Detailed information for compound 1428482

Basic information

Technical information
  • TDR Targets ID: 1428482
  • Name: 2,2-dimethyl-6-nitro-1,3-benzodioxol-5-amine
  • MW: 210.187 | Formula: C9H10N2O4
  • H donors: 1 H acceptors: 2 LogP: 2.05 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: [O-][N+](=O)c1cc2OC(Oc2cc1N)(C)C
  • InChi: 1S/C9H10N2O4/c1-9(2)14-7-3-5(10)6(11(12)13)4-8(7)15-9/h3-4H,10H2,1-2H3
  • InChiKey: IANVKUIMAHXNOX-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • (2,2-dimethyl-6-nitro-1,3-benzodioxol-5-yl)amine
  • Oprea1_705738
  • ZINC04115592
  • AE-562/12222259
  • MLS000543442
  • SMR000162749

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens ATPase family, AAA domain containing 5 Starlite/ChEMBL No references
Homo sapiens cytochrome P450, family 1, subfamily A, polypeptide 2 Starlite/ChEMBL No references
Homo sapiens muscleblind-like splicing regulator 1 Starlite/ChEMBL No references
Homo sapiens cytochrome P450, family 2, subfamily C, polypeptide 19 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis muscleblind protein 1 Get druggable targets OG5_132352 All targets in OG5_132352
Echinococcus granulosus muscleblind protein Get druggable targets OG5_132352 All targets in OG5_132352
Echinococcus multilocularis muscleblind protein Get druggable targets OG5_132352 All targets in OG5_132352
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132352 All targets in OG5_132352
Brugia malayi Cytochrome P450 family protein Get druggable targets OG5_126582 All targets in OG5_126582
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132352 All targets in OG5_132352
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core Get druggable targets OG5_139225 All targets in OG5_139225
Loa Loa (eye worm) cytochrome P450 family protein Get druggable targets OG5_126582 All targets in OG5_126582
Brugia malayi Muscleblind-like protein Get druggable targets OG5_132352 All targets in OG5_132352
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Leishmania major cytochrome p450-like protein cytochrome P450, family 2, subfamily C, polypeptide 19 490 aa 411 aa 23.1 %
Brugia malayi Cytochrome P450 family protein cytochrome P450, family 1, subfamily A, polypeptide 2 516 aa 470 aa 26.2 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0229 0.0956
Loa Loa (eye worm) hypothetical protein 0.0031 0.0229 0.1057
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0229 0.0956
Trypanosoma cruzi threonyl-tRNA synthetase, putative 0.0012 0.0039 0.0555
Trypanosoma cruzi hexose transporter, putative 0.0068 0.0612 0.8726
Echinococcus granulosus solute carrier family 22 0.0031 0.0229 0.1057
Brugia malayi Sugar transporter family protein 0.0031 0.0229 0.1057
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0067 0.0603 0.278
Brugia malayi Major Facilitator Superfamily protein 0.0031 0.0229 0.1057
Schistosoma mansoni neuropeptide F-like receptor 0.001 0.0015 0.0067
Onchocerca volvulus 0.0031 0.0229 1
Echinococcus granulosus rhodopsin orphan GPCR 0.001 0.0015 0.0067
Onchocerca volvulus 0.0031 0.0229 1
Brugia malayi RE15519p 0.001 0.0015 0.0067
Echinococcus granulosus rhodopsin orphan GPCR 0.001 0.0015 0.0067
Treponema pallidum prolyl-tRNA synthetase 0.0023 0.0151 1
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.001 0.0015 0.0015
Schistosoma mansoni serine/threonine protein kinase 0.0067 0.0603 0.278
Schistosoma mansoni glucose transport protein 0.0219 0.2169 1
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.001 0.0015 0.0067
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0229 0.0956
Loa Loa (eye worm) hypothetical protein 0.001 0.0015 0.0067
Brugia malayi G protein-coupled receptor F59B2.13 0.001 0.0015 0.0067
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.001 0.0015 0.0015
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0066 0.0589 0.0589
Echinococcus granulosus 7tm_1 domain containing protein 0.001 0.0015 0.0067
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0026 0.0184 0.5414
Loa Loa (eye worm) hypothetical protein 0.001 0.0015 0.0067
Brugia malayi Sugar transporter family protein 0.0031 0.0229 0.1057
Brugia malayi Melatonin receptor type 1A 0.001 0.0015 0.0067
Loa Loa (eye worm) hypothetical protein 0.001 0.0015 0.0067
Onchocerca volvulus 0.0031 0.0229 1
Leishmania major hypothetical protein, conserved 0.0031 0.0229 0.327
Echinococcus multilocularis tachykinin peptides receptor 99D 0.001 0.0015 0.0015
Plasmodium vivax acyl-CoA synthetase, putative 0.002 0.0115 0.0081
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0019 0.0104 0.3063
Echinococcus granulosus allatostatin A receptor 0.001 0.0015 0.0067
Entamoeba histolytica acyl-CoA synthetase, putative 0.0026 0.0184 0.2571
Loa Loa (eye worm) hypothetical protein 0.0031 0.0229 0.1057
Trypanosoma brucei glucose transporter, putative 0.0068 0.0612 0.8726
Echinococcus granulosus neuropeptide s receptor 0.001 0.0015 0.0067
Giardia lamblia Sugar-proton symporter 0.0031 0.0229 0.346
Trypanosoma brucei glucose transporter, putative 0.0068 0.0612 0.8726
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0229 0.0956
Mycobacterium ulcerans hypothetical protein 0.0026 0.0184 0.4425
Giardia lamblia Hexose transporter 0.0031 0.0229 0.346
Echinococcus granulosus neuropeptides capa receptor 0.001 0.0015 0.0067
Loa Loa (eye worm) hypothetical protein 0.001 0.0015 0.0067
Loa Loa (eye worm) melatonin receptor type 1A 0.001 0.0015 0.0067
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0067 0.0603 0.0603
Loa Loa (eye worm) hypothetical protein 0.0031 0.0229 0.1057
Brugia malayi Major Facilitator Superfamily protein 0.0031 0.0229 0.1057
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0229 0.0956
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0229 0.0956
Echinococcus multilocularis glycyl tRNA synthetase 0.0012 0.0039 0.0039
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.001 0.0015 0.0067
Trypanosoma brucei glucose transporter, putative 0.0068 0.0612 0.8726
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0219 0.2169 0.2169
Echinococcus multilocularis rhodopsin orphan GPCR 0.001 0.0015 0.0015
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0229 0.0956
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0229 0.0956
Trypanosoma brucei glucose transporter 2A 0.0068 0.0612 0.8726
Onchocerca volvulus 0.0031 0.0229 1
Loa Loa (eye worm) glycyl-tRNA synthetase 0.0012 0.0039 0.0179
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0067 0.0603 0.0597
Echinococcus granulosus calcium dependent protein kinase 0.0063 0.056 0.2583
Echinococcus granulosus glycyl tRNA synthetase 0.0012 0.0039 0.0179
Schistosoma mansoni lysyl-tRNA synthetase 0.0049 0.0416 0.1917
Giardia lamblia Lysyl-tRNA synthetase 0.0049 0.0416 0.6849
Echinococcus granulosus neuropeptide receptor 0.001 0.0015 0.0067
Echinococcus granulosus rhodopsin orphan GPCR 0.001 0.0015 0.0067
Loa Loa (eye worm) hypothetical protein 0.002 0.0115 0.0531
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0077 0.0701 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.001 0.0015 0.0067
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0067 0.0603 0.278
Loa Loa (eye worm) hypothetical protein 0.001 0.0015 0.0067
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0067 0.0603 0.278
Mycobacterium ulcerans fatty-acid-CoA ligase 0.002 0.0115 0.2771
Schistosoma mansoni amine GPCR 0.001 0.0015 0.0067
Echinococcus granulosus muscleblind protein 0.018 0.177 0.8163
Trypanosoma cruzi hexose transporter 0.0068 0.0612 0.8726
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.001 0.0015 0.0067
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.001 0.0015 0.0067
Echinococcus multilocularis calcium dependent protein kinase 0.0063 0.056 0.056
Trypanosoma cruzi glucose transporter, putative 0.0031 0.0229 0.327
Brugia malayi Cytochrome P450 family protein 0.0032 0.0237 0.1095
Loa Loa (eye worm) hypothetical protein 0.001 0.0015 0.0067
Schistosoma mansoni neuropeptide receptor 0.001 0.0015 0.0067
Echinococcus multilocularis muscleblind protein 1 0.018 0.177 0.177
Trypanosoma cruzi hypothetical protein, conserved 0.0011 0.0024 0.0344
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0067 0.0603 0.0603
Loa Loa (eye worm) hypothetical protein 0.001 0.0015 0.0067
Schistosoma mansoni glucose transport protein 0.0219 0.2169 1
Mycobacterium ulcerans glycyl-tRNA synthetase 0.0012 0.0039 0.0936
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0067 0.0603 0.096
Loa Loa (eye worm) hypothetical protein 0.0053 0.0462 0.213
Mycobacterium tuberculosis Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter) 0.0031 0.0229 0.6748
Trypanosoma brucei glucose transporter 1E 0.0068 0.0612 0.8726
Loa Loa (eye worm) threonyl-tRNA synthetase 0.0012 0.0039 0.0179
Entamoeba histolytica acyl-coA synthetase, putative 0.0026 0.0184 0.2571
Loa Loa (eye worm) hypothetical protein 0.001 0.0015 0.0067
Loa Loa (eye worm) hypothetical protein 0.002 0.0115 0.0531
Trypanosoma brucei glycyl-tRNA synthetase, putative 0.0012 0.0039 0.0555
Echinococcus multilocularis sex peptide receptor 0.001 0.0015 0.0015
Loa Loa (eye worm) hypothetical protein 0.0031 0.0229 0.1057
Echinococcus granulosus solute carrier family 22 0.0031 0.0229 0.1057
Toxoplasma gondii sugar transporter ST2 0.0031 0.0229 0.0365
Loa Loa (eye worm) hypothetical protein 0.0031 0.0229 0.1057
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.001 0.0015 0.0067
Brugia malayi putative neuropeptide receptor NPR1 0.001 0.0015 0.0067
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.001 0.0015 0.0067
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.001 0.0015 0.0067
Trichomonas vaginalis glucose transporter, putative 0.0068 0.0612 0.274
Plasmodium falciparum mitogen-activated protein kinase 2 0.0354 0.3558 0.3724
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.001 0.0015 0.0015
Schistosoma mansoni opsin-like receptor 0.001 0.0015 0.0067
Brugia malayi ORL1-like opioid receptor 0.001 0.0015 0.0067
Plasmodium falciparum calcium-dependent protein kinase 5 0.0067 0.0603 0.0597
Trypanosoma brucei sugar transporter, putative 0.0031 0.0229 0.327
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0229 0.0956
Schistosoma mansoni hypothetical protein 0.001 0.0015 0.0067
Onchocerca volvulus 0.0031 0.0229 1
Echinococcus granulosus tm gpcr rhodopsin 0.001 0.0015 0.0067
Schistosoma mansoni protein kinase 0.0067 0.0603 0.278
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0229 0.0956
Trypanosoma cruzi hexose transporter, putative 0.0068 0.0612 0.8726
Loa Loa (eye worm) hypothetical protein 0.0031 0.0229 0.1057
Echinococcus granulosus tm gpcr rhodopsin 0.001 0.0015 0.0067
Echinococcus multilocularis lysyl tRNA synthetase 0.0049 0.0416 0.0416
Brugia malayi G-protein coupled receptor 0.001 0.0015 0.0067
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.001 0.0015 0.0067
Echinococcus granulosus neuropeptide FF receptor 2 0.001 0.0015 0.0067
Loa Loa (eye worm) hypothetical protein 0.001 0.0015 0.0067
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0229 0.0956
Echinococcus multilocularis serotonin receptor 0.001 0.0015 0.0015
Brugia malayi sulfakinin receptor protein 0.001 0.0015 0.0067
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0066 0.0589 0.2716
Leishmania major glucose transporter, lmgt3 0.0068 0.0612 0.8726
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.0042 0.034 1
Mycobacterium ulcerans threonyl-tRNA synthetase 0.0012 0.0039 0.0936
Brugia malayi follicle stimulating hormone receptor 0.001 0.0015 0.0067
Loa Loa (eye worm) hypothetical protein 0.001 0.0015 0.0067
Echinococcus granulosus solute carrier family 22 0.0031 0.0229 0.1057
Plasmodium vivax proline--tRNA ligase, putative 0.0077 0.0701 0.0701
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0229 0.0956
Trypanosoma cruzi Aminoacyl-tRNA editing domain containing protein, putative 0.0011 0.0024 0.0344
Plasmodium vivax sugar transporter, putative 0.0031 0.0229 0.0201
Trichomonas vaginalis conserved hypothetical protein 0.0068 0.0612 0.274
Echinococcus granulosus g-protein coupled receptor 0.001 0.0015 0.0067
Trypanosoma brucei glucose transporter, putative 0.0068 0.0612 0.8726
Trypanosoma brucei THT1 - hexose transporter, putative 0.0068 0.0612 0.8726
Plasmodium vivax CDK-related protein kinase 6, putative 0.093 0.949 1
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0219 0.2169 0.2169
Mycobacterium leprae Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase) (ThrRS) (Threonine-tRNA ligase) 0.0012 0.0039 0.0661
Mycobacterium tuberculosis Probable conserved integral membrane transport protein 0.0031 0.0229 0.6748
Trypanosoma brucei Aminoacyl-tRNA editing domain containing protein, putative 0.0011 0.0024 0.0344
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0229 0.0956
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0066 0.0589 0.2716
Schistosoma mansoni rhodopsin-like orphan GPCR 0.001 0.0015 0.0067
Loa Loa (eye worm) hypothetical protein 0.001 0.0015 0.0067
Brugia malayi hypothetical protein 0.001 0.0015 0.0067
Trypanosoma brucei glucose transporter, putative 0.0068 0.0612 0.8726
Loa Loa (eye worm) hypothetical protein 0.0026 0.0184 0.0848
Loa Loa (eye worm) hypothetical protein 0.001 0.0015 0.0067
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0184 0.0848
Trichomonas vaginalis conserved hypothetical protein 0.0068 0.0612 0.274
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.001 0.0015 0.0067
Echinococcus multilocularis allatostatin A receptor 0.001 0.0015 0.0015
Loa Loa (eye worm) hypothetical protein 0.0049 0.0416 0.1917
Schistosoma mansoni rhodopsin-like orphan GPCR 0.001 0.0015 0.0067
Schistosoma mansoni neuropeptide f receptor 76f 0.001 0.0015 0.0067
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0229 0.0956
Echinococcus multilocularis neuropeptide s receptor 0.001 0.0015 0.0015
Loa Loa (eye worm) hypothetical protein 0.0026 0.0184 0.0848
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.001 0.0015 0.0015
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0066 0.0589 0.2716
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0067 0.0603 0.86
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0067 0.0603 0.096
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0066 0.0589 0.2716
Echinococcus multilocularis rhodopsin orphan GPCR 0.001 0.0015 0.0015
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.001 0.0015 0.0067
Echinococcus granulosus biogenic amine 5HT receptor 0.001 0.0015 0.0067
Entamoeba histolytica hypothetical protein 0.0049 0.0416 0.6679
Loa Loa (eye worm) hypothetical protein 0.018 0.177 0.8163
Mycobacterium ulcerans integral membrane transport protein 0.0031 0.0229 0.5515
Plasmodium falciparum calcium-dependent protein kinase 3 0.0067 0.0603 0.0597
Brugia malayi G-protein coupled receptor 0.001 0.0015 0.0067
Trichomonas vaginalis CAMK family protein kinase 0.0067 0.0603 0.2699
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0229 0.0956
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.0184 0.4425
Echinococcus multilocularis General substrate transporter 0.0188 0.1851 0.1851
Loa Loa (eye worm) hypothetical protein 0.001 0.0015 0.0067
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0354 0.3558 0.5659
Onchocerca volvulus Putative transporter 0.0031 0.0229 1
Brugia malayi hypothetical protein 0.001 0.0015 0.0067
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.001 0.0015 0.0015
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.001 0.0015 0.0067
Echinococcus multilocularis Threonyl tRNA synthetase, C 0.0012 0.0039 0.0039
Echinococcus multilocularis neuropeptide receptor A26 0.001 0.0015 0.0015
Echinococcus multilocularis neuropeptide receptor 0.001 0.0015 0.0015
Echinococcus multilocularis solute carrier family 22 0.0031 0.0229 0.0229
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0229 0.0956
Trichomonas vaginalis threonyl-tRNA synthetase, putative 0.0012 0.0039 0.0069
Schistosoma mansoni hypothetical protein 0.001 0.0015 0.0067
Plasmodium falciparum acyl-CoA synthetase 0.002 0.0115 0.0081
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.002 0.0115 0.339
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0229 0.0956
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.001 0.0015 0.0067
Loa Loa (eye worm) hypothetical protein 0.001 0.0015 0.0067
Loa Loa (eye worm) hypothetical protein 0.0031 0.0229 0.1057
Echinococcus multilocularis neuropeptides capa receptor 0.001 0.0015 0.0015
Trypanosoma brucei THT1 - hexose transporter, putative 0.0068 0.0612 0.8726
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0067 0.0603 0.0597
Plasmodium falciparum calcium-dependent protein kinase 2 0.0067 0.0603 0.0597
Brugia malayi gonadotropin-releasing hormone receptor 2 0.001 0.0015 0.0067
Trypanosoma brucei THT1 - hexose transporter, putative 0.0068 0.0612 0.8726
Loa Loa (eye worm) G-protein coupled receptor 0.001 0.0015 0.0067
Loa Loa (eye worm) major facilitator superfamily transporter 0.0031 0.0229 0.1057
Echinococcus granulosus rhodopsin orphan GPCR 0.001 0.0015 0.0067
Onchocerca volvulus 0.0031 0.0229 1
Echinococcus multilocularis muscleblind protein 0.018 0.177 0.177
Echinococcus multilocularis solute carrier family 22 0.0031 0.0229 0.0229
Loa Loa (eye worm) hypothetical protein 0.001 0.0015 0.0067
Brugia malayi hypothetical protein 0.001 0.0015 0.0067
Schistosoma mansoni amine GPCR 0.001 0.0015 0.0067
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.001 0.0015 0.0067
Echinococcus granulosus alpha 1A adrenergic receptor 0.001 0.0015 0.0067
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0066 0.0589 1
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0219 0.2169 1
Brugia malayi AKH receptor 0.001 0.0015 0.0067
Trypanosoma brucei myo-inositol/proton symporter (MIT) 0.0031 0.0229 0.327
Brugia malayi Major Facilitator Superfamily protein 0.0031 0.0229 0.1057
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0049 0.0416 0.1826
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0184 0.0848
Echinococcus granulosus rhodopsin orphan GPCR 0.001 0.0015 0.0067
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0077 0.0701 0.1115
Echinococcus granulosus biogenic amine 5HT receptor 0.001 0.0015 0.0067
Trypanosoma brucei threonyl-tRNA synthetase, putative 0.0012 0.0039 0.0555
Brugia malayi lysyl-tRNA synthetase 0.0049 0.0416 0.1917
Schistosoma mansoni amine GPCR 0.001 0.0015 0.0067
Entamoeba histolytica acyl-CoA synthetase, putative 0.0026 0.0184 0.2571
Loa Loa (eye worm) hypothetical protein 0.001 0.0015 0.0067
Loa Loa (eye worm) hypothetical protein 0.001 0.0015 0.0067
Entamoeba histolytica protein kinase, putative 0.0067 0.0603 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0015 0.0067
Onchocerca volvulus 0.0031 0.0229 1
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0067 0.0603 0.0603
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0077 0.0701 1
Brugia malayi threonyl-tRNA synthetase, cytoplasmic 0.0012 0.0039 0.0179
Brugia malayi Dopamine receptor 0.001 0.0015 0.0067
Echinococcus granulosus G protein coupled receptor 139 0.001 0.0015 0.0067
Schistosoma mansoni hypothetical protein 0.001 0.0015 0.0067
Onchocerca volvulus 0.0031 0.0229 1
Toxoplasma gondii glycyl-tRNA synthetase 0.0012 0.0039 0.0062
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0229 0.0956
Toxoplasma gondii facilitative glucose transporter GT1 0.0219 0.2169 0.3449
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.0184 0.4425
Toxoplasma gondii protein kinase, putative 0.0619 0.6288 1
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0229 0.0956
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.001 0.0015 0.0015
Loa Loa (eye worm) hypothetical protein 0.0031 0.0229 0.1057
Plasmodium falciparum proline--tRNA ligase 0.0077 0.0701 0.0701
Loa Loa (eye worm) hypothetical protein 0.001 0.0015 0.0067
Brugia malayi Dopamine receptor protein 1 0.001 0.0015 0.0067
Brugia malayi hypothetical protein 0.001 0.0015 0.0067
Echinococcus granulosus peptide allatostatin:somatostatin 0.001 0.0015 0.0067
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.001 0.0015 0.0067
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0229 0.0956
Toxoplasma gondii sugar transporter ST3 0.0031 0.0229 0.0365
Mycobacterium leprae conserved hypothetical protein 0.0011 0.0024 0.041
Echinococcus granulosus rhodopsin orphan GPCR 0.001 0.0015 0.0067
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0019 0.0104 0.3063
Loa Loa (eye worm) hypothetical protein 0.001 0.0015 0.0067
Onchocerca volvulus 0.0031 0.0229 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0015 0.0067
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0219 0.2169 0.2169
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0229 0.0956
Echinococcus multilocularis rhodopsin orphan GPCR 0.001 0.0015 0.0015
Toxoplasma gondii lysine-tRNA ligase 0.0049 0.0416 0.0661
Loa Loa (eye worm) hypothetical protein 0.001 0.0015 0.0067
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0229 0.0956
Brugia malayi hypothetical protein 0.001 0.0015 0.0067
Schistosoma mansoni rhodopsin-like orphan GPCR 0.001 0.0015 0.0067
Echinococcus granulosus Sugar transporter ERD6 protein 0.0031 0.0229 0.1057
Echinococcus granulosus General substrate transporter 0.0188 0.1851 0.8537
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.001 0.0015 0.0067
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0229 0.0956
Leishmania major threonyl-tRNA synthetase, putative 0.0012 0.0039 0.0555
Echinococcus granulosus neuropeptides capa receptor 0.001 0.0015 0.0067
Toxoplasma gondii transporter, major facilitator family protein 0.0031 0.0229 0.0365
Brugia malayi Cam kinase protein 1 0.0067 0.0603 0.278
Brugia malayi Muscleblind-like protein 0.018 0.177 0.8163
Trichomonas vaginalis glucose transporter, putative 0.0068 0.0612 0.274
Loa Loa (eye worm) hypothetical protein 0.0012 0.0039 0.0179
Echinococcus multilocularis biogenic amine (5HT) receptor 0.001 0.0015 0.0015
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.001 0.0015 0.0015
Loa Loa (eye worm) hypothetical protein 0.001 0.0015 0.0067
Echinococcus granulosus tachykinin peptides receptor 99D 0.001 0.0015 0.0067
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.001 0.0015 0.0015
Echinococcus granulosus thyrotropin releasing hormone receptor 0.001 0.0015 0.0067
Loa Loa (eye worm) hypothetical protein 0.001 0.0015 0.0067
Trichomonas vaginalis myo-inositol transporter, putative 0.0031 0.0229 0.0956
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.0031 0.0229 0.5515
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.0031 0.0229 1
Echinococcus granulosus 7TM GPCR rhodopsin 0.001 0.0015 0.0067
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0229 0.0956
Schistosoma mansoni opsin-like receptor 0.001 0.0015 0.0067
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0066 0.0589 0.2634
Mycobacterium ulcerans prolyl-tRNA synthetase 0.0023 0.0151 0.3635
Brugia malayi GnHR receptor homolog 0.001 0.0015 0.0067
Schistosoma mansoni myosin xvIII 0.001 0.0015 0.0067
Brugia malayi G protein-coupled receptor 0.001 0.0015 0.0067
Schistosoma mansoni protein kinase 0.0067 0.0603 0.278
Echinococcus granulosus g protein coupled receptor 0.001 0.0015 0.0067
Loa Loa (eye worm) hypothetical protein 0.0031 0.0229 0.1057
Echinococcus granulosus hypothetical protein 0.001 0.0015 0.0067
Giardia lamblia Prolyl-tRNA synthetase 0.0066 0.0589 1
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0042 0.034 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.001 0.0015 0.0067
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.001 0.0015 0.0067
Echinococcus multilocularis g protein coupled receptor 0.001 0.0015 0.0015
Loa Loa (eye worm) hypothetical protein 0.0067 0.0603 0.278
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.001 0.0015 0.0015
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0049 0.0416 1
Leishmania major lysyl-tRNA synthetase, putative 0.0049 0.0416 0.5928
Brugia malayi probable proline-trna synthetase - fission yeast, putative 0.0012 0.0039 0.0179
Echinococcus multilocularis neuropeptides capa receptor 0.001 0.0015 0.0015
Schistosoma mansoni adenoreceptor 0.001 0.0015 0.0067
Echinococcus multilocularis G-protein coupled receptor, putative 0.001 0.0015 0.0015
Loa Loa (eye worm) hypothetical protein 0.0066 0.0589 0.2716
Echinococcus granulosus lysyl tRNA synthetase 0.0049 0.0416 0.1917
Loa Loa (eye worm) hypothetical protein 0.0026 0.0184 0.0848
Loa Loa (eye worm) hypothetical protein 0.002 0.0115 0.0531
Leishmania major myo-inositol/proton symporter (MIT) 0.0031 0.0229 0.327
Echinococcus multilocularis g protein coupled receptor 0.001 0.0015 0.0015
Schistosoma mansoni biogenic amine (dopamine) receptor 0.001 0.0015 0.0067
Echinococcus granulosus fmrfamide receptor 0.001 0.0015 0.0067
Schistosoma mansoni sugar transporter 0.0031 0.0229 0.1057
Echinococcus granulosus dro:myosuppressin receptor 0.001 0.0015 0.0067
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0049 0.0416 0.5928
Trypanosoma cruzi hexose transporter, putative 0.0031 0.0229 0.327
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0229 0.0956
Chlamydia trachomatis lysine--tRNA ligase 0.0049 0.0416 1
Brugia malayi larval opioid receptor 0.001 0.0015 0.0067
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0031 0.0229 0.0229
Trypanosoma brucei glucose transporter, putative 0.0068 0.0612 0.8726
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0066 0.0589 0.9752
Loa Loa (eye worm) hypothetical protein 0.002 0.0115 0.0531
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0229 0.0956
Schistosoma mansoni rhodopsin-like orphan GPCR 0.001 0.0015 0.0067
Trichomonas vaginalis sugar transporter, putative 0.0068 0.0612 0.274
Echinococcus multilocularis somatostatin receptor 0.001 0.0015 0.0015
Schistosoma mansoni neuropeptide receptor 0.001 0.0015 0.0067
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.001 0.0015 0.0067
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0026 0.0184 0.4425
Brugia malayi hypothetical protein 0.001 0.0015 0.0067
Onchocerca volvulus 0.0031 0.0229 1
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0049 0.0416 0.7057
Loa Loa (eye worm) hypothetical protein 0.001 0.0015 0.0067
Schistosoma mansoni sugar transporter 0.0031 0.0229 0.1057
Trypanosoma brucei glucose transporter, putative 0.0068 0.0612 0.8726
Leishmania major 4-coumarate:coa ligase-like protein 0.0026 0.0184 0.2623
Brugia malayi hypothetical protein 0.0031 0.0229 0.1057
Loa Loa (eye worm) hypothetical protein 0.001 0.0015 0.0067
Onchocerca volvulus 0.0031 0.0229 1
Schistosoma mansoni glucose transporter 0.0031 0.0229 0.1057
Schistosoma mansoni biogenic amine (dopamine) receptor 0.001 0.0015 0.0067
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.001 0.0015 0.0067
Loa Loa (eye worm) hypothetical protein 0.001 0.0015 0.0067
Loa Loa (eye worm) hypothetical protein 0.0066 0.0589 0.2716
Loa Loa (eye worm) hypothetical protein 0.001 0.0015 0.0067
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0067 0.0603 0.0603
Leishmania major protein kinase, putative 0.0067 0.0603 0.86
Echinococcus granulosus solute carrier family 22 0.0031 0.0229 0.1057
Echinococcus granulosus tm gpcr rhodopsin 0.001 0.0015 0.0067
Onchocerca volvulus 0.0031 0.0229 1
Leishmania major hypothetical protein, conserved 0.0011 0.0024 0.0344
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0026 0.0184 0.3123
Schistosoma mansoni neuropeptide F-like receptor 0.001 0.0015 0.0067
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0067 0.0603 0.278
Loa Loa (eye worm) hypothetical protein 0.001 0.0015 0.0067
Loa Loa (eye worm) hypothetical protein 0.001 0.0015 0.0067
Echinococcus multilocularis dro:myosuppressin receptor 0.001 0.0015 0.0015
Loa Loa (eye worm) hypothetical protein 0.001 0.0015 0.0067
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0026 0.0184 0.4425
Plasmodium vivax hexose transporter 0.0219 0.2169 0.2253
Plasmodium falciparum hexose transporter 0.0219 0.2169 0.2253
Loa Loa (eye worm) hypothetical protein 0.001 0.0015 0.0067
Toxoplasma gondii threonyl-tRNA synthetase family protein 0.0012 0.0039 0.0062
Loa Loa (eye worm) follicle stimulating hormone receptor 0.001 0.0015 0.0067
Plasmodium falciparum lysine--tRNA ligase 0.0049 0.0416 0.0399
Loa Loa (eye worm) hypothetical protein 0.001 0.0015 0.0067
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0066 0.0589 0.2716
Leishmania major 4-coumarate:coa ligase-like protein 0.0026 0.0184 0.2623
Brugia malayi major facilitator superfamily protein 0.0031 0.0229 0.1057
Schistosoma mansoni rhodopsin-like orphan GPCR 0.001 0.0015 0.0067
Schistosoma mansoni sugar transporter 0.0031 0.0229 0.1057
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0067 0.0603 0.0597
Loa Loa (eye worm) hypothetical protein 0.001 0.0015 0.0067
Schistosoma mansoni glycyl-tRNA synthetase 0.0012 0.0039 0.0179
Loa Loa (eye worm) hypothetical protein 0.001 0.0015 0.0067
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0219 0.2169 1
Leishmania major glucose transporter, lmgt2 0.0068 0.0612 0.8726
Plasmodium vivax lysine--tRNA ligase, putative 0.0049 0.0416 0.0399
Trypanosoma cruzi sugar transporter, putative 0.0031 0.0229 0.327
Schistosoma mansoni opsin-like receptor 0.001 0.0015 0.0067
Echinococcus multilocularis rhodopsin orphan GPCR 0.001 0.0015 0.0015
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.001 0.0015 0.0067
Brugia malayi major facilitator superfamily protein 0.0031 0.0229 0.1057
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0026 0.0184 0.3123
Brugia malayi hypothetical protein 0.001 0.0015 0.0067
Trypanosoma cruzi hexose transporter, putative 0.0037 0.0295 0.42
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0219 0.2169 0.2169
Echinococcus multilocularis g protein coupled receptor 0.001 0.0015 0.0015
Schistosoma mansoni growth hormone secretagogue receptor 0.001 0.0015 0.0067
Loa Loa (eye worm) hypothetical protein 0.0031 0.0229 0.1057
Loa Loa (eye worm) hypothetical protein 0.001 0.0015 0.0067
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0067 0.0603 0.278
Leishmania major glucose transporter, lmgt1 0.0068 0.0612 0.8726
Loa Loa (eye worm) hypothetical protein 0.001 0.0015 0.0067
Loa Loa (eye worm) hypothetical protein 0.001 0.0015 0.0067
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0219 0.2169 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.001 0.0015 0.0067
Loa Loa (eye worm) neuropeptide F receptor 0.001 0.0015 0.0067
Loa Loa (eye worm) hypothetical protein 0.0031 0.0229 0.1057
Echinococcus multilocularis fmrfamide receptor 0.001 0.0015 0.0015
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.0184 0.4425
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.0031 0.0229 0.5515
Echinococcus multilocularis neuropeptide FF receptor 2 0.001 0.0015 0.0015
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0077 0.0701 1
Brugia malayi Tachykinin-like peptides receptor 99D 0.001 0.0015 0.0067
Schistosoma mansoni amine GPCR 0.001 0.0015 0.0067
Echinococcus multilocularis rhodopsin orphan GPCR 0.001 0.0015 0.0015
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0229 0.0956
Echinococcus granulosus synaptic vesicle 2 protein 0.0031 0.0229 0.1057
Echinococcus granulosus serotonin receptor 0.001 0.0015 0.0067
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0019 0.0104 0.3063
Brugia malayi hypothetical protein 0.001 0.0015 0.0067
Brugia malayi Sugar transporter family protein 0.0219 0.2169 1
Loa Loa (eye worm) sugar transporter 0.0219 0.2169 1
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0077 0.0701 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0115 0.0531
Leishmania major glucose transporter/membrane transporter D2, putative 0.0068 0.0612 0.8726
Trypanosoma cruzi hypothetical protein, conserved 0.0011 0.0024 0.0344
Brugia malayi glycyl-tRNA synthetase 0.0012 0.0039 0.0179
Echinococcus multilocularis g-protein coupled receptor 0.001 0.0015 0.0015
Brugia malayi neuropeptide F receptor 0.001 0.0015 0.0067
Echinococcus multilocularis solute carrier family 22 0.0031 0.0229 0.0229
Loa Loa (eye worm) hypothetical protein 0.0031 0.0229 0.1057
Trypanosoma cruzi threonyl-tRNA synthetase, putative 0.0012 0.0039 0.0555
Mycobacterium leprae Probable lysyl-tRNA synthase LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0042 0.034 0.5768
Brugia malayi Serotonin/octopamine receptor family protein 7 0.001 0.0015 0.0067
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.001 0.0015 0.0015
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0229 0.0956
Trichomonas vaginalis sugar transporter, putative 0.0068 0.0612 0.274
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0229 0.0956
Trichomonas vaginalis glucose transporter, putative 0.0031 0.0229 0.0956
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0229 0.0956
Loa Loa (eye worm) hypothetical protein 0.001 0.0015 0.0067
Trichomonas vaginalis sugar transporter, putative 0.0068 0.0612 0.274
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0229 0.0956
Brugia malayi Dopamine receptor protein 2 0.001 0.0015 0.0067
Onchocerca volvulus 0.0031 0.0229 1
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0067 0.0603 0.278
Schistosoma mansoni biogenic amine receptor 0.001 0.0015 0.0067
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0026 0.0184 0.5414
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0229 0.0956
Schistosoma mansoni hypothetical protein 0.001 0.0015 0.0067
Onchocerca volvulus 0.0031 0.0229 1
Entamoeba histolytica protein kinase, putative 0.0067 0.0603 1
Schistosoma mansoni peptide (allatostatin)-like receptor 0.001 0.0015 0.0067
Echinococcus multilocularis rhodopsin orphan GPCR 0.001 0.0015 0.0015
Schistosoma mansoni biogenic amine (dopamine) receptor 0.001 0.0015 0.0067
Echinococcus multilocularis rhodopsin orphan GPCR 0.001 0.0015 0.0015
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase 0.0027 0.019 0.0875
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0229 0.0956
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0229 0.0956
Brugia malayi hypothetical protein 0.001 0.0015 0.0067
Onchocerca volvulus 0.0031 0.0229 1
Echinococcus granulosus g protein coupled receptor 0.001 0.0015 0.0067
Loa Loa (eye worm) cytochrome P450 family protein 0.0032 0.0237 0.1095
Brugia malayi neuropeptide F receptor 0.001 0.0015 0.0067
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.001 0.0015 0.0067
Onchocerca volvulus 0.0031 0.0229 1
Loa Loa (eye worm) hypothetical protein 0.0031 0.0229 0.1057
Echinococcus multilocularis fmrfamide receptor 0.001 0.0015 0.0015
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0229 0.0956
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0019 0.0104 0.3063
Mycobacterium tuberculosis Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase)(ThrRS) (threonine-tRNA ligase) 0.0012 0.0039 0.1145
Schistosoma mansoni glucose transport protein 0.0219 0.2169 1
Brugia malayi hypothetical protein 0.0031 0.0229 0.1057
Echinococcus granulosus g protein coupled receptor 0.001 0.0015 0.0067
Loa Loa (eye worm) major facilitator superfamily transporter 0.0031 0.0229 0.1057
Loa Loa (eye worm) hypothetical protein 0.001 0.0015 0.0067
Schistosoma mansoni protein kinase 0.0067 0.0603 0.278
Toxoplasma gondii YbaK/proline-tRNA ligase associated domain-containing protein 0.0011 0.0024 0.0038
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0026 0.0184 0.4425
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.001 0.0015 0.0067
Trichomonas vaginalis conserved hypothetical protein 0.0219 0.2169 1
Plasmodium falciparum major facilitator superfamily domain-containing protein, putative 0.0031 0.0229 0.0201
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0219 0.2169 1
Loa Loa (eye worm) hypothetical protein 0.0031 0.0229 0.1057
Schistosoma mansoni rhodopsin-like orphan GPCR 0.001 0.0015 0.0067
Onchocerca volvulus 0.0026 0.0184 0.7888
Echinococcus granulosus orexin receptor type 2 0.001 0.0015 0.0067
Plasmodium falciparum protein kinase 6 0.093 0.949 1
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0229 0.0956
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.001 0.0015 0.0015
Schistosoma mansoni lysyl-tRNA synthetase 0.0049 0.0416 0.1917
Echinococcus granulosus rhodopsin orphan GPCR 0.001 0.0015 0.0067
Trypanosoma cruzi Aminoacyl-tRNA editing domain containing protein, putative 0.0011 0.0024 0.0344
Loa Loa (eye worm) sugar transporter 0.0031 0.0229 0.1057
Schistosoma mansoni sugar transporter 0.0031 0.0229 0.1057
Echinococcus granulosus neuropeptide receptor 0.001 0.0015 0.0067
Loa Loa (eye worm) hypothetical protein 0.0031 0.0229 0.1057
Echinococcus multilocularis orexin receptor type 2 0.001 0.0015 0.0015
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0077 0.0701 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0015 0.0067
Trypanosoma cruzi hexose transporter, putative 0.0068 0.0612 0.8726
Echinococcus granulosus neuropeptide Y receptor 0.001 0.0015 0.0067
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0049 0.0416 0.5928
Echinococcus multilocularis rhodopsin orphan GPCR 0.001 0.0015 0.0015
Loa Loa (eye worm) hypothetical protein 0.018 0.177 0.8163
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.0031 0.0229 0.1057
Schistosoma mansoni biogenic amine (5HT) receptor 0.001 0.0015 0.0067
Echinococcus multilocularis neuropeptide receptor 0.001 0.0015 0.0015
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0229 0.0956
Echinococcus multilocularis serotonin receptor 0.001 0.0015 0.0015
Loa Loa (eye worm) hypothetical protein 0.001 0.0015 0.0067
Trichomonas vaginalis sugar transport protein, putative 0.0031 0.0229 0.0956
Mycobacterium ulcerans sugar transporter 0.0031 0.0229 0.5515
Loa Loa (eye worm) neuropeptide F receptor 0.001 0.0015 0.0067
Trypanosoma brucei glucose transporter, putative 0.0068 0.0612 0.8726
Plasmodium falciparum protein kinase 7 0.0619 0.6288 0.6612
Echinococcus granulosus neuropeptide receptor A26 0.001 0.0015 0.0067
Brugia malayi hypothetical protein 0.0031 0.0229 0.1057
Brugia malayi Serotonin receptor 0.001 0.0015 0.0067
Plasmodium falciparum calcium-dependent protein kinase 4 0.0067 0.0603 0.0597
Toxoplasma gondii sugar transporter ST1 0.0031 0.0229 0.0365
Loa Loa (eye worm) G-protein coupled receptor 0.001 0.0015 0.0067
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0043 0.0354 0.1536
Plasmodium vivax calcium-dependent protein kinase, putative 0.0067 0.0603 0.0597
Echinococcus multilocularis neuropeptide Y receptor 0.001 0.0015 0.0015
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0184 0.0848
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0026 0.0184 0.4425
Echinococcus granulosus neuropeptide Y receptor 0.001 0.0015 0.0067
Mycobacterium tuberculosis Conserved hypothetical protein 0.0011 0.0024 0.071
Schistosoma mansoni biogenic amine receptor 0.001 0.0015 0.0067
Echinococcus multilocularis neuropeptide Y receptor 0.001 0.0015 0.0015
Brugia malayi hypothetical protein 0.001 0.0015 0.0067
Mycobacterium ulcerans hypothetical protein 0.0011 0.0024 0.0581
Plasmodium falciparum calcium-dependent protein kinase 1 0.0067 0.0603 0.0597
Leishmania major hypothetical protein, conserved 0.0011 0.0024 0.0344
Schistosoma mansoni neuropeptide receptor 0.001 0.0015 0.0067
Echinococcus granulosus somatostatin receptor 0.001 0.0015 0.0067
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0229 0.0956
Brugia malayi putative neuropeptide receptor 0.001 0.0015 0.0067
Echinococcus granulosus sex peptide receptor 0.001 0.0015 0.0067
Echinococcus granulosus Threonyl tRNA synthetase C 0.0012 0.0039 0.0179
Schistosoma mansoni histamine h1 receptor 0.001 0.0015 0.0067
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0067 0.0603 0.096
Brugia malayi Serotonin receptor 0.001 0.0015 0.0067
Schistosoma mansoni biogenic amine receptor 0.001 0.0015 0.0067
Schistosoma mansoni neuropeptide receptor 0.001 0.0015 0.0067
Echinococcus multilocularis G protein coupled receptor 139 0.001 0.0015 0.0015
Schistosoma mansoni alpha-1 adrenergic receptor 0.001 0.0015 0.0067
Chlamydia trachomatis proline--tRNA ligase 0.0023 0.0151 0.2978
Echinococcus multilocularis synaptic vesicle 2 protein 0.0031 0.0229 0.0229
Loa Loa (eye worm) hypothetical protein 0.001 0.0015 0.0067
Loa Loa (eye worm) hypothetical protein 0.001 0.0015 0.0067
Schistosoma mansoni amine GPCR 0.001 0.0015 0.0067
Loa Loa (eye worm) hypothetical protein 0.001 0.0015 0.0067
Loa Loa (eye worm) TYRA-2 protein 0.001 0.0015 0.0067
Echinococcus multilocularis alpha 1A adrenergic receptor 0.001 0.0015 0.0015
Echinococcus multilocularis solute carrier family 22 0.0031 0.0229 0.0229
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.002 0.0115 0.2024
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0049 0.0416 1
Schistosoma mansoni hypothetical protein 0.0219 0.2169 1
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0229 0.0956
Schistosoma mansoni biogenic amine (5HT) receptor 0.001 0.0015 0.0067
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0229 0.0956
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0067 0.0603 0.278
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0354 0.3558 0.3724
Leishmania major 4-coumarate:coa ligase-like protein 0.0026 0.0184 0.2623

Activities

Activity type Activity value Assay description Source Reference
AC50 (functional) PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2d6 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp3a4 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) = 8.912509381 uM PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp1a2 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) = 10 uM PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2c19 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) = 35.48133892 uM PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2c9 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
Potency (binding) 12.5893 uM PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 16.3601 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 25.1189 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference
Potency (functional) 30.1313 uM PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] ChEMBL. No reference
Potency (functional) 31.6228 uM PubChem BioAssay. qHTS Assay for Activators of ClpP. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 31.6228 uM PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Kappa. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588638] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.