Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | GNAS complex locus | Starlite/ChEMBL | No references |
Rattus norvegicus | Inositol monophosphatase 1 | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | cdc2-related kinase 3 | 0.0052 | 0.0482 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.0602 | 0.0426 |
Onchocerca volvulus | 0.0294 | 1 | 0.5 | |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.0602 | 0.0426 |
Toxoplasma gondii | cell-cycle-associated protein kinase CDK, putative | 0.0052 | 0.0482 | 1 |
Loa Loa (eye worm) | CMGC/CDK/CDC2 protein kinase | 0.0052 | 0.0482 | 0.0303 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0055 | 0.0602 | 0.0426 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0294 | 1 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0294 | 1 | 1 |
Mycobacterium tuberculosis | Inositol-1-monophosphatase SuhB | 0.004 | 0 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0294 | 1 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0294 | 1 | 1 |
Entamoeba histolytica | cell division protein kinase 2, putative | 0.0052 | 0.0482 | 1 |
Giardia lamblia | Kinase, CDC7 | 0.0294 | 1 | 1 |
Leishmania major | cell division related protein kinase 2,cdc2-related kinase | 0.0052 | 0.0482 | 1 |
Echinococcus granulosus | cyclin dependent kinase 5 | 0.0052 | 0.0482 | 0.0303 |
Loa Loa (eye worm) | CMGC/CDK/CDC2 protein kinase | 0.0052 | 0.0482 | 0.0303 |
Echinococcus multilocularis | cyclin dependent kinase 1 | 0.0052 | 0.0482 | 0.0303 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0052 | 0.0482 | 0.0303 |
Entamoeba histolytica | cell division protein kinase 2, putative | 0.0052 | 0.0482 | 1 |
Loa Loa (eye worm) | CDC7 protein kinase | 0.0294 | 1 | 1 |
Trypanosoma brucei | cdc2-related kinase 1 | 0.0052 | 0.0482 | 1 |
Mycobacterium ulcerans | extragenic suppressor protein SuhB | 0.0045 | 0.0184 | 0.5 |
Trypanosoma cruzi | cdc2-related kinase 3 | 0.0052 | 0.0482 | 1 |
Trypanosoma cruzi | cdc2-related kinase 3 | 0.0052 | 0.0482 | 1 |
Trypanosoma cruzi | cdc2-related kinase 1 | 0.0052 | 0.0482 | 1 |
Echinococcus granulosus | CDC7 cell division cycle 7 | 0.0294 | 1 | 1 |
Echinococcus granulosus | cyclin dependent kinase | 0.0052 | 0.0482 | 0.0303 |
Echinococcus granulosus | cyclin dependent kinase 1 | 0.0052 | 0.0482 | 0.0303 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.0602 | 0.0426 |
Leishmania major | cell division protein kinase 2,cdc2-related kinase | 0.0052 | 0.0482 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0052 | 0.0482 | 0.0303 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.0602 | 0.0426 |
Loa Loa (eye worm) | CMGC/CDK/CDK5 protein kinase | 0.0052 | 0.0482 | 0.0303 |
Onchocerca volvulus | 0.0294 | 1 | 0.5 | |
Echinococcus multilocularis | cyclin dependent kinase 5 | 0.0052 | 0.0482 | 0.0303 |
Echinococcus granulosus | 5'partial|cyclin dependent kinase 1 | 0.0052 | 0.0482 | 0.0303 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0055 | 0.0602 | 0.0426 |
Plasmodium falciparum | protein kinase 5 | 0.0052 | 0.0482 | 0.5 |
Echinococcus multilocularis | cyclin dependent kinase | 0.0052 | 0.0482 | 0.0303 |
Plasmodium vivax | protein kinase Crk2 | 0.0052 | 0.0482 | 0.5 |
Echinococcus multilocularis | cyclin dependent kinase 1 | 0.0052 | 0.0482 | 0.0303 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.0602 | 0.0426 |
Brugia malayi | cell division control protein 2 homolog | 0.0052 | 0.0482 | 0.0303 |
Mycobacterium leprae | possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). | 0.004 | 0 | 0.5 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0052 | 0.0482 | 0.0303 |
Trypanosoma cruzi | cdc2-related kinase 1 | 0.0052 | 0.0482 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0052 | 0.0482 | 0.0303 |
Echinococcus multilocularis | CDC7 cell division cycle 7 | 0.0294 | 1 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.0602 | 0.0426 |
Brugia malayi | Protein kinase domain containing protein | 0.0052 | 0.0482 | 0.0303 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.0347 | 0.0166 |
Wolbachia endosymbiont of Brugia malayi | fructose-1,6-bisphosphatase | 0.0045 | 0.0184 | 0.5 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.0602 | 0.0426 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0052 | 0.0482 | 0.0303 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 10 um | PUBCHEM_BIOASSAY: qHTS Assay for Identifying the Cell-Membrane Permeable IMPase Inhibitors: Potentiation with Lithium. (Class of assay: confirmatory) [Related pubchem assays: 901 ] | ChEMBL. | No reference |
Potency (functional) | 11.6891 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 13.1154 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 15.8489 uM | PubChem BioAssay. qHTS for Antagonists of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 25.1189 um | PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 25.929 uM | PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.