Detailed information for compound 1460604

Basic information

Technical information
  • TDR Targets ID: 1460604
  • Name: ethyl 5-cyano-1-(3,4-dimethylphenyl)-4-methyl -6-oxopyridazine-3-carboxylate
  • MW: 311.335 | Formula: C17H17N3O3
  • H donors: 0 H acceptors: 3 LogP: 2.7 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOC(=O)c1nn(c2ccc(c(c2)C)C)c(=O)c(c1C)C#N
  • InChi: 1S/C17H17N3O3/c1-5-23-17(22)15-12(4)14(9-18)16(21)20(19-15)13-7-6-10(2)11(3)8-13/h6-8H,5H2,1-4H3
  • InChiKey: CLYIFAJAPCYIOE-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • ethyl 5-cyano-1-(3,4-dimethylphenyl)-4-methyl-6-oxo-pyridazine-3-carboxylate
  • 5-cyano-1-(3,4-dimethylphenyl)-4-methyl-6-oxo-3-pyridazinecarboxylic acid ethyl ester
  • 5-cyano-1-(3,4-dimethylphenyl)-6-keto-4-methyl-pyridazine-3-carboxylic acid ethyl ester
  • ZINC00780455
  • BAS 04293089

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens muscleblind-like splicing regulator 1 Starlite/ChEMBL No references
Homo sapiens GNAS complex locus Starlite/ChEMBL No references
Homo sapiens SMAD family member 2 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Brugia malayi Muscleblind-like protein Get druggable targets OG5_132352 All targets in OG5_132352
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis muscleblind protein 1 Get druggable targets OG5_132352 All targets in OG5_132352
Loa Loa (eye worm) MH2 domain-containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Echinococcus granulosus muscleblind protein Get druggable targets OG5_132352 All targets in OG5_132352
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) transcription factor SMAD2 Get druggable targets OG5_131716 All targets in OG5_131716
Brugia malayi MH2 domain containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis muscleblind protein Get druggable targets OG5_132352 All targets in OG5_132352
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132352 All targets in OG5_132352
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132352 All targets in OG5_132352
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi MH2 domain containing protein SMAD family member 2 467 aa 405 aa 31.6 %
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni smad 0.001 0.0003 0.0004
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.002 0.0181 0.2916
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.002 0.0181 0.0219
Loa Loa (eye worm) RecQ helicase 0.002 0.0181 0.0178
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0823 0.082
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0086 0.137 0.282
Schistosoma mansoni metabotropic glutamate receptor 0.0384 0.6749 0.7318
Trypanosoma cruzi hypothetical protein, conserved 0.0042 0.059 0.9773
Mycobacterium tuberculosis Probable lipase LipE 0.0042 0.059 0.1139
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.002 0.0181 0.227
Loa Loa (eye worm) hypothetical protein 0.0043 0.0603 0.06
Loa Loa (eye worm) hypothetical protein 0.0043 0.0603 0.06
Trichomonas vaginalis D-aminoacylase, putative 0.0042 0.059 1
Loa Loa (eye worm) ATP-dependent DNA helicase 0.002 0.0181 0.0178
Brugia malayi Thioredoxin reductase 0.0038 0.0503 0.0618
Mycobacterium tuberculosis Conserved protein 0.0042 0.059 0.1139
Entamoeba histolytica recQ family DNA helicase 0.001 0.0007 0.0114
Echinococcus granulosus glutamate receptor 2 0.0043 0.0603 0.06
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0095 0.1542 0.3191
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.002 0.0181 0.3065
Loa Loa (eye worm) transcription factor SMAD2 0.0144 0.2427 0.2424
Brugia malayi hypothetical protein 0.0043 0.0603 0.0742
Echinococcus granulosus glutamate receptor 2 0.0043 0.0603 0.06
Trypanosoma cruzi cytochrome P450, putative 0.0016 0.011 0.1722
Trypanosoma cruzi extracellular receptor, putative 0.0043 0.0603 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0013 0.0061 0.0902
Trypanosoma cruzi trypanothione reductase, putative 0.0013 0.0061 0.0902
Echinococcus granulosus muscleblind protein 0.018 0.308 0.3078
Onchocerca volvulus Metabotropic glutamate receptor homolog 0.0074 0.1167 1
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0042 0.059 0.0587
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0823 0.082
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0013 0.0061 0.5
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0013 0.0061 0.0902
Schistosoma mansoni glutamate receptor NMDA 0.0043 0.0603 0.0654
Loa Loa (eye worm) hypothetical protein 0.002 0.0181 0.0178
Schistosoma mansoni tyrosine kinase 0.0043 0.0603 0.0654
Loa Loa (eye worm) metabotropic glutamate receptor 8 0.0043 0.0603 0.06
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0013 0.0061 0.0066
Loa Loa (eye worm) glutamate receptor 0.018 0.3077 0.3075
Entamoeba histolytica hypothetical protein 0.0043 0.0603 1
Onchocerca volvulus 0.0043 0.0603 0.0234
Mycobacterium ulcerans beta-lactamase 0.0042 0.059 1
Onchocerca volvulus 0.0043 0.0603 0.0234
Loa Loa (eye worm) RGC/RGC protein kinase 0.0043 0.0603 0.06
Mycobacterium tuberculosis Probable oxidoreductase 0.0095 0.1542 0.3191
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0823 0.0892
Trypanosoma brucei hypothetical protein, conserved 0.0042 0.059 1
Trichomonas vaginalis penicillin-binding protein, putative 0.0042 0.059 1
Mycobacterium tuberculosis Probable dehydrogenase 0.0086 0.137 0.282
Echinococcus multilocularis atrial natriuretic peptide receptor 0.0043 0.0603 0.06
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0086 0.137 0.282
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0013 0.0061 0.0902
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0013 0.0061 0.0902
Loa Loa (eye worm) cytochrome P450 family protein 0.0016 0.011 0.0106
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0823 0.0892
Brugia malayi glutathione reductase 0.0038 0.0503 0.0618
Echinococcus granulosus thioredoxin glutathione reductase 0.0038 0.0512 0.0509
Brugia malayi Muscleblind-like protein 0.018 0.308 0.3805
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.002 0.0181 0.2213
Echinococcus multilocularis thioredoxin glutathione reductase 0.0038 0.0512 0.0509
Brugia malayi Metabotropic glutamate receptor precursor. 0.0458 0.809 1
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0043 0.0603 0.06
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0042 0.059 0.0725
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0013 0.0061 0.5
Loa Loa (eye worm) hypothetical protein 0.0043 0.0603 0.06
Trypanosoma brucei cytochrome P450, putative 0.0016 0.011 0.0924
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0013 0.0061 0.0071
Treponema pallidum NADH oxidase 0.0013 0.0061 1
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0086 0.137 0.8192
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.002 0.0181 0.2715
Echinococcus multilocularis metabotropic glutamate receptor 5 0.0564 1 1
Toxoplasma gondii thioredoxin reductase 0.0038 0.0503 0.853
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0095 0.1542 0.3191
Loa Loa (eye worm) hypothetical protein 0.001 0.0007 0.0004
Echinococcus granulosus tyrosine kinase 0.0043 0.0603 0.06
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0086 0.137 0.282
Brugia malayi Guanylyl cyclase protein 23 0.0043 0.0603 0.0742
Toxoplasma gondii ABC1 family protein 0.0042 0.059 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0013 0.0061 0.0902
Brugia malayi beta-lactamase family protein 0.0042 0.059 0.0725
Loa Loa (eye worm) hypothetical protein 0.001 0.0007 0.0004
Brugia malayi metabotropic GABA-B receptor subtype 2 0.0074 0.1167 0.144
Echinococcus granulosus beta LACTamase domain containing family member 0.0042 0.059 0.0587
Trypanosoma brucei trypanothione reductase 0.0038 0.0503 0.8362
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0013 0.0061 0.5
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0043 0.0603 0.06
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0095 0.1542 1
Loa Loa (eye worm) CYP4Cod1 0.0016 0.011 0.0106
Loa Loa (eye worm) hypothetical protein 0.018 0.308 0.3078
Loa Loa (eye worm) cytochrome P450 family protein 0.0016 0.011 0.0106
Brugia malayi Receptor family ligand binding region containing protein 0.0043 0.0603 0.0742
Trichomonas vaginalis DNA helicase recq1, putative 0.002 0.0181 0.227
Echinococcus granulosus nmda type glutamate receptor 0.0043 0.0603 0.06
Onchocerca volvulus Atrial natriuretic peptide receptor 3 homolog 0.0043 0.0603 0.0234
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0038 0.0503 0.0953
Plasmodium vivax hypothetical protein, conserved 0.0042 0.059 1
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.0043 0.0603 0.06
Brugia malayi beta-lactamase 0.0042 0.059 0.0725
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0013 0.0061 0.1029
Mycobacterium tuberculosis Probable reductase 0.0086 0.137 0.282
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0013 0.0061 0.0057
Leishmania major trypanothione reductase 0.0038 0.0503 0.8154
Leishmania major cytochrome p450-like protein 0.0016 0.011 0.0901
Plasmodium falciparum thioredoxin reductase 0.0038 0.0503 1
Echinococcus multilocularis muscleblind protein 0.018 0.308 0.3078
Mycobacterium tuberculosis Possible penicillin-binding protein 0.027 0.4704 1
Schistosoma mansoni DNA helicase recq1 0.002 0.0181 0.0196
Schistosoma mansoni metabotropic glutamate receptor 2 3 (mglur group 2) 0.0521 0.9223 1
Trypanosoma cruzi trypanothione reductase, putative 0.0038 0.0503 0.832
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0823 0.082
Leishmania major hypothetical protein, conserved 0.0042 0.059 0.9751
Plasmodium vivax thioredoxin reductase, putative 0.0038 0.0503 0.853
Echinococcus granulosus GPCR family 3 C terminal 0.0074 0.1167 0.1165
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.002 0.0181 0.2715
Echinococcus multilocularis tyrosine kinase 0.0043 0.0603 0.06
Brugia malayi Bloom's syndrome protein homolog 0.002 0.0181 0.0219
Brugia malayi Cytochrome P450 family protein 0.0016 0.011 0.0131
Loa Loa (eye worm) beta-lactamase 0.0042 0.059 0.0587
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0823 0.082
Brugia malayi Cytochrome P450 family protein 0.0016 0.011 0.0131
Loa Loa (eye worm) hypothetical protein 0.0117 0.1945 0.1942
Loa Loa (eye worm) cytochrome P450 family protein 0.0026 0.0294 0.0291
Echinococcus multilocularis nmda type glutamate receptor 0.0043 0.0603 0.06
Loa Loa (eye worm) hypothetical protein 0.0042 0.059 0.0587
Schistosoma mansoni tyrosine kinase 0.0043 0.0603 0.0654
Loa Loa (eye worm) hypothetical protein 0.0564 1 1
Schistosoma mansoni TGF-beta signal transducer Smad2 0.001 0.0003 0.0004
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.002 0.0181 0.3065
Loa Loa (eye worm) hypothetical protein 0.0043 0.0603 0.06
Loa Loa (eye worm) glutamate receptor 0.0458 0.809 0.809
Loa Loa (eye worm) hypothetical protein 0.0074 0.1167 0.1165
Brugia malayi metabotropic glutamate receptor subtype 5a (mGluR5a), putative 0.0415 0.7313 0.9039
Loa Loa (eye worm) hypothetical protein 0.0042 0.059 0.0587
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.0823 0.1013
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0013 0.0061 0.0902
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0042 0.059 0.1139
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0016 0.011 0.0924
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0043 0.0603 0.06
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.001 0.0007 0.0117
Trichomonas vaginalis D-aminoacylase, putative 0.0042 0.059 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0042 0.059 0.0639
Loa Loa (eye worm) hypothetical protein 0.0043 0.0603 0.06
Plasmodium vivax glutathione reductase, putative 0.0038 0.0503 0.853
Mycobacterium tuberculosis Probable hydrolase 0.0042 0.059 0.1139
Schistosoma mansoni smad1 5 8 and 0.001 0.0003 0.0004
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0042 0.059 0.0639
Loa Loa (eye worm) hypothetical protein 0.0043 0.0603 0.06
Loa Loa (eye worm) hypothetical protein 0.0042 0.059 0.0587
Echinococcus multilocularis beta LACTamase domain containing family member 0.0042 0.059 0.0587
Loa Loa (eye worm) hypothetical protein 0.0042 0.059 0.0587
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.002 0.0181 0.0178
Schistosoma mansoni protein kinase 0.0043 0.0603 0.0654
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0042 0.059 0.1139
Mycobacterium ulcerans esterase/lipase LipP 0.0042 0.059 1
Mycobacterium tuberculosis Probable lipase LipD 0.0042 0.059 0.1139
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0043 0.0603 0.06
Loa Loa (eye worm) thioredoxin reductase 0.0038 0.0503 0.05
Schistosoma mansoni blooms syndrome DNA helicase 0.001 0.0007 0.0007
Trypanosoma cruzi cytochrome P450, putative 0.0016 0.011 0.1722
Schistosoma mansoni Smad4 0.001 0.0003 0.0004
Mycobacterium ulcerans lipase LipD 0.0042 0.059 1
Loa Loa (eye worm) RGC/RGC protein kinase 0.0043 0.0603 0.06
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0013 0.0061 0.1029
Schistosoma mansoni smad1 5 8 and 0.001 0.0003 0.0004
Echinococcus multilocularis glutamate receptor 2 0.0043 0.0603 0.06
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0013 0.0061 0.0902
Schistosoma mansoni hypothetical protein 0.0074 0.1167 0.1266
Echinococcus granulosus bloom syndrome protein 0.002 0.0181 0.0178
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0043 0.0603 0.06
Brugia malayi MH2 domain containing protein 0.0144 0.2427 0.2997
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.001 0.0007 0.0117
Loa Loa (eye worm) glutathione reductase 0.0038 0.0503 0.05
Echinococcus multilocularis muscleblind protein 1 0.018 0.308 0.3078
Leishmania major extracellular receptor, putative 0.0043 0.0603 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.0823 0.082
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0013 0.0061 0.0902
Echinococcus multilocularis glutamate receptor 2 0.0043 0.0603 0.06
Trichomonas vaginalis esterase, putative 0.0042 0.059 1
Onchocerca volvulus Poor gastrulation protein homolog 0.0074 0.1167 1
Trichomonas vaginalis D-aminoacylase, putative 0.0042 0.059 1
Loa Loa (eye worm) receptor family ligand binding region containing protein 0.0117 0.1945 0.1942
Loa Loa (eye worm) metabotropic GABA-B receptor subtype 2 0.0117 0.1945 0.1942
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.0043 0.0603 0.06
Plasmodium falciparum glutathione reductase 0.0038 0.0503 1
Echinococcus granulosus atrial natriuretic peptide receptor 0.0043 0.0603 0.06
Echinococcus multilocularis GPCR, family 3, C terminal 0.0074 0.1167 0.1165
Trichomonas vaginalis penicillin-binding protein, putative 0.0042 0.059 1
Trichomonas vaginalis DNA helicase recq, putative 0.002 0.0181 0.227
Schistosoma mansoni DNA helicase recq5 0.002 0.0181 0.0196
Schistosoma mansoni metabotropic glutamate receptor 0.0223 0.3854 0.4179
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0013 0.0061 0.1029
Loa Loa (eye worm) hypothetical protein 0.0042 0.059 0.0587
Brugia malayi Cytochrome P450 family protein 0.0026 0.0294 0.036
Brugia malayi metabotropic GABA-B receptor subtype 2 0.0043 0.0603 0.0742
Echinococcus granulosus metabotropic glutamate receptor 2 0.0384 0.6749 0.6748
Loa Loa (eye worm) MH2 domain-containing protein 0.0144 0.2427 0.2424
Loa Loa (eye worm) hypothetical protein 0.0043 0.0603 0.06
Giardia lamblia Sgs1 DNA helicase, putative 0.002 0.0181 1
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0086 0.137 0.282
Toxoplasma gondii NADPH-glutathione reductase 0.0013 0.0061 0.1029
Trichomonas vaginalis DNA helicase recq, putative 0.002 0.0181 0.227
Mycobacterium tuberculosis Conserved protein 0.0042 0.059 0.1139
Brugia malayi metabotropic glutamate receptor type 2 0.0223 0.3854 0.4762
Echinococcus multilocularis bloom syndrome protein 0.002 0.0181 0.0178
Loa Loa (eye worm) RGC/RGC protein kinase 0.0043 0.0603 0.06
Entamoeba histolytica recQ family helicase, putative 0.002 0.0181 0.2997
Loa Loa (eye worm) hypothetical protein 0.0042 0.059 0.0587
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0013 0.0061 0.0057
Brugia malayi Receptor family ligand binding region containing protein 0.0117 0.1945 0.24
Loa Loa (eye worm) hypothetical protein 0.018 0.308 0.3078
Schistosoma mansoni smad1 5 8 and 0.001 0.0003 0.0004
Mycobacterium ulcerans hypothetical protein 0.0042 0.059 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0823 0.0892
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0042 0.059 1
Echinococcus multilocularis metabotropic glutamate receptor 2 0.0384 0.6749 0.6748
Echinococcus granulosus ATP dependent DNA helicase Q1 0.002 0.0181 0.0178
Brugia malayi beta-lactamase family protein 0.0042 0.059 0.0725
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.002 0.0181 0.0178
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.002 0.0181 0.0219
Echinococcus multilocularis receptor type guanylyl cyclase 0.0043 0.0603 0.06
Mycobacterium tuberculosis Conserved protein 0.0042 0.059 0.1139
Echinococcus granulosus receptor type guanylyl cyclase 0.0043 0.0603 0.06
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0042 0.059 0.1139
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0043 0.0603 0.06
Mycobacterium tuberculosis Probable esterase LipL 0.0042 0.059 0.1139
Trypanosoma cruzi hypothetical protein, conserved 0.0042 0.059 0.9773
Echinococcus granulosus ATP dependent DNA helicase Q5 0.002 0.0181 0.0178

Activities

Activity type Activity value Assay description Source Reference
Potency (binding) 4.4668 uM PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 11.2202 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 15.8489 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) 44.6684 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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