Detailed information for compound 1429284

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 431.456 | Formula: C21H19F2N3O3S
  • H donors: 0 H acceptors: 3 LogP: 2.6 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(c1cccc(c1)n1cccc1)N1CCN(CC1)S(=O)(=O)c1c(F)cccc1F
  • InChi: 1S/C21H19F2N3O3S/c22-18-7-4-8-19(23)20(18)30(28,29)26-13-11-25(12-14-26)21(27)16-5-3-6-17(15-16)24-9-1-2-10-24/h1-10,15H,11-14H2
  • InChiKey: UXCQNHWAPQVNFA-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens polymerase (DNA directed), beta Starlite/ChEMBL No references
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Homo sapiens polymerase (DNA directed), eta Starlite/ChEMBL No references
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal Starlite/ChEMBL No references
Trypanosoma brucei gambiense ATP-dependent phosphofructokinase,6-phospho-1-fructokinase No references
Homo sapiens GNAS complex locus Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Cryptosporidium parvum DinB/family X-type DNA polymerase Get druggable targets OG5_128521 All targets in OG5_128521
Trypanosoma cruzi DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania major mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Schistosoma japonicum ko:K03509 DNA polymerase eta subunit, putative Get druggable targets OG5_128521 All targets in OG5_128521
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Trichomonas vaginalis phosphofructokinase, putative Get druggable targets OG5_126758 All targets in OG5_126758
Leishmania mexicana DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania braziliensis DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania braziliensis ATP-dependent phosphofructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Trypanosoma congolense DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Trypanosoma cruzi DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Loa Loa (eye worm) 6-phosphofructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Echinococcus granulosus 6 phosphofructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Trichomonas vaginalis phosphofructokinase, putative Get druggable targets OG5_126758 All targets in OG5_126758
Brugia malayi 6-phosphofructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Trypanosoma brucei gambiense DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum ko:K00850 6-phosphofructokinase [EC2.7.1.11], putative Get druggable targets OG5_126758 All targets in OG5_126758
Schistosoma mansoni 6-phosphofructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Trypanosoma congolense ATP-dependent 6-phosphofructokinase, glycosomal Get druggable targets OG5_126758 All targets in OG5_126758
Toxoplasma gondii ImpB/MucB/SamB family protein Get druggable targets OG5_128521 All targets in OG5_128521
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal Get druggable targets OG5_126758 All targets in OG5_126758
Leishmania major DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania major DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) Get druggable targets OG5_126758 All targets in OG5_126758
Trypanosoma brucei gambiense ATP-dependent phosphofructokinase,6-phospho-1-fructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Leishmania donovani mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Trichomonas vaginalis phosphofructokinase, putative Get druggable targets OG5_126758 All targets in OG5_126758
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni 6-phosphofructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Echinococcus granulosus dna polymerase eta Get druggable targets OG5_128521 All targets in OG5_128521
Mycobacterium ulcerans hypothetical protein Get druggable targets OG5_130965 All targets in OG5_130965
Leishmania mexicana Get druggable targets OG5_128521 All targets in OG5_128521
Trypanosoma brucei gambiense mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Schistosoma japonicum ko:K03509 DNA polymerase eta subunit, putative Get druggable targets OG5_128521 All targets in OG5_128521
Brugia malayi phosphofructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Entamoeba histolytica phosphofructokinase, putative Get druggable targets OG5_126758 All targets in OG5_126758
Neospora caninum Pc21g17280 protein, related Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania infantum DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Candida albicans phosphofructokinase alpha subunit that can functionally substitute for S. cerevisiae PFK1 (YGR240C) Get druggable targets OG5_126758 All targets in OG5_126758
Trypanosoma congolense mitochondrial DNA polymerase beta, putative Get druggable targets OG5_130965 All targets in OG5_130965
Echinococcus multilocularis 6 phosphofructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Mycobacterium tuberculosis Conserved hypothetical protein Get druggable targets OG5_130965 All targets in OG5_130965
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal Get druggable targets OG5_126758 All targets in OG5_126758
Candida albicans phosphofructokinase beta-subunit that can functionally substitute for S. cerevisiae PFK2 (YMR205C) Get druggable targets OG5_126758 All targets in OG5_126758
Leishmania donovani ATP-dependent 6-phosphofructokinase, glycosomal Get druggable targets OG5_126758 All targets in OG5_126758
Brugia malayi ImpB/MucB/SamB family protein Get druggable targets OG5_128521 All targets in OG5_128521
Loa Loa (eye worm) 6-phosphofructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Trypanosoma brucei mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Mycobacterium ulcerans 6-phosphofructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Candida albicans similar to S. cerevisiae DNA polymerase pol-eta, involved in the bypass of distorted DNA lesions Get druggable targets OG5_128521 All targets in OG5_128521
Echinococcus multilocularis dna polymerase eta Get druggable targets OG5_128521 All targets in OG5_128521
Candida albicans hypothetical protein Get druggable targets OG5_126758 All targets in OG5_126758
Loa Loa (eye worm) phosphofructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Leishmania mexicana 6-phospho-1-fructokinase, putative Get druggable targets OG5_126758 All targets in OG5_126758
Entamoeba histolytica phosphofructokinase, putative Get druggable targets OG5_126758 All targets in OG5_126758
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Trypanosoma brucei DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative Get druggable targets OG5_130965 All targets in OG5_130965
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase Get druggable targets OG5_126758 All targets in OG5_126758
Schistosoma mansoni DNA polymerase eta Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania braziliensis mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) Get druggable targets OG5_126758 All targets in OG5_126758
Leishmania infantum mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Entamoeba histolytica phosphofructokinase, putative Get druggable targets OG5_126758 All targets in OG5_126758
Candida albicans similar to S. cerevisiae DNA polymerase pol-eta, involved in the bypass of distorted DNA lesions Get druggable targets OG5_128521 All targets in OG5_128521
Candida albicans phosphofructokinase beta-subunit that can functionally substitute for S. cerevisiae PFK2 (YMR205C) Get druggable targets OG5_126758 All targets in OG5_126758
Leishmania mexicana mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Leishmania infantum DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Brugia malayi 6-phosphofructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania major ATP-dependent phosphofructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Trichomonas vaginalis phosphofructokinase, putative Get druggable targets OG5_126758 All targets in OG5_126758
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative Get druggable targets OG5_130965 All targets in OG5_130965
Candida albicans phosphofructokinase alpha subunit that can functionally substitute for S. cerevisiae PFK1 (YGR240C) Get druggable targets OG5_126758 All targets in OG5_126758
Leishmania infantum ATP-dependent phosphofructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Leishmania braziliensis DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative polymerase (DNA directed), beta 335 aa 303 aa 32.3 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0131 0.2304 0.5153
Entamoeba histolytica phosphofructokinase, putative 0.0131 0.2304 0.2304
Echinococcus granulosus NAD dependent deacetylase sirtuin 7 0.0067 0.0748 0.0315
Giardia lamblia Sirtuin type 2 0.0067 0.0748 0.0748
Giardia lamblia Hypothetical protein 0.0451 1 1
Plasmodium falciparum transcriptional regulatory protein sir2b 0.0067 0.0748 1
Leishmania major mitochondrial DNA polymerase beta 0.0365 0.7917 0.7904
Trypanosoma cruzi Silent information regulator 2 related protein 3 0.0067 0.0748 0.0692
Entamoeba histolytica phosphofructokinase, putative 0.0131 0.2304 0.2304
Brugia malayi transcriptional regulator, Sir2 family protein 0.0067 0.0748 0.062
Schistosoma mansoni chromatin regulatory protein sir2 0.0451 1 1
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0451 1 1
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0067 0.0748 0.0748
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0173 0.3298 0.3257
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0173 0.3298 0.3033
Mycobacterium ulcerans 6-phosphofructokinase 0.0131 0.2304 0.5153
Trypanosoma brucei DNA polymerase eta, putative 0.0054 0.0447 0.007
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0067 0.0748 0.0748
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0476 0.0029
Loa Loa (eye worm) hypothetical protein 0.0067 0.0748 0.062
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0035 0 0.5
Leishmania major DNA polymerase eta, putative 0.0054 0.0447 0.0389
Entamoeba histolytica hypothetical protein, conserved 0.0067 0.0748 0.0748
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0067 0.0748 0.0748
Brugia malayi transcriptional regulator, Sir2 family protein 0.0067 0.0748 0.062
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.0595 0.0464
Toxoplasma gondii histone deacetylase SIR2 0.0067 0.0748 1
Trypanosoma brucei Silent information regulator 2 related protein 1 0.0451 1 1
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0067 0.0748 0.0748
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.0476 0.0343
Toxoplasma gondii hypothetical protein 0.0059 0.0562 0.7506
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0131 0.2304 0.1999
Trichomonas vaginalis phosphofructokinase, putative 0.0131 0.2304 0.2304
Plasmodium falciparum transcriptional regulatory protein sir2a 0.0067 0.0748 1
Echinococcus granulosus NAD dependent deacetylase sirtuin 6 0.0067 0.0748 0.0315
Trichomonas vaginalis phosphofructokinase, putative 0.0131 0.2304 0.2304
Brugia malayi 6-phosphofructokinase 0.0131 0.2304 0.2197
Brugia malayi NAD-dependent deacetylase SIRT1 0.0067 0.0748 0.062
Loa Loa (eye worm) transcriptional regulator 0.0067 0.0748 0.062
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0067 0.0748 0.0748
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0067 0.0748 0.0748
Trypanosoma cruzi DNA polymerase eta, putative 0.0054 0.0447 0.0389
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0035 0 0.5
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0051 0.038 0.0321
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0067 0.0748 0.0748
Giardia lamblia Transcriptional regulator, Sir2 family 0.0067 0.0748 0.0748
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0131 0.2304 1
Echinococcus multilocularis chromatin regulatory protein sir2 0.0451 1 1
Trypanosoma cruzi Silent information regulator 2 related protein 1 0.0451 1 1
Echinococcus multilocularis NAD dependent deacetylase sirtuin 1 0.0067 0.0748 0.0315
Brugia malayi ImpB/MucB/SamB family protein 0.0054 0.0447 0.0315
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0451 1 1
Entamoeba histolytica phosphofructokinase, putative 0.0131 0.2304 0.2304
Schistosoma mansoni chromatin regulatory protein sir2 0.0067 0.0748 0.062
Giardia lamblia NAD-dependent histone deacetylase Sir2 0.0067 0.0748 0.0748
Mycobacterium tuberculosis Conserved hypothetical protein 0.0192 0.3767 1
Toxoplasma gondii histone deacetylase SIR2-like 0.0067 0.0748 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0476 0.0343
Schistosoma mansoni chromatin regulatory protein sir2 0.0067 0.0748 0.062
Brugia malayi 6-phosphofructokinase 0.0131 0.2304 0.2197
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0051 0.038 0.0321
Brugia malayi phosphofructokinase 0.0131 0.2304 0.2197
Loa Loa (eye worm) transcriptional regulator 0.0451 1 1
Echinococcus multilocularis NAD dependent deacetylase sirtuin 6 0.0067 0.0748 0.0315
Loa Loa (eye worm) 6-phosphofructokinase 0.0131 0.2304 0.2197
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0476 0.0029
Schistosoma mansoni chromatin regulatory protein sir2 0.0451 1 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.0595 0.0464
Leishmania major sir2-family protein-like protein 0.0067 0.0748 0.0692
Plasmodium vivax NAD-dependent deacetylase, putative 0.0067 0.0748 1
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0365 0.7917 0.7835
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.0476 0.0343
Trypanosoma cruzi Silent information regulator 2 related protein 1 0.0451 1 1
Echinococcus granulosus NAD dependent deacetylase sirtuin 3 0.0451 1 1
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0365 0.7917 0.7904
Schistosoma mansoni chromatin regulatory protein sir2 0.0067 0.0748 0.062
Entamoeba histolytica NAD-dependent deacetylase 1, putative 0.0067 0.0748 0.0748
Loa Loa (eye worm) hypothetical protein 0.0054 0.0447 0.0315
Trypanosoma brucei SIR2-like protein 4, putative 0.0067 0.0748 0.0383
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0476 0.0343
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0451 1 1
Schistosoma mansoni chromatin regulatory protein sir2 0.0067 0.0748 0.062
Leishmania major ATP-dependent phosphofructokinase 0.0131 0.2304 0.2256
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0038 0.0061 0.0814
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0476 0.0343
Loa Loa (eye worm) 6-phosphofructokinase 0.0131 0.2304 0.2197
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0476 0.0029
Loa Loa (eye worm) hypothetical protein 0.006 0.0595 0.0464
Trypanosoma cruzi Silent information regulator 2 related protein 3 0.0067 0.0748 0.0692
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0067 0.0748 0.0748
Trypanosoma brucei Silent information regulator 2 related protein 3 0.0067 0.0748 0.0383
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0067 0.0748 0.0748
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0365 0.7917 0.7904
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0131 0.2304 0.5
Loa Loa (eye worm) sirtuin 4 0.0067 0.0748 0.062
Schistosoma mansoni chromatin regulatory protein sir2 0.0451 1 1
Plasmodium vivax hypothetical protein, conserved 0.0067 0.0748 1
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0173 0.3298 0.3257
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0131 0.2304 0.2256
Trichomonas vaginalis phosphofructokinase, putative 0.0131 0.2304 0.2304
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0451 1 1
Mycobacterium ulcerans hypothetical protein 0.0192 0.3767 1
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0062 0.065 0.0593
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0051 0.038 0.0321
Loa Loa (eye worm) transcriptional regulator 0.0067 0.0748 0.062
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0476 0.0029
Echinococcus multilocularis 6 phosphofructokinase 0.0131 0.2304 0.1943
Schistosoma mansoni 6-phosphofructokinase 0.0131 0.2304 0.2197
Leishmania major silent information regulator 2, putative 0.0451 1 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.0595 0.0464
Echinococcus granulosus 6 phosphofructokinase 0.0131 0.2304 0.1943
Echinococcus multilocularis NAD dependent deacetylase sirtuin 7 0.0067 0.0748 0.0315
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0067 0.0748 0.0748
Loa Loa (eye worm) phosphofructokinase 0.0131 0.2304 0.2197
Echinococcus multilocularis NAD dependent deacetylase sirtuin 3 0.0451 1 1
Trichomonas vaginalis phosphofructokinase, putative 0.0131 0.2304 0.2304
Echinococcus granulosus NAD dependent deacetylase sirtuin 1 0.0067 0.0748 0.0315
Schistosoma mansoni DNA polymerase eta 0.0054 0.0447 0.0315
Schistosoma mansoni 6-phosphofructokinase 0.0131 0.2304 0.2197
Leishmania major NAD dependent deacetylase, putative,transcriptional regulator, Sir2 family protein, nicotinic acid mononucleotide 5,6-dimethylbe 0.0067 0.0748 0.0692
Echinococcus granulosus chromatin regulatory protein sir2 0.0451 1 1

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.7943 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference
Potency (functional) = 2.5119 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of DNA Polymerase Beta. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 3.1623 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 6.012 uM PUBCHEM_BIOASSAY: qHTS Assay to Find Inhibitors of T. brucei phosphofructokinase. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488768, AID492961] ChEMBL. No reference
Potency (functional) 10 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 18.526 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 19.9526 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Eta. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588636] ChEMBL. No reference
Potency (functional) 22.3872 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] ChEMBL. No reference
Potency (functional) 44.6684 uM PubChem BioAssay. qHTS for Inhibitors of WRN Helicase. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 50.1187 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference
Potency (functional) 67.0158 uM PubChem BioAssay. qHTS for Inhibitors of Polymerase Iota: Confirmatory Assay for Cherry-picked Compounds. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 70.7946 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 75.6863 uM PubChem BioAssay. qHTS for Inhibitors of Polymerase Eta: Confirmatory Assay for Cherry-picked Compounds. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Kappa. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588638] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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