TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 264.345 | Formula: C17H18N3+
H donors: 1 H acceptors: 1 LogP: 3.58 Rotable bonds: 2
Rule of 5 violations (Lipinski): 1
SMILES: C[n+]1cccc(c1)/C=C/c1[nH]c2c(n1)cc(c(c2)C)C
InChi: 1S/C17H18N3/c1-12-9-15-16(10-13(12)2)19-17(18-15)7-6-14-5-4-8-20(3)11-14/h4-11H,1-3H3,(H,18,19)/q+1/b7-6+
InChiKey: LRZVXQDGXVAFDM-VOTSOKGWSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1189	0.0722	0.9893
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0665	0.0387	0.4441
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1187	0.0721	0.9866
Trypanosoma cruzi	phosphatidylinositol 4-kinase alpha, putative	0.0295	0.0151	0.0435
Schistosoma mansoni	phosphatidylinositol 3-and 4-kinase	0.1222	0.0744	1
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0238	0.0114	0.5
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative	0.0367	0.0197	0.1343
Trypanosoma brucei	phosphatidylinositol 3-kinase catalytic subunit, putative	0.0238	0.0114	0.1566
Trypanosoma cruzi	phosphatidylinositol 4-kinase, putative	0.0238	0.0114	0.0329
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0686	0.04	0.4655
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0681	0.0398	0.4612
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1179	0.0716	0.9786
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1199	0.0729	1
Entamoeba histolytica	phosphatidylinositol-4,5-bisphosphate 3-kinase, putative	0.0295	0.0151	0.0597
Trypanosoma cruzi	phosphatidylinositol 3-kinase vps34-like	0.0367	0.0197	0.0568
Trypanosoma cruzi	phosphatidylinositol 3-kinase 2, putative	0.0678	0.0396	0.1141
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1166	0.0708	0.9652
Toxoplasma gondii	FATC domain-containing protein	0.0681	0.0398	0.4674
Echinococcus granulosus	FKBP12 rapamycin complex associated protein	0.1199	0.0729	0.0622
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.0295	0.0151	0.0583
Brugia malayi	phosphatidylinositol 4-kinase, catalytic, alpha polypeptide	0.0295	0.0151	0.2029
Trypanosoma cruzi	phosphatidylinositol 3-related kinase, putative	0.1222	0.0744	0.2145
Echinococcus granulosus	phosphatidylinositol 4 kinase alpha	0.0295	0.0151	0.0037
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1166	0.0708	0.9652
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0295	0.0151	0.0597
Giardia lamblia	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	0.0496	0.0279	0.2688
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	0.0238	0.0114	0.1566
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.0443	0.0246	0.0708
Leishmania major	phosphatidylinositol 4-kinase alpha, putative	0.0295	0.0151	0.0417
Loa Loa (eye worm)	phosphatidylinositol 3	0.1178	0.0715	0.9812
Leishmania major	phosphatidylinositol kinase related protein, putative	0.0254	0.0125	0.0344
Entamoeba histolytica	FKBP-rapamycin associated protein (FRAP), putative	0.1199	0.0729	1
Trypanosoma cruzi	phosphatidylinositol 3-related kinase, putative	0.1222	0.0744	0.2145
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0686	0.04	0.4655
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0367	0.0197	0.1343
Trypanosoma brucei	phosphatidylinositol 3-kinase, putative	0.1166	0.0708	0.9706
Trypanosoma cruzi	hypothetical protein, conserved	0.5481	0.3467	1
Trichomonas vaginalis	phosphatidylinositol 4-kinase, putative	0.0295	0.0151	0.0597
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0762	0.0449	0.5452
Leishmania major	phosphatidylinositol 3-kinase, putative	0.0295	0.0151	0.0417
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1187	0.0721	0.9866
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1166	0.0708	0.9652
Loa Loa (eye worm)	hypothetical protein	0.0477	0.0267	0.3663
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	0.0295	0.0151	0.0597
Mycobacterium leprae	conserved hypothetical protein	0.0238	0.0114	0.5
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0606	0.035	0.3832
Loa Loa (eye worm)	hypothetical protein	0.0739	0.0435	0.5961
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1187	0.0721	0.9866
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0665	0.0387	0.5207
Loa Loa (eye worm)	cytochrome P450 family protein	0.0126	0.0042	0.058
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1176	0.0714	0.9759
Trypanosoma brucei	phosphatidylinositol kinase related protein, putative	0.0681	0.0398	0.5455
Echinococcus granulosus	phosphatidylinositol 3 and 4 kinase	0.1222	0.0744	0.0637
Echinococcus multilocularis	phosphatidylinositol 4,5 bisphosphate 3 kinase	0.0871	0.0519	0.041
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0248	0.0121	0.0107
Leishmania major	target of rapamycin (TOR) kinase 2, putative	0.1199	0.0729	0.2014
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0681	0.0398	0.5348
Echinococcus granulosus	serine:threonine protein kinase SMG1	0.0665	0.0387	0.0276
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1176	0.0714	0.9759
Toxoplasma gondii	phosphatidylinositol 3- and 4-kinase	0.0295	0.0151	0.0605
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1176	0.0714	0.9759
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0427	0.0235	0.1966
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0238	0.0114	0.1535
Toxoplasma gondii	non-specific serine/threonine protein kinase	0.0739	0.0435	0.5282
Echinococcus multilocularis	DNA dependent protein kinase catalytic subunit	1.5698	1	1
Loa Loa (eye worm)	hypothetical protein	0.0443	0.0246	0.3368
Trypanosoma brucei	phosphatidylinositol 3-kinase, putative	0.0367	0.0197	0.2699
Onchocerca volvulus		0.0238	0.0114	0.5
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	0.0367	0.0197	0.1343
Echinococcus granulosus	serine protein kinase ATM	0.0681	0.0398	0.0287
Giardia lamblia	GTOR	0.1199	0.0729	1
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0367	0.0197	0.1343
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1176	0.0714	0.9759
Toxoplasma gondii	target of rapamycin (TOR), putative	0.1187	0.0721	1
Leishmania major	phosphatidylinositol 3-kinase, putative	0.1166	0.0708	0.1955
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1176	0.0714	0.9759
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1178	0.0715	0.9777
Entamoeba histolytica	hypothetical protein	0.0606	0.035	0.3832
Echinococcus multilocularis	phosphatidylinositol 4 phosphate 3 kinase C2	0.0477	0.0267	0.0155
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0367	0.0197	0.2646
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1187	0.0721	0.9866
Loa Loa (eye worm)	phosphatidylinositol 3	0.0238	0.0114	0.1566
Loa Loa (eye worm)	hypothetical protein	0.0501	0.0282	0.3873
Entamoeba histolytica	phosphatidylinositol3-kinaseTor2, putative	0.1199	0.0729	1
Plasmodium vivax	phosphatidylinositol 3-kinase, putative	0.0295	0.0151	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1187	0.0721	0.9866
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0677	0.0395	0.4566
Trypanosoma brucei	phosphatidylinositol 3-kinase tor, putative	0.0259	0.0127	0.1746
Loa Loa (eye worm)	hypothetical protein	0.0665	0.0387	0.5311
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0678	0.0396	0.4578
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.0367	0.0197	0.1312
Brugia malayi	FAT domain containing protein	0.0501	0.0282	0.3797
Trypanosoma brucei	Phosphatidylinositol 3-kinase tor1	0.1199	0.0729	1
Loa Loa (eye worm)	hypothetical protein	0.0201	0.0091	0.1242
Echinococcus multilocularis	serine protein kinase ATM	0.0681	0.0398	0.0287
Trypanosoma cruzi	phosphatidylinositol 4-kinase, putative	0.0238	0.0114	0.0329
Loa Loa (eye worm)	phosphatidylinositol 3	0.0238	0.0114	0.1566
Trypanosoma cruzi	phosphatidylinositol 4-kinase alpha, putative	0.0295	0.0151	0.0435
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1189	0.0722	0.9893
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0477	0.0267	0.3591
Loa Loa (eye worm)	phosphatidylinositol 3	0.1199	0.0729	1
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0678	0.0396	0.4578
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1187	0.0721	0.9866
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	0.0568	0.0325	0.3434
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1189	0.0722	0.9893
Trypanosoma brucei	target of rapamycin kinase 3, putative	0.1189	0.0722	0.991
Trypanosoma cruzi	target of rapamycin kinase 3	0.1189	0.0722	0.2084
Trichomonas vaginalis	phopsphatidylinositol 3-kinase, drosophila, putative	0.0678	0.0396	0.4578
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	0.1199	0.0729	1
Entamoeba histolytica	Phosphatidylinositol 3- and 4-kinase family	0.0677	0.0395	0.4566
Echinococcus granulosus	PIK kinase FAT and Armadillo domain containing protein	0.0501	0.0282	0.017
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0238	0.0114	0.1535
Loa Loa (eye worm)	phosphatidylinositol 3	0.0129	0.0045	0.0611
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0688	0.0402	0.4682
Trichomonas vaginalis	conserved hypothetical protein	0.0739	0.0435	0.5211
Echinococcus multilocularis	phosphatidylinositol 3 and 4 kinase	0.1222	0.0744	0.0637
Trypanosoma cruzi	phosphatidylinositol 3-kinase 2, putative	0.0678	0.0396	0.1141
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1199	0.0729	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1199	0.0729	1
Loa Loa (eye worm)	phosphatidylinositol 3	0.0238	0.0114	0.1566
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0367	0.0197	0.1343
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.0254	0.0125	0.036
Entamoeba histolytica	phosphatidylinositol 3-kinase 1, putative	0.044	0.0243	0.2103
Schistosoma mansoni	hypothetical protein	0.0501	0.0282	0.2672
Trypanosoma cruzi	phosphatidylinositol 3-kinase, putative	0.0665	0.0387	0.1117
Trypanosoma cruzi	phosphatidylinositol 3-kinase, putative	0.0238	0.0114	0.0329
Echinococcus multilocularis	PIK kinase, FAT and Armadillo domain containing protein	0.0501	0.0282	0.017
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0686	0.04	0.4655
Schistosoma mansoni	ataxia telangiectasia mutated (atm)-related	0.1199	0.0729	0.9768
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor1	0.1199	0.0729	0.2103
Trypanosoma brucei	FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative	0.0749	0.0441	0.6051
Brugia malayi	phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative	0.0193	0.0086	0.1151
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1189	0.0722	0.9893
Onchocerca volvulus		0.0238	0.0114	0.5
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1189	0.0722	0.9893
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1187	0.0721	0.9866
Trypanosoma brucei	phosphatidylinositol 3-related kinase, putative	0.1178	0.0715	0.9812
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.1199	0.0729	0.9803
Loa Loa (eye worm)	hypothetical protein	0.0238	0.0114	0.1566
Echinococcus multilocularis	phosphatidylinositol 4 kinase alpha	0.0295	0.0151	0.0037
Leishmania major	hypothetical protein, unknown function	0.0238	0.0114	0.0315
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit gamma, putative	0.0678	0.0396	0.4578
Leishmania major	target of rapamycin (TOR) kinase 1, putative	0.1199	0.0729	0.2014
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1176	0.0714	0.9759
Loa Loa (eye worm)	phosphatidylinositol 4-kinase type 3 alpha isoform 1	0.0295	0.0151	0.207
Plasmodium falciparum	phosphatidylinositol 3-kinase	0.0295	0.0151	1
Toxoplasma gondii	phosphatidylinositol 3- and 4-kinase	0.0295	0.0151	0.0605
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.0871	0.0519	0.6435
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor2	0.1199	0.0729	0.2103
Leishmania major	phosphatidylinositol kinase, putative	0.0238	0.0114	0.0315
Echinococcus multilocularis	Zinc finger, PHD finger	0.0295	0.0151	0.0037
Echinococcus multilocularis	serine:threonine protein kinase SMG1	0.0665	0.0387	0.0276
Loa Loa (eye worm)	phosphatidylinositol kinase	0.0238	0.0114	0.1566
Echinococcus granulosus	phosphatidylinositol 45 bisphosphate 3 kinase	0.0871	0.0519	0.041
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0698	0.0409	0.4789
Schistosoma mansoni	phosphatidylinositol 4-kinase	0.0295	0.0151	0.0583
Schistosoma mansoni	fkbp-rapamycin associated protein	0.0665	0.0387	0.4338
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0238	0.0114	0.1535
Echinococcus granulosus	phosphatidylinositol 4 phosphate 3 kinase C2	0.0477	0.0267	0.0155
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1176	0.0714	0.9759
Leishmania major	hypothetical protein, conserved	0.5719	0.3619	1
Entamoeba histolytica	phosphatidylinositol 4-kinase, putative	0.0295	0.0151	0.0597
Giardia lamblia	Phosphoinositide-3-kinase, class 3	0.031	0.016	0.0746
Trypanosoma cruzi	phosphatidylinositol kinase, putative	0.0238	0.0114	0.0329
Entamoeba histolytica	hypothetical protein	0.0681	0.0398	0.4612
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.0681	0.0398	0.1147
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1166	0.0708	0.9652
Trypanosoma cruzi	phosphatidylinositol 3-kinase, putative	0.0129	0.0045	0.0129
Loa Loa (eye worm)	phosphatidylinositol 3	0.08	0.0473	0.6493
Entamoeba histolytica	protein kinase rad3, putative	0.0665	0.0387	0.4441
Brugia malayi	Cytochrome P450 family protein	0.0126	0.0042	0.0568
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1179	0.0716	0.9786
Mycobacterium ulcerans	cytochrome P450 185A4 Cyp185A4	0.0059	0	0.5
Echinococcus multilocularis	FKBP12 rapamycin complex associated protein	0.1199	0.0729	0.0622
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.1222	0.0744	1
Loa Loa (eye worm)	phosphatidylinositol 3	0.0238	0.0114	0.1566
Leishmania major	phosphatidylinositol 3-related kinase, putative	0.1178	0.0715	0.1977
Leishmania major	phosphatidylinositol 4-kinase, putative	0.0238	0.0114	0.0315
Trichomonas vaginalis	conserved hypothetical protein	0.0427	0.0235	0.1966
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0405	0.0221	0.1741
Trichomonas vaginalis	conserved hypothetical protein	0.0501	0.0282	0.2736
Schistosoma mansoni	ataxia telangiectasia mutated (atm)	0.0681	0.0398	0.4504
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative	0.0568	0.0325	0.3434
Trypanosoma brucei	phosphatidylinositol 4-kinase alpha, putative	0.0295	0.0151	0.207
Echinococcus granulosus	phosphatidylinositol 3 kinase catalytic subunit	0.0295	0.0151	0.0037
Leishmania major	target of rapamycin kinase (TOR) kinase 3	0.1189	0.0722	0.1996
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0678	0.0396	0.532

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1615431

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1464776