Detailed information for compound 1434261

Basic information

Technical information
  • TDR Targets ID: 1434261
  • Name: 1-[3-(4-chlorophenyl)-4-phenyl-4,5-dihydropyr azol-1-yl]ethanone
  • MW: 298.767 | Formula: C17H15ClN2O
  • H donors: 0 H acceptors: 1 LogP: 3.5 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1ccc(cc1)C1=NN(CC1c1ccccc1)C(=O)C
  • InChi: 1S/C17H15ClN2O/c1-12(21)20-11-16(13-5-3-2-4-6-13)17(19-20)14-7-9-15(18)10-8-14/h2-10,16H,11H2,1H3
  • InChiKey: PRUOQZRMPIEBLB-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • MLS000700441
  • SMR000230299
  • AR-016/42300643
  • 1-acetyl-3-(4-chlorophenyl)-4-phenyl-4,5-dihydro-1H-pyrazole

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens TAR DNA binding protein Starlite/ChEMBL No references
Mus musculus RAR-related orphan receptor gamma Starlite/ChEMBL No references
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Escherichia coli penicillin-binding protein Starlite/ChEMBL No references
Bacillus subtilis (strain 168) ATP-dependent Clp protease proteolytic subunit Starlite/ChEMBL No references
Homo sapiens GNAS complex locus Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma mansoni peptidase Clp (S14 family) Get druggable targets OG5_127187 All targets in OG5_127187
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein Get druggable targets OG5_127187 All targets in OG5_127187
Theileria parva ATP-dependent Clp protease proteolytic subunit, putative Get druggable targets OG5_127187 All targets in OG5_127187
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127187 All targets in OG5_127187
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Treponema pallidum ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Plasmodium berghei ATP-dependent Clp protease proteolytic subunit, putative Get druggable targets OG5_127187 All targets in OG5_127187
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) Get druggable targets OG5_127187 All targets in OG5_127187
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Mycobacterium tuberculosis Possible penicillin-binding protein Get druggable targets OG5_149948 All targets in OG5_149948
Schistosoma japonicum ko:K01358 ATP-dependent Clp protease, protease subunit [EC3.4.21.92], putative Get druggable targets OG5_127187 All targets in OG5_127187
Loa Loa (eye worm) TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Neospora caninum ATP-dependent Clp protease proteolytic subunit, related Get druggable targets OG5_127187 All targets in OG5_127187
Babesia bovis ATP-dependent Clp protease proteolytic subunit 1, putative Get druggable targets OG5_127187 All targets in OG5_127187
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative Get druggable targets OG5_127187 All targets in OG5_127187
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Echinococcus granulosus peptidase Clp S14 family Get druggable targets OG5_127187 All targets in OG5_127187
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein Get druggable targets OG5_127187 All targets in OG5_127187
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi RNA recognition motif domain containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi Probable ClpP-like protease Get druggable targets OG5_127187 All targets in OG5_127187
Loa Loa (eye worm) RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis peptidase Clp (S14 family) Get druggable targets OG5_127187 All targets in OG5_127187
Plasmodium knowlesi ATP-dependent Clp protease proteolytic subunit, putative Get druggable targets OG5_127187 All targets in OG5_127187
Schistosoma japonicum ko:K06275 parvin, putative Get druggable targets OG5_127187 All targets in OG5_127187
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) Get druggable targets OG5_127187 All targets in OG5_127187
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) Get druggable targets OG5_127187 All targets in OG5_127187
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) Get druggable targets OG5_127187 All targets in OG5_127187
Plasmodium yoelii ATP-dependent Clp protease, proteolytic subunit ClpP, putative Get druggable targets OG5_127187 All targets in OG5_127187
Echinococcus multilocularis tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus granulosus tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Brugia malayi TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Theileria parva ATP-dependent Clp protease proteolytic subunit, putative Get druggable targets OG5_127187 All targets in OG5_127187
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Plasmodium knowlesi ATP-dependent Clp protease proteolytic subunit, putative ATP-dependent Clp protease proteolytic subunit   197 aa 189 aa 36.0 %
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Treponema pallidum ATP-dependent Clp protease proteolytic subunit ATP-dependent Clp protease proteolytic subunit   197 aa 186 aa 40.3 %
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit ATP-dependent Clp protease proteolytic subunit   197 aa 183 aa 36.1 %
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative ATP-dependent Clp protease proteolytic subunit   197 aa 189 aa 35.5 %
Plasmodium yoelii Clp protease ATP-dependent Clp protease proteolytic subunit   197 aa 183 aa 36.6 %
Plasmodium berghei ATP-dependent Clp protease proteolytic subunit, putative ATP-dependent Clp protease proteolytic subunit   197 aa 180 aa 36.7 %
Chlamydia trachomatis hypothetical protein ATP-dependent Clp protease proteolytic subunit   197 aa 171 aa 22.8 %
Babesia bovis ATP-dependent Clp protease proteolytic subunit, putative ATP-dependent Clp protease proteolytic subunit   197 aa 188 aa 41.5 %
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Schistosoma mansoni neuropeptide receptor ATP-dependent Clp protease proteolytic subunit   197 aa 174 aa 20.1 %
Babesia bovis ATP-dependent Clp protease proteolytic subunit, putative ATP-dependent Clp protease proteolytic subunit   197 aa 188 aa 41.5 %
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 ATP-dependent Clp protease proteolytic subunit   197 aa 172 aa 57.0 %
Onchocerca volvulus Putative V-type proton ATPase subunit F ATP-dependent Clp protease proteolytic subunit   197 aa 194 aa 54.1 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.0098 0.5
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0094 0.2252 1
Brugia malayi Muscle positioning protein 4 0.0171 0.5482 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0098 0.0179
Schistosoma mansoni cercarial elastase (S01 family) 0.0042 0.0023 0.0042
Loa Loa (eye worm) beta-lactamase 0.0043 0.0098 0.0179
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0094 0.2252 1
Loa Loa (eye worm) RNA binding protein 0.0076 0.1494 0.2725
Loa Loa (eye worm) hypothetical protein 0.0171 0.5482 1
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0094 0.2252 1
Loa Loa (eye worm) hypothetical protein 0.006 0.0805 0.1468
Toxoplasma gondii kringle domain-containing protein 0.0155 0.4823 1
Loa Loa (eye worm) hypothetical protein 0.0043 0.0098 0.0179
Loa Loa (eye worm) hypothetical protein 0.0043 0.0098 0.0179
Schistosoma mansoni cercarial elastase (S01 family) 0.0042 0.0023 0.0042
Loa Loa (eye worm) hypothetical protein 0.0042 0.0023 0.0042
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.0595 0.1086
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.0805 0.1468
Onchocerca volvulus 0.0043 0.0098 0.0138
Onchocerca volvulus 0.0171 0.5482 1
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0094 0.2252 0.4558
Echinococcus granulosus tar DNA binding protein 0.0076 0.1494 0.3064
Echinococcus multilocularis peptidase Clp (S14 family) 0.0062 0.0877 0.1779
Loa Loa (eye worm) hypothetical protein 0.0042 0.0023 0.0042
Trichomonas vaginalis esterase, putative 0.0043 0.0098 0.5
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0098 0.5
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0094 0.2252 0.5
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0595 0.1193
Schistosoma mansoni cercarial elastase (S01 family) 0.0042 0.0023 0.0042
Loa Loa (eye worm) hypothetical protein 0.0094 0.2252 0.4108
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0155 0.4823 1
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0069 0.1172 0.2138
Echinococcus multilocularis beta LACTamase domain containing family member 0.0043 0.0098 0.0157
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0595 0.1086
Brugia malayi beta-lactamase family protein 0.0043 0.0098 0.0179
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0043 0.0098 0.0179
Onchocerca volvulus 0.0043 0.0098 0.0138
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0094 0.2252 0.4558
Brugia malayi beta-lactamase 0.0043 0.0098 0.0179
Loa Loa (eye worm) hypothetical protein 0.0042 0.0023 0.0042
Schistosoma mansoni tar DNA-binding protein 0.0076 0.1494 0.2725
Brugia malayi Kringle domain containing protein 0.0155 0.4823 0.8798
Loa Loa (eye worm) trypsin family protein 0.0042 0.0023 0.0042
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0043 0.0098 0.0179
Onchocerca volvulus 0.0171 0.5482 1
Schistosoma mansoni tar DNA-binding protein 0.0076 0.1494 0.2725
Mycobacterium ulcerans lipase LipD 0.0043 0.0098 0.0339
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0098 0.0179
Onchocerca volvulus 0.0171 0.5482 1
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0042 0.0023 0.0042
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.0098 0.5
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0042 0.0023 0.0042
Brugia malayi RNA recognition motif domain containing protein 0.0076 0.1494 0.2725
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0043 0.0098 0.0339
Loa Loa (eye worm) hypothetical protein 0.0155 0.4823 0.8798
Loa Loa (eye worm) hypothetical protein 0.0042 0.0023 0.0042
Plasmodium falciparum cysteine repeat modular protein 1 0.0155 0.4823 1
Brugia malayi Trypsin family protein 0.0042 0.0023 0.0042
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0062 0.0877 0.0786
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0062 0.0877 0.3615
Echinococcus granulosus tissue type plasminogen activator 0.0155 0.4823 1
Loa Loa (eye worm) TAR-binding protein 0.0076 0.1494 0.2725
Onchocerca volvulus 0.0043 0.0098 0.0138
Brugia malayi hypothetical protein 0.0042 0.0023 0.0042
Schistosoma mansoni hypothetical protein 0.0042 0.0023 0.0042
Loa Loa (eye worm) hypothetical protein 0.0042 0.0023 0.0042
Echinococcus granulosus beta LACTamase domain containing family member 0.0043 0.0098 0.0157
Schistosoma mansoni cercarial elastase (S01 family) 0.0042 0.0023 0.0042
Mycobacterium ulcerans esterase/lipase LipP 0.0043 0.0098 0.0339
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.0805 0.1468
Brugia malayi Trypsin family protein 0.0042 0.0023 0.0042
Loa Loa (eye worm) hypothetical protein 0.0043 0.0098 0.0179
Schistosoma mansoni hypothetical protein 0.0155 0.4823 0.8798
Brugia malayi Trypsin-like protease protein 5 0.0042 0.0023 0.0042
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0094 0.2252 0.5
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.005 0.0382 0.0697
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0595 0.1086
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0094 0.2252 0.5
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0595 0.1086
Schistosoma mansoni tar DNA-binding protein 0.0076 0.1494 0.2725
Echinococcus multilocularis tissue type plasminogen activator 0.0155 0.4823 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.0595 0.1086
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0595 0.1193
Trypanosoma brucei hypothetical protein, conserved 0.0043 0.0098 0.5
Brugia malayi RNA binding protein 0.0076 0.1494 0.2725
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0098 0.5
Echinococcus granulosus peptidase Clp S14 family 0.0062 0.0877 0.1779
Mycobacterium ulcerans beta-lactamase 0.0043 0.0098 0.0339
Schistosoma mansoni hypothetical protein 0.0171 0.5482 1
Loa Loa (eye worm) TK/ROR protein kinase 0.0155 0.4823 0.8798
Loa Loa (eye worm) hypothetical protein 0.0043 0.0098 0.0179
Echinococcus multilocularis tar DNA binding protein 0.0076 0.1494 0.3064
Schistosoma mansoni peptidase Clp (S14 family) 0.0094 0.2252 0.4108
Brugia malayi beta-lactamase family protein 0.0043 0.0098 0.0179
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0076 0.1494 0.2725
Schistosoma mansoni cercarial elastase (S01 family) 0.0042 0.0023 0.0042
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0595 0.1193
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0094 0.2252 0.4558
Brugia malayi Protein kinase domain containing protein 0.0155 0.4823 0.8798
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0042 0.0023 0.0042
Loa Loa (eye worm) hypothetical protein 0.0043 0.0098 0.0179
Schistosoma mansoni hypothetical protein 0.0042 0.0023 0.0042
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0042 0.0023 0.0042
Loa Loa (eye worm) hypothetical protein 0.0043 0.0098 0.0179
Schistosoma mansoni cercarial elastase (S01 family) 0.0042 0.0023 0.0042
Loa Loa (eye worm) hypothetical protein 0.0042 0.0023 0.0042
Loa Loa (eye worm) DOMON domain-containing protein 0.0171 0.5482 1
Schistosoma mansoni cercarial elastase (S01 family) 0.0042 0.0023 0.0042
Brugia malayi TAR-binding protein 0.0076 0.1494 0.2725
Brugia malayi SEA domain containing protein 0.0171 0.5482 1
Loa Loa (eye worm) hypothetical protein 0.0171 0.5482 1
Schistosoma mansoni tar DNA-binding protein 0.0076 0.1494 0.2725
Onchocerca volvulus 0.0171 0.5482 1
Brugia malayi Trypsin family protein 0.0042 0.0023 0.0042
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0042 0.0023 0.0042
Leishmania major hypothetical protein, conserved 0.0155 0.4823 1
Brugia malayi Probable ClpP-like protease 0.0094 0.2252 0.4108
Brugia malayi Chymotrypsin-like protease CTRL-1 precursor 0.0042 0.0023 0.0042
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0062 0.0877 0.0786
Loa Loa (eye worm) hypothetical protein 0.0042 0.0023 0.0042
Schistosoma mansoni cercarial elastase (S01 family) 0.0042 0.0023 0.0042
Onchocerca volvulus 0.0155 0.4823 0.8793
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0098 0.5
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.0805 0.1468
Schistosoma mansoni cercarial elastase (S01 family) 0.0042 0.0023 0.0042
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0042 0.0023 0.0042
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0094 0.2252 0.4644
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0595 0.1193
Trypanosoma cruzi hypothetical protein, conserved 0.0155 0.4823 1
Brugia malayi Trypsin family protein 0.0042 0.0023 0.0042
Schistosoma mansoni cercarial elastase (S01 family) 0.0042 0.0023 0.0042
Schistosoma mansoni tar DNA-binding protein 0.0076 0.1494 0.2725
Onchocerca volvulus 0.0171 0.5482 1
Mycobacterium ulcerans hypothetical protein 0.0043 0.0098 0.0339
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0094 0.2252 0.4644
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0094 0.2252 0.5
Schistosoma mansoni cercarial elastase (S01 family) 0.0042 0.0023 0.0042

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 0.8913 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference
Potency (functional) 5.0119 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 5.6234 um PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 11.2202 uM PubChem BioAssay. qHTS Assay for Activators of ClpP. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 11.2202 uM PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 14.1254 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase). (Class of assay: confirmatory) [Related pubchem assays: 2429 (Confirmation qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2407 (Probe Development Summary for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2427 (Thermal Shift Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase))] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

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