Detailed information for compound 1450191

Basic information

Technical information
  • TDR Targets ID: 1450191
  • Name: N-(3-acetylphenyl)-3-[6-(furan-2-ylmethylamin o)-[1,2,4]triazolo[5,4-f]pyridazin-3-yl]propa namide
  • MW: 404.422 | Formula: C21H20N6O3
  • H donors: 2 H acceptors: 5 LogP: 1.44 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(Nc1cccc(c1)C(=O)C)CCc1nnc2n1nc(NCc1ccco1)cc2
  • InChi: 1S/C21H20N6O3/c1-14(28)15-4-2-5-16(12-15)23-21(29)10-9-20-25-24-19-8-7-18(26-27(19)20)22-13-17-6-3-11-30-17/h2-8,11-12H,9-10,13H2,1H3,(H,22,26)(H,23,29)
  • InChiKey: OPFQGNZXDOMAQW-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • N-(3-acetylphenyl)-3-[6-(2-furylmethylamino)-[1,2,4]triazolo[5,4-f]pyridazin-3-yl]propanamide
  • N-(3-acetylphenyl)-3-[6-(2-furylmethylamino)-[1,2,4]triazolo[5,4-f]pyridazin-3-yl]propionamide
  • N-(3-ethanoylphenyl)-3-[6-(furan-2-ylmethylamino)-[1,2,4]triazolo[5,4-f]pyridazin-3-yl]propanamide

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens Bloom syndrome, RecQ helicase-like Starlite/ChEMBL No references
Homo sapiens glutaminase Starlite/ChEMBL No references
Homo sapiens eukaryotic translation initiation factor 4H Starlite/ChEMBL No references
Homo sapiens polymerase (DNA directed), eta Starlite/ChEMBL No references
Homo sapiens ataxin 2 Starlite/ChEMBL No references
Homo sapiens GNAS complex locus Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus granulosus dna polymerase eta Get druggable targets OG5_128521 All targets in OG5_128521
Babesia bovis ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Candida albicans DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium knowlesi ADP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni glutaminase Get druggable targets OG5_129245 All targets in OG5_129245
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132232 All targets in OG5_132232
Brugia malayi glutaminase DH11.1 Get druggable targets OG5_129245 All targets in OG5_129245
Leishmania braziliensis ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Candida albicans DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis Eukaryotic translation initiation factor 4H Get druggable targets OG5_132232 All targets in OG5_132232
Toxoplasma gondii ImpB/MucB/SamB family protein Get druggable targets OG5_128521 All targets in OG5_128521
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Entamoeba histolytica recQ family helicase, putative Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Cryptosporidium parvum DinB/family X-type DNA polymerase Get druggable targets OG5_128521 All targets in OG5_128521
Brugia malayi ImpB/MucB/SamB family protein Get druggable targets OG5_128521 All targets in OG5_128521
Schistosoma mansoni eukaryotic translation initiation factor 4h Get druggable targets OG5_132232 All targets in OG5_132232
Leishmania infantum ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) glutaminase Get druggable targets OG5_129245 All targets in OG5_129245
Entamoeba histolytica recQ family DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Neospora caninum Pc21g17280 protein, related Get druggable targets OG5_128521 All targets in OG5_128521
Neospora caninum hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Cryptosporidium hominis DEAD/DEAH box helicase Get druggable targets OG5_126644 All targets in OG5_126644
Treponema pallidum ATP-dependent DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Brugia malayi ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania braziliensis DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Trichomonas vaginalis DNA helicase recq1, putative Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum ko:K03509 DNA polymerase eta subunit, putative Get druggable targets OG5_128521 All targets in OG5_128521
Schistosoma mansoni eukaryotic translation initiation factor 4h Get druggable targets OG5_132232 All targets in OG5_132232
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Leishmania braziliensis DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Babesia bovis ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Mycobacterium ulcerans glutaminase Get druggable targets OG5_129245 All targets in OG5_129245
Trichomonas vaginalis glutaminase, putative Get druggable targets OG5_129245 All targets in OG5_129245
Schistosoma mansoni DNA helicase recq5 Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania mexicana ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma congolense DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus ATP dependent DNA helicase Q5 Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium knowlesi ATP-dependent DNA helicase Q1, putative Get druggable targets OG5_126644 All targets in OG5_126644
Candida albicans similar to S. cerevisiae DNA polymerase pol-eta, involved in the bypass of distorted DNA lesions Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania donovani ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium falciparum ADP-dependent DNA helicase RecQ Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma brucei gambiense ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania major DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Schistosoma mansoni DNA helicase recq1 Get druggable targets OG5_126644 All targets in OG5_126644
Cryptosporidium parvum RecQ bloom helicase (RNA helicase+hrdc) Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis ATP dependent DNA helicase Q5 Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium yoelii ATP-dependent DNA helicase-related Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania infantum DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Echinococcus multilocularis ATP dependent DNA helicase Q1 Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania mexicana Get druggable targets OG5_128521 All targets in OG5_128521
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Theileria parva DNA helicase, putative Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma japonicum ko:K03509 DNA polymerase eta subunit, putative Get druggable targets OG5_128521 All targets in OG5_128521
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium falciparum ATP-dependent DNA helicase Q1 Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium berghei ATP-dependent DNA helicase Q1, putative Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania mexicana DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis dna polymerase eta Get druggable targets OG5_128521 All targets in OG5_128521
Echinococcus multilocularis bloom syndrome protein Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania major DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Schistosoma mansoni blooms syndrome DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium yoelii ATP-dependent DNA helicase recQ-related Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma japonicum Eukaryotic translation initiation factor 4H, putative Get druggable targets OG5_132232 All targets in OG5_132232
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus ATP dependent DNA helicase Q1 Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) RecQ helicase Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Trichomonas vaginalis DNA helicase recq, putative Get druggable targets OG5_126644 All targets in OG5_126644
Giardia lamblia Sgs1 DNA helicase, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma brucei gambiense DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Schistosoma mansoni DNA polymerase eta Get druggable targets OG5_128521 All targets in OG5_128521
Echinococcus granulosus Eukaryotic translation initiation factor 4H Get druggable targets OG5_132232 All targets in OG5_132232
Trypanosoma brucei DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Loa Loa (eye worm) glutaminase 2 Get druggable targets OG5_129245 All targets in OG5_129245
Loa Loa (eye worm) ATP-dependent DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus granulosus bloom syndrome protein Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128521 All targets in OG5_128521
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Neospora caninum hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Brugia malayi Bloom's syndrome protein homolog Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni eukaryotic translation initiation factor 4h Get druggable targets OG5_132232 All targets in OG5_132232
Brugia malayi RNA binding protein Get druggable targets OG5_132232 All targets in OG5_132232
Brugia malayi ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Candida albicans similar to S. cerevisiae DNA polymerase pol-eta, involved in the bypass of distorted DNA lesions Get druggable targets OG5_128521 All targets in OG5_128521
Plasmodium berghei ADP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma japonicum ko:K03654 ATP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Theileria parva hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma cruzi DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania infantum DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Trichomonas vaginalis DNA helicase recq, putative Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma japonicum Bloom syndrome protein homolog, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma cruzi DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Echinococcus granulosus eukaryotic translation initiation factor 4b:4h eukaryotic translation initiation factor 4H 248 aa 217 aa 26.3 %
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.1396 0.1396
Toxoplasma gondii LsmAD domain-containing protein 0.003 0.062 0.7238
Schistosoma mansoni eukaryotic translation initiation factor 4h 0.0163 0.4763 0.4763
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0023 0.0397 0.0302
Loa Loa (eye worm) hypothetical protein 0.0021 0.031 0.031
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0397 0.2367
Brugia malayi RNA binding protein 0.0163 0.4763 0.4763
Trichomonas vaginalis glutaminase, putative 0.033 1 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.1396 0.2931
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.1396 0.1396
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0397 0.2367
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0023 0.0397 0.0397
Leishmania major DNA polymerase eta, putative 0.0038 0.0856 0.6012
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0397 0.2367
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.062 1
Brugia malayi hypothetical protein 0.002 0.0282 0.0282
Echinococcus granulosus Eukaryotic translation initiation factor 4H 0.0163 0.4763 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.1396 0.1396
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.1396 0.2931
Leishmania major DNA polymerase eta, putative 0.0054 0.1359 1
Trypanosoma cruzi DNA polymerase eta, putative 0.0038 0.0856 0.6012
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.017 0.0572
Loa Loa (eye worm) hypothetical protein 0.0054 0.1359 0.1359
Loa Loa (eye worm) glutaminase 2 0.033 1 1
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.062 1
Trypanosoma brucei DNA polymerase eta, putative 0.0054 0.1359 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0397 0.2367
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0397 0.2367
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0023 0.0376 0.6061
Schistosoma mansoni hypothetical protein 0.0014 0.0094 0.0094
Trypanosoma brucei PAB1-binding protein , putative 0.003 0.062 0.4137
Brugia malayi Bloom's syndrome protein homolog 0.0026 0.0474 0.0474
Schistosoma mansoni glutaminase 0.033 1 1
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0014 0.0094 0.0198
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0023 0.0397 0.0833
Mycobacterium tuberculosis Conserved hypothetical protein 0.0023 0.0397 0.5
Loa Loa (eye worm) hypothetical protein 0.003 0.062 0.062
Schistosoma mansoni eukaryotic translation initiation factor 4h 0.0163 0.4763 0.4763
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0397 0.2367
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.1396 0.2931
Loa Loa (eye worm) glutaminase 0.033 1 1
Trypanosoma brucei unspecified product 0.0016 0.017 0.0572
Trichomonas vaginalis DNA helicase recq1, putative 0.0026 0.0474 0.0379
Giardia lamblia DINP protein human, muc B family 0.0023 0.0397 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0397 0.2367
Trypanosoma brucei unspecified product 0.0016 0.017 0.0572
Echinococcus granulosus bloom syndrome protein 0.0026 0.0474 0.0994
Echinococcus multilocularis dna polymerase kappa 0.0023 0.0397 0.0833
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.017 0.0572
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0397 0.2367
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0397 0.2367
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.017 0.0572
Loa Loa (eye worm) RecQ helicase 0.0026 0.0474 0.0474
Schistosoma mansoni DNA polymerase eta 0.0054 0.1359 0.1359
Trypanosoma cruzi DNA polymerase eta, putative 0.0054 0.1359 1
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.062 0.4137
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.1396 0.1396
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0397 0.2367
Leishmania major DNA polymerase kappa, putative 0.0023 0.0397 0.2367
Trichomonas vaginalis DNA helicase recq, putative 0.0026 0.0474 0.0379
Plasmodium vivax ataxin-2 like protein, putative 0.003 0.062 1
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0014 0.0094 0.0198
Trypanosoma brucei unspecified product 0.0023 0.0397 0.2367
Echinococcus multilocularis dna polymerase eta 0.0054 0.1359 0.2854
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0023 0.0397 0.5
Brugia malayi ImpB/MucB/SamB family protein 0.0054 0.1359 0.1359
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0023 0.0397 0.0397
Echinococcus granulosus dna polymerase kappa 0.0023 0.0397 0.0833
Leishmania major hypothetical protein, conserved 0.003 0.062 0.4137
Schistosoma mansoni terminal deoxycytidyl transferase 0.0023 0.0397 0.0397
Brugia malayi hypothetical protein 0.003 0.062 0.062
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0038 0.0856 1
Echinococcus granulosus dna polymerase eta 0.0054 0.1359 0.2854
Brugia malayi ImpB/MucB/SamB family protein 0.0023 0.0397 0.0397
Entamoeba histolytica deoxycytidyl transferase, putative 0.0023 0.0397 1
Schistosoma mansoni eukaryotic translation initiation factor 4h 0.0163 0.4763 0.4763
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0397 0.2367
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0397 0.2367
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0397 0.2367
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0397 0.2367
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0397 0.2367
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.1396 0.1396
Echinococcus multilocularis bloom syndrome protein 0.0026 0.0474 0.0994
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.1396 0.2931
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0023 0.0397 0.2367
Trichomonas vaginalis DNA polymerase eta, putative 0.0023 0.0397 0.0302
Schistosoma mansoni blooms syndrome DNA helicase 0.002 0.0304 0.0304
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0397 0.2367
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0011 0.00000000015164 0.0000000017707
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.062 0.4137
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0017 0.0206 0.2405
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0397 0.2367
Echinococcus multilocularis Eukaryotic translation initiation factor 4H 0.0163 0.4763 1
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0023 0.0397 0.0833
Mycobacterium ulcerans glutaminase 0.033 1 1
Loa Loa (eye worm) hypothetical protein 0.0163 0.4763 0.4763

Activities

Activity type Activity value Assay description Source Reference
EC50 (binding) > 112.219 um PUBCHEM_BIOASSAY: Luminescence Biochemical Dose Response HTS to Identify Inhibitors of Luciferase. (Class of assay: confirmatory) [Related pubchem assays: 1663 (Primary HTS), 1678 (Summary of Project)] ChEMBL. No reference
IC50 (binding) = 12.01 uM PUBCHEM_BIOASSAY: uHTS fluorescence polarization assay for the identification of translation initiation inhibitors (eIF4H). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2014, AID2028, AID435011, AID435018, AID449744, AID449751, AID449752] ChEMBL. No reference
IC50 (binding) = 77.05 uM PUBCHEM_BIOASSAY: uHTS fluorescence polarization assay for the identification of translation initiation inhibitors (PABP). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2012, AID2030, AID435011, AID435018, AID449744, AID449751, AID449752] ChEMBL. No reference
Potency (functional) 10 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 10 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 14.1254 uM PubChem BioAssay. qHTS for Inhibitors of Glutaminase (GLS). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 17.7828 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Eta. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588636] ChEMBL. No reference
Potency (functional) = 19.9526 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Bloom's syndrome helicase (BLM). (Class of assay: confirmatory) [Related pubchem assays: 593 (Fluorescein region spectral profiling screen), 2386 (Probe Development Summary for Inhibitors of Bloom's syndrome helicase (BLM)), 594 (Rhodamine region spectral profiling screen), 2364 (qHTS Validation Assay for Inhibitors of Bloom's syndrome helicase (BLM))] ChEMBL. No reference
Potency (binding) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Tyrosyl-DNA Phosphodiesterase (TDP1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 25.1189 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference
Potency (functional) 37.933 uM PUBCHEM_BIOASSAY: qHTS Assay to Find Inhibitors of T. brucei phosphofructokinase. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488768, AID492961] ChEMBL. No reference
Potency (functional) 67.0158 uM PubChem BioAssay. qHTS for Inhibitors of Polymerase Iota: Confirmatory Assay for Cherry-picked Compounds. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 79.4328 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.