Detailed information for compound 1452674

Basic information

Technical information
  • TDR Targets ID: 1452674
  • Name: 2-[4-[3-chloro-5-(trifluoromethyl)pyridin-2-y l]piperazin-1-yl]ethyl 4-methylbenzoate
  • MW: 427.848 | Formula: C20H21ClF3N3O2
  • H donors: 0 H acceptors: 2 LogP: 4.54 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1ccc(cc1)C(=O)OCCN1CCN(CC1)c1ncc(cc1Cl)C(F)(F)F
  • InChi: 1S/C20H21ClF3N3O2/c1-14-2-4-15(5-3-14)19(28)29-11-10-26-6-8-27(9-7-26)18-17(21)12-16(13-25-18)20(22,23)24/h2-5,12-13H,6-11H2,1H3
  • InChiKey: HCICSJPZYYRNMG-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-[4-[3-chloro-5-(trifluoromethyl)-2-pyridyl]piperazin-1-yl]ethyl 4-methylbenzoate
  • 4-methylbenzoic acid 2-[4-[3-chloro-5-(trifluoromethyl)-2-pyridyl]-1-piperazinyl]ethyl ester
  • 4-methylbenzoic acid 2-[4-[3-chloro-5-(trifluoromethyl)-2-pyridyl]piperazin-1-yl]ethyl ester
  • SMR000179017
  • 3M-949
  • 2-{4-[3-chloro-5-(trifluoromethyl)-2-pyridinyl]piperazino}ethyl 4-methylbenzenecarboxylate
  • MLS000326414

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Bacillus subtilis (strain 168) ATP-dependent Clp protease proteolytic subunit Starlite/ChEMBL No references
Homo sapiens lysine (K)-specific methyltransferase 2A Starlite/ChEMBL No references
Homo sapiens multiple endocrine neoplasia I No references
Homo sapiens microtubule-associated protein tau Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Echinococcus multilocularis peptidase Clp (S14 family) Get druggable targets OG5_127187 All targets in OG5_127187
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) Get druggable targets OG5_127187 All targets in OG5_127187
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Schistosoma japonicum ko:K04380 microtubule-associated protein tau, putative Get druggable targets OG5_133504 All targets in OG5_133504
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative Get druggable targets OG5_127187 All targets in OG5_127187
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) Get druggable targets OG5_127187 All targets in OG5_127187
Plasmodium berghei ATP-dependent Clp protease proteolytic subunit, putative Get druggable targets OG5_127187 All targets in OG5_127187
Echinococcus multilocularis dnaJ subfamily B Get druggable targets OG5_133913 All targets in OG5_133913
Schistosoma mansoni peptidase Clp (S14 family) Get druggable targets OG5_127187 All targets in OG5_127187
Toxoplasma gondii histone lysine methyltransferase SET1 Get druggable targets OG5_130642 All targets in OG5_130642
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Echinococcus granulosus peptidase Clp S14 family Get druggable targets OG5_127187 All targets in OG5_127187
Schistosoma japonicum ko:K06275 parvin, putative Get druggable targets OG5_127187 All targets in OG5_127187
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein Get druggable targets OG5_127187 All targets in OG5_127187
Neospora caninum Multidomain chromatinic protein with the following architecture: 3x PHD-bromo-3xPHD-SET domain and associated cysteine cluster a Get druggable targets OG5_130642 All targets in OG5_130642
Schistosoma japonicum ko:K09188 myeloid/lymphoid or mixed-lineage leukemia protein 3, putative Get druggable targets OG5_130642 All targets in OG5_130642
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein Get druggable targets OG5_127187 All targets in OG5_127187
Echinococcus multilocularis microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Schistosoma mansoni mixed-lineage leukemia protein mll Get druggable targets OG5_130642 All targets in OG5_130642
Babesia bovis ATP-dependent Clp protease proteolytic subunit 1, putative Get druggable targets OG5_127187 All targets in OG5_127187
Schistosoma japonicum Menin, putative Get druggable targets OG5_133913 All targets in OG5_133913
Echinococcus granulosus microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) Get druggable targets OG5_127187 All targets in OG5_127187
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Theileria parva ATP-dependent Clp protease proteolytic subunit, putative Get druggable targets OG5_127187 All targets in OG5_127187
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Brugia malayi Probable ClpP-like protease Get druggable targets OG5_127187 All targets in OG5_127187
Echinococcus granulosus dnaJ subfamily B Get druggable targets OG5_133913 All targets in OG5_133913
Plasmodium knowlesi ATP-dependent Clp protease proteolytic subunit, putative Get druggable targets OG5_127187 All targets in OG5_127187
Theileria parva ATP-dependent Clp protease proteolytic subunit, putative Get druggable targets OG5_127187 All targets in OG5_127187
Plasmodium yoelii ATP-dependent Clp protease, proteolytic subunit ClpP, putative Get druggable targets OG5_127187 All targets in OG5_127187
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Treponema pallidum ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Schistosoma japonicum ko:K01358 ATP-dependent Clp protease, protease subunit [EC3.4.21.92], putative Get druggable targets OG5_127187 All targets in OG5_127187
Schistosoma mansoni hypothetical protein Get druggable targets OG5_133913 All targets in OG5_133913
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Schistosoma mansoni microtubule-associated protein tau Get druggable targets OG5_133504 All targets in OG5_133504
Neospora caninum ATP-dependent Clp protease proteolytic subunit, related Get druggable targets OG5_127187 All targets in OG5_127187
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127187 All targets in OG5_127187
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) Get druggable targets OG5_127187 All targets in OG5_127187
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Chlamydia trachomatis hypothetical protein ATP-dependent Clp protease proteolytic subunit   197 aa 171 aa 22.8 %
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 ATP-dependent Clp protease proteolytic subunit   197 aa 172 aa 57.0 %
Plasmodium knowlesi ATP-dependent Clp protease proteolytic subunit, putative ATP-dependent Clp protease proteolytic subunit   197 aa 189 aa 36.0 %
Treponema pallidum ATP-dependent Clp protease proteolytic subunit ATP-dependent Clp protease proteolytic subunit   197 aa 186 aa 40.3 %
Babesia bovis ATP-dependent Clp protease proteolytic subunit, putative ATP-dependent Clp protease proteolytic subunit   197 aa 188 aa 41.5 %
Babesia bovis ATP-dependent Clp protease proteolytic subunit, putative ATP-dependent Clp protease proteolytic subunit   197 aa 188 aa 41.5 %
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit ATP-dependent Clp protease proteolytic subunit   197 aa 183 aa 36.1 %
Onchocerca volvulus Putative V-type proton ATPase subunit F ATP-dependent Clp protease proteolytic subunit   197 aa 194 aa 54.1 %
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative ATP-dependent Clp protease proteolytic subunit   197 aa 189 aa 35.5 %
Schistosoma mansoni neuropeptide receptor ATP-dependent Clp protease proteolytic subunit   197 aa 174 aa 20.1 %
Plasmodium yoelii Clp protease ATP-dependent Clp protease proteolytic subunit   197 aa 183 aa 36.6 %
Plasmodium berghei ATP-dependent Clp protease proteolytic subunit, putative ATP-dependent Clp protease proteolytic subunit   197 aa 180 aa 36.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0009 0.0037 0.0037
Loa Loa (eye worm) hypothetical protein 0.0029 0.0288 0.0773
Leishmania major DNA polymerase kappa, putative 0.0006 0.0007 0.0097
Echinococcus granulosus glutamate receptor ionotropic kainate 3 0.0007 0.0022 0.0022
Echinococcus multilocularis neuropeptide receptor 0.001 0.0059 0.0059
Brugia malayi hypothetical protein 0.001 0.0059 0.0167
Schistosoma mansoni biogenic amine (5HT) receptor 0.001 0.0059 0.0059
Loa Loa (eye worm) hypothetical protein 0.001 0.0059 0.0159
Echinococcus multilocularis allatostatin A receptor 0.001 0.0059 0.0059
Schistosoma mansoni hypothetical protein 0.001 0.0059 0.0059
Loa Loa (eye worm) hypothetical protein 0.001 0.0059 0.0159
Echinococcus multilocularis importin subunit beta 1 0.0029 0.0288 0.0288
Echinococcus multilocularis rhodopsin orphan GPCR 0.001 0.0059 0.0059
Loa Loa (eye worm) hypothetical protein 0.001 0.0059 0.0159
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0094 0.1074 0.1074
Echinococcus granulosus somatostatin receptor 0.001 0.0059 0.0059
Echinococcus multilocularis peptidase Clp (S14 family) 0.0062 0.0681 0.0681
Echinococcus multilocularis rhodopsin orphan GPCR 0.001 0.0059 0.0059
Schistosoma mansoni neuropeptide receptor 0.001 0.0059 0.0059
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.001 0.0059 0.0059
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.001 0.0059 0.0059
Brugia malayi neuropeptide F receptor 0.001 0.0059 0.0167
Loa Loa (eye worm) hypothetical protein 0.001 0.0059 0.0159
Echinococcus granulosus dnaJ subfamily B 0.0494 0.59 0.59
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0094 0.1074 1
Brugia malayi gonadotropin-releasing hormone receptor 2 0.001 0.0059 0.0167
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0062 0.0682 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.001 0.0059 0.0059
Loa Loa (eye worm) hypothetical protein 0.001 0.0059 0.0159
Echinococcus granulosus neuropeptide Y receptor 0.001 0.0059 0.0059
Plasmodium vivax importin-beta 2, putative 0.0029 0.0288 0.2679
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.017 0.7653
Plasmodium falciparum importin beta, putative 0.0029 0.0288 0.2679
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0194 0.8758
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.002 0.017 0.7723
Loa Loa (eye worm) hypothetical protein 0.0061 0.0666 0.179
Schistosoma mansoni DNA polymerase IV / kappa 0.0006 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.001 0.0059 0.0159
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0006 0.0007 0.0061
Echinococcus granulosus rhodopsin orphan GPCR 0.001 0.0059 0.0059
Echinococcus granulosus max protein X 0.0299 0.3546 0.3546
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0094 0.1074 1
Echinococcus granulosus rhodopsin orphan GPCR 0.001 0.0059 0.0059
Schistosoma mansoni amine GPCR 0.001 0.0059 0.0059
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0094 0.1074 1
Schistosoma mansoni biogenic amine (5HT) receptor 0.001 0.0059 0.0059
Echinococcus granulosus tm gpcr rhodopsin 0.001 0.0059 0.0059
Loa Loa (eye worm) glutamate receptor 2 0.0007 0.0022 0.0059
Echinococcus granulosus orexin receptor type 2 0.001 0.0059 0.0059
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0288 1
Brugia malayi G protein-coupled receptor 0.001 0.0059 0.0167
Loa Loa (eye worm) hypothetical protein 0.001 0.0059 0.0159
Echinococcus granulosus glutamate receptor subunit protein glur 0.0007 0.0022 0.0022
Schistosoma mansoni hypothetical protein 0.0061 0.0666 0.0666
Schistosoma mansoni ATP-binding cassette transporter 0.0007 0.0022 0.0022
Echinococcus granulosus 7TM GPCR rhodopsin 0.001 0.0059 0.0059
Schistosoma mansoni glutamate receptor NMDA 0.0007 0.0022 0.0022
Schistosoma mansoni rhodopsin-like orphan GPCR 0.001 0.0059 0.0059
Echinococcus granulosus G protein coupled receptor 139 0.001 0.0059 0.0059
Echinococcus multilocularis neuropeptides capa receptor 0.001 0.0059 0.0059
Loa Loa (eye worm) hypothetical protein 0.001 0.0059 0.0159
Loa Loa (eye worm) G-protein coupled receptor 0.001 0.0059 0.0159
Schistosoma mansoni caspase-7 (C14 family) 0.0061 0.0666 0.0666
Echinococcus granulosus caspase 2 0.0061 0.0666 0.0666
Loa Loa (eye worm) hypothetical protein 0.001 0.0059 0.0159
Loa Loa (eye worm) hypothetical protein 0.001 0.0059 0.0159
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0006 0.0007 0.0061
Schistosoma mansoni amine GPCR 0.001 0.0059 0.0059
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0062 0.0681 0.9982
Brugia malayi hypothetical protein 0.001 0.0059 0.0167
Echinococcus multilocularis microtubule associated protein 2 0.0833 1 1
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0314 0.372 1
Brugia malayi G-protein coupled receptor 0.001 0.0059 0.0167
Schistosoma mansoni hypothetical protein 0.001 0.0059 0.0059
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.001 0.0059 0.0159
Brugia malayi Importin beta-1 subunit 0.0029 0.0288 0.0811
Schistosoma mansoni biogenic amine (dopamine) receptor 0.001 0.0059 0.0059
Echinococcus granulosus sex peptide receptor 0.001 0.0059 0.0059
Echinococcus granulosus neuropeptide receptor 0.001 0.0059 0.0059
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.001 0.0059 0.0059
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.0011 0.0068 0.0068
Brugia malayi larval opioid receptor 0.001 0.0059 0.0167
Loa Loa (eye worm) hypothetical protein 0.001 0.0059 0.0159
Echinococcus multilocularis g protein coupled receptor 0.001 0.0059 0.0059
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0011 0.0068 0.0068
Echinococcus multilocularis rhodopsin orphan GPCR 0.001 0.0059 0.0059
Loa Loa (eye worm) helix-loop-helix DNA-binding domain-containing protein 0.0299 0.3546 0.9531
Schistosoma mansoni ran 0.0022 0.0194 0.0194
Echinococcus multilocularis inhibitor of apoptosis protein 0.0296 0.3511 0.3511
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0022 0.0194 0.6744
Brugia malayi Dopamine receptor 0.001 0.0059 0.0167
Loa Loa (eye worm) hypothetical protein 0.001 0.0059 0.0159
Brugia malayi polk-prov protein 0.0006 0.0007 0.0019
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0062 0.0681 0.4744
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 0.0682 0.6326
Echinococcus multilocularis neuropeptide FF receptor 2 0.001 0.0059 0.0059
Schistosoma mansoni amine GPCR 0.001 0.0059 0.0059
Brugia malayi Helix-loop-helix DNA-binding domain containing protein 0.0299 0.3546 1
Schistosoma mansoni glutamate receptor kainate 0.0007 0.0022 0.0022
Trypanosoma brucei DNA polymerase kappa, putative 0.0006 0.0007 0.0229
Echinococcus multilocularis dna polymerase kappa 0.002 0.017 0.017
Brugia malayi putative neuropeptide receptor 0.001 0.0059 0.0167
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0074 0.0822 0.0822
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0221 1
Mycobacterium ulcerans DNA polymerase IV 0.002 0.017 0.1534
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0022 0.0194 0.1807
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0028 0.1262
Entamoeba histolytica hypothetical protein 0.0024 0.0221 1
Echinococcus multilocularis tachykinin peptides receptor 99D 0.001 0.0059 0.0059
Schistosoma mansoni neuropeptide receptor 0.001 0.0059 0.0059
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.017 0.5922
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 0.0682 0.6326
Brugia malayi hypothetical protein 0.001 0.0059 0.0167
Brugia malayi Melatonin receptor type 1A 0.001 0.0059 0.0167
Schistosoma mansoni amine GPCR 0.001 0.0059 0.0059
Echinococcus multilocularis NMDA receptor 0.0007 0.0022 0.0022
Brugia malayi F/Y-rich N-terminus family protein 0.0011 0.0061 0.0172
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.002 0.017 0.0179
Echinococcus multilocularis g protein coupled receptor 0.001 0.0059 0.0059
Echinococcus granulosus neuropeptide s receptor 0.001 0.0059 0.0059
Echinococcus granulosus Ribosomal protein S1 RNA binding domain 0.0007 0.0022 0.0022
Loa Loa (eye worm) follicle stimulating hormone receptor 0.001 0.0059 0.0159
Trypanosoma brucei hypothetical protein, conserved 0.0006 0.0007 0.0229
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0006 0.0007 0.0061
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0022 0.0194 0.0521
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0011 0.0068 0.0068
Echinococcus multilocularis caspase 2 0.0061 0.0666 0.0666
Echinococcus multilocularis fmrfamide receptor 0.001 0.0059 0.0059
Echinococcus granulosus glutamate NMDA receptor subunit 0.0007 0.0022 0.0022
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0094 0.1074 1
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.017 0.5922
Echinococcus granulosus apoptotic protease activating factor 1 0.0061 0.0666 0.0666
Loa Loa (eye worm) hypothetical protein 0.0061 0.0666 0.179
Schistosoma mansoni opsin-like receptor 0.001 0.0059 0.0059
Echinococcus multilocularis baculoviral IAP repeat containing protein 0.0296 0.3511 0.3511
Leishmania major DNA polymerase eta, putative 0.0006 0.0007 0.0097
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0097 0.336
Loa Loa (eye worm) hypothetical protein 0.001 0.0059 0.0159
Echinococcus multilocularis somatostatin receptor 0.001 0.0059 0.0059
Loa Loa (eye worm) hypothetical protein 0.001 0.0059 0.0159
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0028 0.1262
Brugia malayi hypothetical protein 0.001 0.0059 0.0167
Loa Loa (eye worm) hypothetical protein 0.001 0.0059 0.0159
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.001 0.0059 0.0059
Echinococcus multilocularis neuropeptide s receptor 0.001 0.0059 0.0059
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.017 0.7653
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.001 0.0059 0.0059
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0288 1
Echinococcus granulosus importin subunit beta 1 0.0029 0.0288 0.0288
Toxoplasma gondii hypothetical protein 0.0033 0.0326 0.3036
Echinococcus granulosus baculoviral IAP repeat containing protein 0.0296 0.3511 0.3511
Echinococcus granulosus snurportin 1 0.0314 0.372 0.372
Schistosoma mansoni glutamate receptor kainate 0.0007 0.0022 0.0022
Echinococcus granulosus glutamate receptor 2 0.0011 0.0068 0.0068
Echinococcus multilocularis nmda type glutamate receptor 0.0026 0.025 0.025
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0028 0.1262
Echinococcus multilocularis orexin receptor type 2 0.001 0.0059 0.0059
Echinococcus granulosus alpha 1A adrenergic receptor 0.001 0.0059 0.0059
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0097 0.336
Echinococcus granulosus rhodopsin orphan GPCR 0.001 0.0059 0.0059
Echinococcus granulosus cpg binding protein 0.0037 0.0376 0.0376
Loa Loa (eye worm) hypothetical protein 0.001 0.0059 0.0159
Schistosoma mansoni myosin xvIII 0.001 0.0059 0.0059
Schistosoma mansoni peptidase Clp (S14 family) 0.0094 0.1074 0.1074
Echinococcus multilocularis rhodopsin orphan GPCR 0.001 0.0059 0.0059
Schistosoma mansoni biogenic amine receptor 0.001 0.0059 0.0059
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.001 0.0059 0.0059
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.0011 0.0068 0.0068
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.002 0.017 0.017
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0011 0.0068 0.0068
Schistosoma mansoni glutamate receptor NMDA 0.0011 0.0068 0.0068
Echinococcus granulosus 7tm_1 domain containing protein 0.001 0.0059 0.0059
Schistosoma mansoni opsin-like receptor 0.001 0.0059 0.0059
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0094 0.1074 0.1074
Echinococcus multilocularis Ribosomal protein S1, RNA binding domain 0.0007 0.0022 0.0022
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0022 0.0194 1
Echinococcus granulosus inhibitor of apoptosis protein 0.0296 0.3511 0.3511
Brugia malayi AKH receptor 0.001 0.0059 0.0167
Echinococcus granulosus biogenic amine 5HT receptor 0.001 0.0059 0.0059
Brugia malayi Dopamine receptor protein 1 0.001 0.0059 0.0167
Echinococcus granulosus dna polymerase kappa 0.002 0.017 0.017
Leishmania major DNA damage repair protein, putative 0.0006 0.0007 0.0097
Echinococcus multilocularis cpg binding protein 0.0037 0.0376 0.0376
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.017 0.5922
Echinococcus granulosus g-protein coupled receptor 0.001 0.0059 0.0059
Loa Loa (eye worm) hypothetical protein 0.002 0.017 0.0458
Echinococcus granulosus rhodopsin orphan GPCR 0.001 0.0059 0.0059
Loa Loa (eye worm) histone methyltransferase 0.0011 0.0063 0.0168
Echinococcus multilocularis rhodopsin orphan GPCR 0.001 0.0059 0.0059
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0062 0.0682 1
Brugia malayi follicle stimulating hormone receptor 0.001 0.0059 0.0167
Schistosoma mansoni microtubule-associated protein tau 0.0833 1 1
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.017 0.5922
Loa Loa (eye worm) hypothetical protein 0.001 0.0059 0.0159
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.001 0.0059 0.0159
Schistosoma mansoni rhodopsin-like orphan GPCR 0.001 0.0059 0.0059
Toxoplasma gondii histone lysine methyltransferase SET1 0.0066 0.0727 0.6768
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.001 0.0059 0.0059
Trichomonas vaginalis importin beta-1, putative 0.0024 0.0221 1
Echinococcus multilocularis neuropeptides capa receptor 0.001 0.0059 0.0059
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.002 0.017 0.0458
Brugia malayi Inhibitor of Apoptosis domain containing protein 0.0296 0.3511 0.9902
Loa Loa (eye worm) hypothetical protein 0.0006 0.0007 0.0018
Echinococcus multilocularis neuropeptide Y receptor 0.001 0.0059 0.0059
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0022 0.0194 0.0547
Loa Loa (eye worm) hypothetical protein 0.001 0.0059 0.0159
Schistosoma mansoni neuropeptide receptor 0.001 0.0059 0.0059
Loa Loa (eye worm) hypothetical protein 0.001 0.0059 0.0159
Leishmania major DNA polymerase kappa, putative 0.002 0.017 0.2499
Loa Loa (eye worm) hypothetical protein 0.001 0.0059 0.0159
Echinococcus granulosus rhodopsin orphan GPCR 0.001 0.0059 0.0059
Echinococcus multilocularis g protein coupled receptor 0.001 0.0059 0.0059
Echinococcus multilocularis neuropeptide receptor 0.001 0.0059 0.0059
Echinococcus granulosus neuropeptide FF receptor 2 0.001 0.0059 0.0059
Mycobacterium ulcerans DNA polymerase IV 0.002 0.017 0.1534
Trypanosoma brucei DNA polymerase kappa, putative 0.0006 0.0007 0.0229
Loa Loa (eye worm) hypothetical protein 0.001 0.0059 0.0159
Trypanosoma brucei chrX additional, unordered contigs 0.0006 0.0007 0.0229
Brugia malayi ORL1-like opioid receptor 0.001 0.0059 0.0167
Schistosoma mansoni glutamate receptor kainate 0.0007 0.0022 0.0022
Trypanosoma brucei unspecified product 0.002 0.017 0.5922
Entamoeba histolytica Ran family GTPase 0.0022 0.0194 0.8795
Loa Loa (eye worm) hypothetical protein 0.001 0.0059 0.0159
Echinococcus multilocularis neuropeptide Y receptor 0.001 0.0059 0.0059
Loa Loa (eye worm) hypothetical protein 0.001 0.0059 0.0159
Schistosoma mansoni biogenic amine (dopamine) receptor 0.001 0.0059 0.0059
Echinococcus multilocularis biogenic amine (5HT) receptor 0.001 0.0059 0.0059
Loa Loa (eye worm) hypothetical protein 0.001 0.0059 0.0159
Loa Loa (eye worm) hypothetical protein 0.001 0.0059 0.0159
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0028 0.1262
Loa Loa (eye worm) G-protein coupled receptor 0.001 0.0059 0.0159
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0094 0.1074 1
Schistosoma mansoni hypothetical protein 0.0314 0.372 0.372
Schistosoma mansoni importin beta-1 0.0029 0.0288 0.0288
Loa Loa (eye worm) melatonin receptor type 1A 0.001 0.0059 0.0159
Brugia malayi Serotonin/octopamine receptor family protein 7 0.001 0.0059 0.0167
Onchocerca volvulus Deterin homolog 0.0296 0.3511 1
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.017 0.5922
Schistosoma mansoni biogenic amine receptor 0.001 0.0059 0.0059
Schistosoma mansoni opsin-like receptor 0.001 0.0059 0.0059
Brugia malayi Glutamate receptor 2 precursor 0.0007 0.0022 0.0062
Echinococcus granulosus hypothetical protein 0.001 0.0059 0.0059
Loa Loa (eye worm) hypothetical protein 0.001 0.0059 0.0159
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.017 0.5922
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.017 0.5922
Brugia malayi hypothetical protein 0.001 0.0059 0.0167
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0028 0.1262
Echinococcus granulosus tachykinin peptides receptor 99D 0.001 0.0059 0.0059
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0094 0.1074 1
Schistosoma mansoni hypothetical protein 0.0494 0.59 0.59
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0028 0.1262
Loa Loa (eye worm) CXXC zinc finger family protein 0.0035 0.0352 0.0946
Brugia malayi hypothetical protein 0.001 0.0059 0.0167
Brugia malayi sulfakinin receptor protein 0.001 0.0059 0.0167
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0011 0.0063 0.0063
Echinococcus granulosus tm gpcr rhodopsin 0.001 0.0059 0.0059
Loa Loa (eye worm) hypothetical protein 0.001 0.0059 0.0159
Trichomonas vaginalis ran, putative 0.0022 0.0194 0.8795
Echinococcus multilocularis G-protein coupled receptor, putative 0.001 0.0059 0.0059
Schistosoma mansoni glutamate receptor AMPA 0.0007 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.001 0.0059 0.0159
Echinococcus multilocularis serotonin receptor 0.001 0.0059 0.0059
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.001 0.0059 0.0059
Loa Loa (eye worm) hypothetical protein 0.001 0.0059 0.0159
Echinococcus granulosus fmrfamide receptor 0.001 0.0059 0.0059
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.017 0.5922
Echinococcus multilocularis max protein X 0.0299 0.3546 0.3546
Schistosoma mansoni rhodopsin-like orphan GPCR 0.001 0.0059 0.0059
Schistosoma mansoni amine GPCR 0.001 0.0059 0.0059
Echinococcus granulosus serotonin receptor 0.001 0.0059 0.0059
Echinococcus granulosus neuropeptides capa receptor 0.001 0.0059 0.0059
Brugia malayi Serotonin receptor 0.001 0.0059 0.0167
Mycobacterium ulcerans glutamine-binding lipoprotein GlnH 0.0019 0.0161 0.1447
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0028 0.1262
Echinococcus granulosus rhodopsin orphan GPCR 0.001 0.0059 0.0059
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 0.0682 0.6326
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 3 0.0026 0.025 0.025
Echinococcus granulosus peptidase Clp S14 family 0.0062 0.0681 0.0681
Echinococcus granulosus g protein coupled receptor 0.001 0.0059 0.0059
Mycobacterium tuberculosis Conserved hypothetical protein 0.002 0.017 0.0179
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.001 0.0059 0.0059
Echinococcus granulosus dna polymerase eta 0.002 0.017 0.017
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.001 0.0059 0.0059
Echinococcus multilocularis dna polymerase eta 0.002 0.017 0.017
Brugia malayi RE15519p 0.001 0.0059 0.0167
Loa Loa (eye worm) hypothetical protein 0.001 0.0059 0.0159
Echinococcus granulosus nmda type glutamate receptor 0.0026 0.025 0.025
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.001 0.0059 0.0059
Schistosoma mansoni neuropeptide F-like receptor 0.001 0.0059 0.0059
Loa Loa (eye worm) hypothetical protein 0.0094 0.1074 0.2886
Echinococcus granulosus g protein coupled receptor 0.001 0.0059 0.0059
Trypanosoma brucei unspecified product 0.0014 0.0097 0.336
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0097 0.336
Echinococcus granulosus biogenic amine 5HT receptor 0.001 0.0059 0.0059
Schistosoma mansoni terminal deoxycytidyl transferase 0.002 0.017 0.017
Echinococcus multilocularis serotonin receptor 0.001 0.0059 0.0059
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0028 0.1262
Plasmodium falciparum DNA repair protein REV1, putative 0.0006 0.0007 0.0061
Loa Loa (eye worm) hypothetical protein 0.001 0.0059 0.0159
Entamoeba histolytica deoxycytidyl transferase, putative 0.002 0.017 0.7723
Echinococcus multilocularis rhodopsin orphan GPCR 0.001 0.0059 0.0059
Echinococcus granulosus neuropeptide Y receptor 0.001 0.0059 0.0059
Brugia malayi hypothetical protein 0.001 0.0059 0.0167
Schistosoma mansoni bhlhzip transcription factor bigmax 0.0299 0.3546 0.3546
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0094 0.1074 1
Toxoplasma gondii aldehyde dehydrogenase 0.0062 0.0682 0.6348
Schistosoma mansoni cpg binding protein 0.0037 0.0376 0.0376
Brugia malayi hypothetical protein 0.001 0.0059 0.0167
Schistosoma mansoni cpg binding protein 0.0037 0.0376 0.0376
Leishmania major importin beta-1 subunit, putative 0.0024 0.0221 0.3236
Echinococcus multilocularis apoptotic protease activating factor 1 0.0061 0.0666 0.0666
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0094 0.1074 1
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0022 0.0194 0.1807
Loa Loa (eye worm) hypothetical protein 0.001 0.0059 0.0159
Schistosoma mansoni biogenic amine (dopamine) receptor 0.001 0.0059 0.0059
Loa Loa (eye worm) hypothetical protein 0.0296 0.3511 0.9438
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.002 0.017 0.017
Onchocerca volvulus 0.0035 0.0352 0.0848
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0033 0.0326 0.1807
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0094 0.1074 1
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0033 0.0326 0.3036
Trypanosoma brucei hypothetical protein, conserved 0.0006 0.0007 0.0229
Schistosoma mansoni neuropeptide f receptor 76f 0.001 0.0059 0.0059
Schistosoma mansoni rhodopsin-like orphan GPCR 0.001 0.0059 0.0059
Schistosoma mansoni rhodopsin-like orphan GPCR 0.001 0.0059 0.0059
Echinococcus multilocularis G protein coupled receptor 139 0.001 0.0059 0.0059
Leishmania major GTP-binding protein, putative 0.0022 0.0194 0.2846
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.001 0.0059 0.0059
Echinococcus granulosus g protein coupled receptor 0.001 0.0059 0.0059
Echinococcus granulosus neuropeptide receptor 0.001 0.0059 0.0059
Loa Loa (eye worm) hypothetical protein 0.001 0.0059 0.0159
Brugia malayi hypothetical protein 0.001 0.0059 0.0167
Echinococcus multilocularis dro:myosuppressin receptor 0.001 0.0059 0.0059
Schistosoma mansoni rhodopsin-like orphan GPCR 0.001 0.0059 0.0059
Echinococcus multilocularis glutamate receptor 2 0.0007 0.0022 0.0022
Schistosoma mansoni ran 0.0022 0.0194 0.0194
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0062 0.0682 0.0682
Schistosoma mansoni alpha-1 adrenergic receptor 0.001 0.0059 0.0059
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.017 0.7653
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0033 0.0326 0.3036
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.001 0.0059 0.0059
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0028 0.1262
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0011 0.0068 0.0068
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.017 0.5922
Echinococcus multilocularis glutamate receptor 2 0.0011 0.0068 0.0068
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0011 0.0063 0.0063
Schistosoma mansoni hypothetical protein 0.001 0.0059 0.0059
Schistosoma mansoni neuropeptide F-like receptor 0.001 0.0059 0.0059
Loa Loa (eye worm) hypothetical protein 0.001 0.0059 0.0159
Brugia malayi Tachykinin-like peptides receptor 99D 0.001 0.0059 0.0167
Loa Loa (eye worm) hypothetical protein 0.001 0.0059 0.0159
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0022 0.0194 0.0194
Schistosoma mansoni adenoreceptor 0.001 0.0059 0.0059
Loa Loa (eye worm) neuropeptide F receptor 0.001 0.0059 0.0159
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.001 0.0059 0.0059
Schistosoma mansoni histamine h1 receptor 0.001 0.0059 0.0059
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.002 0.017 0.017
Schistosoma mansoni cpg binding protein 0.0035 0.0352 0.0352
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0037 0.0037
Trypanosoma brucei unspecified product 0.0014 0.0097 0.336
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0028 0.1262
Brugia malayi G-protein coupled receptor 0.001 0.0059 0.0167
Echinococcus multilocularis alpha 1A adrenergic receptor 0.001 0.0059 0.0059
Echinococcus granulosus rhodopsin orphan GPCR 0.001 0.0059 0.0059
Trypanosoma brucei DNA damage repair protein, putative 0.0006 0.0007 0.0229
Loa Loa (eye worm) hypothetical protein 0.001 0.0059 0.0159
Schistosoma mansoni peptide (allatostatin)-like receptor 0.001 0.0059 0.0059
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.001 0.0059 0.0059
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.017 0.5922
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0009 0.0037 0.0037
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.001 0.0059 0.0059
Trypanosoma cruzi importin beta-1 subunit, putative 0.0024 0.0221 1
Echinococcus multilocularis glutamate receptor subunit protein glur 0.0007 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.001 0.0059 0.0159
Brugia malayi CXXC zinc finger family protein 0.0035 0.0352 0.0992
Trypanosoma brucei DNA polymerase eta, putative 0.002 0.017 0.5922
Schistosoma mansoni inhibitor of apoptosis protein 0.0296 0.3511 0.3511
Echinococcus multilocularis fmrfamide receptor 0.001 0.0059 0.0059
Loa Loa (eye worm) hypothetical protein 0.001 0.0059 0.0159
Schistosoma mansoni hypothetical protein 0.0296 0.3511 0.3511
Loa Loa (eye worm) hypothetical protein 0.001 0.0059 0.0159
Loa Loa (eye worm) hypothetical protein 0.001 0.0059 0.0159
Onchocerca volvulus Cell death protein 3 homolog 0.0061 0.0666 0.1758
Schistosoma mansoni inhibitor of apoptosis (iap) domain family member 0.0296 0.3511 0.3511
Echinococcus multilocularis sex peptide receptor 0.001 0.0059 0.0059
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.001 0.0059 0.0059
Schistosoma mansoni DNA polymerase eta 0.002 0.017 0.017
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.017 0.7653
Echinococcus granulosus thyrotropin releasing hormone receptor 0.001 0.0059 0.0059
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0028 0.1262
Brugia malayi hypothetical protein 0.0061 0.0666 0.1878
Echinococcus multilocularis glutamate (NMDA) receptor subunit 0.0007 0.0022 0.0022
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0062 0.0682 0.0682
Loa Loa (eye worm) hypothetical protein 0.001 0.0059 0.0159
Leishmania major DNA polymerase eta, putative 0.002 0.017 0.2499
Schistosoma mansoni aldehyde dehydrogenase 0.0062 0.0682 0.0682
Brugia malayi GnHR receptor homolog 0.001 0.0059 0.0167
Schistosoma mansoni neuropeptide receptor 0.001 0.0059 0.0059
Loa Loa (eye worm) glutamate receptor 1 0.0007 0.0022 0.0059
Brugia malayi RNA, U transporter 1 0.0084 0.0942 0.2656
Loa Loa (eye worm) hypothetical protein 0.001 0.0059 0.0159
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0094 0.1074 0.5
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.017 0.5922
Echinococcus multilocularis glutamate receptor ionotropic kainate 0.0007 0.0022 0.0022
Trichomonas vaginalis helicase, putative 0.0008 0.0028 0.1262
Brugia malayi Glutamate receptor 1 precursor 0.0007 0.0022 0.0062
Echinococcus granulosus neuropeptide receptor A26 0.001 0.0059 0.0059
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.002 0.017 0.2499
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.001 0.0059 0.0059
Loa Loa (eye worm) hypothetical protein 0.001 0.0059 0.0159
Schistosoma mansoni rhodopsin-like orphan GPCR 0.001 0.0059 0.0059
Brugia malayi Cell death protein 3 precursor 0.0061 0.0666 0.1878
Schistosoma mansoni rhodopsin-like orphan GPCR 0.001 0.0059 0.0059
Echinococcus multilocularis neuropeptide receptor A26 0.001 0.0059 0.0059
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.001 0.0059 0.0059
Plasmodium vivax DNA repair protein REV1, putative 0.0006 0.0007 0.0061
Echinococcus multilocularis g-protein coupled receptor 0.001 0.0059 0.0059
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.017 0.5922
Schistosoma mansoni growth hormone secretagogue receptor 0.001 0.0059 0.0059
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.001 0.0059 0.0159
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0008 0.0028 0.1262
Schistosoma mansoni hypothetical protein 0.0007 0.0022 0.0022
Echinococcus granulosus neuropeptides capa receptor 0.001 0.0059 0.0059
Trypanosoma cruzi DNA polymerase eta, putative 0.002 0.017 0.7653
Toxoplasma gondii HEAT repeat-containing protein 0.0029 0.0288 0.2679
Trichomonas vaginalis DNA polymerase eta, putative 0.002 0.017 0.7723
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0028 0.1262
Giardia lamblia DINP protein human, muc B family 0.002 0.017 0.8738
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.001 0.0059 0.0167
Brugia malayi G protein-coupled receptor F59B2.13 0.001 0.0059 0.0167
Schistosoma mansoni bhlhzip transcription factor bigmax 0.0299 0.3546 0.3546
Echinococcus granulosus tm gpcr rhodopsin 0.001 0.0059 0.0059
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0028 0.1262
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0037 0.0037
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.001 0.0059 0.0059
Echinococcus multilocularis dnaJ subfamily B 0.0494 0.59 0.59
Trypanosoma brucei DNA damage repair protein, putative 0.0006 0.0007 0.0229
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.001 0.0059 0.0167
Echinococcus multilocularis snurportin 1 0.0314 0.372 0.372
Loa Loa (eye worm) neuropeptide F receptor 0.001 0.0059 0.0159
Echinococcus granulosus dro:myosuppressin receptor 0.001 0.0059 0.0059
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.001 0.0059 0.0059
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.001 0.0059 0.0059
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0028 0.1262
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0094 0.1074 1
Echinococcus granulosus mixed lineage leukemia protein mll 0.0009 0.0037 0.0037
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.017 0.048
Loa Loa (eye worm) hypothetical protein 0.001 0.0059 0.0159
Schistosoma mansoni aldehyde dehydrogenase 0.0062 0.0682 0.0682
Echinococcus granulosus glutamate receptor ionotropic kainate 0.0007 0.0022 0.0022
Brugia malayi Serotonin receptor 0.001 0.0059 0.0167
Schistosoma mansoni rhodopsin-like orphan GPCR 0.001 0.0059 0.0059
Echinococcus granulosus GTP binding nuclear protein Ran 0.0022 0.0194 0.0194
Loa Loa (eye worm) hypothetical protein 0.0296 0.3511 0.9438
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0221 1
Schistosoma mansoni biogenic amine receptor 0.001 0.0059 0.0059
Echinococcus multilocularis rhodopsin orphan GPCR 0.001 0.0059 0.0059
Echinococcus granulosus allatostatin A receptor 0.001 0.0059 0.0059
Brugia malayi putative neuropeptide receptor NPR1 0.001 0.0059 0.0167
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0062 0.0681 0.9982
Loa Loa (eye worm) hypothetical protein 0.001 0.0059 0.0159
Schistosoma mansoni glutamate receptor AMPA 0.0007 0.0022 0.0022
Onchocerca volvulus 0.0296 0.3511 1
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0011 0.0068 0.0068
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.017 0.048
Onchocerca volvulus 0.0061 0.0666 0.1758
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0028 0.1262
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.001 0.0059 0.0159
Brugia malayi Inhibitor of Apoptosis domain containing protein 0.0296 0.3511 0.9902
Loa Loa (eye worm) TYRA-2 protein 0.001 0.0059 0.0159
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0194 0.8758
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0022 0.0194 0.1807
Schistosoma mansoni hypothetical protein 0.001 0.0059 0.0059
Echinococcus granulosus peptide allatostatin:somatostatin 0.001 0.0059 0.0059
Brugia malayi hypothetical protein 0.001 0.0059 0.0167
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0011 0.0068 0.0068
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.017 0.5922
Brugia malayi neuropeptide F receptor 0.001 0.0059 0.0167
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.001 0.0059 0.0059
Brugia malayi Dopamine receptor protein 2 0.001 0.0059 0.0167
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.001 0.0059 0.0059
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0008 0.0028 0.1262
Brugia malayi Probable ClpP-like protease 0.0094 0.1074 0.3028
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.001 0.0059 0.0167
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.001 0.0059 0.0059

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 7.0795 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide. (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) = 7.9433 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) 14.1254 uM PubChem BioAssay. qHTS Assay for Activators of ClpP. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 18.526 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 18.526 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference
Potency (functional) 28.1838 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 79.4328 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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