Detailed information for compound 1421909

Basic information

Technical information
  • TDR Targets ID: 1421909
  • Name: 2-(4-chlorophenyl)sulfanyl-N-[4-(4-methylsulf onylpiperazin-1-yl)phenyl]acetamide
  • MW: 439.979 | Formula: C19H22ClN3O3S2
  • H donors: 1 H acceptors: 3 LogP: 3.15 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(Nc1ccc(cc1)N1CCN(CC1)S(=O)(=O)C)CSc1ccc(cc1)Cl
  • InChi: 1S/C19H22ClN3O3S2/c1-28(25,26)23-12-10-22(11-13-23)17-6-4-16(5-7-17)21-19(24)14-27-18-8-2-15(20)3-9-18/h2-9H,10-14H2,1H3,(H,21,24)
  • InChiKey: PMLBASAQPCZXIZ-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

  • 2-[(4-chlorophenyl)thio]-N-[4-(4-methylsulfonyl-1-piperazinyl)phenyl]acetamide
  • 2-[(4-chlorophenyl)thio]-N-[4-(4-mesylpiperazin-1-yl)phenyl]acetamide
  • 2-(4-chlorophenyl)sulfanyl-N-[4-(4-methylsulfonylpiperazin-1-yl)phenyl]ethanamide
  • 2-(4-Chloro-phenylsulfanyl)-N-[4-(4-methanesulfonyl-piperazin-1-yl)-phenyl]-acetamide
  • MLS000123691
  • SMR000124228
  • BAS 07006213
  • ZINC00805055

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens microtubule-associated protein tau Starlite/ChEMBL No references
Trypanosoma cruzi cysteine peptidase, putative Starlite/ChEMBL No references
Homo sapiens SMAD family member 2 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Plasmodium yoelii berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni microtubule-associated protein tau Get druggable targets OG5_133504 All targets in OG5_133504
Leishmania donovani cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi MH2 domain containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 2b Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin L-like proteinase precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K04380 microtubule-associated protein tau, putative Get druggable targets OG5_133504 All targets in OG5_133504
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Toxoplasma gondii cathepsin CPL Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) MH2 domain-containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium berghei berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium parvum cryptopain - cysteine proteinase secreted, possible transmembrane domain near N-terminus Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-3 Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) transcription factor SMAD2 Get druggable targets OG5_131716 All targets in OG5_131716
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin F homolog Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum expressed protein Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 3 Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Neospora caninum Cathepsin L, related Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) fibroinase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K01373 cathepsin F [EC3.4.22.41], putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin L cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-4 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 2a Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cruzipain precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) ctsf protein Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium hominis cryptopain precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi MH2 domain containing protein SMAD family member 2 467 aa 405 aa 31.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0161 0.0528 0.4744
Loa Loa (eye worm) nuclear factor I 0.0091 0.0238 0.0075
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0098 0.0265 0.072
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0161 0.0528 1
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0098 0.0265 0.072
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0098 0.0265 1
Schistosoma mansoni hypothetical protein 0.0276 0.101 0.2742
Leishmania major cathepsin L-like protease 0.0077 0.0178 0.0157
Loa Loa (eye worm) hypothetical protein 0.0301 0.1114 0.0965
Echinococcus multilocularis smad 0.0165 0.0547 0.1485
Brugia malayi RNA binding protein 0.0915 0.3685 0.3645
Loa Loa (eye worm) MH2 domain-containing protein 0.2424 1 1
Brugia malayi Latrophilin receptor protein 2 0.0276 0.101 0.0953
Brugia malayi MH1 domain containing protein 0.0091 0.0238 0.0176
Brugia malayi isocitrate dehydrogenase 0.0098 0.0265 0.0203
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0178 0.0157
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0245 0.0881 0.239
Brugia malayi MH1 domain containing protein 0.0165 0.0547 0.0487
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0178 0.0157
Entamoeba histolytica hypothetical protein 0.0293 0.108 0.1979
Echinococcus multilocularis peptidase Clp (S14 family) 0.0161 0.0528 0.1432
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.0178 0.4422
Brugia malayi MH2 domain containing protein 0.0074 0.0165 0.0102
Schistosoma mansoni smad 0.0074 0.0165 0.0448
Brugia malayi MH1 domain containing protein 0.0165 0.0547 0.0487
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0111 0.0321 0.087
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0915 0.3685 0.3579
Schistosoma mansoni hypothetical protein 0.0596 0.235 0.6377
Loa Loa (eye worm) RNA binding protein 0.0915 0.3685 0.3579
Echinococcus multilocularis mothers against decapentaplegic 2 0.0074 0.0165 0.0448
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0276 0.101 0.2742
Loa Loa (eye worm) MH2 domain-containing protein 0.0165 0.0547 0.0389
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.0178 0.4422
Brugia malayi mothers against decapentaplegic homolog 3 0.0074 0.0165 0.0102
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0276 0.101 0.2742
Schistosoma mansoni transcription factor LCR-F1 0.0111 0.0321 0.087
Brugia malayi hypothetical protein 0.0111 0.0321 0.0259
Brugia malayi Probable ClpP-like protease 0.0245 0.0881 0.0823
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0178 0.0157
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0245 0.0881 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0178 0.0157
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0872 0.3504 0.3463
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0098 0.0265 0.1256
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0178 0.0157
Schistosoma mansoni hypothetical protein 0.0276 0.101 0.2742
Schistosoma mansoni Smad4 0.0074 0.0165 0.0448
Toxoplasma gondii isocitrate dehydrogenase 0.0098 0.0265 0.1256
Schistosoma mansoni Smad4 0.0165 0.0547 0.1485
Schistosoma mansoni tar DNA-binding protein 0.0915 0.3685 1
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0165 0.0547 0.1485
Schistosoma mansoni smad1 5 8 and 0.0165 0.0547 0.1485
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0245 0.0881 1
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0098 0.0265 0.072
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0098 0.0265 0.072
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0084 0.0209 0.0457
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0245 0.0881 0.5
Trypanosoma cruzi PAB1-binding protein , putative 0.0077 0.0177 0.4333
Brugia malayi Isocitrate dehydrogenase 0.0098 0.0265 0.0203
Brugia malayi MH2 domain containing protein 0.0165 0.0547 0.0487
Echinococcus multilocularis mothers against decapentaplegic 5 0.0165 0.0547 0.1485
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0245 0.0881 0.239
Leishmania major cathepsin L-like protease 0.0077 0.0178 0.0157
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.007 0.015 0.2629
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0098 0.0265 0.072
Schistosoma mansoni hypothetical protein 0.0276 0.101 0.2742
Brugia malayi hypothetical protein 0.0301 0.1114 0.1057
Loa Loa (eye worm) Smad1 0.0165 0.0547 0.0389
Echinococcus multilocularis GPCR, family 2 0.0276 0.101 0.2742
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0178 0.0157
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0161 0.0528 1
Loa Loa (eye worm) hypothetical protein 0.0091 0.0238 0.0075
Brugia malayi hypothetical protein 0.0077 0.0177 0.0114
Loa Loa (eye worm) hypothetical protein 0.0276 0.101 0.086
Echinococcus granulosus mothers against decapentaplegic 6 0.0074 0.0165 0.0448
Echinococcus multilocularis mothers against decapentaplegic 6 0.0074 0.0165 0.0448
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0245 0.0881 1
Schistosoma mansoni tar DNA-binding protein 0.0915 0.3685 1
Entamoeba histolytica Rad52/22 family double-strand break repair protein, putative 0.0293 0.108 0.1979
Brugia malayi latrophilin 2 splice variant baaae 0.0596 0.235 0.2301
Schistosoma mansoni smad1 5 8 and 0.0165 0.0547 0.1485
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0276 0.101 0.0953
Giardia lamblia DNA repair protein RAD52 0.1028 0.4158 0.5
Schistosoma mansoni tar DNA-binding protein 0.0915 0.3685 1
Echinococcus granulosus GPCR family 2 0.0276 0.101 0.2742
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0245 0.0881 0.5
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0098 0.0265 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0872 0.3504 0.3396
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0245 0.0881 1
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0098 0.0265 1
Brugia malayi RNA recognition motif domain containing protein 0.0915 0.3685 0.3645
Schistosoma mansoni smad1 5 8 and 0.0165 0.0547 0.1485
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0098 0.0265 0.072
Onchocerca volvulus 0.0301 0.1114 1
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.0178 0.4422
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0178 0.0157
Loa Loa (eye worm) isocitrate dehydrogenase 0.0098 0.0265 0.0102
Echinococcus granulosus mothers against decapentaplegic 5 0.0165 0.0547 0.1485
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0165 0.0547 0.1485
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0245 0.0881 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.0276 0.101 0.086
Schistosoma mansoni tar DNA-binding protein 0.0915 0.3685 1
Schistosoma mansoni peptidase Clp (S14 family) 0.0245 0.0881 0.239
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0276 0.101 0.2742
Schistosoma mansoni hypothetical protein 0.0111 0.0321 0.087
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0245 0.0881 0.5
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0098 0.0265 1
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0084 0.0209 0.0457
Brugia malayi MH1 domain containing protein 0.0091 0.0238 0.0176
Loa Loa (eye worm) hypothetical protein 0.0596 0.235 0.2222
Entamoeba histolytica DNA repair and recombination protein RAD52, putative 0.1028 0.4158 1
Schistosoma mansoni microtubule-associated protein tau 0.0833 0.3343 0.9071
Trypanosoma cruzi PAB1-binding protein , putative 0.0077 0.0177 0.4333
Brugia malayi Calcitonin receptor-like protein seb-1 0.0872 0.3504 0.3463
Loa Loa (eye worm) TAR-binding protein 0.0915 0.3685 0.3579
Brugia malayi Smad1 0.0165 0.0547 0.0487
Trypanosoma cruzi cruzipain precursor, putative 0.0077 0.0178 0.4422
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0245 0.0881 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0178 0.0157
Loa Loa (eye worm) MH1 domain-containing protein 0.0165 0.0547 0.0389
Schistosoma mansoni tar DNA-binding protein 0.0915 0.3685 1
Echinococcus granulosus smad 0.0165 0.0547 0.1485
Brugia malayi TAR-binding protein 0.0915 0.3685 0.3645
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0111 0.0321 0.087
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0178 0.0157
Echinococcus multilocularis microtubule associated protein 2 0.0833 0.3343 0.9071
Echinococcus granulosus peptidase Clp S14 family 0.0161 0.0528 0.1432
Loa Loa (eye worm) hypothetical protein 0.0872 0.3504 0.3396
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0178 0.0157
Echinococcus multilocularis Smad4 0.0165 0.0547 0.1485
Toxoplasma gondii isocitrate dehydrogenase 0.0098 0.0265 0.1256
Brugia malayi MH2 domain containing protein 0.0165 0.0547 0.0487
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0245 0.0881 0.5
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0178 0.0157
Schistosoma mansoni Smad4 0.0074 0.0165 0.0448
Schistosoma mansoni smad 0.0165 0.0547 0.1485
Echinococcus granulosus Smad4 0.0165 0.0547 0.1485
Loa Loa (eye worm) transcription factor SMAD2 0.2424 1 1
Toxoplasma gondii hypothetical protein 0.0084 0.0209 0.0457
Echinococcus granulosus mothers against decapentaplegic 2 0.0074 0.0165 0.0448
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0098 0.0265 1
Echinococcus granulosus tar DNA binding protein 0.0915 0.3685 1
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0245 0.0881 0.5
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0276 0.101 0.2742
Echinococcus granulosus microtubule associated protein 2 0.0833 0.3343 0.9071
Leishmania major cathepsin L-like protease 0.0077 0.0178 0.0157
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0098 0.0265 0.1256
Echinococcus granulosus TGF beta signal transducer SmadC 0.0165 0.0547 0.1485
Loa Loa (eye worm) hypothetical protein 0.0077 0.0177 0.0012
Loa Loa (eye worm) hypothetical protein 0.0245 0.0881 0.0728
Schistosoma mansoni hypothetical protein 0.0276 0.101 0.2742
Echinococcus multilocularis tar DNA binding protein 0.0915 0.3685 1
Echinococcus multilocularis isocitrate dehydrogenase 0.0098 0.0265 0.072

Activities

Activity type Activity value Assay description Source Reference
Potency (binding) = 0.5623 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) 3.5481 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) = 3.9811 um PUBCHEM_BIOASSAY: qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (without detergent). (Class of assay: confirmatory) [Related pubchem assays: 2158 (Confirmation qHTS Assay for Inhibitors of Cruzain), 2249 (Probe Development Summary of Promiscuous Inhibitors (Artifacts) of Cruzain), 2161 (qHTS Assay for Inhibitors of Papain: Counterscreen for Cruzain Assay), 1478 (qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (with detergent))] ChEMBL. No reference
Potency (functional) = 56.2341 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human alpha-Glucosidase as a Potential Chaperone Treatment of Pompe Disease. (Class of assay: confirmatory) [Related pubchem assays: 997 ] ChEMBL. No reference
Potency (functional) = 56.2341 um PUBCHEM_BIOASSAY: qHTS Assay for Activators of Human alpha-Glucosidase as a Potential Chaperone Treatment of Pompe Disease. (Class of assay: confirmatory) [Related pubchem assays: 1467, 2100, 2112, 1473, 1466 ] ChEMBL. No reference
Potency (functional) 79.4328 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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