Detailed information for compound 1458797

Basic information

Technical information
  • TDR Targets ID: 1458797
  • Name: 1-cyclohexyl-3-[5-[(4-methoxyphenyl)sulfamoyl ]-2-methylphenyl]urea
  • MW: 417.522 | Formula: C21H27N3O4S
  • H donors: 3 H acceptors: 3 LogP: 3.6 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1)NS(=O)(=O)c1ccc(c(c1)NC(=O)NC1CCCCC1)C
  • InChi: 1S/C21H27N3O4S/c1-15-8-13-19(29(26,27)24-17-9-11-18(28-2)12-10-17)14-20(15)23-21(25)22-16-6-4-3-5-7-16/h8-14,16,24H,3-7H2,1-2H3,(H2,22,23,25)
  • InChiKey: FCJXUCNLYBVYPN-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1-cyclohexyl-3-[5-[(4-methoxyphenyl)sulfamoyl]-2-methyl-phenyl]urea
  • MLS000395045
  • SMR000248420

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens aldehyde dehydrogenase 1 family, member A1 Starlite/ChEMBL No references
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Homo sapiens K(lysine) acetyltransferase 2A Starlite/ChEMBL No references
Equus caballus Ferritin light chain Starlite/ChEMBL No references
Mus musculus RAR-related orphan receptor gamma Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus granulosus histone acetyltransferase KAT2B Get druggable targets OG5_127781 All targets in OG5_127781
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial Get druggable targets OG5_126638 All targets in OG5_126638
Candida albicans Mitochondrial aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Plasmodium knowlesi histone acetyltransferase GCN5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Leishmania major aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma mansoni aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Plasmodium vivax histone acetyltransferase GCN5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Mycobacterium tuberculosis Probable aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum ko:K06062 p300/CBP-associated factor, putative Get druggable targets OG5_127781 All targets in OG5_127781
Trichomonas vaginalis bromodomain-containing protein, putative Get druggable targets OG5_127781 All targets in OG5_127781
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma mansoni aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Candida albicans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Loa Loa (eye worm) acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Brugia malayi acetyltransferase, GNAT family protein Get druggable targets OG5_127781 All targets in OG5_127781
Candida albicans bromodomain protein similar to S. cerevisiae GCN5 (YGR252W) histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Toxoplasma gondii histone lysine acetyltransferase GCN5-A Get druggable targets OG5_127781 All targets in OG5_127781
Candida albicans Mitochondrial aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Entamoeba histolytica acetyltransferase, GNAT family Get druggable targets OG5_127781 All targets in OG5_127781
Candida albicans bromodomain protein similar to S. cerevisiae GCN5 (YGR252W) histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Schistosoma japonicum Aldehyde dehydrogenase, mitochondrial precursor, putative Get druggable targets OG5_126638 All targets in OG5_126638
Babesia bovis histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Plasmodium berghei histone acetyltransferase GCN5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative Get druggable targets OG5_127781 All targets in OG5_127781
Echinococcus granulosus histone acetyltransferase KAT2B Get druggable targets OG5_127781 All targets in OG5_127781
Cryptosporidium parvum GCN5 like acetylase + bromodomain Get druggable targets OG5_127781 All targets in OG5_127781
Plasmodium yoelii histone acetyltransferase GCN5-related Get druggable targets OG5_127781 All targets in OG5_127781
Schistosoma japonicum Retinal dehydrogenase 1, putative Get druggable targets OG5_126638 All targets in OG5_126638
Neospora caninum Bromodomain containing protein, related Get druggable targets OG5_127781 All targets in OG5_127781
Schistosoma japonicum ko:K00128 aldehyde dehydrogenase (NAD+) [EC1.2.1.3], putative Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania infantum aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Neospora caninum hypothetical protein Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 Get druggable targets OG5_127781 All targets in OG5_127781
Candida albicans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum Aldehyde dehydrogenase X, mitochondrial precursor, putative Get druggable targets OG5_126638 All targets in OG5_126638
Toxoplasma gondii histone lysine acetyltransferase GCN5-B Get druggable targets OG5_127781 All targets in OG5_127781
Theileria parva histone acetyltransferase Gcn5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Leishmania mexicana aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus granulosus aldehyde dehydrogenase mitochondrial Get druggable targets OG5_126638 All targets in OG5_126638
Plasmodium falciparum histone acetyltransferase GCN5 Get druggable targets OG5_127781 All targets in OG5_127781
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis Get druggable targets OG5_127781 All targets in OG5_127781
Neospora caninum hypothetical protein Get druggable targets OG5_127781 All targets in OG5_127781
Toxoplasma gondii aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania braziliensis aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Giardia lamblia Histone acetyltransferase GCN5 Get druggable targets OG5_127781 All targets in OG5_127781
Cryptosporidium hominis histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Leishmania donovani aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Echinococcus multilocularis expressed protein Ferritin light chain   175 aa 146 aa 30.1 %
Schistosoma mansoni ferritin Ferritin light chain   175 aa 171 aa 43.9 %
Schistosoma mansoni ferritin Ferritin light chain   175 aa 171 aa 44.4 %
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Echinococcus granulosus expressed protein Ferritin light chain   175 aa 146 aa 28.8 %
Schistosoma mansoni apoferritin-2 Ferritin light chain   175 aa 142 aa 29.6 %
Schistosoma japonicum Ferritin, putative Ferritin light chain   175 aa 144 aa 24.3 %
Schistosoma mansoni apoferritin-2 Ferritin light chain   175 aa 146 aa 28.8 %
Mycobacterium tuberculosis Succinate-semialdehyde dehydrogenase [NADP+] dependent (SSDH) GabD1 aldehyde dehydrogenase 1 family, member A1 501 aa 456 aa 33.3 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Plasmodium falciparum malate dehydrogenase 0.0597 0.6445 1
Echinococcus granulosus malate dehydrogenase 0.0277 0.2695 0.2658
Schistosoma mansoni carbonic anhydrase-related 0.0488 0.5162 0.5009
Trichomonas vaginalis malate dehydrogenase, putative 0.0285 0.2784 1
Trypanosoma cruzi cytosolic malate dehydrogenase, putative 0.0285 0.2784 0.0434
Brugia malayi Probable malate dehydrogenase, mitochondrial precursor 0.0277 0.2695 0.2582
Echinococcus granulosus cytosolic malate dehydrogenase 0.0285 0.2784 0.2748
Schistosoma mansoni carbonic anhydrase 0.0488 0.5162 0.5009
Brugia malayi acetyltransferase, GNAT family protein 0.0175 0.1497 0.1366
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0901 1 1
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0073 0.0306 0.0257
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0488 0.5162 0.5087
Trichomonas vaginalis malate dehydrogenase, putative 0.0257 0.2458 0.8804
Trypanosoma cruzi glycosomal malate dehydrogenase, putative 0.0277 0.2695 0.0315
Echinococcus granulosus lactate dehydrogenase a 0.0597 0.6445 0.6427
Leishmania major mitochondrial malate dehydrogenase 0.0277 0.2695 0.2465
Trichomonas vaginalis malate dehydrogenase, putative 0.0285 0.2784 1
Echinococcus granulosus malate dehydrogenase 0.0277 0.2695 0.2658
Schistosoma mansoni malate dehydrogenase 0.0597 0.6445 0.6333
Toxoplasma gondii lactate dehydrogenase LDH1 0.0597 0.6445 1
Plasmodium falciparum carbonic anhydrase 0.0488 0.5162 0.801
Echinococcus granulosus L lactate dehydrogenase 0.034 0.3435 0.3402
Trichomonas vaginalis malate dehydrogenase, putative 0.0285 0.2784 1
Toxoplasma gondii lactate dehydrogenase LDH2 0.0597 0.6445 1
Leishmania major malate dehydrogenase, putative 0.0257 0.2458 0.2219
Trypanosoma brucei glycosomal malate dehydrogenase 0.0277 0.2695 0.0315
Loa Loa (eye worm) acetyltransferase 0.0175 0.1497 0.1366
Plasmodium vivax lactate dehydrogenase 0.0597 0.6445 1
Echinococcus multilocularis lactate dehydrogenase protein 0.0597 0.6445 0.6333
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0175 0.1497 0.1229
Brugia malayi Malate dehydrogenase, cytoplasmic 0.0285 0.2784 0.2673
Echinococcus multilocularis L lactate dehydrogenase 0.034 0.3435 0.3227
Toxoplasma gondii hypothetical protein 0.0488 0.5162 0.7994
Trichomonas vaginalis malate dehydrogenase, putative 0.0153 0.1241 0.4354
Schistosoma mansoni L-lactate dehydrogenase 0.0257 0.2458 0.2219
Entamoeba histolytica malate dehydrogenase,cytoplasmic, putative 0.0285 0.2784 0.4321
Trichomonas vaginalis malate dehydrogenase, putative 0.0125 0.0914 0.3159
Brugia malayi lactate dehydrogenase. 0.0597 0.6445 0.639
Echinococcus granulosus lactate dehydrogenase a 0.0597 0.6445 0.6427
Leishmania major cytosolic malate dehydrogenase 0.0285 0.2784 0.2557
Schistosoma mansoni hypothetical protein 0.0488 0.5162 0.5009
Loa Loa (eye worm) malate dehydrogenase 0.0277 0.2695 0.2582
Schistosoma mansoni malate dehydrogenase 0.0285 0.2784 0.2557
Leishmania major carbonic anhydrase-like protein 0.0901 1 1
Echinococcus multilocularis lactate dehydrogenase a 0.0597 0.6445 0.6333
Schistosoma mansoni malate dehydrogenase 0.0285 0.2784 0.2557
Loa Loa (eye worm) carbonic anhydrase 3 0.0901 1 1
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0901 1 1
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0488 0.5162 0.5087
Echinococcus multilocularis carbonic anhydrase 0.0488 0.5162 0.5009
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0175 0.1497 0.1229
Leishmania major glycosomal malate dehydrogenase 0.0277 0.2695 0.2465
Trichomonas vaginalis malate dehydrogenase, putative 0.0285 0.2784 1
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0488 0.5162 0.5087
Echinococcus multilocularis cytosolic malate dehydrogenase 0.0285 0.2784 0.2557
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0901 1 1
Echinococcus multilocularis carbonic anhydrase II 0.0901 1 1
Trichomonas vaginalis malate dehydrogenase, putative 0.0285 0.2784 1
Mycobacterium ulcerans malate dehydrogenase 0.0285 0.2784 1
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0488 0.5162 0.5087
Echinococcus multilocularis cytosolic malate dehydrogenase 0.0285 0.2784 0.2557
Echinococcus granulosus carbonic anhydrase 0.0488 0.5162 0.5138
Echinococcus granulosus carbonic anhydrase 0.0488 0.5162 0.5138
Echinococcus granulosus carbonic anhydrase II 0.0901 1 1
Schistosoma mansoni L-lactate dehydrogenase 0.0597 0.6445 0.6333
Chlamydia trachomatis malate dehydrogenase 0.0285 0.2784 0.5
Giardia lamblia Malate dehydrogenase 0.0285 0.2784 1
Schistosoma mansoni carbonic anhydrase-related 0.0488 0.5162 0.5009
Loa Loa (eye worm) malate dehydrogenase 0.0285 0.2784 0.2673
Plasmodium vivax malate dehydrogenase, putative 0.0597 0.6445 1
Schistosoma mansoni malate dehydrogenase 0.0277 0.2695 0.2465
Plasmodium falciparum L-lactate dehydrogenase 0.0597 0.6445 1
Trypanosoma cruzi glycosomal malate dehydrogenase, putative 0.0277 0.2695 0.0315
Echinococcus multilocularis malate dehydrogenase 0.0277 0.2695 0.2465
Trichomonas vaginalis malate dehydrogenase, putative 0.0285 0.2784 1
Toxoplasma gondii aldehyde dehydrogenase 0.0073 0.0306 0.04
Echinococcus multilocularis carbonic anhydrase 0.0488 0.5162 0.5009
Loa Loa (eye worm) hypothetical protein 0.0488 0.5162 0.5087
Echinococcus multilocularis carbonic anhydrase 0.0488 0.5162 0.5009
Trypanosoma brucei carbonic anhydrase-like protein 0.0901 1 1
Echinococcus multilocularis lactate dehydrogenase a 0.0597 0.6445 0.6333
Trichomonas vaginalis malate and lactate dehydrogenase, putative 0.0285 0.2784 1
Echinococcus multilocularis malate dehydrogenase 0.0277 0.2695 0.2465
Mycobacterium tuberculosis Probable malate dehydrogenase Mdh 0.0285 0.2784 1
Trichomonas vaginalis malate dehydrogenase, putative 0.0285 0.2784 1
Echinococcus multilocularis lactate dehydrogenase a 0.0597 0.6445 0.6333
Leishmania major malate dehydrogenase 0.0277 0.2695 0.2465
Echinococcus granulosus carbonic anhydrase 0.0488 0.5162 0.5138
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0488 0.5162 0.5087
Echinococcus granulosus cytosolic malate dehydrogenase 0.0285 0.2784 0.2748
Toxoplasma gondii malate dehydrogenase MDH 0.0597 0.6445 1
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0901 1 1
Trypanosoma brucei cytosolic malate dehydrogenase 0.0285 0.2784 0.0434
Plasmodium falciparum lactate dehydrogenase, putative 0.0257 0.2458 0.3813
Trichomonas vaginalis malate and lactate dehydrogenase, putative 0.0285 0.2784 1
Loa Loa (eye worm) hypothetical protein 0.0488 0.5162 0.5087
Trypanosoma brucei mitochondrial malate dehydrogenase 0.0277 0.2695 0.0315
Entamoeba histolytica malate dehydrogenase, putative 0.0597 0.6445 1
Trypanosoma cruzi mitochondrial malate dehydrogenase, putative 0.0277 0.2695 0.0315
Trichomonas vaginalis malate dehydrogenase, putative 0.0285 0.2784 1
Trichomonas vaginalis malate dehydrogenase, putative 0.0285 0.2784 1
Brugia malayi Putative carbonic anhydrase 5 precursor 0.0901 1 1
Leishmania major malate dehydrogenase, putative 0.0597 0.6445 0.6333
Trichomonas vaginalis malate and lactate dehydrogenase, putative 0.0285 0.2784 1
Loa Loa (eye worm) hypothetical protein 0.0597 0.6445 0.639
Echinococcus multilocularis L lactate dehydrogenase B chain 0.0597 0.6445 0.6333
Schistosoma mansoni carbonic anhydrase-related 0.0488 0.5162 0.5009
Mycobacterium leprae PROBABLE MALATE DEHYDROGENASE MDH 0.0285 0.2784 0.5
Trichomonas vaginalis malate dehydrogenase, putative 0.0285 0.2784 1
Loa Loa (eye worm) hypothetical protein 0.0488 0.5162 0.5087
Trichomonas vaginalis malate and lactate dehydrogenase, putative 0.0285 0.2784 1
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0488 0.5162 0.5087
Echinococcus granulosus lactate dehydrogenase protein 0.0597 0.6445 0.6427
Entamoeba histolytica malate dehydrogenase, putative 0.0285 0.2784 0.4321
Plasmodium vivax lactate/malate dehydrogenase, putative 0.0257 0.2458 0.3765
Echinococcus granulosus histone acetyltransferase KAT2B 0.017 0.144 0.1397
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0901 1 1
Echinococcus granulosus L lactate dehydrogenase B chain 0.0597 0.6445 0.6427
Trypanosoma cruzi cytosolic malate dehydrogenase, putative 0.0285 0.2784 0.0434
Wolbachia endosymbiont of Brugia malayi malate dehydrogenase 0.0597 0.6445 0.5
Trypanosoma cruzi malate dehydrogenase, putative 0.0277 0.2695 0.0315
Trichomonas vaginalis malate dehydrogenase, putative 0.0285 0.2784 1

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 2.2387 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) 3.5481 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of GCN5L2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504398] ChEMBL. No reference
Potency (functional) 10 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 10 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) 11.6891 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 12.5893 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) = 19.9526 um PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: Counterscreen qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. This assay monitors tau fibrillation by fluorescence polarization (FP) of Alexa 594-labeled K18 P301L, which does not fibrillize readily but incorporates into growing filaments of unlabeled tau. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) 29.0929 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) 29.0929 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference
Potency (functional) 50.1187 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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