Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Inositol monophosphatase 1 | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | transitional endoplasmic reticulum ATPase TER94, putative | 0.0674 | 0.3817 | 0.6768 |
Trichomonas vaginalis | spermatogenesis associated factor, putative | 0.1631 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0956 | 0.564 | 1 |
Trichomonas vaginalis | 26S protease regulatory subunit S10b, putative | 0.0386 | 0.195 | 0.195 |
Brugia malayi | vesicle-fusing ATPase | 0.0956 | 0.564 | 1 |
Onchocerca volvulus | Transitional endoplasmic reticulum ATPase homolog | 0.1631 | 1 | 0.5 |
Leishmania major | Transitional endoplasmic reticulum ATPase, putative,valosin-containing protein homolog | 0.1547 | 0.9457 | 1 |
Schistosoma mansoni | cell division control protein 48 aaa family protein | 0.0674 | 0.3817 | 0.3817 |
Trypanosoma brucei | Valosin-containing protein | 0.1547 | 0.9457 | 1 |
Toxoplasma gondii | cell division protein CDC48AP | 0.0976 | 0.5767 | 0.5767 |
Loa Loa (eye worm) | VCP protein | 0.0674 | 0.3817 | 0.6768 |
Brugia malayi | valosin containing protein | 0.0956 | 0.564 | 1 |
Toxoplasma gondii | cell division protein CDC48CY | 0.1631 | 1 | 1 |
Toxoplasma gondii | transitional endoplasmic reticulum ATPase, putative | 0.0976 | 0.5767 | 0.5767 |
Entamoeba histolytica | transitional endoplasmic reticulum ATPase, putative | 0.1547 | 0.9457 | 1 |
Echinococcus multilocularis | transitional endoplasmic reticulum atpase | 0.0674 | 0.3817 | 0.3817 |
Mycobacterium ulcerans | ATPase | 0.0976 | 0.5767 | 0.5 |
Giardia lamblia | AAA family ATPase | 0.0976 | 0.5767 | 1 |
Mycobacterium tuberculosis | Putative conserved ATPase | 0.0976 | 0.5767 | 0.5 |
Plasmodium vivax | cell division cycle protein 48 homologue, putative | 0.1547 | 0.9457 | 1 |
Plasmodium falciparum | cell division cycle protein 48 homologue, putative | 0.1547 | 0.9457 | 1 |
Trypanosoma cruzi | Valosin-containing protein, putative | 0.1547 | 0.9457 | 1 |
Trichomonas vaginalis | proteasome-activating nucleotidase, putative | 0.0386 | 0.195 | 0.195 |
Echinococcus multilocularis | transitional endoplasmic reticulum atpase | 0.1631 | 1 | 1 |
Loa Loa (eye worm) | vesicle-fusing ATPase | 0.0956 | 0.564 | 1 |
Schistosoma mansoni | cell division control protein 48 aaa family protein | 0.1547 | 0.9457 | 0.9457 |
Entamoeba histolytica | cdc48-like protein, putative | 0.1547 | 0.9457 | 1 |
Schistosoma mansoni | cell division control protein 48 aaa family protein | 0.1631 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 0.1259 um | PUBCHEM_BIOASSAY: qHTS Assay for Identifying the Cell-Membrane Permeable IMPase Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 0.1312 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.