to cause growth inhibition of OVCAR-4 ovarian cell line using the MTT Cytototoxicity Assay
|
ChEMBL.
|
2391696
|
IC50 (functional)
|
= 18 uM
|
Evaluated for the inhibitory concentration required to cause growth inhibition of TE85Mer+ sarcoma cell line using the MTT Cytototoxicity Assay
|
ChEMBL.
|
2391696
|
IC50 (functional)
|
= 18 uM
|
Evaluated for the inhibitory concentration required to cause growth inhibition of U251 cell line of central nervous system (CNS) using the MTT Cytotoxicity Assay
|
ChEMBL.
|
2391696
|
IC50 (functional)
|
= 18 uM
|
Evaluated for the inhibitory concentration required to cause growth inhibition of A498Rem- renal cell line using the MTT Cytototoxicity Assay
|
ChEMBL.
|
2391696
|
IC50 (functional)
|
= 18 uM
|
Evaluated for the inhibitory concentration required to cause growth inhibition of OVCAR-4 ovarian cell line using the MTT Cytototoxicity Assay
|
ChEMBL.
|
2391696
|
IC50 (functional)
|
= 18 uM
|
Evaluated for the inhibitory concentration required to cause growth inhibition of TE85Mer+ sarcoma cell line using the MTT Cytototoxicity Assay
|
ChEMBL.
|
2391696
|
IC50 (functional)
|
= 20 uM
|
Evaluated for the inhibitory concentration required to cause growth inhibition of H23 cell line of lung using the Microculture Tetrazolium (MTT) Cytotoxicity Assay
|
ChEMBL.
|
2391696
|
IC50 (functional)
|
= 20 uM
|
Evaluated for the inhibitory concentration required to cause growth inhibition of A172Mer- cell line of central nervous system (CNS) using the MTT Cytotoxicity Assay
|
ChEMBL.
|
2391696
|
IC50 (functional)
|
= 20 uM
|
Evaluated for the inhibitory concentration required to cause growth inhibition of H23 cell line of lung using the Microculture Tetrazolium (MTT) Cytotoxicity Assay
|
ChEMBL.
|
2391696
|
IC50 (functional)
|
= 20 uM
|
Evaluated for the inhibitory concentration required to cause growth inhibition of A172Mer- cell line of central nervous system (CNS) using the MTT Cytotoxicity Assay
|
ChEMBL.
|
2391696
|
IC50 (functional)
|
= 24 uM
|
Evaluated for the inhibitory concentration required to cause growth inhibition of MCF-7ADR breast cell line using the MTT Cytotoxicity Assay
|
ChEMBL.
|
2391696
|
IC50 (functional)
|
= 24 uM
|
Evaluated for the inhibitory concentration required to cause growth inhibition of MCF-7ADR breast cell line using the MTT Cytotoxicity Assay
|
ChEMBL.
|
2391696
|
IC50 (functional)
|
= 25 uM
|
Evaluated for the inhibitory concentration required to cause growth inhibition of MALME-3M melanoma cell line using the MTT Cytototoxicity Assay
|
ChEMBL.
|
2391696
|
IC50 (functional)
|
= 25 uM
|
Evaluated for the inhibitory concentration required to cause growth inhibition of OVCAR-3 ovarian cell line using the MTT Cytototoxicity Assay
|
ChEMBL.
|
2391696
|
IC50 (functional)
|
= 25 uM
|
Evaluated for the inhibitory concentration required to cause growth inhibition of MALME-3M melanoma cell line using the MTT Cytototoxicity Assay
|
ChEMBL.
|
2391696
|
IC50 (functional)
|
= 25 uM
|
Evaluated for the inhibitory concentration required to cause growth inhibition of OVCAR-3 ovarian cell line using the MTT Cytototoxicity Assay
|
ChEMBL.
|
2391696
|
IC50 (functional)
|
= 26 uM
|
Evaluated for the inhibitory concentration required to cause growth inhibition of A549Rem- cell line of lung using the MTT Cytotoxicity Assay
|
ChEMBL.
|
2391696
|
IC50 (functional)
|
= 26 uM
|
Evaluated for the inhibitory concentration required to cause growth inhibition of DOD-1 breast cell line using the MTT Cytototoxicity Assay
|
ChEMBL.
|
2391696
|
IC50 (functional)
|
= 26 uM
|
Evaluated for the inhibitory concentration required to cause growth inhibition of A704Rem- renal cell line using the MTT Cytototoxicity Assay
|
ChEMBL.
|
2391696
|
IC50 (functional)
|
= 26 uM
|
Evaluated for the inhibitory concentration required to cause growth inhibition of A549Rem- cell line of lung using the MTT Cytotoxicity Assay
|
ChEMBL.
|
2391696
|
IC50 (functional)
|
= 26 uM
|
Evaluated for the inhibitory concentration required to cause growth inhibition of A704Rem- renal cell line using the MTT Cytototoxicity Assay
|
ChEMBL.
|
2391696
|
IC50 (functional)
|
= 32 uM
|
Evaluated for the inhibitory concentration required to cause growth inhibition of H322M cell line of lung using the Microculture Tetrazolium (MTT) Cytotoxicity Assay
|
ChEMBL.
|
2391696
|
IC50 (functional)
|
= 32 uM
|
Evaluated for the inhibitory concentration required to cause growth inhibition of H322M cell line of lung using the Microculture Tetrazolium (MTT) Cytotoxicity Assay
|
ChEMBL.
|
2391696
|
IC50 (functional)
|
= 35 uM
|
Evaluated for the inhibitory concentration required to cause growth inhibition of A673Mer+ sarcoma cell line using the MTT Cytototoxicity Assay
|
ChEMBL.
|
2391696
|
IC50 (functional)
|
= 35 uM
|
Evaluated for the inhibitory concentration required to cause growth inhibition of A673Mer+ sarcoma cell line using the MTT Cytototoxicity Assay
|
ChEMBL.
|
2391696
|
IC50 (functional)
|
= 42 uM
|
Evaluated for the inhibitory concentration required to cause growth inhibition of H125 cell line of lung using the Microculture Tetrazolium (MTT) Cytotoxicity Assay
|
ChEMBL.
|
2391696
|
IC50 (functional)
|
= 44 uM
|
Evaluated for the inhibitory concentration required to cause growth inhibition of MAR BEL fibroblasts cell line using the MTT Cytototoxicity Assay
|
ChEMBL.
|
2391696
|
IC50 (functional)
|
= 50 uM
|
Evaluated for the inhibitory concentration required to cause growth inhibition of TE-671 cell line of central nervous system (CNS)using the MTT Cytotoxicity Assay
|
ChEMBL.
|
2391696
|
IC50 (functional)
|
= 50 uM
|
Evaluated for the inhibitory concentration required to cause growth inhibition of TE-671 cell line of central nervous system (CNS)using the MTT Cytotoxicity Assay
|
ChEMBL.
|
2391696
|
IC50 (functional)
|
= 60 uM
|
Evaluated for the inhibitory concentration required to cause growth inhibition of H358M cell line of lung using the Microculture Tetrazolium (MTT) Cytotoxicity Assay
|
ChEMBL.
|
2391696
|
IC50 (functional)
|
= 60 uM
|
Evaluated for the inhibitory concentration required to cause growth inhibition of H460 cell line of lung using the Microculture Tetrazolium (MTT) Cytotoxicity Assay
|
ChEMBL.
|
2391696
|
IC50 (functional)
|
= 60 uM
|
Evaluated for the inhibitory concentration required to cause growth inhibition of CCD-19Lu fibroblasts cell line using the MTT Cytototoxicity Assay
|
ChEMBL.
|
2391696
|
IC50 (functional)
|
= 60 uM
|
Evaluated for the inhibitory concentration required to cause growth inhibition of H358M cell line of lung using the Microculture Tetrazolium (MTT) Cytotoxicity Assay
|
ChEMBL.
|
2391696
|
IC50 (functional)
|
= 60 uM
|
Evaluated for the inhibitory concentration required to cause growth inhibition of H460 cell line of lung using the Microculture Tetrazolium (MTT) Cytotoxicity Assay
|
ChEMBL.
|
2391696
|
IC50 (functional)
|
= 60 uM
|
Evaluated for the inhibitory concentration required to cause growth inhibition of CCD-19Lu fibroblasts cell line using the MTT Cytototoxicity Assay
|
ChEMBL.
|
2391696
|
T/C (functional)
|
= 157 %
|
Evaluated in vivo for antineoplastic activity against P388 murine leukemia tumor xenograft in nude mice after administering intra peritoneal injection at a dose of 13.12 mg/kg
|
ChEMBL.
|
2391696
|
T/C (functional)
|
= 157 %
|
Evaluated in vivo for antineoplastic activity against P388 murine leukemia tumor xenograft in nude mice after administering intra peritoneal injection at a dose of 13.12 mg/kg
|
ChEMBL.
|
2391696
|
T/C (functional)
|
= 217 %
|
Evaluated in vivo for antineoplastic activity against P388 murine leukemia tumor xenograft in nude mice after administering intra peritoneal injection at a dose of 26.25 mg/kg
|
ChEMBL.
|
2391696
|
T/C (functional)
|
= 217 %
|
Evaluated in vivo for antineoplastic activity against P388 murine leukemia tumor xenograft in nude mice after administering intra peritoneal injection at a dose of 26.25 mg/kg
|
ChEMBL.
|
2391696
|
T/C (functional)
|
= 257 %
|
Evaluated in vivo for antineoplastic activity against P388 murine leukemia tumor xenograft in nude mice after administering intra peritoneal injection at a dose of 52.5 mg/kg
|
ChEMBL.
|
2391696
|
T/C (functional)
|
= 257 %
|
Evaluated in vivo for antineoplastic activity against P388 murine leukemia tumor xenograft in nude mice after administering intra peritoneal injection at a dose of 52.5 mg/kg
|
ChEMBL.
|
2391696
|