TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 436.5 | Formula: C25H28N2O5
H donors: 1 H acceptors: 3 LogP: 3.53 Rotable bonds: 9
Rule of 5 violations (Lipinski): 1
SMILES: COC(=O)[C@@]12CCCN2C(=O)[C@@](CC1)(NC(=O)OCc1ccccc1)Cc1ccccc1
InChi: 1S/C25H28N2O5/c1-31-22(29)25-13-8-16-27(25)21(28)24(14-15-25,17-19-9-4-2-5-10-19)26-23(30)32-18-20-11-6-3-7-12-20/h2-7,9-12H,8,13-18H2,1H3,(H,26,30)/t24-,25+/m0/s1
InChiKey: IKKUIVKTPRDZJW-LOSJGSFVSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trypanosoma brucei	trypanothione reductase	0.0049	0.0786	0.2093
Brugia malayi	cathepsin B-like cysteine proteinase	0.0153	0.3327	0.622
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0061	0.1086	0.1086
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0093	0.1856	1
Schistosoma mansoni	tar DNA-binding protein	0.0065	0.1164	0.1164
Plasmodium falciparum	serine repeat antigen 3	0.002	0.0083	0.0448
Toxoplasma gondii	cathepsin B	0.0061	0.1086	0.5852
Trypanosoma cruzi	cysteine peptidase, putative	0.0029	0.03	0.067
Echinococcus multilocularis	cysteine protease	0.0093	0.1856	0.558
Trypanosoma cruzi	trypanothione reductase, putative	0.0049	0.0786	0.2167
Trypanosoma cruzi	cruzipain precursor, putative	0.0093	0.1856	0.5467
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0093	0.1856	1
Trichomonas vaginalis	ubiquitin-conjugating enzyme E2, putative	0.0038	0.0503	0.2709
Echinococcus multilocularis	cathepsin L	0.005	0.0802	0.2411
Echinococcus multilocularis	rac serine:threonine kinase	0.0027	0.0246	0.0738
Brugia malayi	Cathepsin L-like precursor	0.0093	0.1856	0.3471
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.002	0.0083	0.0448
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0093	0.1856	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0093	0.1856	1
Echinococcus granulosus	cathepsin b	0.0153	0.3327	1
Plasmodium vivax	rac-beta serine/threonine protein kinase, putative	0.0025	0.0186	0.1001
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0093	0.1856	1
Plasmodium falciparum	serine repeat antigen 2	0.002	0.0083	0.0448
Schistosoma mansoni	cathepsin F (C01 family)	0.0093	0.1856	0.1856
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.0112	0.2329	0.8342
Leishmania major	cathepsin L-like protease	0.0093	0.1856	1
Loa Loa (eye worm)	thioredoxin reductase	0.0049	0.0786	0.147
Echinococcus multilocularis	nervana 2	0.0024	0.0179	0.0538
Trypanosoma cruzi	cysteine protease, putative	0.005	0.0802	0.2216
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0153	0.3327	0.3327
Onchocerca volvulus		0.0093	0.1856	1
Brugia malayi	Papain family cysteine protease containing protein	0.005	0.0802	0.15
Brugia malayi	cathepsin L-like cysteine proteinase, identical	0.0029	0.03	0.0562
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0093	0.1856	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0093	0.1856	1
Plasmodium vivax	thioredoxin reductase, putative	0.0049	0.0786	0.4235
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.002	0.0083	0.0083
Trypanosoma cruzi	cysteine peptidase, putative	0.0093	0.1856	0.5467
Echinococcus granulosus	nervana 2	0.0024	0.0179	0.0538
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0063	0.1138	0.6128
Plasmodium falciparum	dipeptidyl aminopeptidase 1	0.002	0.0083	0.0448
Trypanosoma cruzi	ubiquitin-conjugating enzyme E2, putative	0.0038	0.0503	0.1294
Brugia malayi	ubiquitin conjugating enzyme protein 13	0.0038	0.0503	0.094
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0093	0.1856	1
Brugia malayi	Protein kinase domain containing protein	0.004	0.055	0.1029
Entamoeba histolytica	cysteine protease, putative	0.005	0.0802	0.4054
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0093	0.1856	0.3471
Trichomonas vaginalis	conserved hypothetical protein	0.002	0.0083	0.0448
Entamoeba histolytica	cysteine protease, putative	0.005	0.0802	0.4054
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0093	0.1856	1
Leishmania major	cathepsin L-like protease	0.0093	0.1856	1
Toxoplasma gondii	AGC kinase	0.0037	0.0491	0.2643
Echinococcus multilocularis	cathepsin L cysteine protease	0.0093	0.1856	0.558
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.0125	0.2636	1
Echinococcus multilocularis	thioredoxin glutathione reductase	0.0049	0.0786	0.2363
Brugia malayi	Ubiquitin conjugating enzyme protein 13	0.0038	0.0503	0.094
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.005	0.0802	0.221
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0029	0.03	0.0562
Toxoplasma gondii	ubiquitin-conjugating enzyme subfamily protein	0.0038	0.0503	0.2709
Loa Loa (eye worm)	hypothetical protein	0.0063	0.1138	0.2127
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0093	0.1856	1
Plasmodium falciparum	serine repeat antigen 1	0.002	0.0083	0.0448
Plasmodium vivax	serine-repeat antigen 4 (SERA)	0.002	0.0083	0.0448
Loa Loa (eye worm)	cysteine proteinase cathepsin Z	0.002	0.0083	0.0156
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0153	0.3327	1
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0093	0.1856	0.558
Echinococcus multilocularis	cathepsin L cysteine protease	0.0093	0.1856	0.558
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.002	0.0083	0.0448
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.002	0.0083	0.0448
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0093	0.1856	1
Plasmodium falciparum	thioredoxin reductase	0.0049	0.0786	0.4235
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.002	0.0083	0.0448
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0093	0.1856	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.002	0.0083	0.0448
Giardia lamblia	Cathepsin B precursor	0.0061	0.1086	1
Brugia malayi	Cathepsin L-like precursor	0.0093	0.1856	0.3471
Echinococcus multilocularis	cathepsin b	0.0153	0.3327	1
Entamoeba histolytica	cysteine proteinase, putative	0.005	0.0802	0.4054
Plasmodium falciparum	ubiquitin-conjugating enzyme E2 N, putative	0.0038	0.0503	0.2709
Entamoeba histolytica	cysteine protease, putative	0.0093	0.1856	1
Schistosoma mansoni	cathepsin F (C01 family)	0.0063	0.1138	0.1138
Giardia lamblia	Cathepsin B precursor	0.0061	0.1086	1
Entamoeba histolytica	protein kinase, putative	0.0037	0.0491	0.2298
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0063	0.1138	0.6128
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0093	0.1856	1
Mycobacterium tuberculosis	Probable reductase	0.0112	0.2329	0.8342
Echinococcus multilocularis	ubiquitin conjugating enzyme E2 N	0.0038	0.0503	0.1512
Onchocerca volvulus		0.0093	0.1856	1
Plasmodium falciparum	serine repeat antigen 4	0.002	0.0083	0.0448
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.002	0.0083	0.0448
Entamoeba histolytica	cysteine protease, putative	0.005	0.0802	0.4054
Loa Loa (eye worm)	hypothetical protein	0.0153	0.3327	0.622
Trichomonas vaginalis	AGC family protein kinase	0.004	0.055	0.2965
Entamoeba histolytica	cysteine protease, putative	0.005	0.0802	0.4054
Loa Loa (eye worm)	ubiquitin conjugating enzyme protein 13	0.0038	0.0503	0.094
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.002	0.0083	0.0448
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.005	0.0802	0.432
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.002	0.0083	0.0448
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0093	0.1856	1
Trypanosoma cruzi	ubiquitin-conjugating enzyme E2, putative	0.0038	0.0503	0.1294
Echinococcus multilocularis	sodium:potassium dependent atpase beta subunit	0.0024	0.0179	0.0538
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0052	0.0852	0.1592
Brugia malayi	cahepsin L-like non-peptiedase homolog	0.002	0.0083	0.0156
Schistosoma mansoni	cathepsin B (C01 family)	0.002	0.0083	0.0083
Schistosoma mansoni	dipeptidyl-peptidase I (C01 family)	0.002	0.0083	0.0083
Onchocerca volvulus		0.0063	0.1138	0.6128
Echinococcus multilocularis	cathepsin b	0.0153	0.3327	1
Leishmania major	cathepsin L-like protease	0.0093	0.1856	1
Brugia malayi	cathepsin Z-like cysteine proteinase	0.002	0.0083	0.0156
Onchocerca volvulus	Cathepsin L homolog	0.0093	0.1856	1
Entamoeba histolytica	cysteine proteinase, putative	0.005	0.0802	0.4054
Entamoeba histolytica	cysteine protease, putative	0.005	0.0802	0.4054
Plasmodium vivax	serine-repeat antigen 5 (SERA)	0.002	0.0083	0.0448
Echinococcus granulosus	serine/threonine protein kinase	0.0027	0.0246	0.0738
Trichomonas vaginalis	AGC family protein kinase	0.004	0.055	0.2965
Entamoeba histolytica	protein kinase, putative	0.004	0.055	0.2635
Trypanosoma brucei	rac serine-threonine kinase, putative	0.004	0.055	0.0351
Entamoeba histolytica	cysteine proteinase 1, putative	0.005	0.0802	0.4054
Schistosoma mansoni	tar DNA-binding protein	0.0065	0.1164	0.1164
Brugia malayi	RNA recognition motif domain containing protein	0.0065	0.1164	0.2177
Schistosoma mansoni	cathepsin S (C01 family)	0.002	0.0083	0.0083
Schistosoma mansoni	serine/threonine-protein kinase	0.0027	0.0246	0.0246
Entamoeba histolytica	cysteine proteinase, putative	0.005	0.0802	0.4054
Brugia malayi	Cathepsin L-like precursor	0.0093	0.1856	0.3471
Leishmania major	cathepsin L-like protease	0.0093	0.1856	1
Loa Loa (eye worm)	hypothetical protein	0.002	0.0083	0.0156
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0093	0.1856	1
Brugia malayi	Papain family cysteine protease containing protein	0.0093	0.1856	0.3471
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0093	0.1856	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0153	0.3327	0.3327
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0093	0.1856	1
Schistosoma mansoni	tar DNA-binding protein	0.0065	0.1164	0.1164
Plasmodium falciparum	serine repeat antigen 5	0.002	0.0083	0.0448
Schistosoma mansoni	tar DNA-binding protein	0.0065	0.1164	0.1164
Trichomonas vaginalis	Clan CA, family C1, cathepsin H-like cysteine peptidase	0.002	0.0083	0.0448
Loa Loa (eye worm)	AGC/AKT protein kinase	0.004	0.055	0.1029
Echinococcus granulosus	ubiquitin conjugating enzyme E2 N	0.0038	0.0503	0.1512
Leishmania major	cathepsin L-like protease	0.0093	0.1856	1
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.002	0.0083	0.0156
Leishmania major	cathepsin L-like protease	0.0093	0.1856	1
Schistosoma mansoni	ubiquitin conjugating enzyme 13	0.0038	0.0503	0.0503
Brugia malayi	Papain family cysteine protease containing protein	0.002	0.0083	0.0156
Trichomonas vaginalis	conserved hypothetical protein	0.002	0.0083	0.0448
Plasmodium vivax	vivapain-2	0.0093	0.1856	1
Schistosoma mansoni	hypothetical protein	0.0035	0.045	0.045
Trypanosoma cruzi	rac serine-threonine kinase, putative	0.0027	0.0246	0.0501
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.002	0.0083	0.0448
Entamoeba histolytica	protein kinase, putative	0.004	0.055	0.2635
Echinococcus granulosus	cathepsin L cysteine protease	0.005	0.0802	0.2411
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0093	0.1856	1
Plasmodium vivax	serine-repeat antigen 3 (SERA)	0.002	0.0083	0.0448
Echinococcus multilocularis	serine threonine protein kinase nrc serine threonine protein kinase gad	0.0025	0.0186	0.0559
Plasmodium vivax	unspecified product	0.005	0.0802	0.432
Onchocerca volvulus		0.0093	0.1856	1
Brugia malayi	Cathepsin L-like precursor	0.0093	0.1856	0.3471
Plasmodium vivax	unspecified product	0.0029	0.03	0.1618
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0093	0.1856	0.3471
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.005	0.0802	0.0802
Toxoplasma gondii	cathepsin CPL	0.0093	0.1856	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0093	0.1856	1
Onchocerca volvulus		0.0093	0.1856	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0093	0.1856	1
Brugia malayi	Thioredoxin reductase	0.0049	0.0786	0.147
Entamoeba histolytica	protein kinase 2, putative	0.0025	0.0186	0.0579
Brugia malayi	Cathepsin L-like precursor	0.0093	0.1856	0.3471
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0093	0.1856	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0093	0.1856	0.5467
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.0125	0.2636	1
Echinococcus granulosus	cathepsin l1	0.0063	0.1138	0.3419
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0063	0.1138	0.2127
Trypanosoma cruzi	cysteine proteinase, putative	0.005	0.0802	0.2216
Loa Loa (eye worm)	RNA binding protein	0.0065	0.1164	0.2177
Plasmodium vivax	glutathione reductase, putative	0.0049	0.0786	0.4235
Brugia malayi	cathepsin L-like cysteine proteinase	0.002	0.0083	0.0156
Plasmodium falciparum	dipeptidyl aminopeptidase 2	0.002	0.0083	0.0448
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0093	0.1856	0.558
Trichomonas vaginalis	AGC family protein kinase	0.004	0.055	0.2965
Leishmania major	cysteine peptidase A (CPA)	0.0093	0.1856	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0093	0.1856	1
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0235	0.5348	1
Brugia malayi	Papain family cysteine protease containing protein	0.002	0.0083	0.0156
Plasmodium falciparum	serine repeat antigen 6	0.002	0.0083	0.0448
Trichomonas vaginalis	AGC family protein kinase	0.004	0.055	0.2965
Brugia malayi	follicle stimulating hormone receptor	0.0235	0.5348	1
Leishmania major	cathepsin L-like protease	0.0093	0.1856	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0093	0.1856	1
Entamoeba histolytica	cysteine proteinase 2	0.005	0.0802	0.4054
Entamoeba histolytica	cysteine proteinase, putative	0.005	0.0802	0.4054
Entamoeba histolytica	ubiquitin-conjugating enzyme family protein	0.0038	0.0503	0.2367
Brugia malayi	p70 ribosomal S6 kinase beta	0.0037	0.0491	0.0917
Echinococcus multilocularis	nervana 2	0.0024	0.0179	0.0538
Echinococcus granulosus	cathepsin L	0.005	0.0802	0.2411
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0061	0.1086	0.5852
Brugia malayi	RNA binding protein	0.0065	0.1164	0.2177
Entamoeba histolytica	cysteine proteinase, putative	0.0063	0.1138	0.5946
Echinococcus multilocularis	Glutaredoxin protein 5	0.0024	0.0179	0.0538
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0063	0.1138	0.325
Brugia malayi	cathepsin F-like cysteine proteinase	0.0029	0.03	0.0562
Toxoplasma gondii	cathepsin CPC1	0.002	0.0083	0.0448
Giardia lamblia	Cathepsin B precursor	0.0061	0.1086	1
Echinococcus granulosus	cathepsin L	0.002	0.0083	0.025
Schistosoma mansoni	cathepsin s	0.0029	0.03	0.03
Echinococcus granulosus	thioredoxin glutathione reductase	0.0049	0.0786	0.2363
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or H-like cysteine peptidase	0.002	0.0083	0.0448
Trichomonas vaginalis	Clan CA, family C1, cathepsin F-like cysteine peptidase	0.002	0.0083	0.0448
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.0112	0.2329	0.8342
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.002	0.0083	0.0448
Onchocerca volvulus	Cathepsin L homolog	0.002	0.0083	0.0448
Brugia malayi	Cathepsin L-like precursor	0.0093	0.1856	0.3471
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0093	0.1856	1
Loa Loa (eye worm)	cysteine protease	0.0093	0.1856	0.3471
Onchocerca volvulus		0.0093	0.1856	1
Echinococcus granulosus	cathepsin b	0.0153	0.3327	1
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.0112	0.2329	0.8342
Loa Loa (eye worm)	AGC/RSK/P70 protein kinase	0.0037	0.0491	0.0917
Schistosoma mansoni	tar DNA-binding protein	0.0065	0.1164	0.1164
Trypanosoma cruzi	rac serine-threonine kinase, putative	0.0025	0.0186	0.0316
Loa Loa (eye worm)	glutathione reductase	0.0049	0.0786	0.147
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0093	0.1856	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0093	0.1856	1
Plasmodium vivax	dipeptidyl aminopeptidase 3, putative	0.002	0.0083	0.0448
Brugia malayi	cathepsin Z-like cysteine proteinase	0.002	0.0083	0.0156
Plasmodium falciparum	serine repeat antigen 8	0.002	0.0083	0.0448
Loa Loa (eye worm)	hypothetical protein	0.0063	0.1138	0.2127
Loa Loa (eye worm)	cathepsin B	0.0061	0.1086	0.2031
Brugia malayi	Papain family cysteine protease containing protein	0.005	0.0802	0.15
Entamoeba histolytica	cysteine protease, putative	0.005	0.0802	0.4054
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0027	0.0246	0.0916
Plasmodium vivax	vivapain-3	0.005	0.0802	0.432
Plasmodium vivax	vivapain-1	0.005	0.0802	0.432
Onchocerca volvulus	Cathepsin F homolog	0.0093	0.1856	1
Echinococcus granulosus	Glutaredoxin protein 5	0.0024	0.0179	0.0538
Entamoeba histolytica	cysteine protease, putative	0.005	0.0802	0.4054
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	0.0061	0.1086	0.4311
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.002	0.0083	0.0156
Echinococcus multilocularis	cysteine protease	0.0093	0.1856	0.558
Leishmania major	cathepsin L-like protease	0.0093	0.1856	1
Echinococcus multilocularis	tar DNA binding protein	0.0065	0.1164	0.35
Trichomonas vaginalis	AGC family protein kinase	0.004	0.055	0.2965
Brugia malayi	cathepsin L-like precursor	0.0063	0.1138	0.2127
Brugia malayi	fibroinase precursor	0.002	0.0083	0.0156
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.0153	0.3327	0.3327
Entamoeba histolytica	cysteine protease, putative	0.005	0.0802	0.4054
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.002	0.0083	0.0083
Echinococcus granulosus	calcium:calmodulin dependent protein kinase	0.0025	0.0186	0.0559
Trypanosoma cruzi	cysteine peptidase, putative	0.005	0.0802	0.2216
Trypanosoma cruzi	cruzipain precursor, putative	0.0029	0.03	0.067
Echinococcus granulosus	serine threonine protein kinase nrc	0.0025	0.0186	0.0559
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0093	0.1856	1
Loa Loa (eye worm)	hypothetical protein	0.002	0.0083	0.0156
Plasmodium falciparum	serine repeat antigen 7	0.002	0.0083	0.0448
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.002	0.0083	0.0448
Brugia malayi	Cathepsin L-like precursor	0.0063	0.1138	0.2127
Loa Loa (eye worm)	fibroinase	0.0093	0.1856	0.3471
Loa Loa (eye worm)	ctsf protein	0.0093	0.1856	0.3471
Entamoeba histolytica	cysteine proteinase, putative	0.0093	0.1856	1
Entamoeba histolytica	cysteine protease, putative	0.005	0.0802	0.4054
Toxoplasma gondii	preprocathepsin c precursor, putative	0.002	0.0083	0.0448
Trypanosoma cruzi	cysteine peptidase, putative	0.0093	0.1856	0.5467
Loa Loa (eye worm)	hypothetical protein	0.002	0.0083	0.0156
Loa Loa (eye worm)	hypothetical protein	0.0035	0.045	0.0841
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.005	0.0802	0.2216
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0027	0.0246	0.0916
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.002	0.0083	0.0083
Brugia malayi	Cathepsin L-like precursor	0.0029	0.03	0.0562
Echinococcus granulosus	cysteine protease	0.005	0.0802	0.2411
Loa Loa (eye worm)	hypothetical protein	0.0029	0.03	0.0562
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0093	0.1856	1
Plasmodium vivax	unspecified product	0.002	0.0083	0.0448
Toxoplasma gondii	cathepsin CPC2	0.002	0.0083	0.0448
Trypanosoma cruzi	cysteine peptidase, putative	0.0093	0.1856	0.5467
Trypanosoma brucei	cysteine peptidase C (CPC)	0.0061	0.1086	0.4311
Brugia malayi	Papain family cysteine protease containing protein	0.002	0.0083	0.0156
Loa Loa (eye worm)	hypothetical protein	0.002	0.0083	0.0156
Brugia malayi	cathepsin L precursor	0.002	0.0083	0.0156
Brugia malayi	sulfakinin receptor protein	0.0217	0.49	0.9162
Plasmodium vivax	dipeptidyl aminopeptidase 2, putative	0.002	0.0083	0.0448
Plasmodium vivax	serine-repeat antigen (SERA)	0.002	0.0083	0.0448
Plasmodium falciparum	cysteine proteinase falcipain 1	0.005	0.0802	0.432
Entamoeba histolytica	cysteine protease, putative	0.005	0.0802	0.4054
Brugia malayi	latrophilin 2 splice variant baaae	0.0035	0.045	0.0841
Plasmodium vivax	serine-repeat antigen 4 (SERA), putative	0.002	0.0083	0.0448
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0852	0.1592
Trichomonas vaginalis	AGC family protein kinase	0.004	0.055	0.2965
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.002	0.0083	0.0083
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0093	0.1856	0.558
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.0125	0.2636	1
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.005	0.0802	0.0802
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0093	0.1856	1
Plasmodium vivax	serine-repeat antigen (SERA), putative	0.002	0.0083	0.0448
Loa Loa (eye worm)	hypothetical protein	0.002	0.0083	0.0156
Entamoeba histolytica	cysteine protease, putative	0.005	0.0802	0.4054
Trichomonas vaginalis	ubiquitin-conjugating enzyme E2, putative	0.0038	0.0503	0.2709
Plasmodium vivax	vivapain-2	0.0093	0.1856	1
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0093	0.1856	0.558
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0093	0.1856	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.002	0.0083	0.0448
Trypanosoma cruzi	Protein kinase B	0.0027	0.0246	0.0501
Onchocerca volvulus		0.0093	0.1856	1
Plasmodium vivax	serine-repeat antigen 2 (SERA)	0.002	0.0083	0.0448
Echinococcus granulosus	nervana 2	0.0024	0.0179	0.0538
Loa Loa (eye worm)	ubiquitin conjugating enzyme protein 13	0.0038	0.0503	0.094
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.002	0.0083	0.0448
Entamoeba histolytica	cysteine proteinase, putative	0.0093	0.1856	1
Plasmodium vivax	ubiquitin-conjugating enzyme E2 N, putative	0.0038	0.0503	0.2709
Echinococcus granulosus	cathepsin l1	0.0093	0.1856	0.558
Echinococcus granulosus	tar DNA binding protein	0.0065	0.1164	0.35
Plasmodium falciparum	dipeptidyl aminopeptidase 3	0.002	0.0083	0.0448
Toxoplasma gondii	thioredoxin reductase	0.0049	0.0786	0.4235
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.002	0.0083	0.0083
Trichomonas vaginalis	Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase	0.002	0.0083	0.0448
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.002	0.0083	0.0083
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0052	0.0852	0.1592
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0093	0.1856	1
Brugia malayi	cathepsin F-like cysteine proteinase	0.002	0.0083	0.0156
Brugia malayi	glutathione reductase	0.0049	0.0786	0.147
Brugia malayi	TAR-binding protein	0.0065	0.1164	0.2177
Loa Loa (eye worm)	TAR-binding protein	0.0065	0.1164	0.2177
Onchocerca volvulus		0.002	0.0083	0.0448
Echinococcus multilocularis	cathepsin L	0.002	0.0083	0.025
Onchocerca volvulus	Cathepsin L homolog	0.0093	0.1856	1
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0061	0.1086	0.3093
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.005	0.0802	0.221
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.005	0.0802	0.432
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0093	0.1856	1
Plasmodium falciparum	RAC-beta serine/threonine protein kinase	0.0025	0.0186	0.1001
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0093	0.1856	1
Plasmodium vivax	dipeptidyl aminopeptidase 1, putative	0.002	0.0083	0.0448
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0093	0.1856	1
Schistosoma mansoni	serine/threonine-protein kinase	0.0027	0.0246	0.0246
Plasmodium vivax	serine-repeat antigen (SERA), putative	0.002	0.0083	0.0448
Schistosoma mansoni	cathepsin F (C01 family)	0.0093	0.1856	0.1856
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.002	0.0083	0.0083
Entamoeba histolytica	cysteine protease, putative	0.005	0.0802	0.4054
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0052	0.0852	0.1592
Entamoeba histolytica	cysteine protease, putative	0.005	0.0802	0.4054
Schistosoma mansoni	cathepsin C	0.002	0.0083	0.0083
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0093	0.1856	1
Loa Loa (eye worm)	hypothetical protein	0.0029	0.03	0.0562
Loa Loa (eye worm)	hypothetical protein	0.0093	0.1856	0.3471
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.0112	0.2329	0.8342
Leishmania major	trypanothione reductase	0.0049	0.0786	0.2093
Trichomonas vaginalis	AGC family protein kinase	0.004	0.055	0.2965
Trypanosoma cruzi	cysteine proteinase, putative	0.005	0.0802	0.2216
Brugia malayi	Cathepsin L-like precursor	0.0063	0.1138	0.2127
Echinococcus granulosus	sodium:potassium dependent atpase beta subunit	0.0024	0.0179	0.0538
Plasmodium falciparum	glutathione reductase	0.0049	0.0786	0.4235
Loa Loa (eye worm)	hypothetical protein	0.002	0.0083	0.0156
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0065	0.1164	0.2177
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0153	0.3327	0.3327
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0093	0.1856	1
Mycobacterium tuberculosis	Probable oxidoreductase	0.0125	0.2636	1
Schistosoma mansoni	subfamily C1A non-peptidase homologue (C01 family)	0.002	0.0083	0.0083
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0093	0.1856	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0093	0.1856	1
Onchocerca volvulus		0.0093	0.1856	1
Mycobacterium tuberculosis	Probable dehydrogenase	0.0112	0.2329	0.8342
Giardia lamblia	Kinase, AGC PKA	0.0025	0.0186	0.1023
Plasmodium vivax	serine-repeat antigen (SERA)	0.002	0.0083	0.0448
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.005	0.0802	0.0802
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0093	0.1856	1
Plasmodium falciparum	serine repeat antigen 9	0.002	0.0083	0.0448
Loa Loa (eye worm)	hypothetical protein	0.0217	0.49	0.9162
Brugia malayi	hypothetical protein	0.0217	0.49	0.9162
Loa Loa (eye worm)	hypothetical protein	0.0029	0.03	0.0562
Loa Loa (eye worm)	hypothetical protein	0.0063	0.1138	0.2127

Activities

Activity type	Activity value	Assay description	Source	Reference
Kd (binding)	= 0.000124 M	Binding affinity towards cyclophilin A by fluorescence	ChEMBL.	11472213
Kd (binding)	= 0.000124 M	Binding affinity towards cyclophilin A by fluorescence	ChEMBL.	11472213

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 144337