Detailed information for compound 1424310

Basic information

Technical information
  • TDR Targets ID: 1424310
  • Name: 3-hydroxy-1-(phenylmethyl)-3-(trifluoromethyl )-6,7-dihydro-5H-indole-2,4-dione
  • MW: 325.282 | Formula: C16H14F3NO3
  • H donors: 1 H acceptors: 3 LogP: 1.53 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C1CCCC2=C1C(O)(C(=O)N2Cc1ccccc1)C(F)(F)F
  • InChi: 1S/C16H14F3NO3/c17-16(18,19)15(23)13-11(7-4-8-12(13)21)20(14(15)22)9-10-5-2-1-3-6-10/h1-3,5-6,23H,4,7-9H2
  • InChiKey: KKPSSYKVGIGRGH-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 1-(benzyl)-3-hydroxy-3-(trifluoromethyl)-6,7-dihydro-5H-indole-2,4-quinone
  • A3354/0142331
  • 1-benzyl-3-hydroxy-3-(trifluoromethyl)-3,5,6,7-tetrahydro-1H-indole-2,4-dione
  • MLS000045735
  • SMR000027692

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) MH1 domain-containing protein 0.0151 0.0621 0.0621
Plasmodium falciparum ataxin-2 like protein, putative 0.0105 0.0413 0.5013
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0156 0.0644 1
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0102 0.04 0.0888
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.002 0.0028 0.067
Brugia malayi Cytochrome P450 family protein 0.0032 0.0079 0.0079
Loa Loa (eye worm) MH2 domain-containing protein 0.0151 0.0621 0.0621
Brugia malayi TAR-binding protein 0.0663 0.2946 0.2946
Echinococcus granulosus mothers against decapentaplegic 5 0.0151 0.0621 0.2035
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0151 0.0621 0.2035
Schistosoma mansoni Smad4 0.0151 0.0621 0.2035
Entamoeba histolytica hypothetical protein 0.0107 0.042 0.2821
Brugia malayi Probable ClpP-like protease 0.0156 0.0644 0.0644
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.002 0.0028 0.067
Brugia malayi hypothetical protein 0.0068 0.0244 0.0244
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0156 0.0644 1
Echinococcus multilocularis isocitrate dehydrogenase 0.0067 0.0238 0.0721
Loa Loa (eye worm) hypothetical protein 0.0033 0.0088 0.0088
Echinococcus granulosus geminin 0.0168 0.0699 0.2301
Echinococcus multilocularis peptidase Clp (S14 family) 0.0102 0.04 0.1276
Mycobacterium ulcerans ornithine aminotransferase RocD1 and RocD2 0.0067 0.0238 0.1057
Mycobacterium leprae Probable 4-aminobutyrate aminotransferase GabT (GAMMA-AMINO-N-BUTYRATE TRANSAMINASE) (GABA TRANSAMINASE) (GLUTAMATE:SUCCINIC SEM 0.0067 0.0238 0.031
Schistosoma mansoni smad1 5 8 and 0.0151 0.0621 0.2035
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.016 0.0664 0.2179
Loa Loa (eye worm) hypothetical protein 0.0067 0.0242 0.0242
Mycobacterium tuberculosis Probable L-lysine-epsilon aminotransferase Lat (L-lysine aminotransferase) (lysine 6-aminotransferase) 0.0067 0.0238 0.0001
Brugia malayi calpain 7 0.002 0.0028 0.0028
Schistosoma mansoni Smad4 0.0067 0.0242 0.0735
Entamoeba histolytica DNA repair and recombination protein RAD52, putative 0.0342 0.149 1
Loa Loa (eye worm) hypothetical protein 0.0048 0.0152 0.0152
Loa Loa (eye worm) Smad1 0.0151 0.0621 0.0621
Brugia malayi isocitrate dehydrogenase 0.0067 0.0238 0.0238
Schistosoma mansoni hypothetical protein 0.016 0.0664 0.2179
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0047 0.015 0.0418
Onchocerca volvulus Mothers against decapentaplegic homolog 0.0067 0.0242 0.2178
Schistosoma mansoni smad 0.0067 0.0242 0.0735
Schistosoma mansoni tar DNA-binding protein 0.0663 0.2946 1
Brugia malayi Cytochrome P450 family protein 0.0019 0.0023 0.0023
Toxoplasma gondii ornithine aminotransferase, mitochondrial precursor, putative 0.0067 0.0238 0.1258
Entamoeba histolytica hypothetical protein 0.0107 0.042 0.2821
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0156 0.0644 0.2465
Loa Loa (eye worm) MH2 domain-containing protein 0.0067 0.0242 0.0242
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.002 0.0028 0.067
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.016 0.0664 0.2179
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0107 0.042 0.1345
Trypanosoma cruzi calpain cysteine peptidase, putative 0.002 0.0028 0.067
Mycobacterium tuberculosis Probable aminotransferase 0.0469 0.2064 1
Brugia malayi hypothetical protein 0.0105 0.0413 0.0413
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0067 0.0238 0.0721
Loa Loa (eye worm) hypothetical protein 0.019 0.0797 0.0797
Trypanosoma brucei PAB1-binding protein , putative 0.0105 0.0413 1
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0067 0.0238 0.5767
Loa Loa (eye worm) hypothetical protein 0.0156 0.0644 0.0644
Schistosoma mansoni Smad4 0.0067 0.0242 0.0735
Plasmodium falciparum ornithine aminotransferase 0.0067 0.0238 0.1258
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.002 0.0028 0.067
Brugia malayi N-terminal motif family protein 0.019 0.0797 0.0797
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0151 0.0621 0.2035
Mycobacterium ulcerans acetylornithine aminotransferase 0.0067 0.0238 0.1057
Brugia malayi mothers against decapentaplegic homolog 3 0.0067 0.0242 0.0242
Brugia malayi MH1 domain containing protein 0.0151 0.0621 0.0621
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0067 0.0238 0.0721
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0067 0.0238 0.0721
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0054 0.018 0.2467
Brugia malayi Isocitrate dehydrogenase 0.0067 0.0238 0.0238
Trypanosoma cruzi cytochrome P450, putative 0.0019 0.0023 0.0546
Schistosoma mansoni hypothetical protein 0.0047 0.015 0.0418
Loa Loa (eye worm) cytochrome P450 family protein 0.0019 0.0023 0.0023
Echinococcus granulosus family C2 unassigned peptidase C02 family 0.0056 0.0191 0.0558
Loa Loa (eye worm) hypothetical protein 0.0054 0.018 0.018
Trypanosoma brucei calpain-like protein, putative 0.002 0.0028 0.067
Leishmania major cytochrome p450-like protein 0.0019 0.0023 0.0546
Schistosoma mansoni tar DNA-binding protein 0.0663 0.2946 1
Brugia malayi latrophilin 2 splice variant baaae 0.0346 0.1508 0.1508
Schistosoma mansoni hypothetical protein 0.0107 0.042 0.1345
Brugia malayi Smad1 0.0151 0.0621 0.0621
Loa Loa (eye worm) calpain family protein 1 0.004 0.0115 0.0115
Echinococcus multilocularis smad 0.0151 0.0621 0.2035
Brugia malayi MH1 domain containing protein 0.0084 0.0315 0.0315
Echinococcus granulosus peptidase Clp S14 family 0.0102 0.04 0.1276
Plasmodium vivax ornithine aminotransferase, putative 0.0067 0.0238 0.3415
Brugia malayi hypothetical protein 0.0107 0.042 0.042
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0102 0.04 0.0888
Schistosoma mansoni hypothetical protein 0.0168 0.0699 0.2301
Loa Loa (eye worm) cytochrome P450 family protein 0.0019 0.0023 0.0023
Echinococcus multilocularis mothers against decapentaplegic 6 0.0067 0.0242 0.0735
Brugia malayi MH1 domain containing protein 0.0151 0.0621 0.0621
Brugia malayi Latrophilin receptor protein 2 0.016 0.0664 0.0664
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.002 0.0028 0.067
Schistosoma mansoni hypothetical protein 0.0346 0.1508 0.5074
Schistosoma mansoni smad1 5 8 and 0.0151 0.0621 0.2035
Loa Loa (eye worm) MH2 domain-containing protein 0.2216 1 1
Brugia malayi RNA recognition motif domain containing protein 0.0663 0.2946 0.2946
Entamoeba histolytica Rad52/22 family double-strand break repair protein, putative 0.0097 0.0378 0.2536
Plasmodium vivax ataxin-2 like protein, putative 0.0105 0.0413 0.6244
Trypanosoma brucei cytochrome P450, putative 0.0019 0.0023 0.0546
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0067 0.0238 0.1252
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0067 0.0238 0.5767
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.016 0.0664 0.2179
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0047 0.015 0.0418
Loa Loa (eye worm) CYP4Cod1 0.0019 0.0023 0.0023
Mycobacterium ulcerans 4-aminobutyrate aminotransferase 0.0067 0.0238 0.1057
Brugia malayi MH2 domain containing protein 0.0151 0.0621 0.0621
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0156 0.0644 0.3046
Echinococcus granulosus mothers against decapentaplegic 6 0.0067 0.0242 0.0735
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0056 0.0191 0.0558
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0067 0.0238 0.0721
Schistosoma mansoni hypothetical protein 0.016 0.0664 0.2179
Schistosoma mansoni ornithine--oxo-acid transaminase 0.0067 0.0238 0.0721
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.016 0.0664 0.0664
Mycobacterium leprae PROBABLE GLUTAMATE-1-SEMIALDEHYDE 2,1-AMINOMUTASE HEML (GSA) (GLUTAMATE-1-SEMIALDEHYDE AMINOTRANSFERASE) (GSA-AT) 0.0067 0.0238 0.031
Trichomonas vaginalis acetylornithine aminotransferase, putative 0.0469 0.2064 0.5
Echinococcus multilocularis ornithine aminotransferase 0.0067 0.0238 0.0721
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0056 0.0191 0.0558
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.002 0.0028 0.067
Loa Loa (eye worm) transcription factor SMAD2 0.2216 1 1
Brugia malayi MH2 domain containing protein 0.0067 0.0242 0.0242
Loa Loa (eye worm) hypothetical protein 0.0084 0.0315 0.0315
Brugia malayi calpain family protein 1 0.0054 0.018 0.018
Brugia malayi RNA binding protein 0.0663 0.2946 0.2946
Leishmania major hypothetical protein, conserved 0.0105 0.0413 1
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0156 0.0644 1
Echinococcus multilocularis geminin 0.0168 0.0699 0.2301
Echinococcus granulosus mothers against decapentaplegic 2 0.0067 0.0242 0.0735
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.002 0.0028 0.067
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0156 0.0644 1
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0107 0.042 0.1345
Echinococcus multilocularis mothers against decapentaplegic 2 0.0067 0.0242 0.0735
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0156 0.0644 1
Loa Loa (eye worm) cytochrome P450 family protein 0.0032 0.0079 0.0079
Echinococcus multilocularis calpain A 0.0056 0.0191 0.0558
Echinococcus granulosus tar DNA binding protein 0.0663 0.2946 1
Loa Loa (eye worm) hypothetical protein 0.004 0.0115 0.0115
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0102 0.04 0.117
Loa Loa (eye worm) hypothetical protein 0.0105 0.0413 0.0413
Brugia malayi MH1 domain containing protein 0.0084 0.0315 0.0315
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0067 0.0238 0.5767
Loa Loa (eye worm) nuclear factor I 0.0084 0.0315 0.0315
Brugia malayi Calcitonin receptor-like protein seb-1 0.0507 0.2236 0.2236
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.016 0.0664 0.2179
Loa Loa (eye worm) hypothetical protein 0.016 0.0664 0.0664
Schistosoma mansoni transcription factor LCR-F1 0.0107 0.042 0.1345
Echinococcus granulosus GPCR family 2 0.016 0.0664 0.2179
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0156 0.0644 1
Mycobacterium ulcerans 4-aminobutyrate aminotransferase 0.0067 0.0238 0.1057
Loa Loa (eye worm) latrophilin receptor protein 2 0.016 0.0664 0.0664
Mycobacterium ulcerans L-lysine aminotransferase 0.0067 0.0238 0.1057
Mycobacterium tuberculosis Adenosylmethionine-8-amino-7-oxononanoate aminotransferase BioA 0.0469 0.2064 1
Echinococcus granulosus Aminotransferase class III 0.0067 0.0238 0.0721
Echinococcus multilocularis tar DNA binding protein 0.0663 0.2946 1
Leishmania major calpain, putative,cysteine peptidase, Clan CA, family C2, putative 0.002 0.0028 0.067
Mycobacterium ulcerans hypothetical protein 0.0469 0.2064 1
Loa Loa (eye worm) MH1 domain-containing protein 0.0067 0.0242 0.0242
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0663 0.2946 0.2946
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0507 0.2236 0.2236
Trypanosoma brucei calpain-like protein, putative 0.002 0.0028 0.067
Trypanosoma brucei calpain-like protein, putative 0.002 0.0028 0.067
Echinococcus granulosus ornithine aminotransferase 0.0067 0.0238 0.0721
Loa Loa (eye worm) RNA binding protein 0.0663 0.2946 0.2946
Mycobacterium tuberculosis Probable acetylornithine aminotransferase ArgD 0.0067 0.0238 0.0001
Trypanosoma cruzi cytochrome P450, putative 0.0019 0.0023 0.0546
Echinococcus granulosus Smad4 0.0151 0.0621 0.2035
Toxoplasma gondii isocitrate dehydrogenase 0.0067 0.0238 0.1252
Schistosoma mansoni tar DNA-binding protein 0.0663 0.2946 1
Echinococcus granulosus TGF beta signal transducer SmadC 0.0151 0.0621 0.2035
Trypanosoma cruzi PAB1-binding protein , putative 0.0105 0.0413 1
Echinococcus granulosus smad 0.0151 0.0621 0.2035
Echinococcus multilocularis calpain family protein 1, d 0.004 0.0115 0.03
Echinococcus multilocularis mothers against decapentaplegic 5 0.0151 0.0621 0.2035
Echinococcus multilocularis ornithine aminotransferase 0.0067 0.0238 0.0721
Entamoeba histolytica hypothetical protein 0.0107 0.042 0.2821
Mycobacterium ulcerans adenosylmethionine-8-amino-7-oxononanoate aminotransferase 0.0469 0.2064 1
Mycobacterium leprae PROBABLE ADENOSYLMETHIONINE-8-AMINO-7-OXONONANOATE AMINOTRANSFERASE BIOA 0.0469 0.2064 1
Schistosoma mansoni smad 0.0151 0.0621 0.2035
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0067 0.0238 0.0721
Trypanosoma cruzi PAB1-binding protein , putative 0.0105 0.0413 1
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0156 0.0644 0.2113
Loa Loa (eye worm) TAR-binding protein 0.0663 0.2946 0.2946
Mycobacterium tuberculosis Probable ornithine aminotransferase (N-terminus part) RocD1 (ornithine--oxo-acid aminotransferase) 0.0067 0.0238 0.0001
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0067 0.0238 0.5767
Echinococcus granulosus calpain A 0.0056 0.0191 0.0558
Brugia malayi calpain family protein 1 0.0054 0.018 0.018
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0507 0.2236 0.2236
Toxoplasma gondii isocitrate dehydrogenase 0.0067 0.0238 0.1252
Giardia lamblia DNA repair protein RAD52 0.0342 0.149 0.5
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0067 0.0238 0.0721
Loa Loa (eye worm) isocitrate dehydrogenase 0.0067 0.0238 0.0238
Brugia malayi MH2 domain containing protein 0.0151 0.0621 0.0621
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.002 0.0028 0.067
Plasmodium falciparum ataxin-2 like protein, putative 0.0105 0.0413 0.5013
Entamoeba histolytica hypothetical protein 0.0107 0.042 0.2821
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0156 0.0644 1
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.002 0.0028 0.067
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.002 0.0028 0.067
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0156 0.0644 0.3046
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.002 0.0028 0.067
Trypanosoma brucei antigen, putative 0.002 0.0028 0.067
Mycobacterium leprae Probable Acetylornithine aminotransferase ArgD 0.0067 0.0238 0.031
Echinococcus multilocularis Aminotransferase class III 0.0067 0.0238 0.0721
Loa Loa (eye worm) calpain family protein 1 0.0054 0.018 0.018
Schistosoma mansoni peptidase Clp (S14 family) 0.0156 0.0644 0.2113
Schistosoma mansoni hypothetical protein 0.016 0.0664 0.2179
Mycobacterium tuberculosis Probable glutamate-1-semialdehyde 2,1-aminomutase HemL (GSA) (glutamate-1-semialdehyde aminotransferase) (GSA-at) 0.0067 0.0238 0.0001
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.002 0.0028 0.067
Mycobacterium ulcerans glutamate-1-semialdehyde aminotransferase 0.0067 0.0238 0.1057
Echinococcus multilocularis GPCR, family 2 0.016 0.0664 0.2179
Schistosoma mansoni smad1 5 8 and 0.0151 0.0621 0.2035
Loa Loa (eye worm) calpain 0.002 0.0028 0.0028
Entamoeba histolytica hypothetical protein 0.0097 0.0378 0.2536
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0156 0.0644 1
Schistosoma mansoni tar DNA-binding protein 0.0663 0.2946 1
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.019 0.0797 1
Brugia malayi 4-aminobutyrate aminotransferase, mitochondrial precursor 0.0067 0.0238 0.0238
Brugia malayi Cytochrome P450 family protein 0.0019 0.0023 0.0023
Trypanosoma brucei calpain-like protein, putative 0.002 0.0028 0.067
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0067 0.0238 0.3411
Schistosoma mansoni tar DNA-binding protein 0.0663 0.2946 1
Schistosoma mansoni hypothetical protein 0.0168 0.0699 0.2301
Loa Loa (eye worm) hypothetical protein 0.0346 0.1508 0.1508
Echinococcus multilocularis Smad4 0.0151 0.0621 0.2035
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.002 0.0028 0.067
Echinococcus multilocularis family C2 unassigned peptidase (C02 family) 0.0056 0.0191 0.0558
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0156 0.0644 0.2113
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0067 0.0238 0.5767
Toxoplasma gondii LsmAD domain-containing protein 0.0105 0.0413 0.5013
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0054 0.018 0.052
Schistosoma mansoni hypothetical protein 0.016 0.0664 0.2179
Loa Loa (eye worm) hypothetical protein 0.0507 0.2236 0.2236

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Screen for Compounds that Selectively Target Cancer Cells with p53 Mutations: Cytotoxicity of p53ts Cells at the Permissive Temperature. (Class of assay: confirmatory) [Related pubchem assays: 902 ] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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