Detailed information for compound 1470023

Basic information

Technical information
  • TDR Targets ID: 1470023
  • Name: 1-[(2-ethoxyphenyl)methyl]-4-methylsulfonylpi perazine
  • MW: 298.401 | Formula: C14H22N2O3S
  • H donors: 0 H acceptors: 2 LogP: 1.16 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOc1ccccc1CN1CCN(CC1)S(=O)(=O)C
  • InChi: 1S/C14H22N2O3S/c1-3-19-14-7-5-4-6-13(14)12-15-8-10-16(11-9-15)20(2,17)18/h4-7H,3,8-12H2,1-2H3
  • InChiKey: IBJUQCVBKFVOAU-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1-[(2-ethoxyphenyl)methyl]-4-methylsulfonyl-piperazine
  • 1-(2-ethoxybenzyl)-4-mesyl-piperazine
  • STK147247
  • Oprea1_057728
  • Oprea1_204167
  • BAS 03152696

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis CMGC family protein kinase 0.0617 1 1
Echinococcus granulosus voltage gated potassium channel 0.0032 0.0171 0.0171
Entamoeba histolytica cell division protein kinase 2, putative 0.0052 0.0502 0.0499
Echinococcus multilocularis casein kinase ii subunit beta 0.0076 0.0906 0.0906
Echinococcus granulosus homeodomain interacting protein kinase 3 0.0185 0.2744 0.2744
Echinococcus granulosus proto oncogene serine:threonine protein kinase 0.0175 0.2569 0.2569
Trichomonas vaginalis casein kinase II beta chain, putative 0.0076 0.0906 0.0906
Echinococcus granulosus cyclin dependent kinase 1 0.0052 0.0502 0.0502
Trichomonas vaginalis CMGC family protein kinase 0.0057 0.059 0.059
Loa Loa (eye worm) casein kinase II 0.0022 0.0004 0.0004
Trypanosoma brucei dual specificity tyrosine-phosphorylation-regulated kinase 2, putative 0.0062 0.0681 0.0188
Plasmodium vivax unspecified product 0.0617 1 1
Onchocerca volvulus Casein kinase II subunit beta homolog 0.0076 0.0906 0.1597
Trichomonas vaginalis casein kinase II beta chain, putative 0.0022 0.0004 0.0004
Trichomonas vaginalis casein kinase II beta chain, putative 0.0022 0.0004 0.0004
Entamoeba histolytica protein kinase domain containing protein 0.0062 0.0681 0.0677
Echinococcus granulosus cyclin dependent kinase 0.0052 0.0502 0.0502
Schistosoma mansoni protein kinase 0.0617 1 1
Toxoplasma gondii CMGC kinase, CK2 family 0.0617 1 1
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.0076 0.0906 0.0902
Trichomonas vaginalis protein kinase ck2-beta, putative 0.0022 0.0004 0.0004
Brugia malayi Csnk2b protein 0.0076 0.0906 0.0906
Giardia lamblia Casein kinase II beta chain 0.0076 0.0906 0.0902
Plasmodium falciparum casein kinase II beta chain 0.0076 0.0906 0.0425
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0103 0.1371 0.1371
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0052 0.0502 0.0502
Entamoeba histolytica protein kinase domain containing protein 0.0617 1 1
Trypanosoma brucei protein kinase, putative 0.0057 0.059 0.0092
Trichomonas vaginalis casein kinase II beta chain, putative 0.0076 0.0906 0.0906
Trypanosoma brucei Casein kinase II subunit beta, putative 0.0076 0.0906 0.0425
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative 0.0057 0.059 0.0092
Giardia lamblia Kinase, CMGC CDK 0.0052 0.0502 0.0499
Entamoeba histolytica protein kinase domain containing protein 0.0057 0.059 0.0586
Leishmania major protein kinase ck2 regulatory subunit, putative 0.0076 0.0906 0.0425
Trichomonas vaginalis CMGC family protein kinase 0.0617 1 1
Trichomonas vaginalis casein kinase II beta chain, putative 0.0076 0.0906 0.0906
Echinococcus granulosus dual specificity 0.0062 0.0681 0.0681
Onchocerca volvulus Serine\/threonine protein kinase homolog 0.0175 0.2569 1
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0032 0.0171 0.0171
Schistosoma mansoni serine/threonine protein kinase 0.0062 0.0681 0.0681
Echinococcus multilocularis casein kinase ii subunit alpha 0.0617 1 1
Trichomonas vaginalis CMGC family protein kinase 0.0062 0.0681 0.0681
Trichomonas vaginalis CMGC family protein kinase 0.0617 1 1
Trichomonas vaginalis casein kinase II beta chain, putative 0.0022 0.0004 0.0004
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0057 0.059 0.059
Trichomonas vaginalis casein kinase II beta chain, putative 0.0022 0.0004 0.0004
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.0076 0.0906 0.0902
Trichomonas vaginalis protein kinase ck2-beta, putative 0.0022 0.0004 0.0004
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0032 0.0171 0.0171
Echinococcus multilocularis cyclin dependent kinase 5 0.0052 0.0502 0.0502
Plasmodium vivax casein kinase II beta chain, putative 0.0076 0.0906 0.0425
Giardia lamblia Kinase, CMGC GSK 0.0057 0.059 0.0586
Toxoplasma gondii casein kinase ii regulatory subunit protein 0.0076 0.0906 0.0425
Giardia lamblia Kinase, CMGC CK2 0.0617 1 1
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.0502 0.0502
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.0502 0.0502
Entamoeba histolytica protein kinase, putative 0.0057 0.059 0.0586
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) 0.0057 0.059 0.059
Trypanosoma cruzi Casein kinase II subunit beta, putative 0.0076 0.0906 0.0425
Echinococcus multilocularis voltage gated potassium channel 0.0032 0.0171 0.0171
Brugia malayi cell division control protein 2 homolog 0.0052 0.0502 0.0502
Trichomonas vaginalis casein kinase II beta chain, putative 0.0076 0.0906 0.0906
Loa Loa (eye worm) hypothetical protein 0.0032 0.0171 0.0171
Entamoeba histolytica protein kinase domain containing protein 0.0185 0.2744 0.2741
Trypanosoma cruzi casein kinase II, putative 0.0617 1 1
Brugia malayi casein kinase II, putaitve 0.0022 0.0004 0.0004
Trichomonas vaginalis casein kinase II beta chain, putative 0.0076 0.0906 0.0906
Brugia malayi intracellular kinase 0.0057 0.059 0.059
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0103 0.1371 0.1371
Echinococcus multilocularis cyclin dependent kinase 1 0.0052 0.0502 0.0502
Brugia malayi Homeodomain interacting protein kinase protein 1 0.0185 0.2744 0.2744
Echinococcus multilocularis glycogen synthase kinase 3 beta 0.0057 0.059 0.059
Trypanosoma cruzi dual specificity tyrosine-phosphorylation-regulated kinase 2, putative 0.0062 0.0681 0.0188
Trichomonas vaginalis CMGC family protein kinase 0.0617 1 1
Trichomonas vaginalis casein kinase II beta chain, putative 0.0076 0.0906 0.0906
Entamoeba histolytica protein kinase domain containing protein 0.0057 0.059 0.0586
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.0076 0.0906 0.0902
Trichomonas vaginalis casein kinase II beta chain, putative 0.0022 0.0004 0.0004
Trichomonas vaginalis casein kinase II beta chain, putative 0.0076 0.0906 0.0906
Echinococcus multilocularis dual specificity 0.0062 0.0681 0.0681
Echinococcus granulosus dual specificity 0.0062 0.0681 0.0681
Trichomonas vaginalis CMGC family protein kinase 0.0062 0.0681 0.0681
Schistosoma mansoni voltage-gated potassium channel 0.0032 0.0171 0.0171
Trichomonas vaginalis CMGC family protein kinase 0.0617 1 1
Giardia lamblia Kinase, CMGC CDK 0.0052 0.0502 0.0499
Schistosoma mansoni voltage-gated potassium channel 0.0121 0.1665 0.1665
Brugia malayi Serine/threonine-protein kinase Pim-3 0.0175 0.2569 0.2569
Trichomonas vaginalis CMGC family protein kinase 0.0617 1 1
Echinococcus multilocularis homeodomain interacting protein kinase 3 0.0185 0.2744 0.2744
Plasmodium falciparum casein kinase II beta chain 0.0076 0.0906 0.0425
Schistosoma mansoni serine/threonine protein kinase 0.0052 0.0502 0.0502
Leishmania major protein kinase, putative,dual-specificity protein kinase, putative 0.0062 0.0681 0.0188
Entamoeba histolytica casein kinase, putative 0.0617 1 1
Echinococcus granulosus glycogen synthase kinase 3 beta 0.0057 0.059 0.059
Loa Loa (eye worm) CMGC/CK2 protein kinase 0.0617 1 1
Trichomonas vaginalis casein kinase II beta chain, putative 0.0022 0.0004 0.0004
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0032 0.0171 0.0171
Trypanosoma brucei Casein kinase II 0.0617 1 1
Echinococcus granulosus protein kinase shaggy 0.0057 0.059 0.059
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 0.0057 0.059 0.0092
Schistosoma mansoni serine/threonine protein kinase 0.0052 0.0502 0.0502
Trichomonas vaginalis casein kinase II beta chain, putative 0.0076 0.0906 0.0906
Echinococcus granulosus dual specificity 0.0062 0.0681 0.0681
Loa Loa (eye worm) CMGC/DYRK/HIPK protein kinase 0.0185 0.2744 0.2744
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0111 0.1494 0.1494
Brugia malayi Protein kinase domain containing protein 0.0052 0.0502 0.0502
Plasmodium vivax casein kinase 2, alpha subunit, putative 0.0617 1 1
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0052 0.0502 0.0502
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.0502 0.0502
Trichomonas vaginalis CMGC family protein kinase 0.0617 1 1
Leishmania major casein kinase II, putative 0.0617 1 1
Trichomonas vaginalis CMGC family protein kinase 0.0057 0.059 0.059
Schistosoma mansoni voltage-gated potassium channel 0.0032 0.0171 0.0171
Entamoeba histolytica cell division protein kinase 2, putative 0.0052 0.0502 0.0499
Trichomonas vaginalis CMGC family protein kinase 0.0062 0.0681 0.0681
Loa Loa (eye worm) hypothetical protein 0.0045 0.0391 0.0391
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0052 0.0502 0.0502
Trichomonas vaginalis casein kinase II beta chain, putative 0.0076 0.0906 0.0906
Onchocerca volvulus Casein kinase II subunit beta homolog 0.0076 0.0906 0.1597
Toxoplasma gondii cell-cycle-associated protein kinase DYRK2, putative 0.0062 0.0681 0.0188
Trichomonas vaginalis casein kinase II beta chain, putative 0.0022 0.0004 0.0004
Schistosoma mansoni voltage-gated potassium channel 0.0121 0.1665 0.1665
Trichomonas vaginalis casein kinase II beta chain, putative 0.0022 0.0004 0.0004
Trichomonas vaginalis casein kinase II beta chain, putative 0.0022 0.0004 0.0004
Schistosoma mansoni serine/threonine protein kinase 0.0175 0.2569 0.2569
Trichomonas vaginalis CMGC family protein kinase 0.0062 0.0681 0.0681
Plasmodium falciparum glycogen synthase kinase 3 0.0057 0.059 0.0092
Trichomonas vaginalis casein kinase II beta chain, putative 0.0076 0.0906 0.0906
Echinococcus multilocularis dual specificity 0.0062 0.0681 0.0681
Echinococcus multilocularis protein kinase shaggy 0.0057 0.059 0.059
Trypanosoma cruzi glycogen synthase kinase 3, putative 0.0057 0.059 0.0092
Echinococcus granulosus casein kinase ii subunit beta 0.0076 0.0906 0.0906
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0175 0.2569 0.2569
Trichomonas vaginalis CMGC family protein kinase 0.0062 0.0681 0.0681
Trypanosoma cruzi Casein kinase II subunit beta, putative 0.0076 0.0906 0.0425
Echinococcus multilocularis cyclin dependent kinase 1 0.0052 0.0502 0.0502
Schistosoma mansoni serine/threonine protein kinase 0.0185 0.2744 0.2744
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0175 0.2569 0.2569
Trichomonas vaginalis CMGC family protein kinase 0.0062 0.0681 0.0681
Trichomonas vaginalis casein kinase II beta chain, putative 0.0076 0.0906 0.0906
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0111 0.1494 0.1494
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0111 0.1494 0.1494
Plasmodium vivax casein kinase II beta chain, putative 0.0076 0.0906 0.0425
Loa Loa (eye worm) hypothetical protein 0.0096 0.1248 0.1248
Entamoeba histolytica protein kinase, putative 0.0062 0.0681 0.0677
Giardia lamblia Kinase, CMGC DYRK 0.0062 0.0681 0.0677
Trichomonas vaginalis casein kinase II beta chain, putative 0.0022 0.0004 0.0004
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0052 0.0502 0.0502
Echinococcus multilocularis dual specificity 0.0062 0.0681 0.0681
Toxoplasma gondii ck2 beta subunit 0.0076 0.0906 0.0425
Loa Loa (eye worm) Csnk2b protein 0.0076 0.0906 0.0906
Trichomonas vaginalis casein kinase II beta chain, putative 0.0022 0.0004 0.0004
Trichomonas vaginalis casein kinase II beta chain, putative 0.0022 0.0004 0.0004
Brugia malayi Dual-specificity tyrosine-phosphorylation regulated kinase 2 0.0062 0.0681 0.0681
Trichomonas vaginalis casein kinase II beta chain, putative 0.0022 0.0004 0.0004
Trichomonas vaginalis casein kinase II beta chain, putative 0.0076 0.0906 0.0906
Plasmodium falciparum casein kinase 2, alpha subunit 0.0617 1 1
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0057 0.059 0.059
Echinococcus granulosus cyclin dependent kinase 5 0.0052 0.0502 0.0502
Echinococcus multilocularis cyclin dependent kinase 0.0052 0.0502 0.0502
Trichomonas vaginalis casein kinase II beta chain, putative 0.0076 0.0906 0.0906
Giardia lamblia Kinase, CMGC GSK 0.0057 0.059 0.0586
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0111 0.1494 0.1494
Schistosoma mansoni casein kinase II beta subunit 0.0076 0.0906 0.0906
Echinococcus multilocularis proto oncogene serine:threonine protein kinase 0.0175 0.2569 0.2569
Trichomonas vaginalis casein kinase II beta chain, putative 0.0076 0.0906 0.0906
Plasmodium vivax glycogen synthase kinase 3, putative 0.0057 0.059 0.0092
Brugia malayi Protein kinase domain containing protein 0.0175 0.2569 0.2569
Echinococcus granulosus casein kinase ii subunit alpha 0.0617 1 1
Loa Loa (eye worm) CMGC/DYRK/DYRK2 protein kinase 0.0062 0.0681 0.0681
Trichomonas vaginalis casein kinase II beta chain, putative 0.0076 0.0906 0.0906

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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