Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | solute carrier family 6 (neurotransmitter transporter), member 2 | Starlite/ChEMBL | References |
Homo sapiens | solute carrier family 6 (neurotransmitter transporter), member 3 | Starlite/ChEMBL | References |
Homo sapiens | solute carrier family 6 (neurotransmitter transporter), member 4 | Starlite/ChEMBL | References |
Homo sapiens | 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Sodium:neurotransmitter symporter family protein | solute carrier family 6 (neurotransmitter transporter), member 2 | 617 aa | 638 aa | 32.5 % |
Brugia malayi | Sodium:neurotransmitter symporter family protein | solute carrier family 6 (neurotransmitter transporter), member 3 | 620 aa | 579 aa | 33.2 % |
Brugia malayi | Sodium:neurotransmitter symporter family protein | solute carrier family 6 (neurotransmitter transporter), member 4 | 630 aa | 574 aa | 31.5 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0103 | 0.1792 | 0.1792 |
Schistosoma mansoni | biogenic amine (5HT) receptor | 0.015 | 0.3823 | 0.3823 |
Trypanosoma cruzi | DNA/RNA non-specific endonuclease protein-like, putative | 0.0062 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0103 | 0.1792 | 0.0792 |
Schistosoma mansoni | sodium/chloride dependent transporter | 0.0292 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0103 | 0.1792 | 0.0792 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0087 | 0.1086 | 0.1086 |
Loa Loa (eye worm) | hypothetical protein | 0.015 | 0.3823 | 0.3071 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0103 | 0.1792 | 0.1792 |
Loa Loa (eye worm) | hypothetical protein | 0.0292 | 1 | 1 |
Echinococcus multilocularis | serotonin receptor | 0.015 | 0.3823 | 0.3823 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0103 | 0.1792 | 0.1792 |
Trypanosoma cruzi | DNA/RNA non-specific endonuclease protein-like, putative | 0.0062 | 0 | 0.5 |
Trypanosoma cruzi | endonuclease G, putative | 0.0062 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0223 | 0.6991 | 0.6991 |
Loa Loa (eye worm) | hypothetical protein | 0.0103 | 0.1792 | 0.0792 |
Onchocerca volvulus | 0.0292 | 1 | 1 | |
Schistosoma mansoni | ectonucleotide pyrophosphatase/phosphodiesterase | 0.0103 | 0.1792 | 0.1792 |
Trypanosoma brucei | endonuclease G, putative | 0.0062 | 0 | 0.5 |
Brugia malayi | Type I phosphodiesterase / nucleotide pyrophosphatase family protein | 0.0103 | 0.1792 | 0.1792 |
Trypanosoma brucei | endonuclease G, putative | 0.0062 | 0 | 0.5 |
Echinococcus granulosus | serotonin transporter | 0.0292 | 1 | 1 |
Loa Loa (eye worm) | serotonin transporter b | 0.0292 | 1 | 1 |
Treponema pallidum | sodium- and chloride- dependent transporter | 0.0292 | 1 | 0.5 |
Trypanosoma brucei | endonuclease G, putative | 0.0062 | 0 | 0.5 |
Loa Loa (eye worm) | solute carrier family 6 member 4 | 0.0292 | 1 | 1 |
Trypanosoma cruzi | endonuclease G, putative | 0.0062 | 0 | 0.5 |
Onchocerca volvulus | 0.0223 | 0.6991 | 0.6334 | |
Loa Loa (eye worm) | hypothetical protein | 0.0292 | 1 | 1 |
Loa Loa (eye worm) | thrombospondin type 1 domain-containing protein | 0.0223 | 0.6991 | 0.6625 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0103 | 0.1792 | 0.1792 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0103 | 0.1792 | 0.1792 |
Brugia malayi | Thrombospondin type 1 domain containing protein | 0.0223 | 0.6991 | 0.6991 |
Echinococcus multilocularis | ectonucleotide | 0.0087 | 0.1086 | 0.1086 |
Schistosoma mansoni | ectonucleotide pyrophosphatase/phosphodiesterase | 0.0103 | 0.1792 | 0.1792 |
Loa Loa (eye worm) | hypothetical protein | 0.0292 | 1 | 1 |
Leishmania major | endonuclease G, putative | 0.0062 | 0 | 0.5 |
Schistosoma mansoni | ectonucleotide pyrophosphatase/phosphodiesterase | 0.0103 | 0.1792 | 0.1792 |
Echinococcus multilocularis | serotonin receptor | 0.015 | 0.3823 | 0.3823 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0103 | 0.1792 | 0.1792 |
Echinococcus multilocularis | serotonin transporter | 0.0292 | 1 | 1 |
Leishmania major | DNA/RNA non-specific endonuclease-like protein | 0.0062 | 0 | 0.5 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0103 | 0.1792 | 0.1792 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0103 | 0.1792 | 0.1792 |
Loa Loa (eye worm) | norepinephrine transporter | 0.0292 | 1 | 1 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0087 | 0.1086 | 0.1086 |
Loa Loa (eye worm) | hypothetical protein | 0.015 | 0.3823 | 0.3071 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0103 | 0.1792 | 0.1792 |
Echinococcus granulosus | ectonucleotide | 0.0087 | 0.1086 | 0.1086 |
Echinococcus granulosus | biogenic amine 5HT receptor | 0.015 | 0.3823 | 0.3823 |
Schistosoma mansoni | norepinephrine/norepinephrine transporter | 0.0292 | 1 | 1 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0103 | 0.1792 | 0.1792 |
Schistosoma mansoni | ectonucleotide pyrophosphatase/phosphodiesterase | 0.0103 | 0.1792 | 0.1792 |
Toxoplasma gondii | DNA/RNA non-specific endonuclease | 0.0062 | 0 | 0.5 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0103 | 0.1792 | 0.1792 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | = 28 nM | Agonist activity at human cloned NET expressed in HEK293 cells by FLIPR assay | ChEMBL. | 21185183 |
EC50 (binding) | = 197 nM | Agonist activity at 5HT1A receptor by GTPgammaS binding assay | ChEMBL. | 21185183 |
Intrinsic activity (binding) | = 40 % | Agonist activity at 5HT1A receptor by GTPgammaS binding assay relative to 5-HT | ChEMBL. | 21185183 |
Ki (binding) | = 1 nM | Displacement of [3H]8-OH-DPAT from human cloned 5HT1A receptor by liquid scintillation spectrophotometry | ChEMBL. | 21185183 |
Ki (binding) | = 138 nM | Displacement of [3H]nisoxetine from human NET by scintillation proximity assay | ChEMBL. | 21185183 |
Ki (binding) | > 4900 nM | Displacement of [3H]citalopram from human SERT by scintillation proximity assay | ChEMBL. | 21185183 |
Ki (binding) | > 6460 nM | Displacement of [3H]WIN-35,428 from human DAT by scintillation proximity assay | ChEMBL. | 21185183 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.