Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | EYA transcriptional coactivator and phosphatase 2 | Starlite/ChEMBL | No references |
Homo sapiens | euchromatic histone-lysine N-methyltransferase 2 | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | serotonin transporter | 0.0272 | 0.9438 | 1 |
Echinococcus granulosus | uncharacterized sodium dependent transporter | 0.0046 | 0.0405 | 0.0429 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.0405 | 0.0429 |
Echinococcus multilocularis | sodium dependent neurotransmitter transporter | 0.0046 | 0.0405 | 0.0429 |
Plasmodium falciparum | amino acid transporter, putative | 0.0046 | 0.0405 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0272 | 0.9438 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.0405 | 0.0429 |
Toxoplasma gondii | Sodium:neurotransmitter symporter family protein | 0.0046 | 0.0405 | 1 |
Echinococcus granulosus | sodium:chloride dependent neurotransmitter | 0.0046 | 0.0405 | 0.0429 |
Echinococcus multilocularis | sodium and chloride dependent glycine | 0.0046 | 0.0405 | 0.0429 |
Echinococcus granulosus | sodium and chloride dependent glycine | 0.0046 | 0.0405 | 0.0429 |
Trichomonas vaginalis | set domain proteins, putative | 0.0286 | 1 | 0.5 |
Onchocerca volvulus | 0.0046 | 0.0405 | 0.0405 | |
Echinococcus granulosus | uncharacterized sodium dependent transporter | 0.0046 | 0.0405 | 0.0429 |
Schistosoma mansoni | sodium-dependent amino acid transporter | 0.0046 | 0.0405 | 0.0429 |
Schistosoma mansoni | sodium/chloride dependent neurotransmitter transporter | 0.0046 | 0.0405 | 0.0429 |
Toxoplasma gondii | Sodium:neurotransmitter symporter family protein | 0.0046 | 0.0405 | 1 |
Onchocerca volvulus | 0.0046 | 0.0405 | 0.0405 | |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.0405 | 0.0429 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.0405 | 0.0429 |
Schistosoma mansoni | sodium-dependent neurotransmitter transporter | 0.0046 | 0.0405 | 0.0429 |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.0272 | 0.9438 | 1 |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.0046 | 0.0405 | 0.0429 |
Schistosoma mansoni | sodium/chloride dependent transporter | 0.0046 | 0.0405 | 0.0429 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.0405 | 0.0429 |
Toxoplasma gondii | Sodium:neurotransmitter symporter family protein | 0.0046 | 0.0405 | 1 |
Brugia malayi | hypothetical protein | 0.0106 | 0.2815 | 0.2982 |
Onchocerca volvulus | 0.0272 | 0.9438 | 0.9438 | |
Schistosoma mansoni | norepinephrine/norepinephrine transporter | 0.0046 | 0.0405 | 0.0429 |
Schistosoma mansoni | sodium-dependent neurotransmitter transporter | 0.0046 | 0.0405 | 0.0429 |
Schistosoma mansoni | sodium-dependent neurotransmitter transporter | 0.0046 | 0.0405 | 0.0429 |
Echinococcus granulosus | sodium and chloride dependent glycine | 0.0046 | 0.0405 | 0.0429 |
Plasmodium vivax | hypothetical protein, conserved | 0.0046 | 0.0405 | 1 |
Schistosoma mansoni | sodium/chloride dependent transporter | 0.0272 | 0.9438 | 1 |
Echinococcus multilocularis | uncharacterized sodium dependent transporter | 0.0046 | 0.0405 | 0.0429 |
Schistosoma mansoni | norepinephrine/norepinephrine transporter | 0.0046 | 0.0405 | 0.0429 |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.0046 | 0.0405 | 0.0429 |
Loa Loa (eye worm) | hypothetical protein | 0.0106 | 0.2815 | 0.2982 |
Brugia malayi | Sodium:neurotransmitter symporter family protein 1, putative | 0.0046 | 0.0405 | 0.0429 |
Loa Loa (eye worm) | Sodium:neurotransmitter symporter family protein | 0.0046 | 0.0405 | 0.0429 |
Loa Loa (eye worm) | serotonin transporter b | 0.0272 | 0.9438 | 1 |
Plasmodium falciparum | transporter, putative | 0.0046 | 0.0405 | 0.5 |
Onchocerca volvulus | 0.0046 | 0.0405 | 0.0405 | |
Loa Loa (eye worm) | norepinephrine transporter | 0.0272 | 0.9438 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0106 | 0.2815 | 0.2982 |
Schistosoma mansoni | eyes absent homolog | 0.0106 | 0.2815 | 0.2982 |
Plasmodium vivax | amine transporter, putative | 0.0046 | 0.0405 | 1 |
Brugia malayi | hypothetical protein | 0.0046 | 0.0405 | 0.0429 |
Echinococcus granulosus | sodium dependent neurotransmitter transporter | 0.0046 | 0.0405 | 0.0429 |
Echinococcus multilocularis | sodium and chloride dependent glycine | 0.0046 | 0.0405 | 0.0429 |
Schistosoma mansoni | norepinephrine/norepinephrine transporter | 0.0272 | 0.9438 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.0405 | 0.0429 |
Chlamydia trachomatis | Ssodium-dependent amino acid transporter | 0.0046 | 0.0405 | 0.5 |
Toxoplasma gondii | hypothetical protein | 0.0046 | 0.0405 | 1 |
Toxoplasma gondii | hypothetical protein | 0.0046 | 0.0405 | 1 |
Loa Loa (eye worm) | Sodium:neurotransmitter symporter family protein | 0.0046 | 0.0405 | 0.0429 |
Loa Loa (eye worm) | solute carrier family 6 member 4 | 0.0272 | 0.9438 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.0405 | 0.0429 |
Schistosoma mansoni | sodium/chloride dependent neurotransmitter transporter | 0.0046 | 0.0405 | 0.0429 |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.0046 | 0.0405 | 0.0429 |
Loa Loa (eye worm) | hypothetical protein | 0.0272 | 0.9438 | 1 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0251 | 0.8611 | 0.9124 |
Brugia malayi | Pre-SET motif family protein | 0.0251 | 0.8611 | 0.9124 |
Echinococcus multilocularis | sodium:chloride dependent neurotransmitter | 0.0046 | 0.0405 | 0.0429 |
Loa Loa (eye worm) | hypothetical protein | 0.0272 | 0.9438 | 1 |
Schistosoma mansoni | sodium/chloride dependent neurotransmitter transporter | 0.0046 | 0.0405 | 0.0429 |
Treponema pallidum | sodium- and chloride- dependent transporter | 0.0272 | 0.9438 | 0.5 |
Echinococcus multilocularis | serotonin transporter | 0.0272 | 0.9438 | 1 |
Schistosoma mansoni | sodium/chloride dependent transporter | 0.0046 | 0.0405 | 0.0429 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 7.0795 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] | ChEMBL. | No reference |
Potency (functional) | 19.9526 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of the Phosphatase Activity of Eya2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488939] | ChEMBL. | No reference |
Potency (functional) | 28.1838 uM | PubChem BioAssay. qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.