Detailed information for compound 1434736

Basic information

Technical information
  • TDR Targets ID: 1434736
  • Name: phenylmethyl N-[2,2,2-trichloro-1-[(3-methylp henyl)carbamothioylamino]ethyl]carbamate
  • MW: 446.778 | Formula: C18H18Cl3N3O2S
  • H donors: 2 H acceptors: 1 LogP: 5.35 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(NC(C(Cl)(Cl)Cl)N=C(Nc1cccc(c1)C)S)OCc1ccccc1
  • InChi: 1S/C18H18Cl3N3O2S/c1-12-6-5-9-14(10-12)22-16(27)23-15(18(19,20)21)24-17(25)26-11-13-7-3-2-4-8-13/h2-10,15H,11H2,1H3,(H,24,25)(H2,22,23,27)
  • InChiKey: XWMMDWNLNSEVAS-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

  • N-[2,2,2-trichloro-1-[[[(3-methylphenyl)amino]-thioxomethyl]amino]ethyl]carbamic acid phenylmethyl ester
  • N-[2,2,2-trichloro-1-[(3-methylphenyl)thiocarbamoylamino]ethyl]carbamic acid benzyl ester
  • AG-690/33250020
  • MLS000560975
  • SMR000173872
  • BAS 00113817
  • [2,2,2-Trichloro-1-(3-m-tolyl-thioureido)-ethyl]-carbamic acid benzyl ester

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens SMAD family member 2 Starlite/ChEMBL No references
Homo sapiens huntingtin Starlite/ChEMBL No references
Homo sapiens isocitrate dehydrogenase 1 (NADP+), soluble Starlite/ChEMBL No references
Mus musculus RAR-related orphan receptor gamma Starlite/ChEMBL No references
Trypanosoma cruzi cysteine peptidase, putative Starlite/ChEMBL No references
Homo sapiens X-box binding protein 1 Starlite/ChEMBL No references
Mus musculus DNA-damage inducible transcript 3 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum expressed protein Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus X box binding protein 1 Get druggable targets OG5_134980 All targets in OG5_134980
Leishmania braziliensis cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Toxoplasma gondii isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium berghei berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132837 All targets in OG5_132837
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin F homolog Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin L-like proteinase precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni NADP-specific isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial Get druggable targets OG5_127057 All targets in OG5_127057
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium yoelii berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132837 All targets in OG5_132837
Loa Loa (eye worm) isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Neospora caninum Cathepsin L, related Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum IPR011700,Basic leucine zipper;IPR004827,Basic-leucine zipper (bZIP) transcription factor;IPR008917,Eukaryotic transcription fac Get druggable targets OG5_134980 All targets in OG5_134980
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Huntingtin homolog Get druggable targets OG5_132837 All targets in OG5_132837
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Candida albicans C terminus of cytosolic NADP-specific isocitrate dehydrogenase. Get druggable targets OG5_127057 All targets in OG5_127057
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Brugia malayi isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni hypothetical protein Get druggable targets OG5_134980 All targets in OG5_134980
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania mexicana isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Brugia malayi MH2 domain containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi isocitrate dehydrogenase [NADP], mitochondrial, putative Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 2b Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Babesia bovis isocitrate dehydrogenase, NADP-dependent family protein Get druggable targets OG5_127057 All targets in OG5_127057
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus granulosus NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Candida albicans N terminus of cytosolic NADP-specific isocitrate dehydrogenase. Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) MH2 domain-containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-3 Get druggable targets OG5_126607 All targets in OG5_126607
Toxoplasma gondii isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania braziliensis isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania donovani isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) fibroinase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) transcription factor SMAD2 Get druggable targets OG5_131716 All targets in OG5_131716
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium yoelii isocitrate dehydrogenase, NADP-dependent, putative Get druggable targets OG5_127057 All targets in OG5_127057
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-4 Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma japonicum IPR011700,Basic leucine zipper;IPR004827,Basic-leucine zipper (bZIP) transcription factor;IPR008917,Eukaryotic transcription fac Get druggable targets OG5_134980 All targets in OG5_134980
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) Get druggable targets OG5_127057 All targets in OG5_127057
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Candida albicans Mitochondrial NADP-specific isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) ctsf protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium parvum cryptopain - cysteine proteinase secreted, possible transmembrane domain near N-terminus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Neospora caninum Isocitrate dehydrogenase-like protein, related Get druggable targets OG5_127057 All targets in OG5_127057
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Neospora caninum hypothetical protein Get druggable targets OG5_127057 All targets in OG5_127057
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis X box binding protein 1 Get druggable targets OG5_134980 All targets in OG5_134980
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva isocitrate dehydrogenase (NADP+), putative Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 3 Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Huntingtin homolog Get druggable targets OG5_132837 All targets in OG5_132837
Theileria parva cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 2a Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium yoelii isocitrate dehydrogenase, NADP-dependent Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania mexicana cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Candida albicans cytosolic NADP-specific isocitrate dehydrogenase. Get druggable targets OG5_127057 All targets in OG5_127057
Candida albicans Mitochondrial NADP-specific isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium berghei isocitrate dehydrogenase [NADP], mitochondrial, putative Get druggable targets OG5_127057 All targets in OG5_127057
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium hominis cryptopain precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Toxoplasma gondii cathepsin CPL Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K00031 isocitrate dehydrogenase [EC1.1.1.42], putative Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma japonicum ko:K01373 cathepsin F [EC3.4.22.41], putative Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin L cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi hypothetical protein Get druggable targets OG5_132837 All targets in OG5_132837
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania donovani cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cruzipain precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi MH2 domain containing protein SMAD family member 2 467 aa 405 aa 31.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni cathepsin F (C01 family) 0.002 0.0214 0.0214
Echinococcus multilocularis cathepsin L cysteine protease 0.002 0.0214 0.0308
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0019 0.0191 0.13
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0012 0.0049 0.007
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0019 0.0191 0.13
Brugia malayi Cathepsin L-like precursor 0.002 0.0214 0.0753
Trypanosoma brucei electron transfer flavoprotein-ubiquinone oxidoreductase, putative 0.0041 0.0648 0.4633
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.1385 1
Brugia malayi hypothetical protein 0.0011 0.0025 0.0087
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0019 0.0191 0.0274
Mycobacterium leprae PROBABLE D-AMINO ACID OXIDASE AAO 0.0495 1 1
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.0011 0.0025 0.0035
Onchocerca volvulus Huntingtin homolog 0.0148 0.2845 1
Brugia malayi hypothetical protein 0.0011 0.0025 0.0087
Brugia malayi Cathepsin L-like precursor 0.0014 0.0076 0.0269
Schistosoma mansoni hypothetical protein 0.0011 0.0025 0.0025
Loa Loa (eye worm) hypothetical protein 0.0014 0.0076 0.0076
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0214 1
Schistosoma mansoni thyroid hormone receptor 0.0012 0.0049 0.0049
Loa Loa (eye worm) bZIP transcription factor family protein 0.0011 0.0025 0.0025
Loa Loa (eye worm) hypothetical protein 0.0148 0.2845 0.2845
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0012 0.0049 0.0086
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0014 0.0076 0.3182
Echinococcus granulosus glycerol 3 phosphate dehydrogenase 0.0041 0.0648 0.093
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0012 0.0049 0.0049
Echinococcus multilocularis cathepsin L 0.001 0.0012 0.0018
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.0049 0.0172
Brugia malayi dimethylglycine dehydrogenase, mitochondrial precursor, putative 0.0041 0.0648 0.2278
Brugia malayi Cathepsin L-like precursor 0.002 0.0214 0.0753
Brugia malayi RE18450p 0.0041 0.0648 0.2278
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0019 0.0191 0.0274
Brugia malayi Isocitrate dehydrogenase 0.0019 0.0191 0.067
Brugia malayi nuclear receptor NHR-88 0.0012 0.0049 0.0172
Plasmodium falciparum cysteine proteinase falcipain 3 0.002 0.0214 0.3176
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0214 1
Echinococcus granulosus FAD dependent oxidoreductase domain containing protein 0.0041 0.0648 0.093
Brugia malayi Papain family cysteine protease containing protein 0.001 0.0012 0.0043
Leishmania major cathepsin L-like protease 0.0077 0.1385 1
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.002 0.0214 0.0214
Trypanosoma brucei glycerol-3-phosphate dehydrogenase (FAD-dependent), mitochondrial 0.0041 0.0648 0.4633
Onchocerca volvulus 0.002 0.0214 0.0672
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0012 0.0049 0.0172
Plasmodium falciparum cysteine proteinase falcipain 2a 0.002 0.0214 0.3176
Echinococcus granulosus cathepsin L 0.001 0.0012 0.0018
Brugia malayi hypothetical protein 0.0148 0.2845 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0049 0.0049
Echinococcus granulosus protocadherin 11 0.0011 0.0025 0.0035
Brugia malayi Cell death specification protein 2 0.0011 0.0025 0.0087
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0012 0.0049 0.007
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0012 0.0049 0.0049
Brugia malayi ecdysteroid receptor 0.0012 0.0049 0.0172
Brugia malayi isocitrate dehydrogenase 0.0019 0.0191 0.067
Loa Loa (eye worm) hypothetical protein 0.0012 0.0049 0.0049
Loa Loa (eye worm) hypothetical protein 0.0012 0.0049 0.0049
Toxoplasma gondii cathepsin CPL 0.002 0.0214 0.0514
Echinococcus multilocularis FAD dependent oxidoreductase domain containing protein 0.0041 0.0648 0.093
Echinococcus granulosus cathepsin l1 0.0014 0.0076 0.011
Loa Loa (eye worm) hypothetical protein 0.0041 0.0648 0.0648
Loa Loa (eye worm) hypothetical protein 0.0011 0.0025 0.0025
Echinococcus granulosus FTZ F1 alpha 0.0012 0.0049 0.007
Entamoeba histolytica hypothetical protein 0.0011 0.0025 0.0196
Giardia lamblia Glycerol-3-phosphate dehydrogenase 0.0041 0.0648 1
Trypanosoma cruzi cysteine peptidase, putative 0.002 0.0214 0.1472
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0214 1
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0012 0.0049 0.0049
Loa Loa (eye worm) hypothetical protein 0.0014 0.0076 0.0076
Schistosoma mansoni steroid hormone receptor ad4bp 0.0012 0.0049 0.0049
Echinococcus granulosus cathepsin L cysteine protease 0.001 0.0012 0.0018
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.001 0.0012 0.0012
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0214 1
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.001 0.0012 0.0012
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.1385 1
Echinococcus multilocularis FTZ F1 alpha 0.0012 0.0049 0.007
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.1385 1
Leishmania major cathepsin L-like protease 0.0077 0.1385 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0214 1
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0012 0.0049 0.007
Trypanosoma cruzi FAD dependent oxidoreductase, putative 0.0041 0.0648 0.4633
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0019 0.0191 0.13
Loa Loa (eye worm) ctsf protein 0.002 0.0214 0.0214
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0012 0.0049 0.0049
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0214 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0214 1
Brugia malayi Cathepsin L-like precursor 0.0014 0.0076 0.0269
Onchocerca volvulus 0.002 0.0214 0.0672
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0019 0.0191 0.2807
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.0011 0.0025 0.0035
Schistosoma mansoni fad oxidoreductase 0.0041 0.0648 0.0648
Entamoeba histolytica NAD(FAD)-dependent dehydrogenase, putative 0.0041 0.0648 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0214 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0214 1
Loa Loa (eye worm) transcription factor SMAD2 0.0144 0.2768 0.2768
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0012 0.0049 0.0172
Chlamydia trachomatis D-amino acid dehydrogenase 0.0041 0.0648 0.5
Brugia malayi Cathepsin L-like precursor 0.002 0.0214 0.0753
Schistosoma mansoni hypothetical protein 0.0011 0.0025 0.0025
Trypanosoma cruzi glycerol-3-phosphate dehydrogenase, putative 0.0041 0.0648 0.4633
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.0049 0.0172
Brugia malayi MH2 domain containing protein 0.0144 0.2768 0.9727
Echinococcus multilocularis cathepsin l cysteine peptidase 0.002 0.0214 0.0308
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.0049 0.0172
Brugia malayi Cathepsin L-like precursor 0.002 0.0214 0.0753
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.1385 1
Leishmania major hypothetical protein, conserved 0.0041 0.0648 0.383
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.1385 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0049 0.0049
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.1385 1
Schistosoma mansoni cathepsin F (C01 family) 0.002 0.0214 0.0214
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0012 0.0049 0.0172
Loa Loa (eye worm) hypothetical protein 0.0011 0.0025 0.0025
Onchocerca volvulus Putative fad oxidoreductase 0.0041 0.0648 0.221
Entamoeba histolytica anaerobic glycerol-3-phosphate dehydrogenase subunit A, putative 0.0041 0.0648 1
Schistosoma mansoni d-amino acid oxidase 0.0495 1 1
Echinococcus multilocularis cathepsin L cysteine protease 0.002 0.0214 0.0308
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 20 0.0041 0.0648 0.4633
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0012 0.0049 0.007
Toxoplasma gondii hypothetical protein 0.0041 0.0648 1
Echinococcus granulosus protocadherin 11 0.0011 0.0025 0.0035
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0214 1
Brugia malayi Nuclear hormone receptor-like 1 0.0012 0.0049 0.0172
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0214 1
Echinococcus granulosus ccaat enhancer binding protein delta 0.0011 0.0025 0.0035
Onchocerca volvulus Cathepsin F homolog 0.002 0.0214 0.0672
Loa Loa (eye worm) papain family cysteine protease containing protein 0.002 0.0214 0.0214
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0214 1
Echinococcus granulosus cathepsin l cysteine peptidase 0.002 0.0214 0.0308
Schistosoma mansoni hypothetical protein 0.0348 0.6965 0.6965
Echinococcus multilocularis cathepsin l cysteine peptidase 0.002 0.0214 0.0308
Entamoeba histolytica cysteine proteinase, putative 0.0014 0.0076 0.1011
Brugia malayi Cell death specification protein 2 0.0011 0.0025 0.0087
Trypanosoma cruzi major cysteine proteinase, putative 0.0061 0.1045 0.7525
Leishmania major cathepsin L-like protease 0.002 0.0214 0.0197
Trypanosoma cruzi glycerol-3-phosphate dehydrogenase (FAD-dependent), putative 0.0041 0.0648 0.4633
Loa Loa (eye worm) hypothetical protein 0.002 0.0214 0.0214
Schistosoma mansoni NAD dehydrogenase 0.0041 0.0648 0.0648
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0012 0.0049 0.007
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0012 0.0049 0.0049
Brugia malayi Cathepsin L-like precursor 0.002 0.0214 0.0753
Brugia malayi photoreceptor-specific nuclear receptor 0.0012 0.0049 0.0172
Leishmania major cathepsin L-like protease 0.002 0.0214 0.0197
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0214 1
Echinococcus granulosus cathepsin L cysteine proteinase 0.002 0.0214 0.0308
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0012 0.0049 0.0049
Brugia malayi hypothetical protein 0.0011 0.0025 0.0087
Onchocerca volvulus Dimethylglycine dehydrogenase, mitochondrial homolog 0.0041 0.0648 0.221
Mycobacterium tuberculosis Probable D-amino acid oxidase Aao 0.0454 0.915 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.1385 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0012 0.0049 0.0049
Loa Loa (eye worm) steroid hormone receptor 0.0012 0.0049 0.0049
Schistosoma mansoni coup transcription factor 0.0012 0.0049 0.0049
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0012 0.0049 0.0172
Brugia malayi Cathepsin L-like precursor 0.002 0.0214 0.0753
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.002 0.0214 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.002 0.0214 1
Schistosoma mansoni fad oxidoreductase 0.0041 0.0648 0.0648
Echinococcus granulosus cathepsin l1 0.002 0.0214 0.0308
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0019 0.0191 0.2807
Echinococcus granulosus X box binding protein 1 0.0348 0.6965 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0049 0.0049
Loa Loa (eye worm) MH2 domain-containing protein 0.0144 0.2768 0.2768
Schistosoma mansoni ATP:guanidino kinase (Smc74) 0.0041 0.0648 0.0648
Onchocerca volvulus 0.002 0.0214 0.0672
Schistosoma mansoni transcriptional factor nfil3/e4bp4 0.0011 0.0025 0.0025
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0214 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0214 1
Brugia malayi Papain family cysteine protease containing protein 0.001 0.0012 0.0043
Onchocerca volvulus 0.002 0.0214 0.0672
Brugia malayi cDNA sequence BC016226 0.0041 0.0648 0.2278
Loa Loa (eye worm) fibroinase 0.002 0.0214 0.0214
Echinococcus multilocularis protocadherin 11 0.0011 0.0025 0.0035
Echinococcus multilocularis cysteine protease 0.002 0.0214 0.0308
Loa Loa (eye worm) hypothetical protein 0.0014 0.0076 0.0076
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.0049 0.007
Onchocerca volvulus 0.002 0.0214 0.0672
Schistosoma mansoni RAR-like nuclear receptor 0.0012 0.0049 0.0049
Trypanosoma brucei FAD dependent oxidoreductase, putative 0.0041 0.0648 0.4633
Leishmania major cathepsin L-like protease 0.002 0.0214 0.0197
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0012 0.0049 0.007
Loa Loa (eye worm) hypothetical protein 0.0148 0.2845 0.2845
Echinococcus multilocularis glycerol 3 phosphate dehydrogenase 0.0041 0.0648 0.093
Trypanosoma cruzi cruzipain precursor, putative 0.0077 0.1385 1
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0012 0.0049 0.0049
Plasmodium falciparum FAD-dependent glycerol-3-phosphate dehydrogenase, putative 0.0041 0.0648 1
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.0011 0.0025 0.0035
Leishmania major hypothetical protein, conserved 0.0041 0.0648 0.383
Loa Loa (eye worm) hypothetical protein 0.0012 0.0049 0.0049
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0012 0.0049 0.0049
Entamoeba histolytica cysteine proteinase, putative 0.002 0.0214 0.3176
Onchocerca volvulus Bile acid receptor homolog 0.0012 0.0049 0.0086
Schistosoma mansoni glycerol-3-phosphate dehydrogenase 0.0041 0.0648 0.0648
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0214 1
Schistosoma mansoni thyroid hormone receptor 0.0012 0.0049 0.0049
Trypanosoma cruzi L-2-hydroxyglutarate dehydrogenase, mitochondrial, putative 0.0041 0.0648 0.4633
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0019 0.0191 0.0274
Entamoeba histolytica cysteine protease, putative 0.002 0.0214 0.3176
Loa Loa (eye worm) hypothetical protein 0.0011 0.0025 0.0025
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0012 0.0049 0.0049
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0019 0.0191 0.13
Brugia malayi bZIP transcription factor family protein 0.0011 0.0025 0.0087
Echinococcus multilocularis X box binding protein 1 0.0348 0.6965 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.0049 0.007
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.1385 1
Onchocerca volvulus Cathepsin L homolog 0.002 0.0214 0.0672
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0012 0.0049 0.0049
Onchocerca volvulus 0.002 0.0214 0.0672
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.1385 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0214 1
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0012 0.0049 0.0049
Brugia malayi Cell death specification protein 2 0.0011 0.0025 0.0087
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0019 0.0191 0.0274
Schistosoma mansoni retinoic acid receptor RXR 0.0012 0.0049 0.0049
Loa Loa (eye worm) hypothetical protein 0.0041 0.0648 0.0648
Trypanosoma cruzi glycerol-3-phosphate dehydrogenase (FAD-dependent), putative 0.0041 0.0648 0.4633
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0012 0.0049 0.0172
Loa Loa (eye worm) hypothetical protein 0.0012 0.0049 0.0049
Mycobacterium tuberculosis Possible thiamine biosynthesis oxidoreductase ThiO 0.0041 0.0648 0.0511
Leishmania major cathepsin L-like protease 0.002 0.0214 0.0197
Schistosoma mansoni cathepsin F (C01 family) 0.0014 0.0076 0.0076
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.0011 0.0025 0.0035
Echinococcus multilocularis isocitrate dehydrogenase 0.0019 0.0191 0.0274
Schistosoma mansoni par domain protein 0.0011 0.0025 0.0025
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.1385 1
Loa Loa (eye worm) hypothetical protein 0.0011 0.0025 0.0025
Onchocerca volvulus 0.0014 0.0076 0.0184
Leishmania major cysteine peptidase A (CPA) 0.002 0.0214 0.0197
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0012 0.0049 0.007
Plasmodium vivax FAD-dependent glycerol-3-phosphate dehydrogenase, putative 0.0041 0.0648 1
Plasmodium vivax vivapain-2 0.002 0.0214 0.3176
Echinococcus granulosus cysteine protease 0.001 0.0012 0.0018
Leishmania major cathepsin L-like protease 0.002 0.0214 0.0197
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0214 1
Echinococcus multilocularis cysteine protease 0.002 0.0214 0.0308
Trypanosoma brucei glycerol-3-phosphate dehydrogenase (FAD-dependent), putative 0.0041 0.0648 0.4633
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0012 0.0049 0.0172
Toxoplasma gondii FAD-dependent glycerol-3-phosphate dehydrogenase 0.0041 0.0648 1
Brugia malayi steroid hormone receptor 0.0012 0.0049 0.0172
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.0049 0.007
Leishmania major cathepsin L-like protease 0.0077 0.1385 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.0049 0.0172
Brugia malayi Hepatic leukemia factor 0.0011 0.0025 0.0087
Schistosoma mansoni thyrotroph embryonic factor related 0.0011 0.0025 0.0025
Loa Loa (eye worm) hypothetical protein 0.0011 0.0025 0.0025
Brugia malayi Cathepsin L-like cysteine proteinase 0.0014 0.0076 0.0269
Brugia malayi nuclear hormone receptor 0.0012 0.0049 0.0172
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0214 1
Echinococcus granulosus ecdysone induced protein 78C 0.0012 0.0049 0.007
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.1385 1
Loa Loa (eye worm) cell death specification protein 2 0.0011 0.0025 0.0025
Onchocerca volvulus Protein ultraspiracle homolog 0.0012 0.0049 0.0086
Loa Loa (eye worm) glycerol-3-phosphate dehydrogenase 0.0041 0.0648 0.0648
Leishmania major glycerol-3-phosphate dehydrogenase-like protein 0.0041 0.0648 0.383
Trypanosoma cruzi L-2-hydroxyglutarate dehydrogenase, mitochondrial, putative 0.0041 0.0648 0.4633
Loa Loa (eye worm) cysteine protease 0.002 0.0214 0.0214
Brugia malayi Steroid receptor seven-up type 2 0.0012 0.0049 0.0172
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0012 0.0049 0.0049
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.0049 0.007
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0012 0.0049 0.007
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.1385 1
Echinococcus multilocularis transcriptional factor nfil3:e4bp4 0.0011 0.0025 0.0035
Mycobacterium ulcerans D-amino acid oxidase Aao 0.0495 1 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.1385 1
Echinococcus multilocularis ecdysone induced protein 78C 0.0012 0.0049 0.007
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.007 0.1247 0.8997
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0014 0.0076 0.3182
Plasmodium falciparum cysteine proteinase falcipain 2b 0.002 0.0214 0.3176
Echinococcus multilocularis protocadherin 11 0.0011 0.0025 0.0035
Brugia malayi cathepsin L-like precursor 0.0014 0.0076 0.0269
Onchocerca volvulus Huntingtin homolog 0.0148 0.2845 1
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0012 0.0049 0.0172
Onchocerca volvulus Cathepsin L homolog 0.002 0.0214 0.0672
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0214 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.0049 0.0172
Onchocerca volvulus Pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial homolog 0.0041 0.0648 0.221
Trypanosoma brucei L-2-hydroxyglutarate dehydrogenase, mitochondrial, putative 0.0041 0.0648 0.4633
Schistosoma mansoni nuclear hormone receptor 0.0012 0.0049 0.0049
Plasmodium vivax vivapain-2 0.002 0.0214 0.3176
Echinococcus multilocularis ccaat enhancer binding protein delta ccaat enhancer binding protein beta 0.0011 0.0025 0.0035
Echinococcus multilocularis cyclic AMP responsive element binding protein 0.0011 0.0025 0.0035
Loa Loa (eye worm) hypothetical protein 0.0012 0.0049 0.0049
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0012 0.0049 0.007
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0214 1
Loa Loa (eye worm) isocitrate dehydrogenase 0.0019 0.0191 0.0191
Onchocerca volvulus 0.0012 0.0049 0.0086
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.001 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.0011 0.0025 0.0025
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0214 1
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.1385 1
Echinococcus granulosus transcriptional factor nfil3:e4bp4 0.0011 0.0025 0.0035
Brugia malayi Papain family cysteine protease containing protein 0.002 0.0214 0.0753
Echinococcus multilocularis thyroid hormone receptor alpha 0.0012 0.0049 0.007
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0019 0.0191 0.0191
Onchocerca volvulus 0.002 0.0214 0.0672
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.0049 0.0172
Brugia malayi pyruvate dehydrogenase phosphatase regulatory subunit precursor 0.0041 0.0648 0.2278
Entamoeba histolytica cysteine proteinase, putative 0.002 0.0214 0.3176
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0019 0.0191 0.0274
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0214 1
Loa Loa (eye worm) hypothetical protein 0.0041 0.0648 0.0648

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 9.44 uM PUBCHEM_BIOASSAY: CHOP dose-response primary assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2732, AID493217] ChEMBL. No reference
IC50 (functional) > 10 uM PUBCHEM_BIOASSAY: XBP1 DR counterscreen for CHOP. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2732, AID493217] ChEMBL. No reference
Potency (functional) = 0.7079 um PUBCHEM_BIOASSAY: qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (with detergent). (Class of assay: confirmatory) [Related pubchem assays: 2158 (Confirmation qHTS Assay for Inhibitors of Cruzain), 2249 (Probe Development Summary of Promiscuous Inhibitors (Artifacts) of Cruzain), 2161 (qHTS Assay for Inhibitors of Papain: Counterscreen for Cruzain Assay), 1476 (qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (without detergent))] ChEMBL. No reference
Potency (functional) 10 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference
Potency (functional) = 11.2202 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 11.2202 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) = 12.5893 um PUBCHEM_BIOASSAY: qHTS Multiplex Assay to Identify Dual Action Probes in a Cell Model of Huntington: Aggregate Formation (GFP). (Class of assay: confirmatory) [Related pubchem assays: 1482, 1471 ] ChEMBL. No reference
Potency (functional) 15.8489 uM PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 20.5962 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) 20.5962 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 28.1838 uM PubChem BioAssay. qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 29.081 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) 29.0929 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS Assay for Enhancers of SMN2 Splice Variant Expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (without detergent). (Class of assay: confirmatory) [Related pubchem assays: 2158 (Confirmation qHTS Assay for Inhibitors of Cruzain), 2249 (Probe Development Summary of Promiscuous Inhibitors (Artifacts) of Cruzain), 2161 (qHTS Assay for Inhibitors of Papain: Counterscreen for Cruzain Assay), 1478 (qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (with detergent))] ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) = 100 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference
Potency (functional) = 112.2018 um PUBCHEM_BIOASSAY: Confirmation of Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide. (Class of assay: confirmatory) [Related pubchem assays: 1768, 2076, 1766 ] ChEMBL. No reference
Potency (functional) = 630.9573 um PUBCHEM_BIOASSAY: Confirmation of Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Fluorescein Labeled MLL-derived Peptide. (Class of assay: confirmatory) [Related pubchem assays: 1768, 1766, 2076 ] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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