TDR Targets

Basic information

Technical information

TDR Targets ID: 1467400
Name: 6-chloro-3-(4-methylpiperazin-1-yl)-1-(4-prop an-2-ylphenyl)sulfonylindole
MW: 431.979 | Formula: C22H26ClN3O2S
H donors: 0 H acceptors: 2 LogP: 4.92 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: CN1CCN(CC1)c1cn(c2c1ccc(c2)Cl)S(=O)(=O)c1ccc(cc1)C(C)C
InChi: 1S/C22H26ClN3O2S/c1-16(2)17-4-7-19(8-5-17)29(27,28)26-15-22(25-12-10-24(3)11-13-25)20-9-6-18(23)14-21(20)26/h4-9,14-16H,10-13H2,1-3H3
InChiKey: AJQQBSCDJFVVMQ-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

6-chloro-1-(4-isopropylphenyl)sulfonyl-3-(4-methylpiperazin-1-yl)indole
6-chloro-1-(4-isopropylphenyl)sulfonyl-3-(4-methyl-1-piperazinyl)indole
6-chloro-3-(4-methylpiperazin-1-yl)-1-(4-propan-2-ylphenyl)sulfonyl-indole

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	5-hydroxytryptamine (serotonin) receptor 6, G protein-coupled	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Echinococcus granulosus	tm gpcr rhodopsin	Get druggable targets OG5_145685	All targets in OG5_145685
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	Get druggable targets OG5_145685	All targets in OG5_145685

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.1198	0.0726	0.982
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1188	0.072	0.9902
Loa Loa (eye worm)	hypothetical protein	0.0502	0.0284	0.3914
Trypanosoma cruzi	phosphatidylinositol 4-kinase alpha, putative	0.029	0.0149	0.0431
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0575	0.0331	0.3521
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1186	0.0719	0.9877
Echinococcus granulosus	serine protein kinase ATM	0.068	0.0397	0.0285
Loa Loa (eye worm)	phosphatidylinositol kinase	0.0237	0.0116	0.1596
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1198	0.0726	1
Schistosoma mansoni	hypothetical protein	0.0502	0.0284	0.27
Trypanosoma brucei	phosphatidylinositol 3-kinase, putative	0.0356	0.0191	0.2633
Entamoeba histolytica	Phosphatidylinositol 3- and 4-kinase family	0.0676	0.0395	0.4569
Trypanosoma cruzi	phosphatidylinositol 3-kinase, putative	0.0237	0.0116	0.0334
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0237	0.0116	0.1567
Schistosoma mansoni	ataxia telangiectasia mutated (atm)	0.068	0.0397	0.4512
Schistosoma mansoni	ataxia telangiectasia mutated (atm)-related	0.1198	0.0726	0.9786
Echinococcus granulosus	PIK kinase FAT and Armadillo domain containing protein	0.0502	0.0284	0.017
Schistosoma mansoni	phosphatidylinositol 4-kinase	0.029	0.0149	0.0537
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0665	0.0388	0.4454
Echinococcus granulosus	serine:threonine protein kinase SMG1	0.0665	0.0388	0.0275
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1186	0.0719	0.9877
Leishmania major	phosphatidylinositol 3-kinase, putative	0.029	0.0149	0.0413
Giardia lamblia	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	0.0474	0.0267	0.247
Trichomonas vaginalis	phopsphatidylinositol 3-kinase, drosophila, putative	0.0641	0.0373	0.4206
Trypanosoma brucei	phosphatidylinositol 3-related kinase, putative	0.1178	0.0714	0.9828
Loa Loa (eye worm)	phosphatidylinositol 3	0.0237	0.0116	0.1596
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1186	0.0719	0.9877
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative	0.0356	0.0191	0.1234
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor1	0.1198	0.0726	0.2093
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0356	0.0191	0.2586
Echinococcus multilocularis	serine protein kinase ATM	0.068	0.0397	0.0285
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0356	0.0191	0.1234
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1176	0.0713	0.9778
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1186	0.0719	0.9877
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1167	0.0707	0.968
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1177	0.0713	0.9779
Echinococcus multilocularis	DNA dependent protein kinase catalytic subunit	1.5798	1	1
Trypanosoma brucei	FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative	0.0749	0.0441	0.6071
Trypanosoma cruzi	phosphatidylinositol kinase, putative	0.0237	0.0116	0.0334
Entamoeba histolytica	phosphatidylinositol 3-kinase 1, putative	0.0404	0.0222	0.1739
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0457	0.0255	0.3453
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1177	0.0713	0.9779
Entamoeba histolytica	protein kinase rad3, putative	0.0665	0.0388	0.4454
Loa Loa (eye worm)	phosphatidylinositol 3	0.0237	0.0116	0.1596
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1176	0.0713	0.9778
Trichomonas vaginalis	conserved hypothetical protein	0.0428	0.0237	0.1986
Trypanosoma brucei	phosphatidylinositol 4-kinase alpha, putative	0.029	0.0149	0.2057
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.068	0.0397	0.1145
Loa Loa (eye worm)	phosphatidylinositol 3	0.0119	0.0041	0.056
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1176	0.0713	0.9778
Leishmania major	target of rapamycin (TOR) kinase 2, putative	0.1198	0.0726	0.2006
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0684	0.04	0.465
Leishmania major	phosphatidylinositol kinase related protein, putative	0.0252	0.0125	0.0347
Echinococcus multilocularis	phosphatidylinositol 4,5 bisphosphate 3 kinase	0.0819	0.0485	0.0374
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.1219	0.0739	1
Echinococcus multilocularis	phosphatidylinositol 4 phosphate 3 kinase C2	0.0457	0.0255	0.0141
Trypanosoma brucei	phosphatidylinositol 3-kinase, putative	0.1167	0.0707	0.9731
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit gamma, putative	0.0641	0.0373	0.4206
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1186	0.0719	0.9877
Trichomonas vaginalis	conserved hypothetical protein	0.0739	0.0435	0.5226
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0641	0.0373	0.4206
Entamoeba histolytica	phosphatidylinositol-4,5-bisphosphate 3-kinase, putative	0.029	0.0149	0.0549
Mycobacterium leprae	conserved hypothetical protein	0.0237	0.0116	0.5
Toxoplasma gondii	target of rapamycin (TOR), putative	0.1186	0.0719	1
Plasmodium vivax	phosphatidylinositol 3-kinase, putative	0.029	0.0149	1
Echinococcus granulosus	phosphatidylinositol 45 bisphosphate 3 kinase	0.0819	0.0485	0.0374
Trypanosoma cruzi	phosphatidylinositol 3-kinase vps34-like	0.0356	0.0191	0.0551
Trypanosoma cruzi	hypothetical protein, conserved	0.5517	0.3469	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0686	0.0401	0.4675
Echinococcus multilocularis	phosphatidylinositol 3 and 4 kinase	0.1219	0.0739	0.0631
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1167	0.0707	0.968
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0356	0.0191	0.1234
Loa Loa (eye worm)	hypothetical protein	0.0457	0.0255	0.3516
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0237	0.0116	0.5
Brugia malayi	FAT domain containing protein	0.0502	0.0284	0.3844
Trypanosoma brucei	phosphatidylinositol 3-kinase tor, putative	0.0256	0.0128	0.1761
Trypanosoma brucei	Phosphatidylinositol 3-kinase tor1	0.1198	0.0726	1
Leishmania major	phosphatidylinositol 4-kinase alpha, putative	0.029	0.0149	0.0413
Loa Loa (eye worm)	phosphatidylinositol 3	0.1178	0.0714	0.9828
Echinococcus granulosus	phosphatidylinositol 3 kinase catalytic subunit	0.029	0.0149	0.0034
Toxoplasma gondii	phosphatidylinositol 3- and 4-kinase	0.029	0.0149	0.0556
Loa Loa (eye worm)	cytochrome P450 family protein	0.0115	0.0039	0.0531
Echinococcus granulosus	FKBP12 rapamycin complex associated protein	0.1198	0.0726	0.0617
Echinococcus multilocularis	Zinc finger, PHD finger	0.029	0.0149	0.0034
Leishmania major	phosphatidylinositol 3-kinase, putative	0.1167	0.0707	0.1952
Trichomonas vaginalis	phosphatidylinositol 4-kinase, putative	0.029	0.0149	0.0549
Trypanosoma cruzi	phosphatidylinositol 3-related kinase, putative	0.1219	0.0739	0.2131
Loa Loa (eye worm)	hypothetical protein	0.0665	0.0388	0.5339
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0356	0.0191	0.1234
Echinococcus multilocularis	FKBP12 rapamycin complex associated protein	0.1198	0.0726	0.0617
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	0.029	0.0149	0.0549
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1179	0.0714	0.9803
Trypanosoma brucei	phosphatidylinositol kinase related protein, putative	0.068	0.0397	0.5471
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1167	0.0707	0.968
Leishmania major	phosphatidylinositol 4-kinase, putative	0.0237	0.0116	0.032
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	0.0356	0.0191	0.1234
Trypanosoma cruzi	phosphatidylinositol 3-related kinase, putative	0.1219	0.0739	0.2131
Echinococcus granulosus	phosphatidylinositol 4 kinase alpha	0.029	0.0149	0.0034
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1188	0.072	0.9902
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0641	0.0373	0.5038
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1186	0.0719	0.9877
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0684	0.04	0.465
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0696	0.0407	0.4774
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.0252	0.0125	0.0362
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0237	0.0116	0.1567
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.029	0.0149	0.0549
Entamoeba histolytica	hypothetical protein	0.0575	0.0331	0.3521
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1188	0.072	0.9902
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0676	0.0395	0.4569
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.029	0.0149	0.0537
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative	0.054	0.0308	0.3155
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0428	0.0237	0.1986
Loa Loa (eye worm)	hypothetical protein	0.0443	0.0247	0.3397
Entamoeba histolytica	hypothetical protein	0.068	0.0397	0.4611
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1179	0.0714	0.9803
Leishmania major	target of rapamycin (TOR) kinase 1, putative	0.1198	0.0726	0.2006
Brugia malayi	Cytochrome P450 family protein	0.0115	0.0039	0.0521
Trypanosoma cruzi	phosphatidylinositol 3-kinase, putative	0.0119	0.0041	0.0117
Trypanosoma cruzi	phosphatidylinositol 3-kinase 2, putative	0.0641	0.0373	0.1074
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	0.0237	0.0116	0.1596
Loa Loa (eye worm)	phosphatidylinositol 3	0.0237	0.0116	0.1596
Leishmania major	phosphatidylinositol 3-related kinase, putative	0.1178	0.0714	0.1971
Echinococcus granulosus	phosphatidylinositol 3 and 4 kinase	0.1219	0.0739	0.0631
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1167	0.0707	0.968
Toxoplasma gondii	FATC domain-containing protein	0.068	0.0397	0.4668
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.068	0.0397	0.5372
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.0819	0.0485	0.5924
Brugia malayi	phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative	0.0177	0.0078	0.1055
Plasmodium falciparum	phosphatidylinositol 3-kinase	0.029	0.0149	1
Leishmania major	hypothetical protein, conserved	0.5754	0.362	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0246	0.0122	0.0098
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.0356	0.0191	0.1208
Toxoplasma gondii	phosphatidylinositol 3- and 4-kinase	0.029	0.0149	0.0556
Trypanosoma cruzi	phosphatidylinositol 3-kinase, putative	0.0665	0.0388	0.1117
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.1003	0.0602	0.0492
Loa Loa (eye worm)	hypothetical protein	0.0739	0.0435	0.5988
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1177	0.0713	0.9779
Echinococcus granulosus	phosphatidylinositol 4 phosphate 3 kinase C2	0.0457	0.0255	0.0141
Trypanosoma cruzi	phosphatidylinositol 4-kinase, putative	0.0237	0.0116	0.0334
Onchocerca volvulus		0.0237	0.0116	0.5
Echinococcus multilocularis	phosphatidylinositol 4 kinase alpha	0.029	0.0149	0.0034
Trypanosoma brucei	phosphatidylinositol 3-kinase catalytic subunit, putative	0.0237	0.0116	0.1596
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1198	0.0726	1
Echinococcus granulosus	tm gpcr rhodopsin	0.1003	0.0602	0.0492
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0641	0.0373	0.4206
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1177	0.0713	0.9779
Giardia lamblia	Phosphoinositide-3-kinase, class 3	0.0303	0.0158	0.0685
Schistosoma mansoni	fkbp-rapamycin associated protein	0.0665	0.0388	0.4359
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	0.1198	0.0726	1
Leishmania major	hypothetical protein, unknown function	0.0237	0.0116	0.032
Onchocerca volvulus		0.0237	0.0116	0.5
Entamoeba histolytica	FKBP-rapamycin associated protein (FRAP), putative	0.1198	0.0726	1
Loa Loa (eye worm)	phosphatidylinositol 4-kinase type 3 alpha isoform 1	0.029	0.0149	0.2057
Entamoeba histolytica	phosphatidylinositol 4-kinase, putative	0.029	0.0149	0.0549
Brugia malayi	phosphatidylinositol 4-kinase, catalytic, alpha polypeptide	0.029	0.0149	0.202
Trypanosoma brucei	target of rapamycin kinase 3, putative	0.1188	0.072	0.9918
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0237	0.0116	0.1567
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1178	0.0714	0.9795
Leishmania major	phosphatidylinositol kinase, putative	0.0237	0.0116	0.032
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1186	0.0719	0.9877
Leishmania major	target of rapamycin kinase (TOR) kinase 3	0.1188	0.072	0.1989
Trichomonas vaginalis	PIKK family atypical protein kinase	0.076	0.0448	0.5448
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1198	0.0726	1
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor2	0.1198	0.0726	0.2093
Trichomonas vaginalis	conserved hypothetical protein	0.0502	0.0284	0.2759
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0684	0.04	0.465
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	0.054	0.0308	0.3155
Loa Loa (eye worm)	hypothetical protein	0.0237	0.0116	0.1596
Trypanosoma cruzi	phosphatidylinositol 3-kinase 2, putative	0.0641	0.0373	0.1074
Entamoeba histolytica	phosphatidylinositol3-kinaseTor2, putative	0.1198	0.0726	1
Loa Loa (eye worm)	phosphatidylinositol 3	0.1198	0.0726	1
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.0443	0.0247	0.0711
Trypanosoma cruzi	phosphatidylinositol 4-kinase alpha, putative	0.029	0.0149	0.0431
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0391	0.0214	0.16
Loa Loa (eye worm)	phosphatidylinositol 3	0.0237	0.0116	0.1596
Toxoplasma gondii	non-specific serine/threonine protein kinase	0.0739	0.0435	0.5291
Loa Loa (eye worm)	hypothetical protein	0.0185	0.0083	0.1137
Trypanosoma cruzi	phosphatidylinositol 4-kinase, putative	0.0237	0.0116	0.0334
Echinococcus multilocularis	PIK kinase, FAT and Armadillo domain containing protein	0.0502	0.0284	0.017
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0665	0.0388	0.5243
Schistosoma mansoni	phosphatidylinositol 3-and 4-kinase	0.1219	0.0739	1
Loa Loa (eye worm)	phosphatidylinositol 3	0.0753	0.0443	0.6107
Trichomonas vaginalis	PIKK family atypical protein kinase	0.068	0.0397	0.4611
Trypanosoma cruzi	target of rapamycin kinase 3	0.1188	0.072	0.2076
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1188	0.072	0.9902
Mycobacterium ulcerans	cytochrome P450 185A4 Cyp185A4	0.0055	0	0.5
Giardia lamblia	GTOR	0.1198	0.0726	1
Echinococcus multilocularis	serine:threonine protein kinase SMG1	0.0665	0.0388	0.0275
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1188	0.072	0.9902

Activities

Activity type	Activity value	Assay description	Source	Reference
Ki (binding)	= 55.3 nM	Displacement of [3H]LSD from human cloned 5HT6 receptor expressed in human HeLa cells by glass fiber filtration assay	ChEMBL.	21134749

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1642428

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1467400