Detailed information for compound 1467776

Basic information

Technical information
  • TDR Targets ID: 1467776
  • Name: 1-[1-[1-(furan-2-ylmethyl)tetrazol-5-yl]butyl ]-4-phenylpiperazine
  • MW: 366.46 | Formula: C20H26N6O
  • H donors: 0 H acceptors: 3 LogP: 3.01 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCC(c1nnnn1Cc1ccco1)N1CCN(CC1)c1ccccc1
  • InChi: 1S/C20H26N6O/c1-2-7-19(20-21-22-23-26(20)16-18-10-6-15-27-18)25-13-11-24(12-14-25)17-8-4-3-5-9-17/h3-6,8-10,15,19H,2,7,11-14,16H2,1H3
  • InChiKey: NJRIBQMHMIYBJK-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1-[1-[1-(2-furylmethyl)tetrazol-5-yl]butyl]-4-phenyl-piperazine
  • 1-[1-[1-(2-furylmethyl)-5-tetrazolyl]butyl]-4-phenylpiperazine
  • 1-[1-[1-(furan-2-ylmethyl)-1,2,3,4-tetrazol-5-yl]butyl]-4-phenyl-piperazine
  • 1-[1-(1-Furan-2-ylmethyl-1H-tetrazol-5-yl)-butyl]-4-phenyl-piperazine
  • ASN 05557304

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0465 0.0268 0.2497
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0231 0.0116 0.1595
Loa Loa (eye worm) hypothetical protein 0.0431 0.0247 0.3395
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0283 0.015 0.0414
Loa Loa (eye worm) phosphatidylinositol 3 0.1147 0.0714 0.9826
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.1167 0.0727 0.2007
Leishmania major phosphatidylinositol kinase related protein, putative 0.0246 0.0126 0.0347
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.1167 0.0727 0.9784
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0283 0.015 0.0543
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0283 0.015 0.2023
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0283 0.015 0.0034
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.1187 0.074 0.0632
Leishmania major phosphatidylinositol 3-kinase, putative 0.1137 0.0707 0.1953
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0283 0.015 0.0034
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0348 0.0192 0.1248
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0283 0.015 0.0555
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0648 0.0388 0.0275
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.1167 0.0727 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.1148 0.0715 0.9801
Trichomonas vaginalis PIKK family atypical protein kinase 0.1137 0.0707 0.9677
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0662 0.0398 0.1146
Trichomonas vaginalis PIKK family atypical protein kinase 0.1157 0.0721 0.99
Trichomonas vaginalis PIKK family atypical protein kinase 0.1155 0.0719 0.9875
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0629 0.0376 0.4252
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0283 0.015 0.0432
Mycobacterium tuberculosis Conserved hypothetical protein 0.0231 0.0116 0.5
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.1187 0.074 0.2134
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0348 0.0192 0.2595
Trypanosoma brucei phosphatidylinositol 3-kinase catalytic subunit, putative 0.0231 0.0116 0.1595
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0231 0.0116 0.0334
Trichomonas vaginalis PIKK family atypical protein kinase 0.0666 0.04 0.4651
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0662 0.0398 0.4511
Trichomonas vaginalis PIKK family atypical protein kinase 0.1137 0.0707 0.9677
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0447 0.0257 0.3472
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0283 0.015 0.0555
Mycobacterium leprae conserved hypothetical protein 0.0231 0.0116 0.5
Trichomonas vaginalis PIKK family atypical protein kinase 0.1155 0.0719 0.9875
Toxoplasma gondii non-specific serine/threonine protein kinase 0.072 0.0435 0.529
Entamoeba histolytica hypothetical protein 0.0564 0.0333 0.3559
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0629 0.0376 0.1083
Loa Loa (eye worm) phosphatidylinositol 3 0.0739 0.0447 0.6156
Leishmania major phosphatidylinositol 3-kinase, putative 0.0283 0.015 0.0414
Trichomonas vaginalis PIKK family atypical protein kinase 0.1155 0.0719 0.9875
Trypanosoma cruzi hypothetical protein, conserved 0.5368 0.3469 1
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0283 0.015 0.0555
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.1187 0.074 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0666 0.04 0.4651
Trichomonas vaginalis PIKK family atypical protein kinase 0.1137 0.0707 0.9677
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0348 0.0192 0.1248
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0348 0.0192 0.1221
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0662 0.0398 0.537
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0348 0.0192 0.1248
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.1167 0.0727 0.9818
Trichomonas vaginalis PIKK family atypical protein kinase 0.1146 0.0713 0.9776
Trichomonas vaginalis PIKK family atypical protein kinase 0.1155 0.0719 0.9875
Trichomonas vaginalis PIKK family atypical protein kinase 0.1137 0.0707 0.9677
Trichomonas vaginalis PIKK family atypical protein kinase 0.1146 0.0713 0.9776
Trichomonas vaginalis conserved hypothetical protein 0.072 0.0435 0.5224
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 1.5374 1 1
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0431 0.0247 0.0711
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0348 0.0192 0.2643
Onchocerca volvulus 0.0231 0.0116 0.5
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0629 0.0376 0.5074
Trichomonas vaginalis PIKK family atypical protein kinase 0.1146 0.0713 0.9776
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0283 0.015 0.0562
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0231 0.0116 0.1566
Trichomonas vaginalis PIKK family atypical protein kinase 0.1146 0.0713 0.9776
Entamoeba histolytica phosphatidylinositol 3-kinase 1, putative 0.0398 0.0225 0.1783
Loa Loa (eye worm) cytochrome P450 family protein 0.0113 0.0039 0.0533
Trichomonas vaginalis PIKK family atypical protein kinase 0.1146 0.0713 0.9776
Toxoplasma gondii FATC domain-containing protein 0.0662 0.0398 0.4669
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.1187 0.074 1
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.0804 0.049 0.0378
Trichomonas vaginalis PIKK family atypical protein kinase 0.024 0.0122 0.0099
Echinococcus granulosus serine protein kinase ATM 0.0662 0.0398 0.0285
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.1167 0.0727 1
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0283 0.015 0.0432
Trichomonas vaginalis PIKK family atypical protein kinase 0.1157 0.0721 0.99
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0447 0.0257 0.0143
Trichomonas vaginalis PIKK family atypical protein kinase 0.1167 0.0727 1
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0658 0.0395 0.4569
Trichomonas vaginalis PIKK family atypical protein kinase 0.1155 0.0719 0.9875
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0529 0.0311 0.319
Entamoeba histolytica protein kinase rad3, putative 0.0648 0.0388 0.4452
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0348 0.0192 0.0554
Loa Loa (eye worm) hypothetical protein 0.0489 0.0284 0.3911
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.1167 0.0727 0.2007
Loa Loa (eye worm) hypothetical protein 0.0182 0.0084 0.1152
Trichomonas vaginalis PIKK family atypical protein kinase 0.0662 0.0398 0.4611
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0231 0.0116 0.0334
Loa Loa (eye worm) phosphatidylinositol 3 0.0231 0.0116 0.1595
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.0489 0.0284 0.017
Trichomonas vaginalis PIKK family atypical protein kinase 0.1167 0.0727 1
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0283 0.015 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.1155 0.0719 0.9875
Loa Loa (eye worm) hypothetical protein 0.0648 0.0388 0.5337
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.025 0.0128 0.1762
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0629 0.0376 0.1083
Leishmania major phosphatidylinositol 3-related kinase, putative 0.1147 0.0714 0.1972
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0564 0.0333 0.3559
Loa Loa (eye worm) hypothetical protein 0.0447 0.0257 0.3536
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0348 0.0192 0.1248
Loa Loa (eye worm) phosphatidylinositol 3 0.0231 0.0116 0.1595
Trichomonas vaginalis PIKK family atypical protein kinase 0.1155 0.0719 0.9875
Trichomonas vaginalis PIKK family atypical protein kinase 0.1167 0.0727 1
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.1167 0.0727 1
Loa Loa (eye worm) phosphatidylinositol 3 0.0231 0.0116 0.1595
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0246 0.0126 0.0362
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0348 0.0192 0.1248
Trichomonas vaginalis PIKK family atypical protein kinase 0.0417 0.0237 0.1984
Brugia malayi FAT domain containing protein 0.0489 0.0284 0.384
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0231 0.0116 0.1566
Loa Loa (eye worm) phosphatidylinositol 3 0.0117 0.0041 0.0569
Trichomonas vaginalis PIKK family atypical protein kinase 0.0669 0.0401 0.4676
Loa Loa (eye worm) hypothetical protein 0.072 0.0435 0.5986
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.1187 0.074 0.2134
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0648 0.0388 0.0275
Trichomonas vaginalis PIKK family atypical protein kinase 0.1157 0.0721 0.99
Trypanosoma brucei target of rapamycin kinase 3, putative 0.1157 0.0721 0.9917
Trichomonas vaginalis PIKK family atypical protein kinase 0.0658 0.0395 0.4569
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0648 0.0388 0.524
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.1167 0.0727 0.0618
Trichomonas vaginalis PIKK family atypical protein kinase 0.1157 0.0721 0.99
Loa Loa (eye worm) hypothetical protein 0.0231 0.0116 0.1595
Echinococcus multilocularis Zinc finger, PHD finger 0.0283 0.015 0.0034
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.1167 0.0727 1
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.1167 0.0727 0.2095
Leishmania major hypothetical protein, unknown function 0.0231 0.0116 0.032
Schistosoma mansoni fkbp-rapamycin associated protein 0.0648 0.0388 0.4356
Trichomonas vaginalis PIKK family atypical protein kinase 0.1146 0.0713 0.9776
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0283 0.015 0.2061
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0283 0.015 0.0562
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0283 0.015 1
Brugia malayi phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative 0.0175 0.0079 0.107
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.1157 0.0721 0.1991
Toxoplasma gondii target of rapamycin (TOR), putative 0.1155 0.0719 1
Onchocerca volvulus 0.0231 0.0116 0.5
Trypanosoma cruzi target of rapamycin kinase 3 0.1157 0.0721 0.2077
Trichomonas vaginalis PIKK family atypical protein kinase 0.1147 0.0714 0.9793
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.1167 0.0727 0.2095
Giardia lamblia GTOR 0.1167 0.0727 1
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0729 0.0441 0.607
Schistosoma mansoni hypothetical protein 0.0489 0.0284 0.2696
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0629 0.0376 0.4252
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0231 0.0116 0.0334
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.0489 0.0284 0.017
Trichomonas vaginalis PIKK family atypical protein kinase 0.0666 0.04 0.4651
Leishmania major hypothetical protein, conserved 0.5599 0.362 1
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0283 0.015 0.0555
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0296 0.0158 0.0693
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.0231 0.0116 0.0334
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0804 0.049 0.5987
Trichomonas vaginalis PIKK family atypical protein kinase 0.0678 0.0408 0.4776
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0648 0.0388 0.1118
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0283 0.015 0.0543
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0447 0.0257 0.0143
Trichomonas vaginalis PIKK family atypical protein kinase 0.1146 0.0713 0.9776
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0231 0.0116 0.1566
Loa Loa (eye worm) phosphatidylinositol kinase 0.0231 0.0116 0.1595
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.0804 0.049 0.0378
Loa Loa (eye worm) phosphatidylinositol 3 0.1167 0.0727 1
Leishmania major phosphatidylinositol kinase, putative 0.0231 0.0116 0.032
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0283 0.015 0.0555
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0629 0.0376 0.4252
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0529 0.0311 0.319
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0283 0.015 0.2061
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0283 0.015 0.0034
Trichomonas vaginalis PIKK family atypical protein kinase 0.0648 0.0388 0.4452
Trichomonas vaginalis PIKK family atypical protein kinase 0.1157 0.0721 0.99
Trichomonas vaginalis conserved hypothetical protein 0.0417 0.0237 0.1984
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0382 0.0215 0.1617
Trichomonas vaginalis conserved hypothetical protein 0.0489 0.0284 0.2756
Entamoeba histolytica hypothetical protein 0.0662 0.0398 0.4611
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0629 0.0376 0.4252
Brugia malayi Cytochrome P450 family protein 0.0113 0.0039 0.0524
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0053 0 0.5
Trichomonas vaginalis PIKK family atypical protein kinase 0.1148 0.0715 0.9801
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.1167 0.0727 0.0618
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.1187 0.074 0.0632
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.1147 0.0714 0.9826
Loa Loa (eye worm) phosphatidylinositol 3 0.0231 0.0116 0.1595
Leishmania major phosphatidylinositol 4-kinase, putative 0.0231 0.0116 0.032
Echinococcus multilocularis serine protein kinase ATM 0.0662 0.0398 0.0285
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0662 0.0398 0.547
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.1137 0.0707 0.9728
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0117 0.0041 0.0119
Trichomonas vaginalis PIKK family atypical protein kinase 0.0741 0.0449 0.5448

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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