Detailed information for compound 1432280

Basic information

Technical information
  • TDR Targets ID: 1432280
  • Name: ASN 02070346
  • MW: 368.496 | Formula: C20H24N4OS
  • H donors: 1 H acceptors: 4 LogP: 3.52 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(C(Sc1nnc2c(n1)C1(C)CCC2C1(C)C)C)Nc1ccccc1
  • InChi: 1S/C20H24N4OS/c1-12(17(25)21-13-8-6-5-7-9-13)26-18-22-16-15(23-24-18)14-10-11-20(16,4)19(14,2)3/h5-9,12,14H,10-11H2,1-4H3,(H,21,25)
  • InChiKey: UYHGCPBBCRVDCH-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • MLS000555818
  • N-Phenyl-2-(8,11,11-trimethyl-3,4,6-triaza-tricyclo[6.2.1.0*2,7*]undeca-2,4,6-trien-5-ylsulfanyl)-propionamide
  • SMR000172459

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens APEX nuclease (multifunctional DNA repair enzyme) 1 Starlite/ChEMBL No references
Homo sapiens GNAS complex locus Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Neospora caninum hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Plasmodium knowlesi AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Toxoplasma gondii exonuclease III APE Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K10772 AP endonuclease 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Entamoeba histolytica exodeoxyribonuclease III, putative Get druggable targets OG5_126768 All targets in OG5_126768
Giardia lamblia Endonuclease/Exonuclease/phosphatase Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Brugia malayi exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium hominis dna-(apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania donovani apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium parvum conserved hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Trypanosoma congolense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Wolbachia endosymbiont of Brugia malayi exonuclease III Get druggable targets OG5_126768 All targets in OG5_126768
Theileria parva hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase Get druggable targets OG5_126768 All targets in OG5_126768
Treponema pallidum exodeoxyribonuclease (exoA) Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium yoelii putative AP endonuclease-related Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania major apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania infantum apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Leishmania mexicana apurinic/apyrimidinic endonuclease-redox protein,AP-endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium berghei AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania braziliensis apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei gambiense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum ko:K10771 AP endonuclease 1, putative Get druggable targets OG5_126768 All targets in OG5_126768
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) steroid hormone receptor 0.0012 0.0065 0.0065
Brugia malayi nuclear hormone receptor 0.0012 0.0065 0.0065
Onchocerca volvulus Cirhin homolog 0.0098 0.1036 1
Brugia malayi Nuclear hormone receptor-like 1 0.0012 0.0065 0.0065
Mycobacterium ulcerans hypothetical protein 0.0043 0.0418 1
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0012 0.0065 0.0246
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0023 0.0184 0.0184
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.0065 0.0065
Onchocerca volvulus 0.0043 0.0418 0.3638
Mycobacterium leprae conserved hypothetical protein 0.0043 0.0418 0.5
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0012 0.0065 0.0246
Brugia malayi beta-lactamase family protein 0.0043 0.0418 0.0418
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0012 0.0065 0.0065
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0023 0.0184 0.0184
Loa Loa (eye worm) hypothetical protein 0.0043 0.0418 0.0418
Echinococcus granulosus mitogen activated protein kinase 11 0.0892 1 1
Echinococcus multilocularis beta catenin 0.0099 0.1044 0.1044
Mycobacterium ulcerans esterase/lipase LipP 0.0043 0.0418 1
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0023 0.0184 0.5
Echinococcus granulosus beta LACTamase domain containing family member 0.0043 0.0418 0.0418
Brugia malayi nuclear receptor NHR-88 0.0012 0.0065 0.0065
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0012 0.0065 0.0065
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0551 0.0551
Loa Loa (eye worm) hypothetical protein 0.0012 0.0065 0.0065
Mycobacterium ulcerans lipase LipD 0.0043 0.0418 1
Echinococcus multilocularis protein pangolin J 0.0066 0.0673 0.0673
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0012 0.0065 0.0065
Leishmania major hypothetical protein, conserved 0.0043 0.0418 0.0239
Schistosoma mansoni ap endonuclease 0.0023 0.0184 0.0695
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0012 0.0065 0.0065
Echinococcus multilocularis T cell transcription factor 4 long C terminal 0.0066 0.0673 0.0673
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0418 0.0239
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0418 0.1582
Mycobacterium leprae Probable lipase LipE 0.0043 0.0418 0.5
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.0065 0.0065
Brugia malayi HMG box family protein 0.0066 0.0673 0.0673
Loa Loa (eye worm) hypothetical protein 0.0043 0.0418 0.0418
Brugia malayi Armadillo/beta-catenin-like repeat family protein 0.0099 0.1044 0.1044
Loa Loa (eye worm) hypothetical protein 0.0012 0.0065 0.0065
Echinococcus multilocularis thyroid hormone receptor alpha 0.0012 0.0065 0.0065
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0043 0.0418 0.0418
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0551 0.2084
Echinococcus multilocularis beta LACTamase domain containing family member 0.0043 0.0418 0.0418
Schistosoma mansoni coup transcription factor 0.0012 0.0065 0.0246
Mycobacterium tuberculosis Probable lipase LipD 0.0043 0.0418 0.0814
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0012 0.0065 0.0065
Echinococcus multilocularis mitogen activated protein kinase 14 0.0892 1 1
Brugia malayi exodeoxyribonuclease III family protein 0.0023 0.0184 0.0184
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.0065 0.0065
Loa Loa (eye worm) hypothetical protein 0.0012 0.0065 0.0065
Echinococcus granulosus pangolin 0.0066 0.0673 0.0673
Brugia malayi beta-lactamase family protein 0.0043 0.0418 0.0418
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0012 0.0065 0.0065
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.0065 0.0065
Loa Loa (eye worm) HMG box family protein 0.0066 0.0673 0.0673
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0012 0.0065 0.0065
Echinococcus granulosus beta catenin 0.0099 0.1044 0.1044
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0418 1
Schistosoma mansoni nuclear hormone receptor 0.0012 0.0065 0.0246
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0012 0.0065 0.0065
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0012 0.0065 0.0065
Trichomonas vaginalis esterase, putative 0.0043 0.0418 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.0065 0.0065
Schistosoma mansoni thyroid hormone receptor 0.0012 0.0065 0.0246
Loa Loa (eye worm) hypothetical protein 0.0012 0.0065 0.0065
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0012 0.0065 0.0246
Schistosoma mansoni pangolin 0.0066 0.0673 0.2546
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.0551 0.0551
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0012 0.0065 0.0065
Echinococcus multilocularis mitogen activated protein kinase 11 0.0892 1 1
Onchocerca volvulus 0.0043 0.0418 0.3638
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0892 1 1
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0012 0.0065 0.0065
Mycobacterium tuberculosis Conserved protein 0.0043 0.0418 0.0814
Loa Loa (eye worm) CMGC/MAPK/P38 protein kinase 0.0892 1 1
Schistosoma mansoni RAR-like nuclear receptor 0.0012 0.0065 0.0246
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0012 0.0065 0.0246
Echinococcus granulosus FTZ F1 alpha 0.0012 0.0065 0.0065
Onchocerca volvulus 0.0043 0.0418 0.3638
Loa Loa (eye worm) hypothetical protein 0.0012 0.0065 0.0065
Trypanosoma brucei mitogen-activated protein kinase 3, putative 0.0892 1 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.0551 0.0551
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.0418 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0065 0.0065
Echinococcus granulosus ecdysone induced protein 78C 0.0012 0.0065 0.0065
Loa Loa (eye worm) hypothetical protein 0.0012 0.0065 0.0065
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0012 0.0065 0.0065
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0012 0.0065 0.0065
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0418 0.1582
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0418 1
Brugia malayi photoreceptor-specific nuclear receptor 0.0012 0.0065 0.0065
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0551 0.2084
Echinococcus granulosus mitogen activated protein kinase 14 0.0892 1 1
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0012 0.0065 0.0065
Loa Loa (eye worm) hypothetical protein 0.0043 0.0418 0.0418
Mycobacterium tuberculosis Conserved protein 0.0043 0.0418 0.0814
Brugia malayi steroid hormone receptor 0.0012 0.0065 0.0065
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0023 0.0184 0.5
Echinococcus multilocularis FTZ F1 alpha 0.0012 0.0065 0.0065
Treponema pallidum exodeoxyribonuclease (exoA) 0.0023 0.0184 0.5
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0012 0.0065 0.0246
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0551 0.2084
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0892 1 1
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.0418 1
Schistosoma mansoni retinoic acid receptor RXR 0.0012 0.0065 0.0246
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0278 0.3065 1
Mycobacterium ulcerans beta-lactamase 0.0043 0.0418 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0551 0.0551
Mycobacterium tuberculosis Probable lipase LipE 0.0043 0.0418 0.0814
Echinococcus multilocularis mitogen activated protein kinase 11 0.0892 1 1
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0012 0.0065 0.0065
Schistosoma mansoni ap endonuclease 0.0023 0.0184 0.0695
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0023 0.0184 0.5
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.0065 0.0065
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0551 0.0551
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0043 0.0418 0.0814
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0418 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.0065 0.0065
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0012 0.0065 0.0065
Schistosoma mansoni thyroid hormone receptor 0.0012 0.0065 0.0246
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0012 0.0065 0.0065
Brugia malayi ecdysteroid receptor 0.0012 0.0065 0.0065
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0012 0.0065 0.0065
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.0065 0.0065
Loa Loa (eye worm) HMP-2 protein 0.0099 0.1044 0.1044
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0012 0.0065 0.0065
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0012 0.0065 0.0065
Mycobacterium tuberculosis Probable esterase LipL 0.0043 0.0418 0.0814
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0012 0.0065 0.0065
Brugia malayi Steroid receptor seven-up type 2 0.0012 0.0065 0.0065
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0012 0.0065 0.0065
Schistosoma mansoni beta-catenin 0.0099 0.1044 0.3946
Loa Loa (eye worm) hypothetical protein 0.0043 0.0418 0.0418
Loa Loa (eye worm) beta-lactamase 0.0043 0.0418 0.0418
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.0065 0.0065
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0043 0.0418 0.0418
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0023 0.0184 0.5
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0012 0.0065 0.0065
Schistosoma mansoni hypothetical protein 0.0241 0.2645 1
Mycobacterium tuberculosis Conserved protein 0.0043 0.0418 0.0814
Leishmania major mitogen-activated protein kinase 3, putative,map kinase 3, putative 0.0892 1 1
Mycobacterium tuberculosis Probable hydrolase 0.0043 0.0418 0.0814
Brugia malayi beta-lactamase 0.0043 0.0418 0.0418
Echinococcus multilocularis ecdysone induced protein 78C 0.0012 0.0065 0.0065
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0023 0.0184 0.0184
Plasmodium vivax hypothetical protein, conserved 0.0043 0.0418 1
Loa Loa (eye worm) hypothetical protein 0.0043 0.0418 0.0418
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0418 0.0239
Loa Loa (eye worm) hypothetical protein 0.0012 0.0065 0.0065
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.0065 0.0065
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0043 0.0418 1
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0043 0.0418 0.0814
Echinococcus multilocularis mitogen activated protein kinase 14 0.0892 1 1
Schistosoma mansoni steroid hormone receptor ad4bp 0.0012 0.0065 0.0246
Echinococcus granulosus T cell transcription factor 4 long C terminal 0.0066 0.0673 0.0673
Echinococcus granulosus hypothetical protein 0.0306 0.3384 0.3384
Loa Loa (eye worm) hypothetical protein 0.0043 0.0418 0.0418
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0551 0.0551
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0012 0.0065 0.0246
Toxoplasma gondii ABC1 family protein 0.0043 0.0418 1
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0043 0.0418 0.0814
Trypanosoma brucei hypothetical protein, conserved 0.0043 0.0418 0.0239

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.3162 uM PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 9.1962 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) 11.2202 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 14.7157 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 18.526 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 70.7946 uM PUBCHEM_BIOASSAY: Inhibitors of Regulator of G Protein Signaling (RGS) 4: qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504856] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23
Homo sapiens ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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