Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | TAR DNA binding protein | Starlite/ChEMBL | No references |
Homo sapiens | GNAS complex locus | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Schistosoma mansoni | GTP-binding protein alpha subunit gna | GNAS complex locus | 394 aa | 450 aa | 28.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium leprae | proteasome (beta subunit) PrcB | 0.0335 | 1 | 0.5 |
Giardia lamblia | Proteasome subunit beta type 5 precursor | 0.0335 | 1 | 1 |
Schistosoma mansoni | proteasome subunit beta 2 (T01 family) | 0.0099 | 0.1564 | 0.1564 |
Trypanosoma cruzi | proteasome beta 6 subunit, putative | 0.0153 | 0.3483 | 0.2275 |
Entamoeba histolytica | proteasome subunit beta type 1, putative | 0.0153 | 0.3483 | 0.2275 |
Loa Loa (eye worm) | TAR-binding protein | 0.0076 | 0.076 | 0.076 |
Trichomonas vaginalis | Family T1, proteasome beta subunit, threonine peptidase | 0.0153 | 0.3483 | 0.2275 |
Mycobacterium ulcerans | proteasome PrcB | 0.0335 | 1 | 0.5 |
Plasmodium vivax | proteasome subunit beta type-1, putative | 0.0153 | 0.3483 | 0.2275 |
Echinococcus multilocularis | proteasome (prosome, macropain) | 0.0335 | 1 | 1 |
Trypanosoma cruzi | proteasome subunit beta type-5, putative | 0.0335 | 1 | 1 |
Toxoplasma gondii | proteasome subunit beta type 1, putative | 0.0153 | 0.3483 | 0.2275 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0076 | 0.076 | 0.076 |
Brugia malayi | RNA binding protein | 0.0076 | 0.076 | 0.076 |
Trichomonas vaginalis | Family T1, proteasome beta subunit, threonine peptidase | 0.0335 | 1 | 1 |
Brugia malayi | proteasome subunit beta type 1 | 0.0153 | 0.3483 | 0.3483 |
Echinococcus multilocularis | proteasome (prosome, macropain) subunit, beta | 0.0099 | 0.1564 | 0.1564 |
Brugia malayi | proteasome subunit beta type 2 | 0.0099 | 0.1564 | 0.1564 |
Schistosoma mansoni | proteasome subunit beta 1 (T01 family) | 0.0153 | 0.3483 | 0.3483 |
Echinococcus multilocularis | proteasome (prosome, macropain) subunit, beta | 0.0153 | 0.3483 | 0.3483 |
Echinococcus granulosus | proteasome prosome macropain | 0.0335 | 1 | 1 |
Giardia lamblia | Proteasome subunit beta type 1 | 0.0153 | 0.3483 | 0.2275 |
Plasmodium vivax | proteasome subunit beta type-5, putative | 0.0335 | 1 | 1 |
Trypanosoma cruzi | proteasome subunit beta type-5, putative | 0.0335 | 1 | 1 |
Toxoplasma gondii | proteasome subunit beta type, putative | 0.0335 | 1 | 1 |
Loa Loa (eye worm) | proteasome subunit beta type 1 | 0.0153 | 0.3483 | 0.3483 |
Loa Loa (eye worm) | RNA binding protein | 0.0076 | 0.076 | 0.076 |
Entamoeba histolytica | proteasome subunit beta type 5 precursor, putative | 0.0335 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.076 | 0.076 |
Plasmodium falciparum | proteasome subunit beta type-1, putative | 0.0153 | 0.3483 | 0.2275 |
Plasmodium falciparum | proteasome subunit beta type-5 | 0.0335 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.076 | 0.076 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0076 | 0.076 | 0.076 |
Loa Loa (eye worm) | proteasome A-type and B-type family protein | 0.0335 | 1 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.0076 | 0.076 | 0.076 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.076 | 0.076 |
Schistosoma mansoni | proteasome subunit beta 2 (T01 family) | 0.0099 | 0.1564 | 0.1564 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.076 | 0.076 |
Trypanosoma brucei | proteasome subunit beta type-5, putative | 0.0335 | 1 | 1 |
Brugia malayi | TAR-binding protein | 0.0076 | 0.076 | 0.076 |
Leishmania major | proteasome beta 6 subunit, putative,20S proteasome beta 6 subunit, putative | 0.0153 | 0.3483 | 0.2275 |
Trypanosoma brucei | proteasome beta 6 subunit | 0.0153 | 0.3483 | 0.2275 |
Echinococcus granulosus | proteasome prosome macropain subunit beta | 0.0153 | 0.3483 | 0.3483 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.076 | 0.076 |
Loa Loa (eye worm) | proteasome subunit beta type 2 | 0.0099 | 0.1564 | 0.1564 |
Echinococcus multilocularis | tar DNA binding protein | 0.0076 | 0.076 | 0.076 |
Trypanosoma cruzi | proteasome beta 6 subunit, putative | 0.0153 | 0.3483 | 0.2275 |
Mycobacterium tuberculosis | Proteasome beta subunit PrcB; assembles with alpha subunit PrcA. | 0.0335 | 1 | 0.5 |
Schistosoma mansoni | proteasome catalytic subunit 3 (T01 family) | 0.0335 | 1 | 1 |
Echinococcus granulosus | proteasome prosome macropain subunit beta | 0.0099 | 0.1564 | 0.1564 |
Leishmania major | proteasome beta 5 subunit, putative | 0.0335 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 6.3096 uM | PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 7.0795 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 22.3872 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] | ChEMBL. | No reference |
Potency (functional) | 35.4813 uM | PubChem BioAssay. qHTS for Inhibitors of Glutaminase (GLS). (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.