Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Escherichia coli | penicillin-binding protein | Starlite/ChEMBL | No references |
Homo sapiens | glucagon-like peptide 1 receptor | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Mycobacterium tuberculosis | Possible penicillin-binding protein | Get druggable targets OG5_149948 | All targets in OG5_149948 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Loa Loa (eye worm) | pigment dispersing factor receptor c | glucagon-like peptide 1 receptor | 463 aa | 388 aa | 25.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | fatty acid desaturase, putative | 0.2926 | 1 | 1 |
Echinococcus multilocularis | Peptidase M, neutral zinc metallopeptidases, zinc binding site | 0.0321 | 0.0909 | 0.5 |
Trypanosoma cruzi | fatty acid desaturase, putative | 0.2606 | 0.8881 | 0.8769 |
Mycobacterium ulcerans | transmembrane alkane 1-monooxygenase AlkB | 0.0321 | 0.0909 | 0.5 |
Onchocerca volvulus | 0.2926 | 1 | 1 | |
Echinococcus multilocularis | Fatty acid desaturase, type 1 | 0.0321 | 0.0909 | 0.5 |
Mycobacterium tuberculosis | Probable conserved membrane protein | 0.0321 | 0.0909 | 1 |
Brugia malayi | Fatty acid desaturase family protein | 0.0321 | 0.0909 | 0.1023 |
Mycobacterium tuberculosis | Probable transmembrane alkane 1-monooxygenase AlkB (alkane 1-hydroxylase) (lauric acid omega-hydroxylase) (omega-hydroxylase) (f | 0.0321 | 0.0909 | 1 |
Mycobacterium ulcerans | linoleoyl-CoA desaturase, DesA3 | 0.0321 | 0.0909 | 0.5 |
Loa Loa (eye worm) | fatty acid desaturase | 0.0321 | 0.0909 | 0.1023 |
Trypanosoma brucei | fatty acid desaturase, putative | 0.2926 | 1 | 1 |
Leishmania major | fatty-acid desaturase, putative | 0.2926 | 1 | 1 |
Loa Loa (eye worm) | acyl-CoA desaturase | 0.2606 | 0.8881 | 1 |
Onchocerca volvulus | 0.2926 | 1 | 1 | |
Plasmodium vivax | stearoyl-CoA desaturase (acyl-CoA desaturase, faty acid desaturase), putative | 0.2606 | 0.8881 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.0321 | 0.0909 | 0.5 |
Brugia malayi | acyl-CoA desaturase | 0.2606 | 0.8881 | 1 |
Mycobacterium ulcerans | electron transfer protein FdxB | 0.0321 | 0.0909 | 0.5 |
Echinococcus granulosus | Fatty acid desaturase type 1 | 0.0321 | 0.0909 | 0.5 |
Mycobacterium ulcerans | linoleoyl-CoA desaturase, DesA3 | 0.0321 | 0.0909 | 0.5 |
Plasmodium falciparum | stearoyl-CoA desaturase | 0.2606 | 0.8881 | 0.5 |
Brugia malayi | Fatty acid desaturase family protein | 0.0321 | 0.0909 | 0.1023 |
Loa Loa (eye worm) | hypothetical protein | 0.0321 | 0.0909 | 0.1023 |
Mycobacterium ulcerans | linoleoyl-CoA desaturase, DesA3_2 | 0.0321 | 0.0909 | 0.5 |
Toxoplasma gondii | sphingolipid delta 4 desaturase/c-4 hydroxylase protein des2 family protein | 0.0321 | 0.0909 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.0321 | 0.0909 | 0.5 |
Brugia malayi | Delta5 fatty acid desaturase | 0.0321 | 0.0909 | 0.1023 |
Loa Loa (eye worm) | fatty acid desaturase | 0.0321 | 0.0909 | 0.1023 |
Loa Loa (eye worm) | FAT-3 protein | 0.0321 | 0.0909 | 0.1023 |
Mycobacterium tuberculosis | Possible electron transfer protein FdxB | 0.0321 | 0.0909 | 1 |
Echinococcus granulosus | Sphingolipid delta4 desaturase DES1 | 0.0321 | 0.0909 | 0.5 |
Trypanosoma cruzi | fatty acid desaturase, putative | 0.2606 | 0.8881 | 0.8769 |
Schistosoma mansoni | fatty acid desaturase | 0.0321 | 0.0909 | 0.5 |
Echinococcus multilocularis | Peptidase M, neutral zinc metallopeptidases, zinc binding site | 0.0321 | 0.0909 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 0.631 um | PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] | ChEMBL. | No reference |
Potency (functional) | 7.0795 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 10.4179 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 11.6891 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 35.4813 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Eta. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588636] | ChEMBL. | No reference |
Potency (functional) | 39.8107 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Potency (functional) | 79.4328 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.