Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Phosphatidylinositol 3- and 4-kinase family protein | 0.1221 | 0.0744 | 1 |
Leishmania major | phosphatidylinositol 3-related kinase, putative | 0.1176 | 0.0715 | 0.1977 |
Loa Loa (eye worm) | phosphatidylinositol 3 | 0.0238 | 0.0114 | 0.1568 |
Leishmania major | phosphatidylinositol 4-kinase, putative | 0.0238 | 0.0114 | 0.0316 |
Entamoeba histolytica | protein kinase rad3, putative | 0.0664 | 0.0387 | 0.4441 |
Brugia malayi | Cytochrome P450 family protein | 0.0125 | 0.0042 | 0.0566 |
Echinococcus multilocularis | FKBP12 rapamycin complex associated protein | 0.1198 | 0.0729 | 0.0622 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.1177 | 0.0716 | 0.9786 |
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.0059 | 0 | 0.5 |
Trypanosoma cruzi | phosphatidylinositol 3-kinase, putative | 0.0129 | 0.0045 | 0.0129 |
Loa Loa (eye worm) | phosphatidylinositol 3 | 0.0799 | 0.0474 | 0.6501 |
Entamoeba histolytica | hypothetical protein | 0.068 | 0.0398 | 0.4612 |
Trypanosoma cruzi | phosphatidylinositol kinase related protein, putative | 0.068 | 0.0398 | 0.1148 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.1164 | 0.0708 | 0.9651 |
Echinococcus granulosus | phosphatidylinositol 3 kinase catalytic subunit | 0.0295 | 0.0151 | 0.0037 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.1187 | 0.0723 | 0.9893 |
Brugia malayi | Phosphatidylinositol 3- and 4-kinase family protein | 0.0678 | 0.0396 | 0.5326 |
Trichomonas vaginalis | phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative | 0.0568 | 0.0326 | 0.3439 |
Trypanosoma brucei | phosphatidylinositol 4-kinase alpha, putative | 0.0295 | 0.0151 | 0.2072 |
Schistosoma mansoni | ataxia telangiectasia mutated (atm) | 0.068 | 0.0398 | 0.4504 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0426 | 0.0235 | 0.1966 |
Entamoeba histolytica | phosphatidylinositol 3-kinase, putative | 0.0405 | 0.0222 | 0.1743 |
Trichomonas vaginalis | conserved hypothetical protein | 0.05 | 0.0283 | 0.2736 |
Loa Loa (eye worm) | phosphatidylinositol kinase | 0.0238 | 0.0114 | 0.1568 |
Echinococcus multilocularis | serine:threonine protein kinase SMG1 | 0.0664 | 0.0387 | 0.0276 |
Schistosoma mansoni | phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K | 0.0871 | 0.052 | 0.6444 |
Trypanosoma cruzi | Phosphatidylinositol 3-kinase tor2 | 0.1198 | 0.0729 | 0.2104 |
Leishmania major | phosphatidylinositol kinase, putative | 0.0238 | 0.0114 | 0.0316 |
Echinococcus multilocularis | Zinc finger, PHD finger | 0.0295 | 0.0151 | 0.0037 |
Trypanosoma cruzi | phosphatidylinositol kinase, putative | 0.0238 | 0.0114 | 0.033 |
Giardia lamblia | Phosphoinositide-3-kinase, class 3 | 0.0309 | 0.016 | 0.0747 |
Leishmania major | hypothetical protein, conserved | 0.571 | 0.3619 | 1 |
Entamoeba histolytica | phosphatidylinositol 4-kinase, putative | 0.0295 | 0.0151 | 0.0598 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.1175 | 0.0714 | 0.9759 |
Echinococcus granulosus | phosphatidylinositol 4 phosphate 3 kinase C2 | 0.0477 | 0.0267 | 0.0155 |
Brugia malayi | Phosphatidylinositol 3- and 4-kinase family protein | 0.0238 | 0.0114 | 0.1537 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0697 | 0.0409 | 0.4789 |
Echinococcus granulosus | phosphatidylinositol 45 bisphosphate 3 kinase | 0.0871 | 0.052 | 0.041 |
Schistosoma mansoni | phosphatidylinositol 4-kinase | 0.0295 | 0.0151 | 0.0584 |
Schistosoma mansoni | fkbp-rapamycin associated protein | 0.0664 | 0.0387 | 0.4337 |
Schistosoma mansoni | ataxia telangiectasia mutated (atm)-related | 0.1198 | 0.0729 | 0.9767 |
Trypanosoma cruzi | Phosphatidylinositol 3-kinase tor1 | 0.1198 | 0.0729 | 0.2104 |
Trypanosoma brucei | FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative | 0.0748 | 0.0441 | 0.6052 |
Trypanosoma cruzi | phosphatidylinositol 3-kinase, putative | 0.0664 | 0.0387 | 0.1117 |
Trypanosoma cruzi | phosphatidylinositol 3-kinase, putative | 0.0238 | 0.0114 | 0.033 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0685 | 0.0401 | 0.4655 |
Echinococcus multilocularis | PIK kinase, FAT and Armadillo domain containing protein | 0.05 | 0.0283 | 0.017 |
Schistosoma mansoni | hypothetical protein | 0.05 | 0.0283 | 0.2672 |
Plasmodium falciparum | phosphatidylinositol 3-kinase | 0.0295 | 0.0151 | 1 |
Toxoplasma gondii | phosphatidylinositol 3- and 4-kinase | 0.0295 | 0.0151 | 0.0606 |
Echinococcus multilocularis | phosphatidylinositol 4 kinase alpha | 0.0295 | 0.0151 | 0.0037 |
Loa Loa (eye worm) | hypothetical protein | 0.0238 | 0.0114 | 0.1568 |
Brugia malayi | Phosphatidylinositol 3- and 4-kinase family protein | 0.1198 | 0.0729 | 0.9803 |
Leishmania major | hypothetical protein, unknown function | 0.0238 | 0.0114 | 0.0316 |
Trichomonas vaginalis | phosphatidylinositol 3-kinase catalytic subunit gamma, putative | 0.0678 | 0.0396 | 0.4584 |
Leishmania major | target of rapamycin (TOR) kinase 1, putative | 0.1198 | 0.0729 | 0.2015 |
Loa Loa (eye worm) | phosphatidylinositol 4-kinase type 3 alpha isoform 1 | 0.0295 | 0.0151 | 0.2072 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.1175 | 0.0714 | 0.9758 |
Onchocerca volvulus | 0.0238 | 0.0114 | 0.5 | |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.1185 | 0.0721 | 0.9866 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.1187 | 0.0723 | 0.9893 |
Trypanosoma brucei | phosphatidylinositol 3-related kinase, putative | 0.1176 | 0.0715 | 0.9812 |
Brugia malayi | phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative | 0.0193 | 0.0086 | 0.1155 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.1187 | 0.0723 | 0.9893 |
Trypanosoma brucei | phosphatidylinositol 4-kinase, putative | 0.1198 | 0.0729 | 1 |
Entamoeba histolytica | Phosphatidylinositol 3- and 4-kinase family | 0.0676 | 0.0395 | 0.4566 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.1187 | 0.0723 | 0.9893 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.1187 | 0.0723 | 0.9893 |
Trichomonas vaginalis | phopsphatidylinositol 3-kinase, drosophila, putative | 0.0678 | 0.0396 | 0.4584 |
Leishmania major | target of rapamycin kinase (TOR) kinase 3 | 0.1188 | 0.0723 | 0.1997 |
Loa Loa (eye worm) | phosphatidylinositol 3 | 0.0238 | 0.0114 | 0.1568 |
Trypanosoma cruzi | phosphatidylinositol kinase related protein, putative | 0.0254 | 0.0125 | 0.036 |
Entamoeba histolytica | phosphatidylinositol 3-kinase, putative | 0.0367 | 0.0197 | 0.1345 |
Entamoeba histolytica | phosphatidylinositol 3-kinase 1, putative | 0.044 | 0.0244 | 0.2109 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.1198 | 0.0729 | 1 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.1198 | 0.0729 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0738 | 0.0435 | 0.5211 |
Echinococcus multilocularis | phosphatidylinositol 3 and 4 kinase | 0.1221 | 0.0744 | 0.0637 |
Trypanosoma cruzi | phosphatidylinositol 3-kinase 2, putative | 0.0678 | 0.0396 | 0.1143 |
Echinococcus granulosus | PIK kinase FAT and Armadillo domain containing protein | 0.05 | 0.0283 | 0.017 |
Brugia malayi | Phosphatidylinositol 3- and 4-kinase family protein | 0.0238 | 0.0114 | 0.1537 |
Loa Loa (eye worm) | phosphatidylinositol 3 | 0.0129 | 0.0045 | 0.0615 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0687 | 0.0402 | 0.4682 |
Plasmodium vivax | phosphatidylinositol 3-kinase, putative | 0.0295 | 0.0151 | 1 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0676 | 0.0395 | 0.4566 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.1185 | 0.0721 | 0.9866 |
Trypanosoma brucei | phosphatidylinositol 3-kinase tor, putative | 0.0258 | 0.0128 | 0.1748 |
Loa Loa (eye worm) | hypothetical protein | 0.0664 | 0.0387 | 0.5312 |
Loa Loa (eye worm) | hypothetical protein | 0.05 | 0.0283 | 0.3875 |
Entamoeba histolytica | phosphatidylinositol3-kinaseTor2, putative | 0.1198 | 0.0729 | 1 |
Brugia malayi | Phosphatidylinositol 3- and 4-kinase family protein | 0.0367 | 0.0197 | 0.2649 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.1185 | 0.0721 | 0.9866 |
Loa Loa (eye worm) | phosphatidylinositol 3 | 0.0238 | 0.0114 | 0.1568 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.1176 | 0.0715 | 0.9777 |
Entamoeba histolytica | hypothetical protein | 0.0606 | 0.035 | 0.3837 |
Echinococcus multilocularis | phosphatidylinositol 4 phosphate 3 kinase C2 | 0.0477 | 0.0267 | 0.0155 |
Trichomonas vaginalis | phosphatidylinositol kinase, putative | 0.0678 | 0.0396 | 0.4584 |
Trichomonas vaginalis | phosphatidylinositol 3-kinase class, putative | 0.0568 | 0.0326 | 0.3439 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.1185 | 0.0721 | 0.9866 |
Trypanosoma cruzi | phosphatidylinositol 4-kinase alpha, putative | 0.0295 | 0.0151 | 0.0436 |
Trypanosoma cruzi | target of rapamycin kinase 3 | 0.1188 | 0.0723 | 0.2085 |
Brugia malayi | Phosphatidylinositol 3- and 4-kinase family protein | 0.0477 | 0.0267 | 0.3595 |
Loa Loa (eye worm) | phosphatidylinositol 3 | 0.1198 | 0.0729 | 1 |
Echinococcus multilocularis | serine protein kinase ATM | 0.068 | 0.0398 | 0.0287 |
Trypanosoma cruzi | phosphatidylinositol 4-kinase, putative | 0.0238 | 0.0114 | 0.033 |
Loa Loa (eye worm) | phosphatidylinositol 3 | 0.0238 | 0.0114 | 0.1568 |
Entamoeba histolytica | phosphatidylinositol 3-kinase, putative | 0.0678 | 0.0396 | 0.4584 |
Schistosoma mansoni | phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K | 0.0367 | 0.0197 | 0.1314 |
Brugia malayi | FAT domain containing protein | 0.05 | 0.0283 | 0.3798 |
Trypanosoma brucei | Phosphatidylinositol 3-kinase tor1 | 0.1198 | 0.0729 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0201 | 0.0091 | 0.1246 |
Toxoplasma gondii | phosphatidylinositol 3- and 4-kinase | 0.0295 | 0.0151 | 0.0606 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0426 | 0.0235 | 0.1966 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.1175 | 0.0714 | 0.9759 |
Brugia malayi | Phosphatidylinositol 3- and 4-kinase family protein | 0.0238 | 0.0114 | 0.1537 |
Echinococcus granulosus | serine:threonine protein kinase SMG1 | 0.0664 | 0.0387 | 0.0276 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.1175 | 0.0714 | 0.9759 |
Echinococcus granulosus | phosphatidylinositol 3 and 4 kinase | 0.1221 | 0.0744 | 0.0637 |
Echinococcus multilocularis | phosphatidylinositol 4,5 bisphosphate 3 kinase | 0.0871 | 0.052 | 0.041 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0248 | 0.0121 | 0.0107 |
Brugia malayi | Phosphatidylinositol 3- and 4-kinase family protein | 0.068 | 0.0398 | 0.5349 |
Leishmania major | target of rapamycin (TOR) kinase 2, putative | 0.1198 | 0.0729 | 0.2015 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0125 | 0.0042 | 0.0577 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.1175 | 0.0714 | 0.9758 |
Trypanosoma brucei | phosphatidylinositol kinase related protein, putative | 0.068 | 0.0398 | 0.5456 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.1175 | 0.0714 | 0.9759 |
Leishmania major | phosphatidylinositol 3-kinase, putative | 0.1164 | 0.0708 | 0.1956 |
Toxoplasma gondii | target of rapamycin (TOR), putative | 0.1185 | 0.0721 | 1 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.1175 | 0.0714 | 0.9758 |
Trichomonas vaginalis | phosphatidylinositol 3-kinase class, putative | 0.0367 | 0.0197 | 0.1345 |
Echinococcus granulosus | serine protein kinase ATM | 0.068 | 0.0398 | 0.0287 |
Giardia lamblia | GTOR | 0.1198 | 0.0729 | 1 |
Entamoeba histolytica | phosphatidylinositol 3-kinase, putative | 0.0367 | 0.0197 | 0.1345 |
Loa Loa (eye worm) | hypothetical protein | 0.0443 | 0.0246 | 0.3369 |
Trypanosoma brucei | phosphatidylinositol 3-kinase, putative | 0.0367 | 0.0197 | 0.2702 |
Onchocerca volvulus | 0.0238 | 0.0114 | 0.5 | |
Toxoplasma gondii | non-specific serine/threonine protein kinase | 0.0738 | 0.0435 | 0.5282 |
Echinococcus multilocularis | DNA dependent protein kinase catalytic subunit | 1.5674 | 1 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.5472 | 0.3467 | 1 |
Trichomonas vaginalis | phosphatidylinositol 4-kinase, putative | 0.0295 | 0.0151 | 0.0598 |
Trichomonas vaginalis | phosphatidylinositol kinase, putative | 0.0367 | 0.0197 | 0.1345 |
Trypanosoma brucei | phosphatidylinositol 3-kinase, putative | 0.1164 | 0.0708 | 0.9706 |
Trypanosoma cruzi | phosphatidylinositol 3-related kinase, putative | 0.1221 | 0.0744 | 0.2146 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0685 | 0.0401 | 0.4655 |
Trichomonas vaginalis | phosphatidylinositol 3-kinase class, putative | 0.0295 | 0.0151 | 0.0598 |
Mycobacterium leprae | conserved hypothetical protein | 0.0238 | 0.0114 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0738 | 0.0435 | 0.5962 |
Entamoeba histolytica | phosphatidylinositol 3-kinase, putative | 0.0606 | 0.035 | 0.3837 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.1185 | 0.0721 | 0.9866 |
Brugia malayi | Phosphatidylinositol 3- and 4-kinase family protein | 0.0664 | 0.0387 | 0.5208 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.1164 | 0.0708 | 0.9651 |
Loa Loa (eye worm) | hypothetical protein | 0.0477 | 0.0267 | 0.3668 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0761 | 0.045 | 0.5452 |
Leishmania major | phosphatidylinositol 3-kinase, putative | 0.0295 | 0.0151 | 0.0418 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.1185 | 0.0721 | 0.9866 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.1164 | 0.0708 | 0.9651 |
Toxoplasma gondii | FATC domain-containing protein | 0.068 | 0.0398 | 0.4674 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.1198 | 0.0729 | 1 |
Trypanosoma cruzi | phosphatidylinositol 3-kinase vps34-like | 0.0367 | 0.0197 | 0.0568 |
Trypanosoma cruzi | phosphatidylinositol 3-kinase 2, putative | 0.0678 | 0.0396 | 0.1143 |
Entamoeba histolytica | phosphatidylinositol-4,5-bisphosphate 3-kinase, putative | 0.0295 | 0.0151 | 0.0598 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.1177 | 0.0716 | 0.9786 |
Trypanosoma brucei | phosphatidylinositol 3-kinase catalytic subunit, putative | 0.0238 | 0.0114 | 0.1568 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0685 | 0.0401 | 0.4655 |
Trypanosoma cruzi | phosphatidylinositol 4-kinase, putative | 0.0238 | 0.0114 | 0.033 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.068 | 0.0398 | 0.4612 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.1185 | 0.0721 | 0.9866 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0664 | 0.0387 | 0.4441 |
Trypanosoma brucei | target of rapamycin kinase 3, putative | 0.1188 | 0.0723 | 0.991 |
Trypanosoma cruzi | phosphatidylinositol 4-kinase alpha, putative | 0.0295 | 0.0151 | 0.0436 |
Schistosoma mansoni | phosphatidylinositol 3-and 4-kinase | 0.1221 | 0.0744 | 1 |
Trichomonas vaginalis | phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative | 0.0367 | 0.0197 | 0.1345 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0238 | 0.0114 | 0.5 |
Loa Loa (eye worm) | phosphatidylinositol 3 | 0.1176 | 0.0715 | 0.9812 |
Leishmania major | phosphatidylinositol 4-kinase alpha, putative | 0.0295 | 0.0151 | 0.0418 |
Leishmania major | phosphatidylinositol kinase related protein, putative | 0.0254 | 0.0125 | 0.0345 |
Entamoeba histolytica | FKBP-rapamycin associated protein (FRAP), putative | 0.1198 | 0.0729 | 1 |
Giardia lamblia | Phosphoinositide-3-kinase, catalytic, alpha polypeptide | 0.0496 | 0.028 | 0.2692 |
Trypanosoma brucei | phosphatidylinositol 4-kinase, putative | 0.0238 | 0.0114 | 0.1568 |
Trypanosoma cruzi | phosphatidylinositol kinase related protein, putative | 0.0443 | 0.0246 | 0.0709 |
Echinococcus granulosus | phosphatidylinositol 4 kinase alpha | 0.0295 | 0.0151 | 0.0037 |
Trypanosoma cruzi | phosphatidylinositol 3-related kinase, putative | 0.1221 | 0.0744 | 0.2146 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.1164 | 0.0708 | 0.9651 |
Trichomonas vaginalis | phosphatidylinositol kinase, putative | 0.0295 | 0.0151 | 0.0598 |
Echinococcus granulosus | FKBP12 rapamycin complex associated protein | 0.1198 | 0.0729 | 0.0622 |
Schistosoma mansoni | phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K | 0.0295 | 0.0151 | 0.0584 |
Brugia malayi | phosphatidylinositol 4-kinase, catalytic, alpha polypeptide | 0.0295 | 0.0151 | 0.2031 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.