Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.1295 | 1 | 1 |
Echinococcus multilocularis | endonuclease exonuclease phosphatase | 0.0197 | 0.1363 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1295 | 1 | 1 |
Brugia malayi | Bromodomain containing protein | 0.0079 | 0.0432 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0074 | 0.0397 | 0.027 |
Loa Loa (eye worm) | hypothetical protein | 0.0057 | 0.0262 | 0.0133 |
Echinococcus multilocularis | suppression of tumorigenicity 18 protein | 0.0057 | 0.0262 | 0.192 |
Schistosoma mansoni | sex comb on midleg homolog | 0.005 | 0.0207 | 0.0941 |
Echinococcus granulosus | histone acetyltransferase MYST2 | 0.0057 | 0.0262 | 0.192 |
Brugia malayi | Bromodomain containing protein | 0.004 | 0.013 | 0.2673 |
Schistosoma mansoni | hypothetical protein | 0.0304 | 0.2204 | 1 |
Brugia malayi | C2-HC type zinc finger protein C.e-MyT1 | 0.0057 | 0.0262 | 0.5868 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0038 | 0.011 | 0.0809 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0063 | 0.0306 | 0.2246 |
Brugia malayi | mbt repeat family protein | 0.005 | 0.0207 | 0.455 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0038 | 0.011 | 0.0809 |
Loa Loa (eye worm) | inward rectifying k channel family protein 1 | 0.1295 | 1 | 1 |
Echinococcus multilocularis | polycomb protein SCMH1 | 0.005 | 0.0207 | 0.1521 |
Brugia malayi | mbt repeat family protein | 0.005 | 0.0207 | 0.455 |
Loa Loa (eye worm) | mbt repeat family protein | 0.005 | 0.0207 | 0.0078 |
Echinococcus granulosus | SAM and MBT domain containing protein | 0.005 | 0.0207 | 0.1521 |
Echinococcus multilocularis | SAM and MBT domain containing protein | 0.005 | 0.0207 | 0.1521 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.015 | 0.002 |
Toxoplasma gondii | hypothetical protein | 0.1295 | 1 | 0.5 |
Schistosoma mansoni | myelin transcription factor 1 myt1 | 0.0057 | 0.0262 | 0.1188 |
Echinococcus granulosus | polycomb protein SCMH1 | 0.005 | 0.0207 | 0.1521 |
Schistosoma mansoni | bromodomain containing protein | 0.0066 | 0.0336 | 0.1523 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.0207 | 0.0078 |
Echinococcus granulosus | suppression of tumorigenicity 18 protein | 0.0057 | 0.0262 | 0.192 |
Echinococcus granulosus | endonuclease exonuclease phosphatase | 0.0197 | 0.1363 | 1 |
Schistosoma mansoni | sex comb on midleg homolog | 0.005 | 0.0207 | 0.0941 |
Echinococcus multilocularis | histone acetyltransferase MYST2 | 0.0057 | 0.0262 | 0.192 |
Onchocerca volvulus | 0.005 | 0.0207 | 0.5 | |
Schistosoma mansoni | scm-relatedprotein containing 4 mbt domains (sfmbt) | 0.005 | 0.0207 | 0.0941 |
Loa Loa (eye worm) | MBCTL1 | 0.0057 | 0.0262 | 0.0133 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0063 | 0.0306 | 0.2246 |
Onchocerca volvulus | Polycomb protein Sfmbt homolog | 0.005 | 0.0207 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.0166 | 0.0036 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | = 14 % | Inhibition of human alphaVbeta3 receptor expressed in african green monkey Vero E6 cells assessed as inhibition of SNV infection in cells at 1 uM by immunofluorescent assay | ChEMBL. | 20951038 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.