Detailed information for compound 1438613

Basic information

Technical information
  • TDR Targets ID: 1438613
  • Name: 6,7-dimethoxy-N-(thiophen-2-ylmethyl)quinazol in-4-amine
  • MW: 301.364 | Formula: C15H15N3O2S
  • H donors: 1 H acceptors: 2 LogP: 3.01 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cc2c(ncnc2cc1OC)NCc1cccs1
  • InChi: 1S/C15H15N3O2S/c1-19-13-6-11-12(7-14(13)20-2)17-9-18-15(11)16-8-10-4-3-5-21-10/h3-7,9H,8H2,1-2H3,(H,16,17,18)
  • InChiKey: SZXQNJNKRNPSJD-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 6,7-dimethoxy-N-(2-thienylmethyl)quinazolin-4-amine
  • 6,7-dimethoxy-N-(2-thienylmethyl)-4-quinazolinamine
  • (6,7-dimethoxyquinazolin-4-yl)-(2-thienylmethyl)amine
  • ZINC01405367
  • 12N-055
  • Oprea1_281622
  • MLS000721154
  • SMR000335337

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens lamin A/C Starlite/ChEMBL No references
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references
Homo sapiens mitogen-activated protein kinase 1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis musashi Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania infantum mitogen activated protein kinase, putative,map kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania major mitogen activated protein kinase, putative,map kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum Lamin-C, putative Get druggable targets OG5_128723 All targets in OG5_128723
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma congolense tyrosine protein kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania braziliensis mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440,map kinase Get druggable targets OG5_126781 All targets in OG5_126781
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis lamin Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum ko:K04371 extracellular signal-regulated kinase 1/2, putative Get druggable targets OG5_126781 All targets in OG5_126781
Loa Loa (eye worm) intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Candida albicans MAP kinase-like orf Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma brucei protein kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Brugia malayi Intermediate filament tail domain containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Trypanosoma cruzi mitogen-activated protein kinase 11, putative Get druggable targets OG5_126781 All targets in OG5_126781
Schistosoma japonicum Mitogen-activated protein kinase 3, putative Get druggable targets OG5_126781 All targets in OG5_126781
Brugia malayi MAP kinase sur-1 Get druggable targets OG5_126781 All targets in OG5_126781
Echinococcus granulosus intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum ko:K07611 lamin, putative Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma brucei mitogen activated protein kinase 4, putative Get druggable targets OG5_126781 All targets in OG5_126781
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus mitogen activated protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Trypanosoma brucei gambiense protein kinase, putative,tyrosine protein kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma brucei gambiense mitogen-activated protein kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Candida albicans MAP kinase implicated in PKC1-controlled signalling pathway Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania braziliensis mitogen activated protein kinase, putative,map kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni intermediate filament proteins Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania mexicana mitogen activated protein kinase, putative,map kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Trypanosoma cruzi mitogen activated protein kinase 4, putative Get druggable targets OG5_126781 All targets in OG5_126781
Schistosoma japonicum Intermediate filament protein ifa-1, putative Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Echinococcus granulosus mitogen activated protein kinase 3 Get druggable targets OG5_126781 All targets in OG5_126781
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania donovani mitogen-activated protein kinase 4 Get druggable targets OG5_126781 All targets in OG5_126781
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Candida albicans Serine/threonine protein kinase of MAP kinase family Get druggable targets OG5_126781 All targets in OG5_126781
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 Get druggable targets OG5_126781 All targets in OG5_126781
Echinococcus multilocularis mitogen activated protein kinase 3 Get druggable targets OG5_126781 All targets in OG5_126781
Echinococcus granulosus cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Trypanosoma cruzi mitogen-activated protein kinase 11, putative Get druggable targets OG5_126781 All targets in OG5_126781
Brugia malayi intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Cryptosporidium hominis MAPK Get druggable targets OG5_126781 All targets in OG5_126781
Candida albicans Serine/threonine protein kinase of MAP kinase family Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma cruzi mitogen activated protein kinase 2, putative Get druggable targets OG5_126781 All targets in OG5_126781
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Cryptosporidium parvum MAPK, putative Get druggable targets OG5_126781 All targets in OG5_126781
Echinococcus granulosus lamin Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Giardia lamblia Kinase, CMGC MAPK Get druggable targets OG5_126781 All targets in OG5_126781
Loa Loa (eye worm) intermediate filament tail domain-containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania donovani mitogen activated protein kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Candida albicans MAP kinase-like orf Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania infantum mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania mexicana mitogen-activated protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum Mitogen-activated protein kinase 3, putative Get druggable targets OG5_126781 All targets in OG5_126781
Echinococcus multilocularis mitogen activated protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Echinococcus multilocularis lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trypanosoma brucei mitogen-activated protein kinase 5 mitogen-activated protein kinase 1 360 aa 361 aa 33.2 %
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0359 0.134 0.1876
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0836 0.4597 0.9034
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0836 0.4597 0.728
Entamoeba histolytica phosphatidylinositol 3-kinase 1, putative 0.0797 0.4329 0.8485
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0448 0.195 0.3601
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0836 0.4597 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.027 0.0738 0.1456
Loa Loa (eye worm) phosphatidylinositol 3 0.025 0.0602 0.068
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0905 0.5067 0.8026
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0905 0.5067 1
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.1088 0.6314 0.6242
Trichomonas vaginalis PIKK family atypical protein kinase 0.0576 0.2824 0.5572
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0404 0.1651 0.2986
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.027 0.0738 0.1169
Trichomonas vaginalis PIKK family atypical protein kinase 0.0576 0.282 0.5566
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0836 0.4597 0.4491
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0905 0.5067 0.8026
Trichomonas vaginalis PIKK family atypical protein kinase 0.0576 0.282 0.5566
Trichomonas vaginalis PIKK family atypical protein kinase 0.053 0.2511 0.4956
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.027 0.0738 0.0557
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0359 0.134 0.2348
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.027 0.0738 0.1169
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0191 0.0197 0.5
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0905 0.5067 0.7964
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0191 0.0197 0.0005
Echinococcus multilocularis Zinc finger, PHD finger 0.0191 0.0197 0.0005
Trichomonas vaginalis PIKK family atypical protein kinase 0.0691 0.3609 0.7122
Trichomonas vaginalis PIKK family atypical protein kinase 0.0836 0.4597 0.9071
Echinococcus granulosus DNA dependent protein kinase catalytic subunit 0.0405 0.1658 0.1495
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0836 0.4597 0.4491
Entamoeba histolytica hypothetical protein 0.0737 0.3923 0.7652
Trichomonas vaginalis PIKK family atypical protein kinase 0.0691 0.3609 0.7122
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0836 0.4597 0.728
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0359 0.134 0.2645
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0905 0.5067 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0594 0.2948 0.5817
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0191 0.0197 0.0008
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0191 0.0197 0.0005
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.1628 1 1
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.027 0.0738 0.0557
Trichomonas vaginalis PIKK family atypical protein kinase 0.0691 0.3609 0.7122
Trichomonas vaginalis conserved hypothetical protein 0.019 0.0192 0.0378
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0359 0.134 0.2599
Trichomonas vaginalis PIKK family atypical protein kinase 0.0605 0.3023 0.5965
Trichomonas vaginalis PIKK family atypical protein kinase 0.0576 0.2824 0.5572
Trichomonas vaginalis PIKK family atypical protein kinase 0.0691 0.3609 0.7122
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.1088 0.6314 1
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0359 0.134 0.2348
Trichomonas vaginalis PIKK family atypical protein kinase 0.072 0.3808 0.7515
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0836 0.4597 0.7195
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0594 0.2948 0.6252
Trichomonas vaginalis PIKK family atypical protein kinase 0.046 0.2035 0.4016
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0616 0.3094 0.2959
Trichomonas vaginalis PIKK family atypical protein kinase 0.046 0.2035 0.4016
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.0405 0.1658 0.1495
Trichomonas vaginalis PIKK family atypical protein kinase 0.0836 0.4597 0.9071
Loa Loa (eye worm) hypothetical protein 0.0298 0.093 0.105
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0191 0.0197 0.0005
Trichomonas vaginalis PIKK family atypical protein kinase 0.0501 0.2312 0.4563
Entamoeba histolytica protein kinase rad3, putative 0.027 0.0738 0.1112
Echinococcus granulosus serine protein kinase ATM 0.027 0.0738 0.0557
Echinococcus granulosus serine:threonine protein kinase SMG1 0.027 0.0738 0.0557
Loa Loa (eye worm) hypothetical protein 0.0616 0.3094 0.3494
Leishmania major phosphatidylinositol 3-kinase, putative 0.046 0.2035 0.4178
Trichomonas vaginalis PIKK family atypical protein kinase 0.072 0.3808 0.7515
Trichomonas vaginalis PIKK family atypical protein kinase 0.0404 0.1651 0.3258
Schistosoma mansoni hypothetical protein 0.0205 0.029 0.0101
Trichomonas vaginalis PIKK family atypical protein kinase 0.0836 0.4597 0.9071
Trichomonas vaginalis PIKK family atypical protein kinase 0.0501 0.2312 0.4563
Trichomonas vaginalis PIKK family atypical protein kinase 0.0576 0.2824 0.5572
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0339 0.1207 0.2296
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0836 0.4597 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.072 0.3808 0.7515
Echinococcus multilocularis geminin 0.0205 0.029 0.0101
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.1088 0.6314 1
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0191 0.0197 0.0388
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0191 0.0197 0.0005
Trichomonas vaginalis PIKK family atypical protein kinase 0.0691 0.3609 0.7122
Giardia lamblia GTOR 0.0836 0.4597 1
Toxoplasma gondii FATC domain-containing protein 0.027 0.0738 0.1587
Trichomonas vaginalis PIKK family atypical protein kinase 0.027 0.0738 0.1456
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.1088 0.6314 1
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0191 0.0197 0.0388
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0191 0.0197 0.0005
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0616 0.3094 0.4741
Loa Loa (eye worm) phosphatidylinositol 3 0.0836 0.4597 0.519
Loa Loa (eye worm) hypothetical protein 0.019 0.0192 0.0216
Loa Loa (eye worm) phosphatidylinositol 3 0.1461 0.8856 1
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0191 0.0197 0.0311
Trichomonas vaginalis PIKK family atypical protein kinase 0.0646 0.33 0.6512
Trichomonas vaginalis PIKK family atypical protein kinase 0.0223 0.0418 0.0826
Trichomonas vaginalis PIKK family atypical protein kinase 0.0558 0.2703 0.5334
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.1088 0.6314 0.6242
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0298 0.093 0.2148
Trichomonas vaginalis PIKK family atypical protein kinase 0.0576 0.282 0.5566
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0737 0.3923 0.7652
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0359 0.134 0.2645
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0616 0.3094 0.2959
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.027 0.0738 0.0892
Loa Loa (eye worm) phosphatidylinositol 3 0.0594 0.2948 0.3328
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0721 0.3811 0.8215
Toxoplasma gondii target of rapamycin (TOR), putative 0.0691 0.3609 1
Entamoeba histolytica hypothetical protein 0.027 0.0738 0.1112
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0191 0.0197 0.5
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0359 0.134 0.1171
Trichomonas vaginalis PIKK family atypical protein kinase 0.0691 0.3609 0.7122
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0594 0.2948 0.6252
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.1088 0.6314 0.6242
Trichomonas vaginalis PIKK family atypical protein kinase 0.0501 0.2312 0.4563
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0836 0.4597 1
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0648 0.3313 0.6539
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.046 0.2035 0.4178
Trichomonas vaginalis PIKK family atypical protein kinase 0.0691 0.3609 0.7122
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0648 0.3313 0.6539
Trichomonas vaginalis PIKK family atypical protein kinase 0.0605 0.3023 0.5965
Brugia malayi phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative 0.0723 0.3828 0.5939
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.048 0.217 0.3647
Schistosoma mansoni hypothetical protein 0.0205 0.029 0.0101
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0905 0.5067 1
Echinococcus granulosus geminin 0.0205 0.029 0.0101
Loa Loa (eye worm) hypothetical protein 0.027 0.0738 0.0833
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.025 0.0602 0.0954
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.1628 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0576 0.2824 0.5572
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0359 0.134 0.2645
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0721 0.3811 0.8215
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0191 0.0197 0.0222
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0359 0.134 0.2123
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0836 0.4597 0.9034
Echinococcus multilocularis serine protein kinase ATM 0.027 0.0738 0.0557
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0191 0.0197 0.0311
Trypanosoma cruzi target of rapamycin kinase 3 0.0721 0.3811 0.6036
Trichomonas vaginalis PIKK family atypical protein kinase 0.072 0.3808 0.7515
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.027 0.0738 0.0892
Trichomonas vaginalis conserved hypothetical protein 0.0298 0.093 0.1835
Trichomonas vaginalis PIKK family atypical protein kinase 0.046 0.2035 0.4016
Loa Loa (eye worm) hypothetical protein 0.0289 0.0868 0.098
Trichomonas vaginalis PIKK family atypical protein kinase 0.072 0.3808 0.7515
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0191 0.0197 0.0388
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0905 0.5067 1
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.027 0.0738 0.1231
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0836 0.4597 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.046 0.2035 0.4016
Schistosoma mansoni fkbp-rapamycin associated protein 0.027 0.0738 0.0557
Leishmania major hypothetical protein, conserved 0.0213 0.0351 0.035
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0414 0.1718 0.3458
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0836 0.4597 0.4491

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.2593 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 2.5119 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of the ERK Signaling Pathway using a Homogeneous Screening Assay; Stimulation with EGF. (Class of assay: confirmatory) [Related pubchem assays: 995 ] ChEMBL. No reference
Potency (functional) 2.5929 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 11.6891 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 12.5893 um PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 31.6228 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) = 44.6684 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) 79.4328 uM PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Human Flap endonuclease 1 (FEN1). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488813] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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