Detailed information for compound 1463181

Basic information

Technical information
  • TDR Targets ID: 1463181
  • Name: N-(furan-2-ylmethyl)-4-methoxy-N-[(7-methyl-2 -oxo-1H-quinolin-3-yl)methyl]benzamide
  • MW: 402.442 | Formula: C24H22N2O4
  • H donors: 1 H acceptors: 2 LogP: 3.23 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1)C(=O)N(Cc1cc2ccc(cc2[nH]c1=O)C)Cc1ccco1
  • InChi: 1S/C24H22N2O4/c1-16-5-6-18-13-19(23(27)25-22(18)12-16)14-26(15-21-4-3-11-30-21)24(28)17-7-9-20(29-2)10-8-17/h3-13H,14-15H2,1-2H3,(H,25,27)
  • InChiKey: JMGVFCNHIFUZQY-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(2-furylmethyl)-4-methoxy-N-[(7-methyl-2-oxo-1H-quinolin-3-yl)methyl]benzamide
  • N-(2-furylmethyl)-N-[(2-keto-7-methyl-1H-quinolin-3-yl)methyl]-4-methoxy-benzamide
  • ZINC02214995
  • STOCK5S-37203

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus o acyltransferase membrane bound domain 0.0138 0.0145 0.0137
Schistosoma mansoni alpha-13-mannosyl-glycoprotein beta-1 2-n-acetylglucosaminyltransferase 0.047 0.0629 0.0622
Echinococcus granulosus chromobox protein 1 0.0069 0.0044 0.0036
Trichomonas vaginalis conserved hypothetical protein 0.0478 0.0641 1
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.0138 0.0145 0.0137
Entamoeba histolytica hypothetical protein, conserved 0.0138 0.0145 0.5
Schistosoma mansoni methionine-tRNA synthetase 0.0053 0.0021 0.0013
Trichomonas vaginalis chromobox protein, putative 0.0042 0.0004 0.0067
Loa Loa (eye worm) membrane bound O-acyltransferase domain containing 1 0.0138 0.0145 0.0145
Loa Loa (eye worm) hypothetical protein 0.6898 1 1
Trypanosoma brucei diacylglycerol acyltransferase, putative 0.0314 0.0402 0.1912
Echinococcus granulosus sterol O acyltransferase 1 0.0138 0.0145 0.0137
Loa Loa (eye worm) diacylglycerol acyltransferase 0.1418 0.2011 0.2011
Loa Loa (eye worm) heterochromatin protein 1 0.0069 0.0044 0.0044
Trichomonas vaginalis chromobox protein, putative 0.0069 0.0044 0.0688
Echinococcus multilocularis chromobox protein 1 0.0069 0.0044 0.0036
Leishmania major glycerol uptake protein, putative 0.0138 0.0145 0.0622
Trypanosoma cruzi diacylglycerol acyltransferase, putative 0.1418 0.2011 1
Trypanosoma cruzi diacylglycerol acyltransferase, putative 0.0314 0.0402 0.1912
Schistosoma mansoni beta-12-n-acetylglucosaminyltransferase II 0.6898 1 1
Loa Loa (eye worm) MBOAT family protein 0.0138 0.0145 0.0145
Leishmania major diacylglycerol acyltransferase, putative 0.1418 0.2011 1
Toxoplasma gondii diacylglycerol acyltransferase 0.0314 0.0402 0.1912
Trichomonas vaginalis conserved hypothetical protein 0.0478 0.0641 1
Echinococcus multilocularis methionine tRNA synthetase 0.0053 0.0021 0.0013
Schistosoma mansoni diacylglycerol O-acyltransferase 0.0314 0.0402 0.0394
Leishmania major hypothetical protein, conserved 0.0138 0.0145 0.0622
Brugia malayi Heterochromatin protein 1 0.0069 0.0044 0.0044
Toxoplasma gondii acyl-CoA:cholesterol acyltransferase alpha ACAT1-alpha 0.0821 0.1141 0.5627
Echinococcus granulosus lysophospholipid acyltransferase 7 0.0138 0.0145 0.0137
Schistosoma mansoni membrane-bound acyltransferase/hhat 0.0138 0.0145 0.0137
Brugia malayi Hhat protein 0.0138 0.0145 0.0145
Loa Loa (eye worm) diacylglycerol acyltransferase 0.0821 0.1141 0.1141
Trichomonas vaginalis porcupine, putative 0.0138 0.0145 0.226
Giardia lamblia Methionyl-tRNA synthetase 0.0053 0.0021 0.5
Schistosoma mansoni zinc finger protein 0.0138 0.0145 0.0137
Trichomonas vaginalis conserved hypothetical protein 0.0478 0.0641 1
Wolbachia endosymbiont of Brugia malayi methionyl-tRNA synthetase 0.0053 0.0021 0.5
Trypanosoma cruzi GUP1, putative 0.0138 0.0145 0.0622
Mycobacterium ulcerans hypothetical protein 0.0314 0.0402 1
Trichomonas vaginalis conserved hypothetical protein 0.0478 0.0641 1
Loa Loa (eye worm) hhat protein 0.0138 0.0145 0.0145
Loa Loa (eye worm) hhat protein 0.0138 0.0145 0.0145
Trichomonas vaginalis conserved hypothetical protein 0.0478 0.0641 1
Schistosoma mansoni hypothetical protein 0.0138 0.0145 0.0137
Trypanosoma cruzi glycerol uptake protein, putative 0.0138 0.0145 0.0622
Trypanosoma brucei glycerol uptake protein, putative 0.0138 0.0145 0.0622
Echinococcus multilocularis diacylglycerol O acyltransferase 1 0.0821 0.1141 0.1133
Loa Loa (eye worm) methionyl-tRNA synthetase 0.0053 0.0021 0.0021
Echinococcus multilocularis membrane bound acyltransferase:hhat 0.0138 0.0145 0.0137
Trypanosoma cruzi glycerol uptake protein, putative 0.0138 0.0145 0.0622
Toxoplasma gondii acyl-CoA:diacylglycerol acyltransferase 1-related enzyme 0.0821 0.1141 0.5627
Trypanosoma cruzi GUP1, putative 0.0138 0.0145 0.0622
Trypanosoma cruzi glycerol uptake protein, putative 0.0138 0.0145 0.0622
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0044 0.0008 0.0008
Schistosoma mansoni diacylglycerol O-acyltransferase 0.0314 0.0402 0.0394
Echinococcus granulosus methionine tRNA synthetase 0.0053 0.0021 0.0013
Loa Loa (eye worm) MBOAT family protein 0.0138 0.0145 0.0145
Schistosoma mansoni sterol O-acyltransferase 1 0.0138 0.0145 0.0137
Plasmodium falciparum diacylglycerol O-acyltransferase 0.0821 0.1141 1
Trichomonas vaginalis chromobox protein, putative 0.0042 0.0004 0.0067
Schistosoma mansoni hypothetical protein 0.0314 0.0402 0.0394
Trichomonas vaginalis conserved hypothetical protein 0.0478 0.0641 1
Trichomonas vaginalis methionine-tRNA synthetase, putative 0.0053 0.0021 0.033
Leishmania major diacylglycerol acyltransferase, putative 0.0314 0.0402 0.1912
Echinococcus granulosus membrane bound acyltransferase:hhat 0.0138 0.0145 0.0137
Brugia malayi diacylglycerol acyltransferase 0.0821 0.1141 0.1141
Schistosoma mansoni diacylglycerol O-acyltransferase 1 0.1418 0.2011 0.2004
Loa Loa (eye worm) hypothetical protein 0.016 0.0176 0.0176
Loa Loa (eye worm) MBOAT family protein 0.0138 0.0145 0.0145
Toxoplasma gondii hypothetical protein 0.0138 0.0145 0.0622
Leishmania major hypothetical protein, unknown function,protein, unknown function 0.0314 0.0402 0.1912
Echinococcus multilocularis lysophospholipid acyltransferase 7 0.0138 0.0145 0.0137
Trichomonas vaginalis conserved hypothetical protein 0.0138 0.0145 0.226
Entamoeba histolytica vacuolar protein sorting 26 0.0138 0.0145 0.5
Brugia malayi diacylglycerol acyltransferase family protein 0.1418 0.2011 0.2011
Loa Loa (eye worm) hypothetical protein 0.0138 0.0145 0.0145
Toxoplasma gondii mono- or diacylglycerol acyltransferase 0.0314 0.0402 0.1912
Echinococcus multilocularis o acyltransferase (membrane bound) domain 0.0138 0.0145 0.0137
Schistosoma mansoni diacylglycerol O-acyltransferase 1 0.0821 0.1141 0.1133
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0042 0.0004 0.0021
Leishmania major glycerol uptake protein, putative 0.0138 0.0145 0.0622
Trichomonas vaginalis conserved hypothetical protein 0.0292 0.0369 0.5755
Entamoeba histolytica membrane-bound O-acyltransferase (MBOAT ) family protein 0.0138 0.0145 0.5
Echinococcus multilocularis o acyltransferase (membrane bound) domain 0.0138 0.0145 0.0137
Trichomonas vaginalis conserved hypothetical protein 0.0138 0.0145 0.226
Echinococcus multilocularis sterol O acyltransferase 1 0.0138 0.0145 0.0137
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0222 0.0268 1
Trypanosoma brucei diacylglycerol acyltransferase, putative 0.1418 0.2011 1
Brugia malayi GNT-I family protein 0.047 0.0629 0.0629
Echinococcus granulosus Membrane bound O acyl transferase MBOAT 0.0138 0.0145 0.0137
Echinococcus multilocularis protein cysteine N palmitoyltransferase 0.0138 0.0145 0.0137
Echinococcus granulosus alpha 16 mannosyl glycoprotein 0.6898 1 1
Loa Loa (eye worm) hypothetical protein 0.0683 0.0939 0.0939
Trichomonas vaginalis chromobox protein, putative 0.0069 0.0044 0.0688
Trypanosoma cruzi diacylglycerol acyltransferase, putative 0.0314 0.0402 0.1912
Entamoeba histolytica hypothetical protein 0.0138 0.0145 0.5
Loa Loa (eye worm) hypothetical protein 0.0138 0.0145 0.0145
Loa Loa (eye worm) hypothetical protein 0.047 0.0629 0.0629
Onchocerca volvulus 0.0138 0.0145 0.0721
Brugia malayi MBOAT family protein 0.0138 0.0145 0.0145
Schistosoma mansoni chromobox protein 0.0069 0.0044 0.0036
Brugia malayi MBOAT family protein 0.0138 0.0145 0.0145
Echinococcus granulosus o acyltransferase membrane bound domain 0.0138 0.0145 0.0137
Treponema pallidum alginate O-acetylation protein (algI) 0.0138 0.0145 0.5
Echinococcus granulosus chromobox protein 1 0.0069 0.0044 0.0036
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.0138 0.0145 0.0137
Leishmania major glycerol uptake protein, putative 0.0138 0.0145 0.0622
Echinococcus multilocularis o acyltransferase (membrane bound) domain 0.0138 0.0145 0.0137
Toxoplasma gondii hypothetical protein 0.0187 0.0216 0.0979
Brugia malayi Glycosylation related protein 12, isoform 0.016 0.0176 0.0176
Brugia malayi MBOAT family protein 0.0138 0.0145 0.0145
Echinococcus granulosus diacylglycerol O acyltransferase 1 0.0821 0.1141 0.1133
Trichomonas vaginalis conserved hypothetical protein 0.0138 0.0145 0.226
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.0138 0.0145 0.0137
Trypanosoma cruzi diacylglycerol acyltransferase, putative 0.0314 0.0402 0.1912
Brugia malayi methionyl-tRNA synthetase 0.0053 0.0021 0.0021
Plasmodium vivax diacylglycerol O-acyltransferase, putative 0.0821 0.1141 1
Trypanosoma cruzi diacylglycerol acyltransferase, putative 0.0314 0.0402 0.1912
Echinococcus granulosus alpha 13 mannosyl glycoprotein 0.047 0.0629 0.0622
Toxoplasma gondii dgat2l1-prov protein 0.1418 0.2011 1
Leishmania major glycerol uptake protein, putative 0.0138 0.0145 0.0622
Mycobacterium leprae Probable methionyl-tRNA synthase MetS 0.0053 0.0021 0.5
Loa Loa (eye worm) hypothetical protein 0.047 0.0629 0.0629
Echinococcus multilocularis alpha 1,6 mannosyl glycoprotein 0.6898 1 1
Trichomonas vaginalis conserved hypothetical protein 0.0478 0.0641 1
Schistosoma mansoni leukocyte receptor cluster (lrc) member 4 protein 0.0138 0.0145 0.0137
Loa Loa (eye worm) hypothetical protein 0.0138 0.0145 0.0145
Entamoeba histolytica membrane-bound O-acyltransferase (MBOAT ) family protein 0.0138 0.0145 0.5
Echinococcus multilocularis Membrane bound O acyl transferase, MBOAT 0.0138 0.0145 0.0137
Trypanosoma cruzi diacylglycerol acyltransferase, putative 0.1418 0.2011 1
Echinococcus granulosus o acyltransferase membrane bound domain 0.0138 0.0145 0.0137
Brugia malayi MBOAT family protein 0.0138 0.0145 0.0145
Echinococcus multilocularis chromobox protein 1 0.0069 0.0044 0.0036
Trichomonas vaginalis transmembrane protein nessy, putative 0.0138 0.0145 0.226
Trichomonas vaginalis conserved hypothetical protein 0.0478 0.0641 1
Schistosoma mansoni chromobox protein 0.0069 0.0044 0.0036
Trypanosoma brucei glycerol uptake protein, putative 0.0138 0.0145 0.0622
Brugia malayi MBOAT family protein 0.0138 0.0145 0.0145
Loa Loa (eye worm) hypothetical protein 0.0138 0.0145 0.0145
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0044 0.0008 0.0008
Toxoplasma gondii Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase 0.016 0.0176 0.078
Leishmania major diacylglycerol acyltransferase, putative 0.0314 0.0402 0.1912
Echinococcus multilocularis alpha 1,3 mannosyl glycoprotein 0.047 0.0629 0.0622
Onchocerca volvulus 0.1418 0.2011 1
Leishmania major glycerol uptake protein, putative 0.0138 0.0145 0.0622
Echinococcus granulosus protein cysteine N palmitoyltransferase 0.0138 0.0145 0.0137
Entamoeba histolytica membrane-bound O-acyltransferase (MBOAT ) family protein 0.0138 0.0145 0.5

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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