Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | survival of motor neuron 2, centromeric | Starlite/ChEMBL | No references |
Homo sapiens | geminin, DNA replication inhibitor | Starlite/ChEMBL | No references |
Homo sapiens | GNAS complex locus | Starlite/ChEMBL | No references |
Mus musculus | RAR-related orphan receptor gamma | Starlite/ChEMBL | No references |
Homo sapiens | phosphodiesterase 7A | Starlite/ChEMBL | References |
Homo sapiens | TAR DNA binding protein | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Schistosoma mansoni | GTP-binding protein alpha subunit gna | GNAS complex locus | 394 aa | 450 aa | 28.7 % |
Brugia malayi | Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X | geminin, DNA replication inhibitor | 209 aa | 176 aa | 27.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0119 | 0.2128 | 0.1971 |
Brugia malayi | hypothetical protein | 0.0286 | 0.5819 | 0.5736 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0071 | 0.1076 | 0.1091 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.005 | 0.0606 | 1 |
Brugia malayi | hypothetical protein | 0.0071 | 0.1076 | 0.0897 |
Schistosoma mansoni | jun-related protein | 0.021 | 0.4148 | 0.6016 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.0606 | 0.0418 |
Entamoeba histolytica | hypothetical protein | 0.0071 | 0.1076 | 0.5 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.0728 | 0.0739 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.005 | 0.0606 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.0076 | 0.1198 | 0.1216 |
Brugia malayi | hypothetical protein | 0.0203 | 0.3991 | 0.3871 |
Onchocerca volvulus | 0.0203 | 0.3991 | 0.3472 | |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0031 | 0.0196 | 0.0199 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0071 | 0.1076 | 0.1091 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.0728 | 0.0739 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.1198 | 0.1738 |
Onchocerca volvulus | 0.0475 | 1 | 1 | |
Schistosoma mansoni | hypothetical protein | 0.0334 | 0.6895 | 1 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.005 | 0.0606 | 1 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.005 | 0.0606 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.0728 | 0.1056 |
Entamoeba histolytica | hypothetical protein | 0.0071 | 0.1076 | 0.5 |
Echinococcus multilocularis | jun protein | 0.0258 | 0.5217 | 0.5294 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.005 | 0.0606 | 1 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription factor | 0.0258 | 0.5217 | 0.5294 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.1198 | 0.1738 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0076 | 0.1198 | 0.1022 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0031 | 0.0196 | 0.0199 |
Brugia malayi | hypothetical protein | 0.005 | 0.0606 | 0.0418 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.005 | 0.0606 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.1198 | 0.1738 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0286 | 0.5819 | 0.5905 |
Echinococcus multilocularis | tar DNA binding protein | 0.0076 | 0.1198 | 0.1216 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.0728 | 0.0739 |
Echinococcus multilocularis | isocitrate dehydrogenase 2 (NADP+) | 0.0031 | 0.0196 | 0.0199 |
Entamoeba histolytica | hypothetical protein | 0.0071 | 0.1076 | 0.5 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0031 | 0.0196 | 0.0199 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.1198 | 0.1738 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.005 | 0.0606 | 1 |
Echinococcus granulosus | geminin | 0.0334 | 0.6895 | 0.6996 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.1198 | 0.1738 |
Schistosoma mansoni | hypothetical protein | 0.0071 | 0.1076 | 0.156 |
Echinococcus multilocularis | high affinity cAMP specific 3',5' cyclic | 0.0468 | 0.9855 | 1 |
Brugia malayi | MH2 domain containing protein | 0.0119 | 0.2128 | 0.1971 |
Loa Loa (eye worm) | RNA binding protein | 0.0076 | 0.1198 | 0.1022 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0071 | 0.1076 | 0.156 |
Echinococcus multilocularis | isocitrate dehydrogenase | 0.0031 | 0.0196 | 0.0199 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.0728 | 0.0739 |
Brugia malayi | hypothetical protein | 0.0032 | 0.0217 | 0.0021 |
Brugia malayi | RNA binding protein | 0.0076 | 0.1198 | 0.1022 |
Mycobacterium tuberculosis | Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) | 0.0031 | 0.0196 | 0.5 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.0728 | 0.1056 |
Schistosoma mansoni | hypothetical protein | 0.0334 | 0.6895 | 1 |
Loa Loa (eye worm) | pax transcription factor protein 2 | 0.0475 | 1 | 1 |
Echinococcus granulosus | high affinity cAMP specific 3'5' cyclic | 0.0468 | 0.9855 | 1 |
Leishmania major | hypothetical protein, conserved | 0.005 | 0.0606 | 1 |
Brugia malayi | bZIP transcription factor family protein | 0.0258 | 0.5217 | 0.5122 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0076 | 0.1198 | 0.1022 |
Schistosoma mansoni | survival motor neuron protein | 0.0058 | 0.0795 | 0.1153 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0286 | 0.5819 | 0.5905 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription factor | 0.0258 | 0.5217 | 0.5294 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0055 | 0.0728 | 0.0543 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0055 | 0.0728 | 0.0543 |
Echinococcus granulosus | jun protein | 0.0258 | 0.5217 | 0.5294 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0119 | 0.2128 | 0.1971 |
Echinococcus multilocularis | geminin | 0.0334 | 0.6895 | 0.6996 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.0728 | 0.1056 |
Echinococcus granulosus | NADP dependent isocitrate dehydrogenase | 0.0031 | 0.0196 | 0.0199 |
Schistosoma mansoni | hypothetical protein | 0.0058 | 0.0795 | 0.1153 |
Brugia malayi | TAR-binding protein | 0.0076 | 0.1198 | 0.1022 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0058 | 0.0795 | 0.0611 |
Schistosoma mansoni | NADP-specific isocitrate dehydrogenase | 0.0031 | 0.0196 | 0.0284 |
Schistosoma mansoni | hypothetical protein | 0.021 | 0.4148 | 0.6016 |
Entamoeba histolytica | hypothetical protein | 0.0071 | 0.1076 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0251 | 0.5061 | 0.4962 |
Loa Loa (eye worm) | hypothetical protein | 0.0286 | 0.5819 | 0.5736 |
Loa Loa (eye worm) | TAR-binding protein | 0.0076 | 0.1198 | 0.1022 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 7.6 uM | Inhibition of human recombinant PDE7A1 assessed as inhibition of hydrolysis of [3H]cAMP after 20 mins by scintillation proximity assay | ChEMBL. | 25264825 |
Potency (functional) | 0.0052 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 0.0316 um | PUBCHEM_BIOASSAY: qHTS Assay for Enhancers of SMN2 Splice Variant Expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 4.6109 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 11.2202 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 12.5893 um | PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 17.7828 uM | PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (binding) | 25.1189 uM | PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (binding) | = 35.4813 um | PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] | ChEMBL. | No reference |
Potency (functional) | 50.1187 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] | ChEMBL. | No reference |
Potency (functional) | 50.1187 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] | ChEMBL. | No reference |
Potency (functional) | 50.1187 uM | PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.