Detailed information for compound 1433180

Basic information

Technical information
  • TDR Targets ID: 1433180
  • Name: N-[6-(propan-2-ylsulfamoyl)-1,3-benzothiazol- 2-yl]-3-(3,4,5-trimethoxyphenyl)prop-2-enamid e
  • MW: 491.58 | Formula: C22H25N3O6S2
  • H donors: 2 H acceptors: 4 LogP: 3.65 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cc(/C=C/C(=O)Nc2nc3c(s2)cc(cc3)S(=O)(=O)NC(C)C)cc(c1OC)OC
  • InChi: 1S/C22H25N3O6S2/c1-13(2)25-33(27,28)15-7-8-16-19(12-15)32-22(23-16)24-20(26)9-6-14-10-17(29-3)21(31-5)18(11-14)30-4/h6-13,25H,1-5H3,(H,23,24,26)/b9-6+
  • InChiKey: HXBIPQXDUQGJRN-RMKNXTFCSA-N  


Substructure search Similarity search

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Synonyms

  • (E)-N-[6-(propan-2-ylsulfamoyl)-1,3-benzothiazol-2-yl]-3-(3,4,5-trimethoxyphenyl)prop-2-enamide
  • (E)-N-[6-(isopropylsulfamoyl)-1,3-benzothiazol-2-yl]-3-(3,4,5-trimethoxyphenyl)prop-2-enamide
  • N-[6-(isopropylsulfamoyl)-1,3-benzothiazol-2-yl]-3-(3,4,5-trimethoxyphenyl)prop-2-enamide
  • N-[6-(isopropylsulfamoyl)-1,3-benzothiazol-2-yl]-3-(3,4,5-trimethoxyphenyl)acrylamide
  • (E)-N-[6-(isopropylsulfamoyl)-1,3-benzothiazol-2-yl]-3-(3,4,5-trimethoxyphenyl)acrylamide
  • MLS000697405
  • SMR000238027
  • ZINC01917492

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens like-glycosyltransferase Starlite/ChEMBL No references
Trypanosoma cruzi cysteine peptidase, putative Starlite/ChEMBL No references
Homo sapiens lysine (K)-specific demethylase 4E Starlite/ChEMBL No references
Homo sapiens sphingomyelin phosphodiesterase 1, acid lysosomal Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum Cathepsin L-like proteinase precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Candida albicans one of four genes similar to C. elegans asm2 lysosomal acid sphingomyelin phosphodiesterase (XL940) Get druggable targets OG5_128629 All targets in OG5_128629
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Candida albicans one of four genes similar to C. elegans asm2 lysosomal acid sphingomyelin phosphodiesterase (XL940) Get druggable targets OG5_128629 All targets in OG5_128629
Plasmodium knowlesi knowpain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Toxoplasma gondii cathepsin CPL Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) glycosyl transferase family 8 protein Get druggable targets OG5_130765 All targets in OG5_130765
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium yoelii berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis glycosyltransferase protein LARGE2 Get druggable targets OG5_130765 All targets in OG5_130765
Brugia malayi cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis Glycosyl transferase, family 8 Get druggable targets OG5_130765 All targets in OG5_130765
Loa Loa (eye worm) ctsf protein Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-4 Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128629 All targets in OG5_128629
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) fibroinase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus Glycosyl transferase family 8 Get druggable targets OG5_130765 All targets in OG5_130765
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Neospora caninum Cathepsin L, related Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin F homolog Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania donovani cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Candida albicans one of four genes similar to C. elegans asm2 lysosomal acid sphingomyelin phosphodiesterase (XL940) Get druggable targets OG5_128629 All targets in OG5_128629
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 3 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis glycosyltransferase protein LARGE2 Get druggable targets OG5_130765 All targets in OG5_130765
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 2a Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium berghei berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis Glycosyltransferase protein LARGE1 Get druggable targets OG5_130765 All targets in OG5_130765
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Candida albicans one of four genes similar to C. elegans asm2 lysosomal acid sphingomyelin phosphodiesterase (XL940) Get druggable targets OG5_128629 All targets in OG5_128629
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Candida albicans one of four genes similar to C. elegans asm2 lysosomal acid sphingomyelin phosphodiesterase (XL940) Get druggable targets OG5_128629 All targets in OG5_128629
Plasmodium knowlesi knowpain-3 Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum expressed protein Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K09668 glycosyltransferase-like protein LARGE, putative Get druggable targets OG5_130765 All targets in OG5_130765
Cryptosporidium parvum cryptopain - cysteine proteinase secreted, possible transmembrane domain near N-terminus Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus Glycosyltransferase protein LARGE1 Get druggable targets OG5_130765 All targets in OG5_130765
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Glycosyl transferase family 8 protein Get druggable targets OG5_130765 All targets in OG5_130765
Entamoeba histolytica Acid sphingomyelinase-like phosphodiesterase, putative Get druggable targets OG5_128629 All targets in OG5_128629
Echinococcus granulosus cathepsin L cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni glycosyltransferase-related Get druggable targets OG5_130765 All targets in OG5_130765
Echinococcus multilocularis conserved hypothetical protein Get druggable targets OG5_130765 All targets in OG5_130765
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Candida albicans one of four genes similar to C. elegans asm2 lysosomal acid sphingomyelin phosphodiesterase (XL940) Get druggable targets OG5_128629 All targets in OG5_128629
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica Acid sphingomyelinase-like phosphodiesterase, putative Get druggable targets OG5_128629 All targets in OG5_128629
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 2b Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis glycosyltransferase protein LARGE2 Get druggable targets OG5_130765 All targets in OG5_130765
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cruzipain precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Candida albicans one of four genes similar to C. elegans asm2 lysosomal acid sphingomyelin phosphodiesterase (XL940) Get druggable targets OG5_128629 All targets in OG5_128629
Schistosoma japonicum ko:K01373 cathepsin F [EC3.4.22.41], putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Candida albicans one of four genes similar to C. elegans asm2 lysosomal acid sphingomyelin phosphodiesterase (XL940) Get druggable targets OG5_128629 All targets in OG5_128629
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus glycosyltransferase protein LARGE2 Get druggable targets OG5_130765 All targets in OG5_130765
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium hominis cryptopain precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0016 0.0324 0.0381
Schistosoma mansoni cathepsin F (C01 family) 0.002 0.0775 0.0913
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0016 0.0324 0.0381
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.7367 1
Brugia malayi jmjC domain containing protein 0.0071 0.6669 0.785
Echinococcus granulosus JmjC domain containing protein 4 0.0019 0.0627 0.0738
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.002 0.0775 1
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.007 0.6592 0.8849
Echinococcus multilocularis lysine specific demethylase 6a 0.0019 0.0627 0.0371
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0016 0.0324 0.0381
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0016 0.0324 0.0381
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0016 0.0324 0.0381
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.002 0.0775 1
Brugia malayi jmjC domain containing protein 0.0019 0.0627 0.0738
Schistosoma mansoni thyroid hormone receptor 0.0016 0.0324 0.0381
Schistosoma mansoni retinoic acid receptor RXR 0.0016 0.0324 0.0381
Onchocerca volvulus 0.002 0.0775 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0016 0.0324 0.0381
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0775 1
Onchocerca volvulus 0.002 0.0775 1
Leishmania major cathepsin L-like protease 0.0077 0.7367 1
Echinococcus multilocularis glycosyltransferase protein LARGE2 0.0084 0.8176 0.9609
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0775 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0775 1
Loa Loa (eye worm) hypothetical protein 0.0022 0.1026 0.1026
Loa Loa (eye worm) hypothetical protein 0.0016 0.0324 0.0324
Onchocerca volvulus 0.002 0.0775 1
Schistosoma mansoni steroid hormone receptor ad4bp 0.0016 0.0324 0.0381
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0019 0.0627 0.0738
Loa Loa (eye worm) jmjC domain-containing protein 0.0071 0.6669 0.6669
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.7367 1
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0016 0.0324 0.0381
Entamoeba histolytica cysteine protease, putative 0.002 0.0775 0.0775
Loa Loa (eye worm) hypothetical protein 0.0016 0.0324 0.0324
Schistosoma mansoni protein phosphatase 2C 0.0019 0.0627 0.0738
Schistosoma mansoni nuclear hormone receptor 0.0016 0.0324 0.0381
Echinococcus multilocularis cysteine protease 0.002 0.0775 0.0553
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0775 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0016 0.0324 0.0324
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.7367 1
Loa Loa (eye worm) ctsf protein 0.002 0.0775 0.0775
Loa Loa (eye worm) fibroinase 0.002 0.0775 0.0775
Leishmania major cathepsin L-like protease 0.0077 0.7367 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0775 1
Brugia malayi jmjC domain containing protein 0.0019 0.0627 0.0738
Echinococcus granulosus Glycosyltransferase protein LARGE1 0.0064 0.5899 0.6944
Brugia malayi nuclear hormone receptor 0.0016 0.0324 0.0381
Leishmania major cathepsin L-like protease 0.0077 0.7367 1
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0016 0.0324 0.0381
Toxoplasma gondii cathepsin CPL 0.002 0.0775 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0016 0.0324 0.0381
Onchocerca volvulus Cathepsin L homolog 0.002 0.0775 1
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0016 0.0324 0.0381
Onchocerca volvulus Bile acid receptor homolog 0.0016 0.0324 0.4177
Echinococcus granulosus lysine specific demethylase 6a 0.0019 0.0627 0.0738
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.7367 1
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0071 0.6669 0.785
Loa Loa (eye worm) hypothetical protein 0.0016 0.0324 0.0324
Echinococcus granulosus glycosyltransferase protein LARGE2 0.0084 0.8176 0.9624
Echinococcus multilocularis Glycosyltransferase protein LARGE1 0.0064 0.5899 0.6822
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0016 0.0324 0.0381
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0775 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0016 0.0324 0.0324
Schistosoma mansoni jumonji domain containing protein 0.0019 0.0627 0.0738
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0016 0.0324 0.0381
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0016 0.0324 0.0324
Brugia malayi Cathepsin L-like precursor 0.002 0.0775 0.0913
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.7367 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0775 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0775 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.7367 1
Trypanosoma cruzi cysteine peptidase, putative 0.002 0.0775 0.022
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0016 0.0324 0.0381
Loa Loa (eye worm) hypothetical protein 0.0016 0.0324 0.0324
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.7367 1
Leishmania major cathepsin L-like protease 0.002 0.0775 0.022
Brugia malayi jmjC domain containing protein 0.0019 0.0627 0.0738
Echinococcus granulosus cathepsin l cysteine peptidase 0.002 0.0775 0.0913
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0016 0.0324 0.0324
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0016 0.0324 0.0381
Echinococcus multilocularis jumonji domain containing 1A 0.0019 0.0627 0.0371
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0775 1
Brugia malayi Cathepsin L-like precursor 0.002 0.0775 0.0913
Echinococcus granulosus jumonji domain containing 1A 0.0019 0.0627 0.0738
Leishmania major cathepsin L-like protease 0.002 0.0775 0.022
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.7367 1
Loa Loa (eye worm) jmjC domain-containing protein 0.0019 0.0627 0.0627
Schistosoma mansoni jumonji domain containing protein 0.0071 0.6669 0.785
Leishmania major cathepsin L-like protease 0.002 0.0775 0.022
Schistosoma mansoni glycosyltransferase-related 0.0087 0.8496 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0775 1
Loa Loa (eye worm) glycosyl transferase family 8 protein 0.0087 0.8496 0.8496
Echinococcus multilocularis JmjC domain containing protein 4 0.0019 0.0627 0.0371
Echinococcus multilocularis cathepsin l cysteine peptidase 0.002 0.0775 0.0553
Echinococcus multilocularis glycosyltransferase protein LARGE2 0.0084 0.8176 0.9609
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0016 0.0324 0.0324
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0016 0.0324 0.0381
Brugia malayi jmjC domain containing protein 0.0019 0.0627 0.0738
Loa Loa (eye worm) jmjC domain-containing protein 0.0019 0.0627 0.0627
Echinococcus granulosus phd:f box containing protein 0.0019 0.0627 0.0738
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0775 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0016 0.0324 0.0381
Entamoeba histolytica Acid sphingomyelinase-like phosphodiesterase, putative 0.01 1 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.7367 1
Onchocerca volvulus Cathepsin F homolog 0.002 0.0775 1
Brugia malayi nuclear receptor NHR-88 0.0016 0.0324 0.0381
Echinococcus granulosus FTZ F1 alpha 0.0016 0.0324 0.0381
Loa Loa (eye worm) hypothetical protein 0.0016 0.0324 0.0324
Loa Loa (eye worm) hypothetical protein 0.0019 0.0627 0.0627
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0016 0.0324 0.0381
Brugia malayi Nuclear hormone receptor-like 1 0.0016 0.0324 0.0381
Onchocerca volvulus 0.002 0.0775 1
Loa Loa (eye worm) hypothetical protein 0.0016 0.0324 0.0324
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0775 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0775 1
Plasmodium vivax vivapain-2 0.002 0.0775 1
Entamoeba histolytica cysteine proteinase, putative 0.002 0.0775 0.0775
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0071 0.6669 0.7765
Echinococcus multilocularis glycosyltransferase protein LARGE2 0.0084 0.8176 0.9609
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0775 1
Schistosoma mansoni phosphatidylserine receptor 0.0019 0.0627 0.0738
Trypanosoma cruzi major cysteine proteinase, putative 0.0061 0.5454 0.7162
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0775 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0016 0.0324 0.0381
Leishmania major cysteine peptidase A (CPA) 0.002 0.0775 0.022
Echinococcus multilocularis cathepsin l cysteine peptidase 0.002 0.0775 0.0553
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0016 0.0324 0.4177
Echinococcus multilocularis phd:f box containing protein 0.0019 0.0627 0.0371
Schistosoma mansoni jumonji/arid domain-containing protein 0.0071 0.6669 0.785
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0016 0.0324 0.0324
Echinococcus granulosus Glycosyl transferase family 8 0.0087 0.8496 1
Entamoeba histolytica cysteine proteinase, putative 0.002 0.0775 0.0775
Schistosoma mansoni phd/f-box containing protein 0.0019 0.0627 0.0738
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.7367 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0775 1
Echinococcus multilocularis lysine specific demethylase 5A 0.0071 0.6669 0.7765
Loa Loa (eye worm) hypothetical protein 0.0016 0.0324 0.0324
Onchocerca volvulus 0.002 0.0775 1
Brugia malayi Glycosyl transferase family 8 protein 0.0087 0.8496 1
Leishmania major cathepsin L-like protease 0.002 0.0775 0.022
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0016 0.0324 0.0381
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0016 0.0324 0.0381
Brugia malayi steroid hormone receptor 0.0016 0.0324 0.0381
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0775 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0775 1
Brugia malayi ecdysteroid receptor 0.0016 0.0324 0.0381
Brugia malayi photoreceptor-specific nuclear receptor 0.0016 0.0324 0.0381
Brugia malayi jmjC domain containing protein 0.0071 0.6669 0.785
Onchocerca volvulus Protein ultraspiracle homolog 0.0016 0.0324 0.4177
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0016 0.0324 0.0381
Onchocerca volvulus 0.002 0.0775 1
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.002 0.0775 0.0775
Leishmania major cathepsin L-like protease 0.002 0.0775 0.022
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0016 0.0324 0.0381
Loa Loa (eye worm) hypothetical protein 0.0016 0.0324 0.0324
Schistosoma mansoni thyroid hormone receptor 0.0016 0.0324 0.0381
Loa Loa (eye worm) hypothetical protein 0.0019 0.0627 0.0627
Brugia malayi Cathepsin L-like precursor 0.002 0.0775 0.0913
Brugia malayi Cathepsin L-like precursor 0.002 0.0775 0.0913
Loa Loa (eye worm) jmjC domain-containing protein 0.0019 0.0627 0.0627
Schistosoma mansoni cathepsin F (C01 family) 0.002 0.0775 0.0913
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.7367 1
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0019 0.0627 0.0738
Plasmodium falciparum cysteine proteinase falcipain 2b 0.002 0.0775 1
Brugia malayi AT16019p 0.0022 0.1026 0.1208
Schistosoma mansoni coup transcription factor 0.0016 0.0324 0.0381
Plasmodium falciparum cysteine proteinase falcipain 3 0.002 0.0775 1
Onchocerca volvulus 0.0016 0.0324 0.4177
Brugia malayi Papain family cysteine protease containing protein 0.002 0.0775 0.0913
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.7367 1
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0016 0.0324 0.0381
Loa Loa (eye worm) steroid hormone receptor 0.0016 0.0324 0.0324
Echinococcus granulosus cathepsin l1 0.002 0.0775 0.0913
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0775 1
Plasmodium vivax vivapain-2 0.002 0.0775 1
Echinococcus granulosus cathepsin L cysteine proteinase 0.002 0.0775 0.0913
Schistosoma mansoni RAR-like nuclear receptor 0.0016 0.0324 0.0381
Echinococcus granulosus ecdysone induced protein 78C 0.0016 0.0324 0.0381
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0016 0.0324 0.0381
Loa Loa (eye worm) papain family cysteine protease containing protein 0.002 0.0775 0.0775
Trypanosoma cruzi cruzipain precursor, putative 0.0077 0.7367 1
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0016 0.0324 0.0381
Loa Loa (eye worm) cysteine protease 0.002 0.0775 0.0775
Echinococcus multilocularis Glycosyl transferase, family 8 0.0087 0.8496 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0775 0.0775
Echinococcus multilocularis conserved hypothetical protein 0.0064 0.5899 0.6822
Brugia malayi Cathepsin L-like precursor 0.002 0.0775 0.0913
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0775 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0016 0.0324 0.0324
Echinococcus multilocularis cathepsin L cysteine protease 0.002 0.0775 0.0553
Echinococcus granulosus lysine specific demethylase 5A 0.0071 0.6669 0.785
Brugia malayi Cathepsin L-like precursor 0.002 0.0775 0.0913
Onchocerca volvulus Cathepsin L homolog 0.002 0.0775 1
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0016 0.0324 0.0381
Brugia malayi Steroid receptor seven-up type 2 0.0016 0.0324 0.0381
Plasmodium falciparum cysteine proteinase falcipain 2a 0.002 0.0775 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0775 1
Onchocerca volvulus 0.002 0.0775 1
Loa Loa (eye worm) hypothetical protein 0.01 1 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.7367 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0627 0.0627
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0775 1
Schistosoma mansoni jumonji/arid domain-containing protein 0.0071 0.6669 0.785
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.7367 1
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0019 0.0627 0.0371
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0775 1
Echinococcus multilocularis cathepsin L cysteine protease 0.002 0.0775 0.0553
Echinococcus multilocularis cysteine protease 0.002 0.0775 0.0553

Activities

Activity type Activity value Assay description Source Reference
EC50 (functional) 9.21 uM PubChem BioAssay. Dose response confirmation of small molecule activators of alpha dystroglycan glycosylation. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 3.1623 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 10 uM PubChem BioAssay. Inhibitors of Secretory Acid Sphingomyelinase (S-ASM): qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 11.6891 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 15.8489 um PUBCHEM_BIOASSAY: qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (without detergent). (Class of assay: confirmatory) [Related pubchem assays: 2158 (Confirmation qHTS Assay for Inhibitors of Cruzain), 2249 (Probe Development Summary of Promiscuous Inhibitors (Artifacts) of Cruzain), 2161 (qHTS Assay for Inhibitors of Papain: Counterscreen for Cruzain Assay), 1478 (qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (with detergent))] ChEMBL. No reference
Potency (functional) 25.1189 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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