Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | glyceraldehyde 3-phosphate dehydrogenase | 0.0134 | 0.175 | 0.243 |
Schistosoma mansoni | glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) | 0.0205 | 0.2876 | 0.2554 |
Schistosoma mansoni | glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) | 0.0205 | 0.2876 | 0.2554 |
Echinococcus multilocularis | tar DNA binding protein | 0.0065 | 0.0651 | 0.0229 |
Trypanosoma cruzi | glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative | 0.0205 | 0.2876 | 1 |
Trichomonas vaginalis | glyceraldehyde 3-phosphate dehydrogenase, putative | 0.0134 | 0.175 | 0.5392 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0052 | 0.0432 | 0.1503 |
Plasmodium falciparum | glyceraldehyde-3-phosphate dehydrogenase | 0.0205 | 0.2876 | 1 |
Mycobacterium tuberculosis | Probable glyceraldehyde 3-phosphate dehydrogenase Gap (GAPDH) | 0.0071 | 0.0738 | 1 |
Trichomonas vaginalis | glyceraldehyde 3-phosphate dehydrogenase, putative | 0.0205 | 0.2876 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.0065 | 0.0651 | 0.0229 |
Entamoeba histolytica | glyceraldehyde-3-phosphate dehydrogenase, putative | 0.0205 | 0.2876 | 1 |
Mycobacterium leprae | Probable glyceraldehyde 3-phosphate dehydrogenase Gap (GAPDH) | 0.0071 | 0.0738 | 1 |
Onchocerca volvulus | 0.0052 | 0.0432 | 1 | |
Plasmodium vivax | serine/threonine kinase-1, putative | 0.0064 | 0.0639 | 0.0845 |
Loa Loa (eye worm) | glyceraldehyde 3-phosphate dehydrogenase | 0.0134 | 0.175 | 0.243 |
Schistosoma mansoni | hypothetical protein | 0.0338 | 0.5009 | 0.4783 |
Loa Loa (eye worm) | CMGC/GSK protein kinase | 0.0052 | 0.0432 | 0.06 |
Loa Loa (eye worm) | CMGC/CLK protein kinase | 0.0064 | 0.0639 | 0.0887 |
Echinococcus granulosus | glyceraldehyde 3 phosphate dehydrogenase | 0.0205 | 0.2876 | 0.2554 |
Echinococcus multilocularis | glyceraldehyde 3 phosphate dehydrogenase | 0.0205 | 0.2876 | 0.2554 |
Trichomonas vaginalis | glyceraldehyde 3-phosphate dehydrogenase, putative | 0.0134 | 0.175 | 0.5392 |
Brugia malayi | RNA binding protein | 0.0065 | 0.0651 | 0.0905 |
Trypanosoma cruzi | glyceraldehyde 3-phosphate dehydrogenase, putative | 0.0205 | 0.2876 | 1 |
Trypanosoma cruzi | kinetoplastid kinetochore protein 10, putative | 0.0064 | 0.0639 | 0.0845 |
Chlamydia trachomatis | glyceraldehyde-3-phosphate dehydrogenase | 0.0205 | 0.2876 | 0.5 |
Echinococcus granulosus | glyceraldehyde 3 phosphate dehydrogenase | 0.0205 | 0.2876 | 0.2554 |
Trichomonas vaginalis | glyceraldehyde 3-phosphate dehydrogenase, putative | 0.0205 | 0.2876 | 1 |
Brugia malayi | Stress-activated protein kinase jnk-1 | 0.0476 | 0.7201 | 1 |
Toxoplasma gondii | glyceraldehyde-3-phosphate dehydrogenase GAPDH1 | 0.0205 | 0.2876 | 1 |
Trichomonas vaginalis | glyceraldehyde 3-phosphate dehydrogenase, putative | 0.0205 | 0.2876 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0065 | 0.0651 | 0.0229 |
Trypanosoma cruzi | glyceraldehyde-3-phosphate dehydrogenase, putative | 0.0134 | 0.1748 | 0.5385 |
Echinococcus multilocularis | intestinal type alkaline phosphatase | 0.0651 | 1 | 1 |
Leishmania major | glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 | 0.0052 | 0.0432 | 0.1503 |
Trypanosoma cruzi | glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative | 0.0205 | 0.2876 | 1 |
Echinococcus multilocularis | glyceraldehyde 3 phosphate dehydrogenase | 0.0205 | 0.2876 | 0.2554 |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.0608 | 0.0845 |
Leishmania major | glyceraldehyde 3-phosphate dehydrogenase, glycosomal | 0.0205 | 0.2876 | 1 |
Loa Loa (eye worm) | glyceraldehyde-3-phosphate dehydrogenase | 0.0141 | 0.1864 | 0.2589 |
Echinococcus multilocularis | dual specificity protein kinase clk2 | 0.0064 | 0.0639 | 0.0216 |
Echinococcus granulosus | intestinal type alkaline phosphatase 1 | 0.0651 | 1 | 1 |
Trypanosoma brucei | glyceraldehyde 3-phosphate dehydrogenase, glycosomal | 0.0205 | 0.2876 | 1 |
Echinococcus granulosus | glyceraldehyde 3 phosphate dehydrogenase | 0.0134 | 0.175 | 0.1377 |
Trypanosoma cruzi | glyceraldehyde 3-phosphate dehydrogenase, putative | 0.0205 | 0.2876 | 1 |
Echinococcus multilocularis | 0.0063 | 0.0608 | 0.0184 | |
Brugia malayi | TAR-binding protein | 0.0065 | 0.0651 | 0.0905 |
Trypanosoma brucei | glyceraldehyde-3-phosphate dehydrogenase, putative | 0.0134 | 0.1748 | 0.5385 |
Entamoeba histolytica | glyceraldehyde-3-phosphate dehydrogenase, putative | 0.0205 | 0.2876 | 1 |
Echinococcus multilocularis | c Jun NH2 terminal kinase | 0.0476 | 0.7201 | 0.7074 |
Echinococcus granulosus | c-Jun N-terminal kinases | 0.0476 | 0.7201 | 0.7074 |
Treponema pallidum | glyceraldehyde 3-phosphate dehydrogenase (gap) | 0.0205 | 0.2876 | 0.5 |
Brugia malayi | intracellular kinase | 0.0052 | 0.0432 | 0.06 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0065 | 0.0651 | 0.0905 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0476 | 0.7201 | 0.7074 |
Plasmodium falciparum | protein serine/threonine kinase-1 | 0.0064 | 0.0639 | 0.0845 |
Schistosoma mansoni | alkaline phosphatase | 0.0651 | 1 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0064 | 0.0639 | 0.0216 |
Schistosoma mansoni | glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) | 0.0205 | 0.2876 | 0.2554 |
Trypanosoma brucei | glyceraldehyde 3-phosphate dehydrogenase, cytosolic | 0.0205 | 0.2876 | 1 |
Leishmania major | protein kinase, putative | 0.0064 | 0.0639 | 0.2221 |
Wolbachia endosymbiont of Brugia malayi | glyceraldehyde-3-phosphate dehydrogenase, GapA | 0.0205 | 0.2876 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0064 | 0.0639 | 0.0845 |
Giardia lamblia | Glyceraldehyde 3-phosphate dehydrogenase | 0.0134 | 0.1748 | 0.5385 |
Trypanosoma brucei | glyceraldehyde 3-phosphate dehydrogenase, glycosomal | 0.0205 | 0.2876 | 1 |
Trypanosoma cruzi | glyceraldehyde-3-phosphate dehydrogenase, putative | 0.0134 | 0.1748 | 0.5385 |
Trichomonas vaginalis | glyceraldehyde 3-phosphate dehydrogenase, putative | 0.0205 | 0.2876 | 1 |
Brugia malayi | Glyceraldehyde 3-phosphate dehydrogenase | 0.0205 | 0.2876 | 0.3994 |
Trichomonas vaginalis | glyceraldehyde 3-phosphate dehydrogenase, putative | 0.0071 | 0.0737 | 0.1245 |
Leishmania major | glyceraldehyde-3-phosphate dehydrogenase-like protein | 0.0134 | 0.1748 | 0.6078 |
Trypanosoma cruzi | glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative | 0.0063 | 0.0622 | 0.0777 |
Entamoeba histolytica | glyceraldehyde-3-phosphate dehydrogenase, putative | 0.0205 | 0.2876 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0065 | 0.0651 | 0.0229 |
Loa Loa (eye worm) | RNA binding protein | 0.0065 | 0.0651 | 0.0905 |
Echinococcus multilocularis | alkaline phosphatase | 0.0651 | 1 | 1 |
Leishmania major | glyceraldehyde 3-phosphate dehydrogenase, glycosomal | 0.0205 | 0.2876 | 1 |
Trypanosoma cruzi | glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative | 0.0205 | 0.2876 | 1 |
Plasmodium vivax | glyceraldehyde-3-phosphate dehydrogenase, putative | 0.0205 | 0.2876 | 1 |
Trypanosoma cruzi | glyceraldehyde 3-phosphate dehydrogenase, putative | 0.0205 | 0.2876 | 1 |
Trypanosoma cruzi | glyceraldehyde 3-phosphate dehydrogenase, putative | 0.0063 | 0.0622 | 0.0777 |
Brugia malayi | Glyceraldehyde 3-phosphate dehydrogenase | 0.0071 | 0.0737 | 0.1023 |
Schistosoma mansoni | glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) | 0.0205 | 0.2876 | 0.2554 |
Toxoplasma gondii | glyceraldehyde-3-phosphate dehydrogenase GAPDH2 | 0.0205 | 0.2876 | 1 |
Trypanosoma cruzi | kinetoplastid kinetochore protein 19, putative | 0.0064 | 0.0639 | 0.0845 |
Trypanosoma cruzi | kinetoplastid kinetochore protein 19, putative | 0.0064 | 0.0639 | 0.0845 |
Schistosoma mansoni | tar DNA-binding protein | 0.0065 | 0.0651 | 0.0229 |
Brugia malayi | glyceraldehyde 3-phosphate dehydrogenase | 0.0063 | 0.0622 | 0.0864 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0052 | 0.0432 | 0.1503 |
Brugia malayi | Protein kinase domain containing protein | 0.0064 | 0.0639 | 0.0887 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0064 | 0.0639 | 0.0216 |
Trypanosoma cruzi | glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative | 0.0063 | 0.0622 | 0.0777 |
Giardia lamblia | Kinase, CMGC CLK | 0.0064 | 0.0639 | 0.0845 |
Echinococcus granulosus | dual specificity protein kinase clk2 | 0.0064 | 0.0639 | 0.0216 |
Trypanosoma cruzi | glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain, putative | 0.0063 | 0.0622 | 0.0777 |
Loa Loa (eye worm) | TAR-binding protein | 0.0065 | 0.0651 | 0.0905 |
Mycobacterium ulcerans | glyceraldehyde 3-phosphate dehydrogenase Gap | 0.0205 | 0.2876 | 1 |
Giardia lamblia | Glyceraldehyde 3-phosphate dehydrogenase | 0.0205 | 0.2876 | 1 |
Trypanosoma cruzi | glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain, putative | 0.0063 | 0.0622 | 0.0777 |
Schistosoma mansoni | alkaline phosphatase | 0.0651 | 1 | 1 |
Echinococcus granulosus | alkaline phosphatase | 0.0651 | 1 | 1 |
Echinococcus multilocularis | intestinal type alkaline phosphatase 1 | 0.0651 | 1 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.0052 | 0.0432 | 0.1503 |
Echinococcus multilocularis | alkaline phosphatase, intestinal, gene 2 | 0.0651 | 1 | 1 |
Echinococcus granulosus | alkaline phosphatase intestinal gene 2 | 0.0651 | 1 | 1 |
Echinococcus multilocularis | glyceraldehyde 3 phosphate dehydrogenase | 0.0134 | 0.175 | 0.1377 |
Echinococcus granulosus | hypothetical protein | 0.0063 | 0.0608 | 0.0184 |
Trichomonas vaginalis | glyceraldehyde 3-phosphate dehydrogenase, putative | 0.0205 | 0.2876 | 1 |
Trypanosoma brucei | kinetoplastid kinetochore protein 10 | 0.0064 | 0.0639 | 0.0845 |
Loa Loa (eye worm) | CMGC/GSK protein kinase | 0.0052 | 0.0432 | 0.06 |
Trypanosoma brucei | kinetoplastid kinetochore protein 19 | 0.0064 | 0.0639 | 0.0845 |
Schistosoma mansoni | tar DNA-binding protein | 0.0065 | 0.0651 | 0.0229 |
Toxoplasma gondii | cell-cycle-associated protein kinase CLK, putative | 0.0064 | 0.0639 | 0.0845 |
Leishmania major | protein kinase, putative | 0.0064 | 0.0639 | 0.2221 |
Trypanosoma cruzi | kinetoplastid kinetochore protein 10, putative | 0.0064 | 0.0639 | 0.0845 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0065 | 0.0651 | 0.0905 |
Schistosoma mansoni | tar DNA-binding protein | 0.0065 | 0.0651 | 0.0229 |
Loa Loa (eye worm) | CMGC/MAPK/JNK protein kinase | 0.0476 | 0.7201 | 1 |
Trypanosoma cruzi | glyceraldehyde 3-phosphate dehydrogenase, putative | 0.0205 | 0.2876 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0134 | 0.175 | 0.243 |
Loa Loa (eye worm) | glyceraldehyde-3-phosphate dehydrogenase | 0.0141 | 0.1864 | 0.2589 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | = 30 uM | Antiparasitic activity against axenic amastigotes of Leishmania donovani | ChEMBL. | 20846867 |
EC50 (functional) | = 43 uM | Antiparasitic activity against blood stream form of Trypanosoma brucei rhodesiense | ChEMBL. | 20846867 |
EC50 (functional) | = 181 uM | Antiparasitic activity against amastigotes of Trypanosoma cruzi | ChEMBL. | 20846867 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.