Detailed information for compound 1421442

Basic information

Technical information
  • TDR Targets ID: 1421442
  • Name: [2-(3-bromo-4-methoxyphenyl)-2-oxoethyl] 3-(p henylsulfonylamino)propanoate
  • MW: 456.308 | Formula: C18H18BrNO6S
  • H donors: 1 H acceptors: 4 LogP: 2.78 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1Br)C(=O)COC(=O)CCNS(=O)(=O)c1ccccc1
  • InChi: 1S/C18H18BrNO6S/c1-25-17-8-7-13(11-15(17)19)16(21)12-26-18(22)9-10-20-27(23,24)14-5-3-2-4-6-14/h2-8,11,20H,9-10,12H2,1H3
  • InChiKey: FWVIMJQPMXUHGO-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • [2-(3-bromo-4-methoxy-phenyl)-2-oxo-ethyl] 3-(phenylsulfonylamino)propanoate
  • 3-(phenylsulfonylamino)propanoic acid [2-(3-bromo-4-methoxyphenyl)-2-oxoethyl] ester
  • 3-(phenylsulfonylamino)propionic acid [2-(3-bromo-4-methoxy-phenyl)-2-keto-ethyl] ester

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3D Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis Threonyl tRNA synthetase, C 0.0022 0.0032 0.0012
Brugia malayi Major Facilitator Superfamily protein 0.0054 0.0233 0.1023
Entamoeba histolytica protein kinase, putative 0.0119 0.0627 1
Leishmania major glucose transporter, lmgt3 0.012 0.0637 0.868
Trichomonas vaginalis sugar transporter, putative 0.0054 0.0233 0.0956
Trichomonas vaginalis sugar transporter, putative 0.0054 0.0233 0.0956
Mycobacterium ulcerans hypothetical protein 0.015 0.0822 1
Plasmodium vivax lysine--tRNA ligase, putative 0.0086 0.043 0.0401
Trichomonas vaginalis sugar transporter, putative 0.0054 0.0233 0.0956
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0625 0.3744 0.5643
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0073 0.035 0.4133
Mycobacterium ulcerans 4-aminobutyrate aminotransferase 0.0021 0.003 0.0161
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0056 0.0026
Trichomonas vaginalis myo-inositol transporter, putative 0.0054 0.0233 0.0956
Trypanosoma brucei glucose transporter, putative 0.012 0.0637 0.868
Loa Loa (eye worm) hypothetical protein 0.0051 0.021 0.0789
Trichomonas vaginalis sugar transporter, putative 0.0054 0.0233 0.0956
Chlamydia trachomatis lysine--tRNA ligase 0.0086 0.043 1
Trypanosoma cruzi threonyl-tRNA synthetase, putative 0.0022 0.0032 0.0218
Mycobacterium tuberculosis Probable glutamate-1-semialdehyde 2,1-aminomutase HemL (GSA) (glutamate-1-semialdehyde aminotransferase) (GSA-at) 0.0021 0.003 0.0161
Trypanosoma brucei glycyl-tRNA synthetase, putative 0.0022 0.0032 0.0218
Schistosoma mansoni sugar transporter 0.0054 0.0233 0.0904
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0387 0.2279 1
Giardia lamblia Sugar-proton symporter 0.0054 0.0233 0.346
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0119 0.0628 0.06
Loa Loa (eye worm) hypothetical protein 0.0054 0.0233 0.0894
Trichomonas vaginalis conserved hypothetical protein 0.0387 0.2279 1
Trichomonas vaginalis sugar transporter, putative 0.0054 0.0233 0.0956
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0086 0.043 0.1826
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0056 0.0546
Loa Loa (eye worm) hypothetical protein 0.0054 0.0233 0.0894
Toxoplasma gondii LsmAD domain-containing protein 0.0026 0.0056 0.0059
Leishmania major glucose transporter, lmgt2 0.012 0.0637 0.868
Echinococcus multilocularis solute carrier family 22 0.0054 0.0233 0.0904
Trichomonas vaginalis sugar transporter, putative 0.0054 0.0233 0.0956
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0135 0.0731 0.1081
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0086 0.043 0.5783
Schistosoma mansoni sugar transporter 0.0054 0.0233 0.0904
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0119 0.0628 0.0925
Trichomonas vaginalis conserved hypothetical protein 0.0054 0.0233 0.0956
Plasmodium vivax proline--tRNA ligase, putative 0.0135 0.0731 0.0703
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0119 0.0628 0.06
Wolbachia endosymbiont of Brugia malayi prolyl-tRNA synthetase 0.0022 0.0032 0.0127
Giardia lamblia Hexose transporter 0.0054 0.0233 0.346
Toxoplasma gondii lysine-tRNA ligase 0.0086 0.043 0.0625
Mycobacterium tuberculosis Adenosylmethionine-8-amino-7-oxononanoate aminotransferase BioA 0.015 0.0822 1
Plasmodium vivax threonine--tRNA ligase, putative 0.0022 0.0032 0.0003
Schistosoma mansoni glycyl-tRNA synthetase 0.0022 0.0032 0.0012
Plasmodium falciparum lysine--tRNA ligase 0.0086 0.043 0.0401
Trichomonas vaginalis conserved hypothetical protein 0.012 0.0637 0.274
Mycobacterium leprae Probable lysyl-tRNA synthase LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0073 0.035 0.4133
Trichomonas vaginalis conserved hypothetical protein 0.012 0.0637 0.274
Leishmania major glucose transporter/membrane transporter D2, putative 0.012 0.0637 0.868
Trypanosoma brucei threonyl-tRNA synthetase, putative 0.0022 0.0032 0.0218
Trichomonas vaginalis conserved hypothetical protein 0.0054 0.0233 0.0956
Treponema pallidum prolyl-tRNA synthetase 0.0041 0.0151 1
Plasmodium falciparum calcium-dependent protein kinase 5 0.0119 0.0628 0.06
Trichomonas vaginalis sugar transporter, putative 0.012 0.0637 0.274
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0387 0.2279 1
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0116 0.0613 0.2591
Leishmania major hypothetical protein, conserved 0.0026 0.0056 0.0546
Trypanosoma brucei myo-inositol/proton symporter (MIT) 0.0054 0.0233 0.303
Brugia malayi Cam kinase protein 1 0.0119 0.0627 0.2753
Echinococcus granulosus solute carrier family 22 0.0054 0.0233 0.0904
Trichomonas vaginalis sugar transporter, putative 0.0054 0.0233 0.0956
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0387 0.2279 1
Loa Loa (eye worm) hypothetical protein 0.0054 0.0233 0.0894
Trichomonas vaginalis CAMK family protein kinase 0.0119 0.0627 0.2699
Leishmania major myo-inositol/proton symporter (MIT) 0.0054 0.0233 0.303
Entamoeba histolytica protein kinase, putative 0.0119 0.0627 1
Trypanosoma brucei glucose transporter, putative 0.012 0.0637 0.868
Toxoplasma gondii transporter, major facilitator family protein 0.0054 0.0233 0.0327
Trypanosoma brucei THT1 - hexose transporter, putative 0.012 0.0637 0.868
Plasmodium falciparum calcium-dependent protein kinase 2 0.0119 0.0628 0.06
Plasmodium falciparum proline--tRNA ligase 0.0135 0.0731 0.0703
Trypanosoma brucei glucose transporter, putative 0.012 0.0637 0.868
Loa Loa (eye worm) hypothetical protein 0.0054 0.0233 0.0894
Trichomonas vaginalis sugar transporter, putative 0.0054 0.0233 0.0956
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0119 0.0627 0.2657
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0056 0.0026
Onchocerca volvulus 0.0182 0.1021 1
Mycobacterium ulcerans glycyl-tRNA synthetase 0.0022 0.0032 0.0193
Plasmodium falciparum major facilitator superfamily domain-containing protein, putative 0.0054 0.0233 0.0204
Trichomonas vaginalis sugar transporter, putative 0.0054 0.0233 0.0956
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0119 0.0627 0.2657
Trichomonas vaginalis sugar transporter, putative 0.012 0.0637 0.274
Mycobacterium tuberculosis Probable ornithine aminotransferase (N-terminus part) RocD1 (ornithine--oxo-acid aminotransferase) 0.0021 0.003 0.0161
Mycobacterium ulcerans threonyl-tRNA synthetase 0.0022 0.0032 0.0193
Trichomonas vaginalis sugar transporter, putative 0.0054 0.0233 0.0956
Mycobacterium tuberculosis Probable conserved integral membrane transport protein 0.0054 0.0233 0.2686
Leishmania major glucose transporter, lmgt1 0.012 0.0637 0.868
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0116 0.0613 0.7397
Toxoplasma gondii sugar transporter ST3 0.0054 0.0233 0.0327
Trypanosoma brucei glucose transporter, putative 0.012 0.0637 0.868
Trichomonas vaginalis sugar transporter, putative 0.0054 0.0233 0.0956
Trichomonas vaginalis sugar transporter, putative 0.0054 0.0233 0.0956
Mycobacterium ulcerans integral membrane transport protein 0.0054 0.0233 0.2686
Echinococcus granulosus solute carrier family 22 0.0054 0.0233 0.0904
Trichomonas vaginalis sugar transporter, putative 0.0054 0.0233 0.0956
Trichomonas vaginalis threonyl-tRNA synthetase, putative 0.0022 0.0032 0.0069
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase 0.0048 0.0192 0.0709
Chlamydia trachomatis threonine--tRNA ligase 0.0022 0.0032 0.0065
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.0073 0.035 0.4133
Loa Loa (eye worm) hypothetical protein 0.0086 0.043 0.1769
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0119 0.0627 0.2657
Echinococcus granulosus Sugar transporter ERD6 protein 0.0054 0.0233 0.0904
Trypanosoma brucei glucose transporter, putative 0.012 0.0637 0.868
Trichomonas vaginalis sugar transporter, putative 0.0054 0.0233 0.0956
Brugia malayi major facilitator superfamily protein 0.0054 0.0233 0.1023
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0054 0.0233 0.0904
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0135 0.0731 1
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0119 0.0628 0.0925
Echinococcus granulosus glycyl tRNA synthetase 0.0022 0.0032 0.0012
Plasmodium vivax sugar transporter, putative 0.0054 0.0233 0.0204
Trichomonas vaginalis conserved hypothetical protein 0.0054 0.0233 0.0956
Loa Loa (eye worm) sugar transporter 0.0387 0.2279 1
Toxoplasma gondii threonyl-tRNA synthetase family protein 0.0022 0.0032 0.0024
Plasmodium falciparum calcium-dependent protein kinase 1 0.0119 0.0628 0.06
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0056 0.0546
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0051 0.021 0.0789
Trichomonas vaginalis glucose transporter, putative 0.012 0.0637 0.274
Trichomonas vaginalis sugar transporter, putative 0.0054 0.0233 0.0956
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0135 0.0731 1
Loa Loa (eye worm) hypothetical protein 0.0054 0.0233 0.0894
Plasmodium vivax calcium-dependent protein kinase, putative 0.0119 0.0628 0.06
Mycobacterium ulcerans L-lysine aminotransferase 0.0021 0.003 0.0161
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0116 0.0613 0.2591
Brugia malayi Sugar transporter family protein 0.0054 0.0233 0.1023
Schistosoma mansoni hypothetical protein 0.0035 0.0111 0.0362
Echinococcus granulosus synaptic vesicle 2 protein 0.0054 0.0233 0.0904
Schistosoma mansoni sugar transporter 0.0054 0.0233 0.0904
Loa Loa (eye worm) hypothetical protein 0.0054 0.0233 0.0894
Trichomonas vaginalis sugar transporter, putative 0.0054 0.0233 0.0956
Trypanosoma cruzi threonyl-tRNA synthetase, putative 0.0022 0.0032 0.0218
Loa Loa (eye worm) hypothetical protein 0.0094 0.0479 0.1987
Echinococcus granulosus lysyl tRNA synthetase 0.0086 0.043 0.1778
Echinococcus granulosus solute carrier family 22 0.0054 0.0233 0.0904
Loa Loa (eye worm) hypothetical protein 0.0054 0.0233 0.0894
Schistosoma mansoni glucose transport protein 0.0387 0.2279 1
Trichomonas vaginalis sugar transporter, putative 0.0054 0.0233 0.0956
Echinococcus multilocularis synaptic vesicle 2 protein 0.0054 0.0233 0.0904
Mycobacterium ulcerans glutamate-1-semialdehyde aminotransferase 0.0021 0.003 0.0161
Giardia lamblia Lysyl-tRNA synthetase 0.0086 0.043 0.6849
Trichomonas vaginalis acetylornithine aminotransferase, putative 0.015 0.0822 0.3561
Loa Loa (eye worm) hypothetical protein 0.0182 0.1021 0.44
Mycobacterium leprae PROBABLE GLUTAMATE-1-SEMIALDEHYDE 2,1-AMINOMUTASE HEML (GSA) (GLUTAMATE-1-SEMIALDEHYDE AMINOTRANSFERASE) (GSA-AT) 0.0021 0.003 0.0161
Mycobacterium tuberculosis Probable acetylornithine aminotransferase ArgD 0.0021 0.003 0.0161
Mycobacterium ulcerans 4-aminobutyrate aminotransferase 0.0021 0.003 0.0161
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.0054 0.0233 0.2686
Mycobacterium leprae Probable Acetylornithine aminotransferase ArgD 0.0021 0.003 0.0161
Trichomonas vaginalis sugar transporter, putative 0.012 0.0637 0.274
Mycobacterium ulcerans acetylornithine aminotransferase 0.0021 0.003 0.0161
Echinococcus granulosus calcium dependent protein kinase 0.0111 0.0582 0.2456
Trichomonas vaginalis conserved hypothetical protein 0.0054 0.0233 0.0956
Trypanosoma cruzi hexose transporter, putative 0.012 0.0637 0.868
Plasmodium falciparum protein kinase 7 0.1093 0.6623 0.6613
Brugia malayi Major Facilitator Superfamily protein 0.0054 0.0233 0.1023
Loa Loa (eye worm) hypothetical protein 0.0054 0.0233 0.0894
Trichomonas vaginalis sugar transporter, putative 0.0054 0.0233 0.0956
Mycobacterium ulcerans sugar transporter 0.0054 0.0233 0.2686
Plasmodium falciparum calcium-dependent protein kinase 4 0.0119 0.0628 0.06
Leishmania major lysyl-tRNA synthetase, putative 0.0086 0.043 0.5783
Mycobacterium leprae Probable 4-aminobutyrate aminotransferase GabT (GAMMA-AMINO-N-BUTYRATE TRANSAMINASE) (GABA TRANSAMINASE) (GLUTAMATE:SUCCINIC SEM 0.0021 0.003 0.0161
Plasmodium falciparum mitogen-activated protein kinase 2 0.0625 0.3744 0.3726
Trypanosoma brucei glucose transporter, putative 0.012 0.0637 0.868
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0116 0.0613 0.2591
Trypanosoma cruzi hexose transporter, putative 0.012 0.0637 0.868
Trichomonas vaginalis glucose transporter, putative 0.012 0.0637 0.274
Trichomonas vaginalis sugar transporter, putative 0.0054 0.0233 0.0956
Entamoeba histolytica hypothetical protein 0.0086 0.043 0.6679
Schistosoma mansoni protein kinase 0.0119 0.0627 0.2657
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0387 0.2279 1
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0116 0.0613 0.2591
Brugia malayi Major Facilitator Superfamily protein 0.0054 0.0233 0.1023
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0119 0.0627 0.2657
Leishmania major hypothetical protein, conserved 0.0054 0.0233 0.303
Schistosoma mansoni serine/threonine protein kinase 0.0119 0.0627 0.2657
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0086 0.043 0.5783
Mycobacterium tuberculosis Probable L-lysine-epsilon aminotransferase Lat (L-lysine aminotransferase) (lysine 6-aminotransferase) 0.0021 0.003 0.0161
Leishmania major protein kinase, putative 0.0119 0.0627 0.855
Brugia malayi hypothetical protein 0.0182 0.1021 0.4479
Trypanosoma cruzi hexose transporter 0.012 0.0637 0.868
Chlamydia trachomatis proline--tRNA ligase 0.0041 0.0151 0.3023
Schistosoma mansoni sugar transporter 0.0054 0.0233 0.0904
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0119 0.0627 0.2657
Trichomonas vaginalis sugar transporter, putative 0.0054 0.0233 0.0956
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0086 0.043 0.5127
Trichomonas vaginalis sugar transporter, putative 0.0054 0.0233 0.0956
Loa Loa (eye worm) hypothetical protein 0.0026 0.0056 0.0104
Loa Loa (eye worm) major facilitator superfamily transporter 0.0054 0.0233 0.0894
Mycobacterium leprae PROBABLE ADENOSYLMETHIONINE-8-AMINO-7-OXONONANOATE AMINOTRANSFERASE BIOA 0.015 0.0822 1
Plasmodium vivax CDK-related protein kinase 6, putative 0.1643 1 1
Trypanosoma brucei glucose transporter 2A 0.012 0.0637 0.868
Trichomonas vaginalis conserved hypothetical protein 0.0054 0.0233 0.0956
Mycobacterium leprae Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase) (ThrRS) (Threonine-tRNA ligase) 0.0022 0.0032 0.0193
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0387 0.2279 1
Schistosoma mansoni lysyl-tRNA synthetase 0.0086 0.043 0.1778
Trypanosoma brucei glucose transporter, putative 0.012 0.0637 0.868
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0086 0.043 0.5127
Echinococcus multilocularis lysyl tRNA synthetase 0.0086 0.043 0.1778
Trypanosoma brucei sugar transporter, putative 0.0054 0.0233 0.303
Mycobacterium ulcerans prolyl-tRNA synthetase 0.0041 0.0151 0.1663
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0119 0.0627 0.2657
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.0054 0.0233 1
Schistosoma mansoni protein kinase 0.0119 0.0627 0.2657
Plasmodium falciparum calcium-dependent protein kinase 3 0.0119 0.0628 0.06
Loa Loa (eye worm) hypothetical protein 0.0054 0.0233 0.0894
Schistosoma mansoni glucose transporter 0.0054 0.0233 0.0904
Brugia malayi threonyl-tRNA synthetase, cytoplasmic 0.0022 0.0032 0.0142
Trypanosoma cruzi glucose transporter, putative 0.0054 0.0233 0.303
Echinococcus multilocularis solute carrier family 22 0.0054 0.0233 0.0904
Plasmodium vivax hexose transporter 0.0387 0.2279 0.2255
Trichomonas vaginalis sugar transporter, putative 0.0054 0.0233 0.0956
Trichomonas vaginalis sugar transporter, putative 0.0054 0.0233 0.0956
Mycobacterium ulcerans adenosylmethionine-8-amino-7-oxononanoate aminotransferase 0.015 0.0822 1
Brugia malayi Sugar transporter family protein 0.0054 0.0233 0.1023
Schistosoma mansoni glucose transport protein 0.0387 0.2279 1
Brugia malayi lysyl-tRNA synthetase 0.0086 0.043 0.1886
Schistosoma mansoni protein kinase 0.0119 0.0627 0.2657
Echinococcus granulosus Threonyl tRNA synthetase C 0.0022 0.0032 0.0012
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0387 0.2279 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.0051 0.021 0.092
Toxoplasma gondii sugar transporter ST1 0.0054 0.0233 0.0327
Brugia malayi latrophilin 2 splice variant baaae 0.0035 0.0111 0.0488
Brugia malayi Sugar transporter family protein 0.0387 0.2279 1
Trichomonas vaginalis sugar transport protein, putative 0.0054 0.0233 0.0956
Plasmodium vivax glycine--tRNA ligase, putative 0.0022 0.0032 0.0003
Giardia lamblia Prolyl-tRNA synthetase 0.0116 0.0613 1
Toxoplasma gondii sugar transporter ST2 0.0054 0.0233 0.0327
Brugia malayi hypothetical protein 0.0054 0.0233 0.1023
Trichomonas vaginalis sugar transporter, putative 0.0054 0.0233 0.0956
Plasmodium vivax ataxin-2 like protein, putative 0.0026 0.0056 0.0026
Trichomonas vaginalis sugar transporter, putative 0.0054 0.0233 0.0956
Trypanosoma brucei THT1 - hexose transporter, putative 0.012 0.0637 0.868
Toxoplasma gondii glycyl-tRNA synthetase 0.0022 0.0032 0.0024
Trichomonas vaginalis glucose transporter, putative 0.0054 0.0233 0.0956
Trypanosoma cruzi hexose transporter, putative 0.0054 0.0233 0.303
Trichomonas vaginalis sugar transporter, putative 0.0054 0.0233 0.0956
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0116 0.0613 0.2688
Brugia malayi glycyl-tRNA synthetase 0.0022 0.0032 0.0142
Schistosoma mansoni glucose transport protein 0.0387 0.2279 1
Trypanosoma brucei PAB1-binding protein , putative 0.0026 0.0056 0.0546
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0119 0.0627 0.2657
Trichomonas vaginalis sugar transporter, putative 0.0054 0.0233 0.0956
Loa Loa (eye worm) hypothetical protein 0.0054 0.0233 0.0894
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0135 0.0731 1
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0119 0.0627 0.2657
Trypanosoma cruzi sugar transporter, putative 0.0054 0.0233 0.303
Echinococcus granulosus solute carrier family 22 0.0054 0.0233 0.0904
Trichomonas vaginalis sugar transporter, putative 0.0054 0.0233 0.0956
Loa Loa (eye worm) hypothetical protein 0.0054 0.0233 0.0894
Brugia malayi hypothetical protein 0.0054 0.0233 0.1023
Plasmodium falciparum hexose transporter 0.0387 0.2279 0.2255
Loa Loa (eye worm) sugar transporter 0.0054 0.0233 0.0894
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0051 0.021 0.092
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.0054 0.0233 0.0904
Trypanosoma cruzi hexose transporter, putative 0.0066 0.0302 0.3994
Wolbachia endosymbiont of Brugia malayi threonyl-tRNA synthetase 0.0022 0.0032 0.0127
Toxoplasma gondii ornithine aminotransferase, mitochondrial precursor, putative 0.0021 0.003 0.002
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0135 0.0731 1
Echinococcus granulosus General substrate transporter 0.0333 0.1944 0.8512
Trypanosoma cruzi hexose transporter, putative 0.012 0.0637 0.868
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0119 0.0627 0.855
Schistosoma mansoni lysyl-tRNA synthetase 0.0086 0.043 0.1778
Toxoplasma gondii facilitative glucose transporter GT1 0.0387 0.2279 0.3424
Trichomonas vaginalis sugar transporter, putative 0.0054 0.0233 0.0956
Trichomonas vaginalis sugar transporter, putative 0.0054 0.0233 0.0956
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.0054 0.0233 0.2686
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0116 0.0613 0.2688
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0387 0.2279 1
Schistosoma mansoni hypothetical protein 0.0387 0.2279 1
Loa Loa (eye worm) hypothetical protein 0.0119 0.0627 0.2648
Brugia malayi hypothetical protein 0.0054 0.0233 0.1023
Loa Loa (eye worm) hypothetical protein 0.0054 0.0233 0.0894
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0119 0.0627 0.2648
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0116 0.0613 0.2634
Loa Loa (eye worm) hypothetical protein 0.0035 0.0111 0.0351
Trypanosoma brucei glucose transporter 1E 0.012 0.0637 0.868
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0119 0.0628 0.0925
Loa Loa (eye worm) hypothetical protein 0.0054 0.0233 0.0894
Loa Loa (eye worm) hypothetical protein 0.0054 0.0233 0.0894
Loa Loa (eye worm) hypothetical protein 0.0116 0.0613 0.2583
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0116 0.0613 0.9752
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0135 0.0731 1
Echinococcus multilocularis glycyl tRNA synthetase 0.0022 0.0032 0.0012
Trichomonas vaginalis sugar transporter, putative 0.0054 0.0233 0.0956
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0625 0.3744 0.3726
Leishmania major threonyl-tRNA synthetase, putative 0.0022 0.0032 0.0218
Mycobacterium ulcerans ornithine aminotransferase RocD1 and RocD2 0.0021 0.003 0.0161
Loa Loa (eye worm) hypothetical protein 0.0116 0.0613 0.2583
Loa Loa (eye worm) hypothetical protein 0.0054 0.0233 0.0894
Brugia malayi 4-aminobutyrate aminotransferase, mitochondrial precursor 0.0021 0.003 0.0131
Brugia malayi hypothetical protein 0.0026 0.0056 0.0245
Trypanosoma brucei THT1 - hexose transporter, putative 0.012 0.0637 0.868
Loa Loa (eye worm) major facilitator superfamily transporter 0.0054 0.0233 0.0894
Mycobacterium tuberculosis Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter) 0.0054 0.0233 0.2686
Echinococcus multilocularis solute carrier family 22 0.0054 0.0233 0.0904
Trichomonas vaginalis sugar transporter, putative 0.0054 0.0233 0.0956
Brugia malayi probable proline-trna synthetase - fission yeast, putative 0.0022 0.0032 0.0142
Plasmodium falciparum threonine--tRNA ligase 0.0022 0.0032 0.0003
Echinococcus multilocularis General substrate transporter 0.0333 0.1944 0.8512
Trypanosoma brucei glucose transporter, putative 0.012 0.0637 0.868
Mycobacterium tuberculosis Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase)(ThrRS) (threonine-tRNA ligase) 0.0022 0.0032 0.0193
Mycobacterium tuberculosis Probable aminotransferase 0.015 0.0822 1
Toxoplasma gondii protein kinase, putative 0.1093 0.6623 1
Brugia malayi major facilitator superfamily protein 0.0054 0.0233 0.1023
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0076 0.0364 0.1536
Trichomonas vaginalis sugar transporter, putative 0.0054 0.0233 0.0956
Echinococcus multilocularis calcium dependent protein kinase 0.0111 0.0582 0.2456
Trichomonas vaginalis sugar transporter, putative 0.0054 0.0233 0.0956
Trichomonas vaginalis sugar transporter, putative 0.0054 0.0233 0.0956
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0119 0.0627 0.2753
Echinococcus multilocularis solute carrier family 22 0.0054 0.0233 0.0904
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0119 0.0628 0.06
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0387 0.2279 1
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0086 0.043 0.5127
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0119 0.0627 0.2648

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 11.2202 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Vif-A3F Interactions: qHTS. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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