Detailed information for compound 1434784

Basic information

Technical information
  • TDR Targets ID: 1434784
  • Name: 4-(4-fluorophenyl)-5-(1-piperidin-1-ylethyl)- 2H-1,2,4-triazole-3-thione
  • MW: 306.402 | Formula: C15H19FN4S
  • H donors: 0 H acceptors: 2 LogP: 2.79 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: Fc1ccc(cc1)n1c(S)nnc1C(N1CCCCC1)C
  • InChi: 1S/C15H19FN4S/c1-11(19-9-3-2-4-10-19)14-17-18-15(21)20(14)13-7-5-12(16)6-8-13/h5-8,11H,2-4,9-10H2,1H3,(H,18,21)
  • InChiKey: KNOGJOJWLPDNRE-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 4-(4-fluorophenyl)-5-[1-(1-piperidyl)ethyl]-2H-1,2,4-triazole-3-thione
  • 4-(4-fluorophenyl)-5-(1-piperidinoethyl)-2H-1,2,4-triazole-3-thione
  • MLS000771079
  • SMR000344187

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens lysine (K)-specific demethylase 4A Starlite/ChEMBL No references
Leishmania mexicana pyruvate kinase, putative Starlite/ChEMBL No references
Homo sapiens lamin A/C Starlite/ChEMBL No references
Homo sapiens growth factor, augmenter of liver regeneration Starlite/ChEMBL No references
Mus musculus RAR-related orphan receptor gamma Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Candida albicans pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Trypanosoma cruzi ERV/ALR sulfhydryl oxidase domain-containing protein Get druggable targets OG5_127535 All targets in OG5_127535
Schistosoma japonicum ko:K07611 lamin, putative Get druggable targets OG5_128723 All targets in OG5_128723
Giardia lamblia Pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Theileria parva hypothetical protein, conserved Get druggable targets OG5_127535 All targets in OG5_127535
Plasmodium berghei FAD-linked sulfhydryl oxidase ERV1, putative Get druggable targets OG5_127535 All targets in OG5_127535
Trypanosoma brucei gambiense hypothetical protein, conserved Get druggable targets OG5_127535 All targets in OG5_127535
Schistosoma mansoni jumonji domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Echinococcus multilocularis FAD linked sulfhydryl oxidase ALR Get druggable targets OG5_127535 All targets in OG5_127535
Plasmodium falciparum pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Leishmania major pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Echinococcus granulosus FAD linked sulfhydryl oxidase ALR Get druggable targets OG5_127535 All targets in OG5_127535
Onchocerca volvulus Pyruvate kinase homolog Get druggable targets OG5_126685 All targets in OG5_126685
Toxoplasma gondii Erv1 / Alr family protein Get druggable targets OG5_127535 All targets in OG5_127535
Candida albicans one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp Get druggable targets OG5_127917 All targets in OG5_127917
Trypanosoma cruzi pyruvate kinase 2, putative Get druggable targets OG5_126685 All targets in OG5_126685
Schistosoma japonicum expressed protein Get druggable targets OG5_127917 All targets in OG5_127917
Trypanosoma brucei pyruvate kinase 1, putative Get druggable targets OG5_126685 All targets in OG5_126685
Mycobacterium tuberculosis Probable pyruvate kinase PykA Get druggable targets OG5_126685 All targets in OG5_126685
Leishmania mexicana pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Schistosoma mansoni intermediate filament proteins Get druggable targets OG5_128723 All targets in OG5_128723
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Plasmodium knowlesi pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Candida albicans similar to S. cerevisiae ERV2 (YPR037C) endoplasmic reticulum flavin-linked sulfhydryl oxidase Get druggable targets OG5_127535 All targets in OG5_127535
Plasmodium yoelii hypothetical protein Get druggable targets OG5_127917 All targets in OG5_127917
Loa Loa (eye worm) pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Echinococcus multilocularis pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Candida albicans one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp Get druggable targets OG5_127917 All targets in OG5_127917
Schistosoma japonicum Pyruvate kinase isozyme R, putative Get druggable targets OG5_126685 All targets in OG5_126685
Echinococcus granulosus lamin Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum Lamin-C, putative Get druggable targets OG5_128723 All targets in OG5_128723
Trypanosoma congolense pyruvate kinase 1, putative Get druggable targets OG5_126685 All targets in OG5_126685
Leishmania infantum pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Theileria parva pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Candida albicans pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Schistosoma mansoni pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Echinococcus granulosus pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Leishmania mexicana hypothetical protein, conserved Get druggable targets OG5_127535 All targets in OG5_127535
Loa Loa (eye worm) pyruvate kinase-PB Get druggable targets OG5_126685 All targets in OG5_126685
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127917 All targets in OG5_127917
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 4 Get druggable targets OG5_127535 All targets in OG5_127535
Neospora caninum Pyruvate kinase (EC 2.7.1.40), related Get druggable targets OG5_126685 All targets in OG5_126685
Schistosoma mansoni pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Plasmodium yoelii hypothetical protein Get druggable targets OG5_127535 All targets in OG5_127535
Echinococcus multilocularis jumonji domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Onchocerca volvulus Pyruvate kinase homolog Get druggable targets OG5_126685 All targets in OG5_126685
Plasmodium yoelii pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Mycobacterium leprae Probable pyruvate kinase PykA Get druggable targets OG5_126685 All targets in OG5_126685
Entamoeba histolytica pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Echinococcus multilocularis Transcription factor, JmjC domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Onchocerca volvulus Pyruvate kinase homolog Get druggable targets OG5_126685 All targets in OG5_126685
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania mexicana pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Leishmania infantum hypothetical protein, conserved Get druggable targets OG5_127535 All targets in OG5_127535
Candida albicans hypothetical protein Get druggable targets OG5_127535 All targets in OG5_127535
Schistosoma japonicum Probable JmjC domain-containing histone demethylation protein 3B, putative Get druggable targets OG5_127917 All targets in OG5_127917
Schistosoma japonicum Intermediate filament protein ifa-1, putative Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi Augmenter of liver regeneration Get druggable targets OG5_127535 All targets in OG5_127535
Leishmania major hypothetical protein, conserved Get druggable targets OG5_127535 All targets in OG5_127535
Trypanosoma brucei gambiense pyruvate kinase 1, putative Get druggable targets OG5_126685 All targets in OG5_126685
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) intermediate filament tail domain-containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hepatopoietin HPO2 Get druggable targets OG5_127535 All targets in OG5_127535
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Trypanosoma congolense ERV/ALR sulfhydryl oxidase domain-containing protein Get druggable targets OG5_127535 All targets in OG5_127535
Brugia malayi Intermediate filament tail domain containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Babesia bovis human hepatopoietin-like protein, putative Get druggable targets OG5_127535 All targets in OG5_127535
Echinococcus multilocularis lamin Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania braziliensis pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Echinococcus granulosus intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Loa Loa (eye worm) pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126685 All targets in OG5_126685
Leishmania donovani ERV/ALR sulfhydryl oxidase domain-containing protein Get druggable targets OG5_127535 All targets in OG5_127535
Echinococcus granulosus jumonji domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Leishmania donovani pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Cryptosporidium hominis pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Leishmania braziliensis pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Schistosoma japonicum JmjC domain-containing histone demethylation protein 3C, putative Get druggable targets OG5_127917 All targets in OG5_127917
Mycobacterium ulcerans pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Toxoplasma gondii Erv1 / Alr family protein Get druggable targets OG5_127535 All targets in OG5_127535
Echinococcus multilocularis pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Toxoplasma gondii pyruvate kinase PyK1 Get druggable targets OG5_126685 All targets in OG5_126685
Plasmodium berghei pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Schistosoma japonicum ko:K00873 pyruvate kinase [EC2.7.1.40], putative Get druggable targets OG5_126685 All targets in OG5_126685
Trypanosoma brucei pyruvate kinase 1 Get druggable targets OG5_126685 All targets in OG5_126685
Echinococcus multilocularis cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Neospora caninum hypothetical protein Get druggable targets OG5_127535 All targets in OG5_127535
Trypanosoma brucei gambiense pyruvate kinase 1, putative Get druggable targets OG5_126685 All targets in OG5_126685
Trypanosoma cruzi pyruvate kinase 2, putative Get druggable targets OG5_126685 All targets in OG5_126685
Trypanosoma brucei ERV/ALR sulfhydryl oxidase domain-containing protein Get druggable targets OG5_127535 All targets in OG5_127535
Schistosoma japonicum expressed protein Get druggable targets OG5_127917 All targets in OG5_127917
Candida albicans one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp Get druggable targets OG5_127917 All targets in OG5_127917
Candida albicans one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp Get druggable targets OG5_127917 All targets in OG5_127917
Brugia malayi Pyruvate kinase, muscle isozyme Get druggable targets OG5_126685 All targets in OG5_126685
Babesia bovis pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Brugia malayi Pyruvate kinase, M2 isozyme Get druggable targets OG5_126685 All targets in OG5_126685
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Trichomonas vaginalis pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Loa Loa (eye worm) jmjC domain-containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Echinococcus multilocularis musashi Get druggable targets OG5_128723 All targets in OG5_128723
Plasmodium falciparum FAD-linked sulfhydryl oxidase ERV1, putative Get druggable targets OG5_127535 All targets in OG5_127535
Brugia malayi intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Plasmodium vivax FAD-linked sulfhydryl oxidase ERV1, putative Get druggable targets OG5_127535 All targets in OG5_127535
Echinococcus granulosus cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania braziliensis pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Echinococcus multilocularis lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi jmjC domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Leishmania braziliensis hypothetical protein, conserved Get druggable targets OG5_127535 All targets in OG5_127535
Plasmodium knowlesi FAD-linked sulfhydryl oxidase ERV1, putative Get druggable targets OG5_127535 All targets in OG5_127535
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126685 All targets in OG5_126685
Echinococcus granulosus lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Candida albicans similar to S. cerevisiae ERV2 (YPR037C) endoplasmic reticulum flavin-linked sulfhydryl oxidase Get druggable targets OG5_127535 All targets in OG5_127535
Chlamydia trachomatis pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Plasmodium vivax pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Cryptosporidium parvum pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania infantum pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 4 Get druggable targets OG5_127535 All targets in OG5_127535
Trichomonas vaginalis pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Trypanosoma congolense ERV/ALR sulfhydryl oxidase domain-containing protein Get druggable targets OG5_127535 All targets in OG5_127535
Leishmania major pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Echinococcus granulosus Transcription factor JmjC domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Schistosoma japonicum FAD-linked sulfhydryl oxidase ALR, putative Get druggable targets OG5_127535 All targets in OG5_127535
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Echinococcus granulosus pyruvate kinase pyruvate kinase, putative 498 aa 515 aa 27.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus pyruvate kinase 0.004 0.2512 0.2467
Echinococcus granulosus intermediate filament protein 0.0033 0.1741 0.1692
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0035 0.2005 0.2048
Loa Loa (eye worm) hypothetical protein 0.0032 0.1682 0.2927
Chlamydia trachomatis pyruvate kinase 0.004 0.2512 0.5
Toxoplasma gondii PHD-finger domain-containing protein 0.0035 0.2005 0.7002
Loa Loa (eye worm) hypothetical protein 0.0016 0.0059 0.0103
Echinococcus granulosus jumonji domain containing protein 0.0049 0.3381 0.3341
Brugia malayi Augmenter of liver regeneration 0.0041 0.2626 0.245
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 4 0.0041 0.2626 1
Brugia malayi Pyruvate kinase, muscle isozyme 0.004 0.2512 0.2334
Echinococcus multilocularis pyruvate kinase 0.0021 0.0555 0.0498
Loa Loa (eye worm) intermediate filament protein 0.0033 0.1741 0.303
Plasmodium vivax FAD-linked sulfhydryl oxidase ERV1, putative 0.0041 0.2626 1
Trichomonas vaginalis pyruvate kinase, putative 0.004 0.2512 0.5
Loa Loa (eye worm) jmjC domain-containing protein 0.0043 0.2744 0.4775
Plasmodium vivax pyruvate kinase, putative 0.004 0.2512 0.9449
Schistosoma mansoni intermediate filament proteins 0.0033 0.1741 0.1676
Mycobacterium leprae Probable pyruvate kinase PykA 0.004 0.2512 0.5
Plasmodium falciparum FAD-linked sulfhydryl oxidase ERV1, putative 0.0041 0.2626 1
Echinococcus multilocularis pyruvate kinase 0.0021 0.0555 0.0498
Echinococcus multilocularis musashi 0.0033 0.1741 0.1692
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0033 0.1741 0.303
Schistosoma mansoni pyruvate kinase 0.004 0.2512 0.2764
Echinococcus multilocularis pyruvate kinase 0.004 0.2512 0.2467
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 4 0.0041 0.2626 1
Echinococcus granulosus pyruvate kinase 0.0021 0.0555 0.0498
Schistosoma mansoni jumonji domain containing protein 0.0092 0.7635 1
Loa Loa (eye worm) pyruvate kinase-PB 0.0028 0.1295 0.2253
Onchocerca volvulus Pyruvate kinase homolog 0.004 0.2512 1
Brugia malayi Intermediate filament tail domain containing protein 0.0033 0.1741 0.1545
Loa Loa (eye worm) hypothetical protein 0.0035 0.2005 0.3489
Loa Loa (eye worm) PHD-finger family protein 0.0035 0.2005 0.3489
Loa Loa (eye worm) pyruvate kinase 0.004 0.2512 0.4371
Echinococcus granulosus pyruvate kinase 0.0021 0.0555 0.0498
Loa Loa (eye worm) hypothetical protein 0.006 0.4515 0.7857
Echinococcus multilocularis pyruvate kinase 0.0021 0.0555 0.0498
Echinococcus multilocularis pyruvate kinase 0.004 0.2512 0.2467
Plasmodium falciparum pyruvate kinase 0.004 0.2512 0.9449
Giardia lamblia Pyruvate kinase 0.004 0.2512 1
Echinococcus granulosus FAD linked sulfhydryl oxidase ALR 0.0041 0.2626 0.2582
Brugia malayi jmjC domain containing protein 0.0043 0.2744 0.2572
Toxoplasma gondii Erv1 / Alr family protein 0.0041 0.2626 1
Toxoplasma gondii pyruvate kinase PyK1 0.004 0.2512 0.9449
Echinococcus granulosus lamin 0.0033 0.1741 0.1692
Loa Loa (eye worm) jmjC domain-containing protein 0.0073 0.5747 1
Echinococcus granulosus peregrin 0.0035 0.2005 0.1957
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0115 1 1
Echinococcus multilocularis lysine specific demethylase 5A 0.0043 0.2744 0.2701
Brugia malayi PHD-finger family protein 0.0035 0.2005 0.1815
Loa Loa (eye worm) pyruvate kinase 0.004 0.2512 0.4371
Giardia lamblia PHD finger protein 15 0.0035 0.2005 0.7411
Echinococcus granulosus lysine specific demethylase 5A 0.0043 0.2744 0.2701
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0017 0.0232 0.0404
Echinococcus granulosus pyruvate kinase 0.0021 0.0555 0.0498
Loa Loa (eye worm) hypothetical protein 0.0033 0.1741 0.303
Echinococcus multilocularis FAD linked sulfhydryl oxidase ALR 0.0041 0.2626 0.2582
Loa Loa (eye worm) hepatopoietin HPO2 0.0041 0.2626 0.4569
Echinococcus multilocularis lamin 0.0033 0.1741 0.1692
Echinococcus granulosus lamin dm0 0.0033 0.1741 0.1692
Trichomonas vaginalis pyruvate kinase, putative 0.004 0.2512 0.5
Echinococcus granulosus PHD finger protein rhinoceros 0.0035 0.2005 0.1957
Schistosoma mansoni lamin 0.0033 0.1741 0.1676
Brugia malayi intermediate filament protein 0.0033 0.1741 0.1545
Echinococcus granulosus pyruvate kinase 0.004 0.2512 0.2467
Echinococcus multilocularis pyruvate kinase 0.0032 0.1664 0.1615
Onchocerca volvulus Pyruvate kinase homolog 0.004 0.2512 1
Trypanosoma cruzi ERV/ALR sulfhydryl oxidase domain-containing protein 0.0041 0.2626 1
Mycobacterium ulcerans pyruvate kinase 0.004 0.2512 0.5
Schistosoma mansoni lamin 0.0033 0.1741 0.1676
Onchocerca volvulus Pyruvate kinase homolog 0.004 0.2512 1
Leishmania major hypothetical protein, conserved 0.0041 0.2626 1
Toxoplasma gondii PHD-finger domain-containing protein 0.0035 0.2005 0.7002
Plasmodium falciparum phd finger protein, putative 0.0035 0.2005 0.7002
Entamoeba histolytica pyruvate kinase, putative 0.0028 0.1295 0.5
Loa Loa (eye worm) pyruvate kinase 0.004 0.2512 0.4371
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0115 1 1
Loa Loa (eye worm) hypothetical protein 0.004 0.2512 0.4371
Echinococcus multilocularis peregrin 0.0035 0.2005 0.1957
Toxoplasma gondii Erv1 / Alr family protein 0.0041 0.2626 1
Schistosoma mansoni pyruvate kinase 0.004 0.2512 0.2764
Schistosoma mansoni jumonji/arid domain-containing protein 0.0043 0.2744 0.3093
Brugia malayi Pyruvate kinase, M2 isozyme 0.004 0.2512 0.2334
Trypanosoma brucei ERV/ALR sulfhydryl oxidase domain-containing protein 0.0041 0.2626 1
Echinococcus multilocularis lamin dm0 0.0033 0.1741 0.1692
Brugia malayi Bromodomain containing protein 0.0035 0.2005 0.1815
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.004 0.2512 0.5
Echinococcus multilocularis PHD finger protein rhinoceros 0.0035 0.2005 0.1957
Schistosoma mansoni hypothetical protein 0.0035 0.2005 0.2048
Plasmodium vivax hypothetical protein, conserved 0.0035 0.2005 0.7002
Onchocerca volvulus Alhambra homolog 0.0035 0.2005 0.3421
Schistosoma mansoni jumonji/arid domain-containing protein 0.0043 0.2744 0.3093
Loa Loa (eye worm) hypothetical protein 0.0028 0.1295 0.2253
Echinococcus multilocularis jumonji domain containing protein 0.0049 0.3381 0.3341

Activities

Activity type Activity value Assay description Source Reference
AC50 (binding) = 5.027 uM PUBCHEM_BIOASSAY: HTS-Luminescent assay for inhibitors of ALR by detection of hydrogen peroxide production Measured in Biochemical System Using Plate Reader - 2036-02_Inhibitor_Dose_CherryPick_Activity. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488787] ChEMBL. No reference
Potency (functional) 1.122 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) = 2.8184 um PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 7.9433 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] ChEMBL. No reference
Potency (functional) = 12.5893 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Leishmania Mexicana Pyruvate Kinase (LmPK). (Class of assay: confirmatory) [Related pubchem assays: 1379 ] ChEMBL. No reference
Potency (functional) = 12.5893 um PUBCHEM_BIOASSAY: qHTS Assay for Activators of Leishmania Mexicana Pyruvate Kinase (LmPK). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 12.5893 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 28.1838 uM PubChem BioAssay. qHTS of Trypanosoma Brucei Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of L3MBTL1. (Class of assay: confirmatory) [Related pubchem assays: 485292 (Probe Development Summary for Inhibitors of L3MBTL1)] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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