Detailed information for compound 1448023

Basic information

Technical information
  • TDR Targets ID: 1448023
  • Name: 6-amino-1-cyclopropyl-5-[2-[[4-(2-ethylphenyl )-5-morpholin-4-yl-1,2,4-triazol-3-yl]sulfany l]acetyl]pyrimidine-2,4-dione
  • MW: 497.57 | Formula: C23H27N7O4S
  • H donors: 2 H acceptors: 5 LogP: 2.35 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCc1ccccc1n1c(SCC(=O)c2c(=O)[nH]c(=O)n(c2N)C2CC2)nnc1N1CCOCC1
  • InChi: 1S/C23H27N7O4S/c1-2-14-5-3-4-6-16(14)30-21(28-9-11-34-12-10-28)26-27-23(30)35-13-17(31)18-19(24)29(15-7-8-15)22(33)25-20(18)32/h3-6,15H,2,7-13,24H2,1H3,(H,25,32,33)
  • InChiKey: JFGFJEUBESVYGM-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 6-amino-1-cyclopropyl-5-[2-[[4-(2-ethylphenyl)-5-morpholino-1,2,4-triazol-3-yl]sulfanyl]acetyl]pyrimidine-2,4-dione
  • 6-amino-1-cyclopropyl-5-[2-[[4-(2-ethylphenyl)-5-morpholino-1,2,4-triazol-3-yl]thio]-1-oxoethyl]pyrimidine-2,4-dione
  • 6-amino-1-cyclopropyl-5-[2-[[4-(2-ethylphenyl)-5-morpholino-1,2,4-triazol-3-yl]thio]acetyl]pyrimidine-2,4-quinone
  • 6-amino-1-cyclopropyl-5-[2-[[4-(2-ethylphenyl)-5-morpholin-4-yl-1,2,4-triazol-3-yl]sulfanyl]ethanoyl]pyrimidine-2,4-dione
  • T5603489

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3D Starlite/ChEMBL No references
Homo sapiens RAB9A, member RAS oncogene family Starlite/ChEMBL No references
Homo sapiens GNAS complex locus Starlite/ChEMBL No references
Homo sapiens APEX nuclease (multifunctional DNA repair enzyme) 1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Theileria parva hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Trypanosoma cruzi apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania major apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium berghei AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum ko:K10771 AP endonuclease 1, putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania infantum apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Giardia lamblia Endonuclease/Exonuclease/phosphatase Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum ko:K10772 AP endonuclease 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium parvum conserved hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Wolbachia endosymbiont of Brugia malayi exonuclease III Get druggable targets OG5_126768 All targets in OG5_126768
Entamoeba histolytica exodeoxyribonuclease III, putative Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Leishmania braziliensis apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium yoelii putative AP endonuclease-related Get druggable targets OG5_126768 All targets in OG5_126768
Toxoplasma gondii exonuclease III APE Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania donovani apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium hominis dna-(apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Trypanosoma brucei gambiense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania mexicana apurinic/apyrimidinic endonuclease-redox protein,AP-endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma congolense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Brugia malayi exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Plasmodium knowlesi AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Treponema pallidum exodeoxyribonuclease (exoA) Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Neospora caninum hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Plasmodium falciparum ras-related protein Rab-5B RAB9A, member RAS oncogene family 201 aa 165 aa 30.9 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis hypothetical protein 0.0059 0.1127 0.1137
Entamoeba histolytica hypothetical protein 0.0093 0.2198 0.29
Plasmodium falciparum MO15-related protein kinase 0.0062 0.1214 1
Trichomonas vaginalis CAMK family protein kinase 0.0062 0.1214 0.1602
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.1015 0.1015
Trichomonas vaginalis CAMK family protein kinase 0.0062 0.1214 0.1602
Plasmodium vivax serine/threonine protein kinase KIN, putative 0.0062 0.1214 1
Trichomonas vaginalis CAMK family protein kinase 0.0062 0.1214 0.1602
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.1015 0.1023
Entamoeba histolytica protein kinase domain containing protein 0.0062 0.1214 0.1602
Echinococcus granulosus serine:threonine protein kinase haspin 0.0341 0.9914 1
Trichomonas vaginalis CMGC family protein kinase 0.0266 0.7577 1
Echinococcus granulosus Cell division cycle 2 protein kinase 0.0062 0.1214 0.1224
Trichomonas vaginalis CAMK family protein kinase 0.0062 0.1214 0.1602
Trichomonas vaginalis CAMK family protein kinase 0.0062 0.1214 0.1602
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase 0.0093 0.2198 0.2198
Trichomonas vaginalis CAMK family protein kinase 0.0062 0.1214 0.1602
Leishmania major serine/threonine kinase-like protein, putative 0.0062 0.1214 0.1602
Onchocerca volvulus 0.0182 0.4983 0.5
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.1015 0.1023
Trichomonas vaginalis CMGC family protein kinase 0.0062 0.1214 0.1602
Trichomonas vaginalis CAMK family protein kinase 0.0062 0.1214 0.1602
Trichomonas vaginalis CAMK family protein kinase 0.0062 0.1214 0.1602
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.1015 0.1023
Echinococcus multilocularis dual specificity 0.0266 0.7577 0.7643
Leishmania major mitogen-activated protein kinase, putative,map kinase-like protein 0.0062 0.1214 0.1602
Brugia malayi Protein kinase domain containing protein 0.0062 0.1214 0.1224
Loa Loa (eye worm) hypothetical protein 0.009 0.2111 0.2111
Trichomonas vaginalis CAMK family protein kinase 0.0062 0.1214 0.1602
Toxoplasma gondii cell-cycle-associated protein kinase DYRK2, putative 0.0266 0.7577 1
Echinococcus granulosus dual specificity 0.0093 0.2198 0.2217
Trichomonas vaginalis CAMK family protein kinase 0.0062 0.1214 0.1602
Trichomonas vaginalis CAMK family protein kinase 0.0062 0.1214 0.1602
Trypanosoma brucei protein kinase, putative 0.0062 0.1214 0.1602
Entamoeba histolytica hypothetical protein 0.0059 0.1127 0.1488
Trichomonas vaginalis CAMK family protein kinase 0.0062 0.1214 0.1602
Trichomonas vaginalis CAMK family protein kinase 0.0062 0.1214 0.1602
Trichomonas vaginalis AGC family protein kinase 0.0062 0.1214 0.1602
Trypanosoma cruzi Mitogen-activated protein kinase 10, putative 0.0062 0.1214 0.1602
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.1015 0.1023
Trichomonas vaginalis CAMK family protein kinase 0.0062 0.1214 0.1602
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.1015 0.1023
Loa Loa (eye worm) AGC/PDK1 protein kinase 0.0062 0.1214 0.1214
Trichomonas vaginalis CAMK family protein kinase 0.0062 0.1214 0.1602
Echinococcus granulosus cyclin dependent kinase 9 0.0062 0.1214 0.1224
Echinococcus granulosus dual specificity 0.0266 0.7577 0.7643
Echinococcus granulosus serine:threonine protein kinase NLK 0.0062 0.1214 0.1224
Trichomonas vaginalis CMGC family protein kinase 0.0266 0.7577 1
Trypanosoma cruzi Mitogen-activated protein kinase 10, putative 0.0062 0.1214 0.1602
Echinococcus granulosus dual specificity 0.0266 0.7577 0.7643
Trichomonas vaginalis AGC family protein kinase 0.0062 0.1214 0.1602
Echinococcus multilocularis Cell division cycle 2 protein kinase 0.0062 0.1214 0.1224
Trypanosoma brucei Mitogen-activated protein kinase 10, putative 0.0062 0.1214 0.1602
Brugia malayi Dual-specificity tyrosine-phosphorylation regulated kinase 2 0.0266 0.7577 0.7643
Loa Loa (eye worm) CMGC/CDK/CRK7 protein kinase 0.0062 0.1214 0.1214
Trichomonas vaginalis CAMK family protein kinase 0.0062 0.1214 0.1602
Brugia malayi Cell division protein kinase 2 0.0062 0.1214 0.1224
Schistosoma mansoni protein kinase 0.0062 0.1214 0.1224
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0093 0.2198 0.29
Trichomonas vaginalis CAMK family protein kinase 0.0062 0.1214 0.1602
Schistosoma mansoni serine/threonine protein kinase 0.0266 0.7577 0.7643
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0023 0 0.5
Trichomonas vaginalis CAMK family protein kinase 0.0062 0.1214 0.1602
Trichomonas vaginalis AGC family protein kinase 0.0062 0.1214 0.1602
Echinococcus granulosus dual specificity 0.0266 0.7577 0.7643
Plasmodium vivax cyclin dependent kinase 7 (cdk7), putative 0.0062 0.1214 1
Brugia malayi cyclin-dependent kinase 7 homolog 0.0062 0.1214 0.1224
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.1015 0.1023
Entamoeba histolytica protein kinase, putative 0.0266 0.7577 1
Trichomonas vaginalis serine/threonine kinase, putative 0.0062 0.1214 0.1602
Trichomonas vaginalis CAMK family protein kinase 0.0062 0.1214 0.1602
Trichomonas vaginalis CAMK family protein kinase 0.0062 0.1214 0.1602
Trichomonas vaginalis CAMK family protein kinase 0.0062 0.1214 0.1602
Entamoeba histolytica protein kinase, putative 0.0093 0.2198 0.29
Trypanosoma cruzi serine/threonine protein kinase, putative 0.0062 0.1214 0.1602
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.1015 0.1023
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.1015 0.1023
Trichomonas vaginalis CAMK family protein kinase 0.0062 0.1214 0.1602
Loa Loa (eye worm) hypothetical protein 0.009 0.2111 0.2111
Trichomonas vaginalis CAMK family protein kinase 0.0062 0.1214 0.1602
Trichomonas vaginalis CMGC family protein kinase 0.0062 0.1214 0.1602
Leishmania major protein kinase, putative,dual-specificity protein kinase, putative 0.0266 0.7577 1
Trichomonas vaginalis CMGC family protein kinase 0.0266 0.7577 1
Echinococcus multilocularis serine:threonine protein kinase haspin 0.0341 0.9914 1
Echinococcus multilocularis dual specificity 0.0266 0.7577 0.7643
Trichomonas vaginalis CAMK family protein kinase 0.0062 0.1214 0.1602
Schistosoma mansoni serine/threonine kinase 0.0062 0.1214 0.1224
Trypanosoma cruzi dual specificity tyrosine-phosphorylation-regulated kinase 2, putative 0.0266 0.7577 1
Trichomonas vaginalis CAMK family protein kinase 0.0062 0.1214 0.1602
Trichomonas vaginalis protein kinase atmrk1, putative 0.0062 0.1214 0.1602
Trichomonas vaginalis CAMK family protein kinase 0.0062 0.1214 0.1602
Treponema pallidum exodeoxyribonuclease (exoA) 0.0023 0 0.5
Trichomonas vaginalis CAMK family protein kinase 0.0062 0.1214 0.1602
Loa Loa (eye worm) haspin protein kinase 0.0341 0.9914 0.9914
Trichomonas vaginalis CAMK family protein kinase 0.0062 0.1214 0.1602
Brugia malayi GSG2 0.0341 0.9914 1
Echinococcus granulosus serine:threonine protein kinase haspin 0.0341 0.9914 1
Trichomonas vaginalis CMGC family protein kinase 0.0266 0.7577 1
Giardia lamblia Kinase, CAMK CAMKL 0.0062 0.1214 0.1602
Echinococcus multilocularis serine:threonine protein kinase haspin 0.0341 0.9914 1
Trichomonas vaginalis CAMK family protein kinase 0.0062 0.1214 0.1602
Trichomonas vaginalis CAMK family protein kinase 0.0062 0.1214 0.1602
Entamoeba histolytica cell division protein kinase 2, putative 0.0062 0.1214 0.1602
Echinococcus multilocularis cyclin dependent kinase 9 0.0062 0.1214 0.1224
Trichomonas vaginalis CMGC family protein kinase 0.0062 0.1214 0.1602
Loa Loa (eye worm) haspin protein kinase 0.0341 0.9914 0.9914
Trypanosoma brucei CMGC/DYRK protein kinase, putative 0.0093 0.2198 0.29
Entamoeba histolytica protein kinase, putative 0.0093 0.2198 0.29
Schistosoma mansoni serine/threonine protein kinase 0.0093 0.2198 0.2217
Schistosoma mansoni hypothetical protein 0.0341 0.9914 1
Trichomonas vaginalis CAMK family protein kinase 0.0062 0.1214 0.1602
Brugia malayi hypothetical protein 0.0182 0.4983 0.5027
Echinococcus multilocularis dual specificity 0.0266 0.7577 0.7643
Entamoeba histolytica protein kinase domain containing protein 0.0266 0.7577 1
Trichomonas vaginalis CAMK family protein kinase 0.0062 0.1214 0.1602
Trichomonas vaginalis CAMK family protein kinase 0.0062 0.1214 0.1602
Trichomonas vaginalis CAMK family protein kinase 0.0062 0.1214 0.1602
Trichomonas vaginalis CMGC family protein kinase 0.0266 0.7577 1
Giardia lamblia Kinase, CAMK CAMKL 0.0062 0.1214 0.1602
Giardia lamblia Kinase, CAMK CAMKL 0.0062 0.1214 0.1602
Trichomonas vaginalis CAMK family protein kinase 0.0062 0.1214 0.1602
Echinococcus granulosus mitogen activated protein kinase 15 0.0062 0.1214 0.1224
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.0093 0.2198 0.29
Trichomonas vaginalis AGC family protein kinase 0.0062 0.1214 0.1602
Trichomonas vaginalis CAMK family protein kinase 0.0062 0.1214 0.1602
Trichomonas vaginalis AGC family protein kinase 0.0062 0.1214 0.1602
Trichomonas vaginalis CAMK family protein kinase 0.0062 0.1214 0.1602
Loa Loa (eye worm) hypothetical protein 0.0182 0.4983 0.4983
Trichomonas vaginalis G protein-coupled receptor kinase, putative 0.0062 0.1214 0.1602
Schistosoma mansoni serine/threonine protein kinase 0.0062 0.1214 0.1224
Schistosoma mansoni hypothetical protein 0.0059 0.1127 0.1137
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0023 0 0.5
Echinococcus granulosus serine:threonine protein kinase haspin 0.0341 0.9914 1
Trichomonas vaginalis CMGC family protein kinase 0.0062 0.1214 0.1602
Trichomonas vaginalis CAMK family protein kinase 0.0062 0.1214 0.1602
Trichomonas vaginalis CAMK family protein kinase 0.0062 0.1214 0.1602
Trichomonas vaginalis CAMK family protein kinase 0.0062 0.1214 0.1602
Echinococcus multilocularis serine:threonine protein kinase NLK 0.0062 0.1214 0.1224
Trichomonas vaginalis CAMK family protein kinase 0.0062 0.1214 0.1602
Trichomonas vaginalis CAMK family protein kinase 0.0062 0.1214 0.1602
Brugia malayi Protein kinase domain containing protein 0.0093 0.2198 0.2217
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0023 0 0.5
Trypanosoma brucei dual specificity tyrosine-phosphorylation-regulated kinase 2, putative 0.0266 0.7577 1
Giardia lamblia Kinase, CMGC DYRK 0.0266 0.7577 1
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0093 0.2198 0.29
Trichomonas vaginalis CAMK family protein kinase 0.0062 0.1214 0.1602
Trichomonas vaginalis AGC family protein kinase 0.0062 0.1214 0.1602
Echinococcus multilocularis dual specificity 0.0093 0.2198 0.2217
Trichomonas vaginalis CMGC family protein kinase 0.0266 0.7577 1
Echinococcus granulosus Pfam-B_8186 domain containing protein 0.0059 0.1127 0.1137
Loa Loa (eye worm) CMGC/DYRK/DYRK2 protein kinase 0.0266 0.7577 0.7577
Entamoeba histolytica protein kinase domain containing protein 0.0093 0.2198 0.29
Trichomonas vaginalis AGC family protein kinase 0.0062 0.1214 0.1602
Brugia malayi hypothetical protein 0.0341 0.9914 1
Trichomonas vaginalis CAMK family protein kinase 0.0062 0.1214 0.1602

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.2378 uM PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 1.2589 um PUBCHEM_BIOASSAY: qHTS Assay for Rab9 Promoter Activators. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 6.3096 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Vif-A3F Interactions: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 7.9433 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 18.526 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 44.6684 uM PubChem BioAssay. qHTS of Trypanosoma Brucei Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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