Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | SMAD family member 2 | Starlite/ChEMBL | No references |
Homo sapiens | microtubule-associated protein tau | Starlite/ChEMBL | No references |
Homo sapiens | tumor protein p53 | Starlite/ChEMBL | No references |
Homo sapiens | lysine (K)-specific demethylase 4A | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | MH2 domain containing protein | SMAD family member 2 | 467 aa | 405 aa | 31.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | pyruvate-flavodoxin oxidoreductase, putative | 0.0038 | 0 | 0.5 |
Brugia malayi | MH2 domain containing protein | 0.0144 | 0.1338 | 0.469 |
Mycobacterium tuberculosis | Acetolactate synthase (large subunit) IlvB1 (acetohydroxy-acid synthase) | 0.0111 | 0.0919 | 0.3304 |
Trypanosoma brucei | phosphonopyruvate decarboxylase-like protein, putative | 0.0084 | 0.0579 | 0.5 |
Echinococcus granulosus | tumor protein p63 | 0.0408 | 0.4655 | 0.4621 |
Schistosoma mansoni | thyroid hormone receptor | 0.0131 | 0.1178 | 0.1123 |
Mycobacterium ulcerans | pyruvate or indole-3-pyruvate decarboxylase Pdc | 0.0148 | 0.139 | 0.4994 |
Mycobacterium ulcerans | acetolactate synthase large subunit IlvB | 0.0148 | 0.139 | 0.4994 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.0277 | 0.1497 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0073 | 0.044 | 0.2632 |
Trichomonas vaginalis | pyruvate-flavodoxin oxidoreductase, putative | 0.0038 | 0 | 0.5 |
Schistosoma mansoni | microtubule-associated protein tau | 0.0833 | 1 | 1 |
Trypanosoma brucei | phosphonopyruvate decarboxylase-like protein, putative | 0.0084 | 0.0579 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0122 | 0.1055 | 0.0999 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0144 | 0.1338 | 0.8885 |
Mycobacterium tuberculosis | Probable oxalyl-CoA decarboxylase OxcA | 0.0259 | 0.2783 | 1 |
Echinococcus multilocularis | jumonji domain containing protein | 0.0049 | 0.0142 | 0.0081 |
Mycobacterium ulcerans | acetolactate synthase | 0.0148 | 0.139 | 0.4994 |
Trypanosoma cruzi | phosphonopyruvate decarboxylase, putative | 0.0084 | 0.0579 | 0.5 |
Onchocerca volvulus | 0.006 | 0.0277 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.0285 | 0.1552 |
Mycobacterium ulcerans | hypothetical protein | 0.0259 | 0.2783 | 1 |
Schistosoma mansoni | jumonji domain containing protein | 0.0092 | 0.0678 | 0.062 |
Loa Loa (eye worm) | thiamine pyrophosphate enzyme | 0.0149 | 0.1393 | 0.9268 |
Trypanosoma cruzi | phosphonopyruvate decarboxylase, putative | 0.0084 | 0.0579 | 0.5 |
Echinococcus granulosus | Mitotic checkpoint protein PRCC C terminal | 0.0122 | 0.1055 | 0.0999 |
Trichomonas vaginalis | pyruvate-flavodoxin oxidoreductase, putative | 0.0038 | 0 | 0.5 |
Brugia malayi | Thiamine pyrophosphate enzyme, central domain containing protein | 0.0259 | 0.2783 | 1 |
Loa Loa (eye worm) | ILVBL protein | 0.0157 | 0.1498 | 1 |
Treponema pallidum | pyruvate oxidoreductase | 0.0038 | 0 | 0.5 |
Schistosoma mansoni | acetolactate synthase | 0.0221 | 0.2309 | 0.2262 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.0833 | 1 | 1 |
Trichomonas vaginalis | pyruvate-flavodoxin oxidoreductase, putative | 0.0038 | 0 | 0.5 |
Mycobacterium ulcerans | acetolactate synthase 1 catalytic subunit | 0.0259 | 0.2783 | 1 |
Mycobacterium leprae | PROBABLE ACETOLACTATE SYNTHASE (LARGE SUBUNIT) ILVB (ACETOHYDROXY-ACID SYNTHASE) | 0.0259 | 0.2783 | 1 |
Echinococcus multilocularis | tumor protein p63 | 0.0408 | 0.4655 | 0.4621 |
Echinococcus granulosus | jumonji domain containing protein | 0.0049 | 0.0142 | 0.0081 |
Echinococcus granulosus | Transcription factor JmjC domain containing protein | 0.0115 | 0.0975 | 0.0919 |
Trichomonas vaginalis | pyruvate-flavodoxin oxidoreductase, putative | 0.0038 | 0 | 0.5 |
Echinococcus multilocularis | Transcription factor, JmjC domain containing protein | 0.0115 | 0.0975 | 0.0919 |
Mycobacterium tuberculosis | Probable acetolactate synthase IlvG (acetohydroxy-acid synthase)(ALS) | 0.0259 | 0.2783 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.0131 | 0.1178 | 0.1123 |
Schistosoma mansoni | acetolactate synthase | 0.0221 | 0.2309 | 0.2262 |
Giardia lamblia | Pyruvate-flavodoxin oxidoreductase | 0.0038 | 0 | 0.5 |
Brugia malayi | jmjC domain containing protein | 0.0115 | 0.0975 | 0.3357 |
Leishmania major | putative pyruvate/indole-pyruvate carboxylase, putative | 0.0148 | 0.139 | 1 |
Entamoeba histolytica | pyruvate:ferredoxin oxidoreductase | 0.0038 | 0 | 0.5 |
Mycobacterium leprae | Probable Acetolactate synthase IlvG (Acetohydroxy-acid synthase)(ALS) | 0.0259 | 0.2783 | 1 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0144 | 0.1338 | 0.8885 |
Plasmodium vivax | acyl-CoA synthetase, putative | 0.0148 | 0.139 | 0.5 |
Trichomonas vaginalis | pyruvate-flavodoxin oxidoreductase, putative | 0.0038 | 0 | 0.5 |
Schistosoma mansoni | cellular tumor antigen P53 | 0.006 | 0.0277 | 0.0216 |
Mycobacterium ulcerans | putative oxalyl-CoA decarboxylase | 0.0259 | 0.2783 | 1 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0131 | 0.1178 | 0.1123 |
Echinococcus multilocularis | Mitotic checkpoint protein PRCC, C terminal | 0.0122 | 0.1055 | 0.0999 |
Mycobacterium ulcerans | 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase | 0.0046 | 0.0105 | 0.0378 |
Plasmodium falciparum | acyl-CoA synthetase | 0.0148 | 0.139 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.0084 | 0.0579 | 0.208 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 0.3981 um | PUBCHEM_BIOASSAY: qHTS Screen for Compounds that Selectively Target Cancer Cells with p53 Mutations: Cytotoxicity of p53 Null Cells at the Permissive Temperature. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 3.9811 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] | ChEMBL. | No reference |
Potency (functional) | = 11.2202 um | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. (Class of assay: confirmatory) [Related pubchem assays: 596 ] | ChEMBL. | No reference |
Potency (functional) | 19.9526 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] | ChEMBL. | No reference |
Potency (functional) | 50.1187 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of mutant isocitrate dehydrogenase 1 (IDH1): qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 79.4328 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of DNA Polymerase Beta. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.