Detailed information for compound 1415666

Basic information

Technical information
  • TDR Targets ID: 1415666
  • Name: 1-[2-(1H-indol-3-yl)ethyl]-3-[(4-methoxypheny l)methyl]urea
  • MW: 323.389 | Formula: C19H21N3O2
  • H donors: 3 H acceptors: 1 LogP: 2.92 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1)CNC(=O)NCCc1c[nH]c2c1cccc2
  • InChi: 1S/C19H21N3O2/c1-24-16-8-6-14(7-9-16)12-22-19(23)20-11-10-15-13-21-18-5-3-2-4-17(15)18/h2-9,13,21H,10-12H2,1H3,(H2,20,22,23)
  • InChiKey: YYAJYQPIGQSLEG-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1-[2-(1H-indol-3-yl)ethyl]-3-(4-methoxybenzyl)urea
  • STOCK1N-36116
  • ZINC00488914

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens GNAS complex locus Starlite/ChEMBL No references
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni alpha-glucosidase 0.0151 0.6759 0.713
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0039 0.1416 0.1416
Loa Loa (eye worm) latrophilin receptor protein 2 0.0019 0.0474 0.0474
Loa Loa (eye worm) steroid hormone receptor 0.0039 0.1416 0.1416
Brugia malayi Nuclear hormone receptor-like 1 0.0021 0.0544 0.0294
Schistosoma mansoni hypothetical protein 0.014 0.6242 0.6547
Trichomonas vaginalis maltase-glucoamylase, putative 0.0039 0.1422 1
Brugia malayi Nuclear hormone receptor E75 0.0018 0.0439 0.0186
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.1224 0.8306
Schistosoma mansoni retinoic acid receptor RXR 0.0039 0.1416 0.1102
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0019 0.0474 0.0509
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0039 0.1422 1
Schistosoma mansoni steroid hormone receptor ad4bp 0.0039 0.1416 0.1102
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.0173 0.7781 0.8364
Brugia malayi RNA recognition motif domain containing protein 0.0133 0.5899 0.579
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0019 0.0474 0.0221
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0039 0.1416 0.1522
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0039 0.1416 0.1416
Loa Loa (eye worm) hypothetical protein 0.0021 0.0544 0.0544
Brugia malayi hypothetical protein 0.0021 0.0544 0.0294
Schistosoma mansoni hypothetical protein 0.0205 0.9302 1
Loa Loa (eye worm) hypothetical protein 0.0039 0.1416 0.1416
Brugia malayi Nuclear hormone receptor-like 1 0.0039 0.1416 0.1189
Schistosoma mansoni hypothetical protein 0.0019 0.0474 0.0039
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0062 0.2532 0.2361
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0018 0.0439 0.0472
Trypanosoma cruzi membrane transporter protein, putative 0.0035 0.1224 0.8306
Onchocerca volvulus Bile acid receptor homolog 0.0039 0.1416 0.1947
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0039 0.1416 0.1522
Brugia malayi hypothetical protein 0.0018 0.0439 0.0186
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0021 0.0544 0.0118
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0018 0.0439 0.0472
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0039 0.1416 0.1189
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.2195 0.2195
Echinococcus multilocularis multidrug and toxin extrusion protein 2 0.0035 0.1224 0.1316
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0021 0.0544 0.0585
Brugia malayi orphan nuclear receptor NR2E1 0.0018 0.0439 0.0186
Loa Loa (eye worm) hypothetical protein 0.0021 0.0544 0.0544
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0018 0.0439 0.0186
Leishmania major alpha glucosidase II subunit, putative 0.0039 0.1422 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0544 0.0544
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0039 0.1416 0.1102
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.1224 0.8306
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0018 0.0439 0.0439
Echinococcus granulosus ecdysone induced protein 78C 0.0039 0.1416 0.1522
Echinococcus granulosus lysosomal alpha glucosidase 0.0176 0.7923 0.8517
Brugia malayi hypothetical protein 0.0018 0.0439 0.0186
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0039 0.1416 0.1102
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.1224 0.8306
Echinococcus granulosus multidrug and toxin extrusion protein 2 0.0035 0.1224 0.1316
Brugia malayi ecdysteroid receptor 0.0039 0.1416 0.1189
Echinococcus multilocularis lysosomal alpha glucosidase 0.0176 0.7923 0.8517
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0039 0.1416 0.1189
Schistosoma mansoni hypothetical protein 0.0019 0.0474 0.0039
Brugia malayi Glycosyl hydrolases family 31 protein 0.0176 0.7923 0.7868
Loa Loa (eye worm) hypothetical protein 0.006 0.2431 0.2431
Trypanosoma brucei membrane transporter protein, putative 0.0035 0.1224 0.8306
Schistosoma mansoni multidrug resistance protein 0.0035 0.1224 0.0886
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0039 0.1416 0.1947
Brugia malayi Glycosyl hydrolases family 31 protein 0.0039 0.1422 0.1194
Loa Loa (eye worm) hypothetical protein 0.0041 0.1525 0.1525
Brugia malayi nuclear hormone receptor family member nhr-6 0.0018 0.0439 0.0186
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0039 0.1416 0.1522
Echinococcus granulosus neutral alpha glucosidase AB 0.0039 0.1422 0.1528
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0039 0.1416 0.1189
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.0173 0.7781 0.8364
Loa Loa (eye worm) DR-78 0.0018 0.0439 0.0439
Loa Loa (eye worm) hypothetical protein 0.014 0.6207 0.6207
Loa Loa (eye worm) hypothetical protein 0.0039 0.1416 0.1416
Brugia malayi RNA binding protein 0.0133 0.5899 0.579
Echinococcus multilocularis nuclear receptor nhr 48 0.0018 0.0439 0.0472
Loa Loa (eye worm) hypothetical protein 0.0039 0.1416 0.1416
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0039 0.1416 0.1189
Echinococcus multilocularis thyroid hormone receptor alpha 0.0039 0.1416 0.1522
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0039 0.1416 0.1416
Onchocerca volvulus Huntingtin homolog 0.014 0.6207 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0439 0.0439
Brugia malayi photoreceptor-specific nuclear receptor 0.0039 0.1416 0.1189
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0018 0.0439 0.0305
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.2195 0.1981
Brugia malayi CXXC zinc finger family protein 0.0029 0.0965 0.0726
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.1224 0.8306
Onchocerca volvulus 0.0102 0.44 0.6963
Trypanosoma brucei membrane transporter protein, putative 0.0035 0.1224 0.8306
Brugia malayi nuclear receptor NHR-88 0.0039 0.1416 0.1189
Onchocerca volvulus Huntingtin homolog 0.014 0.6207 1
Echinococcus multilocularis jun protein 0.0173 0.7781 0.8364
Trichomonas vaginalis sucrase-isomaltase, putative 0.0039 0.1422 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0439 0.0439
Schistosoma mansoni cpg binding protein 0.0031 0.1045 0.0683
Schistosoma mansoni cpg binding protein 0.0031 0.1045 0.0683
Schistosoma mansoni jun-related protein 0.014 0.6242 0.6547
Echinococcus granulosus FTZ F1 alpha 0.0039 0.1416 0.1522
Brugia malayi nuclear hormone receptor family member odr-7 0.0018 0.0439 0.0186
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0039 0.1416 0.1102
Loa Loa (eye worm) hypothetical protein 0.0018 0.0439 0.0439
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0039 0.1422 1
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0018 0.0439 0.0472
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0018 0.0439 0.0472
Trypanosoma brucei glucosidase, putative 0.0039 0.1422 1
Brugia malayi Nuclear hormone receptor-like 1 0.0021 0.0544 0.0294
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0039 0.1422 1
Echinococcus multilocularis ecdysone induced protein 78C 0.0039 0.1416 0.1522
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0039 0.1422 1
Schistosoma mansoni hypothetical protein 0.0019 0.0474 0.0039
Schistosoma mansoni tar DNA-binding protein 0.0133 0.5899 0.616
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0019 0.0474 0.0509
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0018 0.0439 0.0305
Echinococcus multilocularis FTZ F1 alpha 0.0039 0.1416 0.1522
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0039 0.1416 0.1189
Loa Loa (eye worm) TAR-binding protein 0.0133 0.5899 0.5899
Loa Loa (eye worm) hypothetical protein 0.0039 0.1416 0.1416
Schistosoma mansoni cpg binding protein 0.0029 0.0965 0.0593
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.2195 0.236
Schistosoma mansoni tar DNA-binding protein 0.0133 0.5899 0.616
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0018 0.0439 0.0472
Schistosoma mansoni thyroid hormone receptor 0.0039 0.1416 0.1102
Schistosoma mansoni alpha glucosidase 0.0039 0.1422 0.1108
Loa Loa (eye worm) hypothetical protein 0.0021 0.0544 0.0544
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.2431 0.2231
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0039 0.1416 0.1102
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0039 0.1416 0.1189
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.2195 0.1981
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0039 0.1416 0.1522
Toxoplasma gondii histone lysine methyltransferase SET1 0.0056 0.2216 1
Onchocerca volvulus Protein ultraspiracle homolog 0.0039 0.1416 0.1947
Echinococcus granulosus thyroid hormone receptor alpha 0.0018 0.0439 0.0472
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0039 0.1416 0.1102
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0039 0.1416 0.1189
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0039 0.1416 0.1522
Echinococcus multilocularis geminin 0.0205 0.9302 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0474 0.0474
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0176 0.7923 0.7923
Brugia malayi nuclear receptor RXR 0.0018 0.0439 0.0186
Echinococcus multilocularis lysosomal alpha glucosidase 0.0176 0.7923 0.8517
Schistosoma mansoni alpha-glucosidase 0.0151 0.6759 0.713
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0039 0.1416 0.1522
Brugia malayi Nuclear hormone receptor E75 0.0018 0.0439 0.0186
Brugia malayi tailless protein 0.0018 0.0439 0.0186
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0965 0.0965
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.2195 0.236
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0039 0.1416 0.1522
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0039 0.1416 0.1416
Loa Loa (eye worm) hypothetical protein 0.0015 0.0258 0.0258
Echinococcus multilocularis tar DNA binding protein 0.0133 0.5899 0.6341
Echinococcus multilocularis Multi antimicrobial extrusion protein MatE 0.0032 0.1079 0.116
Echinococcus granulosus cpg binding protein 0.0031 0.1045 0.1123
Loa Loa (eye worm) hypothetical protein 0.0021 0.0544 0.0544
Loa Loa (eye worm) hypothetical protein 0.0018 0.0439 0.0439
Schistosoma mansoni tar DNA-binding protein 0.0133 0.5899 0.616
Brugia malayi hypothetical protein 0.0136 0.6017 0.5911
Loa Loa (eye worm) hypothetical protein 0.0039 0.1416 0.1416
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.2195 0.236
Brugia malayi nuclear receptor NHR-67 0.0018 0.0439 0.0186
Brugia malayi hypothetical protein 0.0021 0.0544 0.0294
Echinococcus granulosus jun protein 0.0173 0.7781 0.8364
Loa Loa (eye worm) hypothetical protein 0.0018 0.0439 0.0439
Schistosoma mansoni hypothetical protein 0.0041 0.1525 0.1225
Loa Loa (eye worm) nuclear hormone receptor 0.0018 0.0439 0.0439
Brugia malayi conserved hypotetical protein 0.0018 0.0439 0.0186
Brugia malayi ecdysone receptor 0.0018 0.0439 0.0186
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.2195 0.1989
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0039 0.1416 0.1522
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0039 0.1416 0.1522
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.2195 0.236
Loa Loa (eye worm) hypothetical protein 0.0168 0.7556 0.7556
Schistosoma mansoni hypothetical protein 0.0205 0.9302 1
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.1525 0.1301
Trichomonas vaginalis alpha-glucosidase, putative 0.0039 0.1422 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0439 0.0439
Schistosoma mansoni RAR-like nuclear receptor 0.0039 0.1416 0.1102
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0018 0.0439 0.0472
Trypanosoma brucei MATE efflux family protein, putative 0.0035 0.1224 0.8306
Echinococcus granulosus Nuclear hormone receptor HR96 0.0018 0.0439 0.0472
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0021 0.0544 0.0544
Brugia malayi steroid hormone receptor 0.0039 0.1416 0.1189
Onchocerca volvulus 0.0136 0.6017 0.9681
Brugia malayi nuclear receptor NHR-88 0.0018 0.0439 0.0186
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.2195 0.1981
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.1422 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0039 0.1422 1
Echinococcus granulosus nuclear receptor nhr 48 0.0018 0.0439 0.0472
Brugia malayi TAR-binding protein 0.0133 0.5899 0.579
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0019 0.0474 0.0509
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0039 0.1416 0.1522
Echinococcus granulosus GPCR family 2 0.0019 0.0474 0.0509
Brugia malayi Latrophilin receptor protein 2 0.0019 0.0474 0.0221
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0039 0.1416 0.1522
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0018 0.0439 0.0472
Brugia malayi nuclear receptor RXR 0.0021 0.0544 0.0294
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0039 0.1416 0.1189
Schistosoma mansoni tar DNA-binding protein 0.0133 0.5899 0.616
Brugia malayi Steroid receptor seven-up type 2 0.0039 0.1416 0.1189
Leishmania major hypothetical protein, conserved 0.0035 0.1224 0.8306
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.1422 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0439 0.0439
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0039 0.1416 0.1189
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0039 0.1416 0.1102
Schistosoma mansoni thyroid hormone receptor 0.0039 0.1416 0.1102
Echinococcus multilocularis neutral alpha glucosidase AB 0.0039 0.1422 0.1528
Loa Loa (eye worm) hypothetical protein 0.0039 0.1416 0.1416
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0039 0.1416 0.1416
Loa Loa (eye worm) hypothetical protein 0.0039 0.1416 0.1416
Schistosoma mansoni coup transcription factor 0.0039 0.1416 0.1102
Loa Loa (eye worm) hypothetical protein 0.014 0.6207 0.6207
Loa Loa (eye worm) hypothetical protein 0.0219 1 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0039 0.1416 0.1189
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0039 0.1416 0.1189
Schistosoma mansoni hypothetical protein 0.0019 0.0474 0.0039
Loa Loa (eye worm) hypothetical protein 0.0018 0.0439 0.0439
Trichomonas vaginalis alpha-glucosidase, putative 0.0039 0.1422 1
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0021 0.0544 0.0585
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0039 0.1422 0.1422
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0019 0.0474 0.0509
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0039 0.1416 0.1189
Echinococcus multilocularis GPCR, family 2 0.0019 0.0474 0.0509
Brugia malayi nuclear hormone receptor 0.0018 0.0439 0.0186
Brugia malayi hypothetical protein 0.014 0.6207 0.6106
Echinococcus granulosus geminin 0.0205 0.9302 1
Onchocerca volvulus 0.0018 0.0439 0.0305
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.2431 0.2431
Onchocerca volvulus 0.0029 0.0965 0.1189
Trichomonas vaginalis alpha-glucosidase, putative 0.0039 0.1422 1
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0133 0.5899 0.5899
Loa Loa (eye worm) hypothetical protein 0.0018 0.0439 0.0439
Loa Loa (eye worm) hypothetical protein 0.0039 0.1416 0.1416
Loa Loa (eye worm) hypothetical protein 0.0018 0.0439 0.0439
Onchocerca volvulus 0.0018 0.0439 0.0305
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0039 0.1416 0.1416
Loa Loa (eye worm) hypothetical protein 0.0018 0.0439 0.0439
Brugia malayi bZIP transcription factor family protein 0.0173 0.7781 0.7722
Schistosoma mansoni tar DNA-binding protein 0.0133 0.5899 0.616
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.2431 0.2231
Echinococcus granulosus tar DNA binding protein 0.0133 0.5899 0.6341
Leishmania major hypothetical protein, conserved 0.0035 0.1224 0.8306
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0039 0.1416 0.1522
Loa Loa (eye worm) RNA binding protein 0.0133 0.5899 0.5899
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0021 0.0544 0.0118
Schistosoma mansoni nuclear hormone receptor 0.0039 0.1416 0.1102
Loa Loa (eye worm) nuclear receptor NHR-67 0.0018 0.0439 0.0439
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0039 0.1416 0.1416
Echinococcus granulosus Nuclear hormone receptor HR96 0.0018 0.0439 0.0472
Loa Loa (eye worm) hypothetical protein 0.0018 0.0439 0.0439
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0039 0.1416 0.1522
Trichomonas vaginalis alpha-glucosidase, putative 0.0039 0.1422 1
Trypanosoma brucei membrane transporter protein, putative 0.0035 0.1224 0.8306
Loa Loa (eye worm) hypothetical protein 0.0018 0.0439 0.0439
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.1224 0.8306
Onchocerca volvulus 0.0039 0.1416 0.1947
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0039 0.1416 0.1189
Brugia malayi nuclear hormone receptor 0.0039 0.1416 0.1189
Echinococcus multilocularis cpg binding protein 0.0031 0.1045 0.1123

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.0291 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 0.7943 uM PubChem BioAssay. qHTS for Antagonists of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 7.9433 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 23.0999 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 79.4328 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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