Detailed information for compound 1471642

Basic information

Technical information
  • TDR Targets ID: 1471642
  • Name: 1-[(2,4-dimethoxyphenyl)methyl]-4-phenylsulfo nylpiperazine
  • MW: 376.47 | Formula: C19H24N2O4S
  • H donors: 0 H acceptors: 2 LogP: 2.32 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cc(OC)ccc1CN1CCN(CC1)S(=O)(=O)c1ccccc1
  • InChi: 1S/C19H24N2O4S/c1-24-17-9-8-16(19(14-17)25-2)15-20-10-12-21(13-11-20)26(22,23)18-6-4-3-5-7-18/h3-9,14H,10-13,15H2,1-2H3
  • InChiKey: CAXSNKMSODPZEI-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1-[(2,4-dimethoxyphenyl)methyl]-4-phenylsulfonyl-piperazine
  • 1-(2,4-dimethoxybenzyl)-4-phenylsulfonyl-piperazine
  • NCGC00026526-02
  • STK146554
  • BAS 01375872
  • Oprea1_067713
  • Oprea1_788027

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens lysine (K)-specific demethylase 4A Starlite/ChEMBL No references
Homo sapiens ubiquitin specific peptidase 1 Starlite/ChEMBL No references
Homo sapiens euchromatic histone-lysine N-methyltransferase 2 Starlite/ChEMBL No references
Homo sapiens chromobox homolog 1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus granulosus chromobox protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Trichomonas vaginalis chromobox protein, putative Get druggable targets OG5_129545 All targets in OG5_129545
Onchocerca volvulus Get druggable targets OG5_129545 All targets in OG5_129545
Schistosoma mansoni chromobox protein Get druggable targets OG5_129545 All targets in OG5_129545
Brugia malayi Pre-SET motif family protein Get druggable targets OG5_131470 All targets in OG5_131470
Onchocerca volvulus Get druggable targets OG5_131470 All targets in OG5_131470
Plasmodium yoelii hypothetical protein Get druggable targets OG5_127917 All targets in OG5_127917
Brugia malayi Heterochromatin protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Schistosoma japonicum expressed protein Get druggable targets OG5_127917 All targets in OG5_127917
Schistosoma mansoni chromobox protein Get druggable targets OG5_129545 All targets in OG5_129545
Schistosoma japonicum expressed protein Get druggable targets OG5_127917 All targets in OG5_127917
Echinococcus multilocularis chromobox protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Candida albicans one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp Get druggable targets OG5_127917 All targets in OG5_127917
Trichomonas vaginalis chromobox protein, putative Get druggable targets OG5_129545 All targets in OG5_129545
Trichomonas vaginalis chromobox protein, putative Get druggable targets OG5_129545 All targets in OG5_129545
Schistosoma mansoni jumonji domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Onchocerca volvulus Heterochromatin protein 1 homolog Get druggable targets OG5_129545 All targets in OG5_129545
Echinococcus multilocularis chromobox protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Trichomonas vaginalis chromobox protein, putative Get druggable targets OG5_129545 All targets in OG5_129545
Theileria parva hypothetical protein Get druggable targets OG5_129545 All targets in OG5_129545
Loa Loa (eye worm) pre-SET domain-containing protein family protein Get druggable targets OG5_131470 All targets in OG5_131470
Candida albicans one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp Get druggable targets OG5_127917 All targets in OG5_127917
Echinococcus granulosus jumonji domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Trichomonas vaginalis set domain proteins, putative Get druggable targets OG5_131470 All targets in OG5_131470
Loa Loa (eye worm) jmjC domain-containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Loa Loa (eye worm) heterochromatin protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Candida albicans one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp Get druggable targets OG5_127917 All targets in OG5_127917
Brugia malayi jmjC domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Echinococcus granulosus chromobox protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Echinococcus multilocularis jumonji domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127917 All targets in OG5_127917
Schistosoma japonicum JmjC domain-containing histone demethylation protein 3C, putative Get druggable targets OG5_127917 All targets in OG5_127917
Echinococcus multilocularis Transcription factor, JmjC domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Candida albicans one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp Get druggable targets OG5_127917 All targets in OG5_127917
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_129545 All targets in OG5_129545
Schistosoma japonicum Chromobox protein homolog 5, putative Get druggable targets OG5_129545 All targets in OG5_129545
Echinococcus granulosus Transcription factor JmjC domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Schistosoma japonicum Probable JmjC domain-containing histone demethylation protein 3B, putative Get druggable targets OG5_127917 All targets in OG5_127917
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Nuclear hormone receptor-like 1 0.019 0.5376 0.5275
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.009 0.1863 0.2896
Schistosoma mansoni jumonji domain containing protein 0.0092 0.1925 0.2992
Brugia malayi Nuclear hormone receptor family member nhr-40 0.019 0.5376 0.5275
Echinococcus multilocularis nuclear receptor nhr 48 0.009 0.1863 0.3466
Schistosoma mansoni nuclear hormone receptor 0.019 0.5376 0.8357
Brugia malayi chromobox protein homolog 3 0.0047 0.0373 0.0162
Loa Loa (eye worm) jmjC domain-containing protein 0.0043 0.0214 0.0197
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0051 0.0498 0.0553
Brugia malayi Nuclear hormone receptor-like 1 0.0101 0.2239 0.2069
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0102 0.2293 0.2125
Loa Loa (eye worm) hypothetical protein 0.0101 0.2239 0.2226
Loa Loa (eye worm) acetylcholinesterase 1 0.008 0.1521 0.1506
Brugia malayi hypothetical protein 0.0101 0.2239 0.2069
Loa Loa (eye worm) hypothetical protein 0.009 0.1863 0.1849
Echinococcus multilocularis FTZ F1 alpha 0.019 0.5376 1
Loa Loa (eye worm) hypothetical protein 0.0102 0.2293 0.228
Brugia malayi hypothetical protein 0.0081 0.1566 0.1381
Brugia malayi Nuclear hormone receptor family member nhr-41 0.019 0.5376 0.5275
Echinococcus granulosus ecdysone induced protein 78C 0.019 0.5376 1
Schistosoma mansoni nuclear receptor nhr-48 0.009 0.1863 0.2896
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.008 0.1521 0.2364
Loa Loa (eye worm) hypothetical protein 0.0101 0.2239 0.2226
Loa Loa (eye worm) hypothetical protein 0.009 0.1863 0.1849
Echinococcus granulosus acetylcholinesterase 0.008 0.1521 0.2829
Schistosoma mansoni Tr4/Tr2 (homologue) 0.019 0.5376 0.8357
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.009 0.1863 0.3466
Brugia malayi nuclear hormone receptor family member nhr-6 0.009 0.1863 0.1685
Brugia malayi nuclear receptor RXR 0.009 0.1863 0.1685
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.019 0.5376 1
Loa Loa (eye worm) hypothetical protein 0.009 0.1863 0.1849
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0323 1 1
Schistosoma mansoni chromobox protein 0.0084 0.1664 0.2586
Loa Loa (eye worm) hypothetical protein 0.008 0.1521 0.1506
Echinococcus multilocularis jumonji domain containing protein 0.0049 0.0437 0.0813
Brugia malayi Nuclear hormone receptor family member nhr-19 0.019 0.5376 0.5275
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.019 0.5376 1
Loa Loa (eye worm) hypothetical protein 0.0101 0.2239 0.2226
Schistosoma mansoni RAR-like nuclear receptor 0.019 0.5376 0.8357
Echinococcus multilocularis chromobox protein 1 0.0084 0.1664 0.3095
Trichomonas vaginalis chromobox protein, putative 0.0051 0.0498 0.015
Loa Loa (eye worm) heterochromatin protein 1 0.0084 0.1664 0.1649
Schistosoma mansoni hypothetical protein 0.0102 0.2293 0.3565
Toxoplasma gondii LsmAD domain-containing protein 0.0081 0.1566 0.5
Brugia malayi Nuclear hormone receptor family member nhr-25 0.019 0.5376 0.5275
Onchocerca volvulus Protein ultraspiracle homolog 0.019 0.5376 0.6162
Onchocerca volvulus 0.019 0.5376 0.6162
Leishmania major hypothetical protein, conserved 0.0081 0.1566 0.5
Brugia malayi nuclear receptor NHR-88 0.019 0.5376 0.5275
Brugia malayi Calcitonin receptor-like protein seb-1 0.0323 1 1
Loa Loa (eye worm) nuclear receptor NHR-67 0.009 0.1863 0.1849
Loa Loa (eye worm) hypothetical protein 0.009 0.1863 0.1849
Echinococcus granulosus carboxylesterase 5A 0.008 0.1521 0.2829
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.019 0.5376 1
Loa Loa (eye worm) hypothetical protein 0.009 0.1863 0.1849
Brugia malayi hypothetical protein 0.009 0.1863 0.1685
Brugia malayi Latrophilin receptor protein 2 0.0102 0.2293 0.2125
Loa Loa (eye worm) hypothetical protein 0.008 0.1521 0.1506
Echinococcus granulosus nuclear receptor 2DBD gamma 0.009 0.1863 0.3466
Brugia malayi steroid hormone receptor 0.019 0.5376 0.5275
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.019 0.5376 0.8357
Brugia malayi Nuclear hormone receptor-like 1 0.0101 0.2239 0.2069
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.019 0.5376 1
Schistosoma mansoni retinoid-x-receptor (RXR) 0.019 0.5376 0.8357
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.019 0.5376 0.5368
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.009 0.1863 0.1685
Loa Loa (eye worm) hypothetical protein 0.009 0.1863 0.1849
Brugia malayi ecdysone receptor 0.009 0.1863 0.1685
Brugia malayi Nuclear hormone receptor family member nhr-1 0.019 0.5376 0.5275
Brugia malayi Nuclear hormone receptor E75 0.009 0.1863 0.1685
Loa Loa (eye worm) hypothetical protein 0.019 0.5376 0.5368
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0102 0.2293 0.4266
Echinococcus multilocularis carboxylesterase 5A 0.008 0.1521 0.2829
Loa Loa (eye worm) hypothetical protein 0.009 0.1863 0.1849
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.019 0.5376 0.5275
Brugia malayi nuclear receptor NHR-88 0.009 0.1863 0.1685
Plasmodium falciparum ataxin-2 like protein, putative 0.0081 0.1566 0.5
Echinococcus granulosus nuclear receptor 2DBD gamma 0.019 0.5376 1
Brugia malayi Carboxylesterase family protein 0.008 0.1521 0.1335
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0047 0.0373 0.0409
Schistosoma mansoni thyroid hormone receptor 0.019 0.5376 0.8357
Echinococcus multilocularis lysine specific demethylase 5A 0.0043 0.0214 0.0399
Trypanosoma cruzi PAB1-binding protein , putative 0.0081 0.1566 0.5
Loa Loa (eye worm) hypothetical protein 0.019 0.5376 0.5368
Trichomonas vaginalis set domain proteins, putative 0.0286 0.8713 1
Schistosoma mansoni coup transcription factor 0.019 0.5376 0.8357
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.019 0.5376 0.6162
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.019 0.5376 1
Schistosoma mansoni thyroid hormone receptor 0.019 0.5376 0.8357
Schistosoma mansoni hypothetical protein 0.0102 0.2293 0.3565
Brugia malayi photoreceptor-specific nuclear receptor 0.019 0.5376 0.5275
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0102 0.2293 0.4266
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.019 0.5376 0.8357
Brugia malayi hypothetical protein 0.0053 0.056 0.0353
Echinococcus granulosus chromobox protein 1 0.0084 0.1664 0.3095
Brugia malayi Carboxylesterase family protein 0.008 0.1521 0.1335
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.019 0.5376 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.019 0.5376 0.5275
Schistosoma mansoni hypothetical protein 0.0102 0.2293 0.3565
Onchocerca volvulus 0.009 0.1863 0.2123
Echinococcus granulosus acetylcholinesterase 0.008 0.1521 0.2829
Loa Loa (eye worm) hypothetical protein 0.0221 0.6433 0.6427
Loa Loa (eye worm) hypothetical protein 0.006 0.0834 0.0818
Brugia malayi Nuclear hormone receptor family member nhr-31 0.019 0.5376 0.5275
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.019 0.5376 0.5275
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.019 0.5376 1
Loa Loa (eye worm) nuclear receptor nhr-7B 0.009 0.1863 0.1849
Trypanosoma cruzi PAB1-binding protein , putative 0.0081 0.1566 0.5
Loa Loa (eye worm) hypothetical protein 0.019 0.5376 0.5368
Brugia malayi Pre-SET motif family protein 0.0251 0.7501 0.7446
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0102 0.2293 0.4266
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.009 0.1863 0.2896
Onchocerca volvulus 0.005 0.0466 0.0516
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0251 0.7501 0.7497
Echinococcus multilocularis acetylcholinesterase 0.008 0.1521 0.2829
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.009 0.1863 0.3466
Brugia malayi tailless protein 0.009 0.1863 0.1685
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.019 0.5376 0.8357
Brugia malayi Steroid receptor seven-up type 2 0.019 0.5376 0.5275
Echinococcus granulosus nuclear receptor 2DBD gamma 0.019 0.5376 1
Echinococcus multilocularis Nuclear hormone receptor HR96 0.009 0.1863 0.3466
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.019 0.5376 1
Schistosoma mansoni hypothetical protein 0.0221 0.6433 1
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.019 0.5376 0.8357
Loa Loa (eye worm) hypothetical protein 0.009 0.1863 0.1849
Echinococcus granulosus nuclear receptor nhr 48 0.009 0.1863 0.3466
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.009 0.1863 0.2123
Loa Loa (eye worm) hypothetical protein 0.019 0.5376 0.5368
Brugia malayi nuclear hormone receptor 0.009 0.1863 0.1685
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.019 0.5376 0.5368
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.019 0.5376 0.5368
Echinococcus multilocularis Nuclear hormone receptor HR96 0.009 0.1863 0.3466
Brugia malayi conserved hypotetical protein 0.009 0.1863 0.1685
Echinococcus multilocularis ecdysone induced protein 78C 0.019 0.5376 1
Echinococcus multilocularis GPCR, family 2 0.0102 0.2293 0.4266
Loa Loa (eye worm) hypothetical protein 0.009 0.1863 0.1849
Brugia malayi jmjC domain containing protein 0.0115 0.2752 0.2594
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.019 0.5376 1
Loa Loa (eye worm) hypothetical protein 0.0323 1 1
Echinococcus multilocularis chromobox protein 1 0.0084 0.1664 0.3095
Loa Loa (eye worm) hypothetical protein 0.009 0.1863 0.1849
Brugia malayi Nuclear hormone receptor family member nhr-19 0.019 0.5376 0.5275
Brugia malayi Nuclear hormone receptor E75 0.009 0.1863 0.1685
Schistosoma mansoni jumonji/arid domain-containing protein 0.0043 0.0214 0.0333
Loa Loa (eye worm) hypothetical protein 0.009 0.1863 0.1849
Loa Loa (eye worm) latrophilin receptor protein 2 0.0102 0.2293 0.228
Schistosoma mansoni hypothetical protein 0.0102 0.2293 0.3565
Brugia malayi Nuclear hormone receptor family member nhr-3 0.019 0.5376 0.5275
Onchocerca volvulus 0.009 0.1863 0.2123
Loa Loa (eye worm) hypothetical protein 0.019 0.5376 0.5368
Brugia malayi nuclear hormone receptor family member odr-7 0.009 0.1863 0.1685
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0101 0.2239 0.3481
Onchocerca volvulus Bile acid receptor homolog 0.019 0.5376 0.6162
Echinococcus multilocularis thyroid hormone receptor alpha 0.019 0.5376 1
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0101 0.2239 0.3481
Loa Loa (eye worm) hypothetical protein 0.0081 0.1566 0.1551
Brugia malayi nuclear hormone receptor 0.019 0.5376 0.5275
Loa Loa (eye worm) hypothetical protein 0.009 0.1863 0.1849
Loa Loa (eye worm) DR-78 0.009 0.1863 0.1849
Onchocerca volvulus 0.0286 0.8713 1
Echinococcus granulosus lysine specific demethylase 5A 0.0043 0.0214 0.0399
Echinococcus granulosus chromobox protein 1 0.0084 0.1664 0.3095
Trichomonas vaginalis chromobox protein, putative 0.0084 0.1664 0.1548
Echinococcus multilocularis acetylcholinesterase 0.008 0.1521 0.2829
Schistosoma mansoni zinc finger protein 0.009 0.1863 0.2896
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0102 0.2293 0.4266
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.019 0.5376 0.5368
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.009 0.1863 0.3466
Brugia malayi ecdysteroid receptor 0.019 0.5376 0.5275
Echinococcus granulosus GPCR family 2 0.0102 0.2293 0.4266
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.019 0.5376 0.5368
Brugia malayi Nuclear hormone receptor family member nhr-14 0.019 0.5376 0.5275
Loa Loa (eye worm) jmjC domain-containing protein 0.0073 0.1264 0.1249
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.019 0.5376 0.5368
Brugia malayi nuclear receptor NHR-67 0.009 0.1863 0.1685
Brugia malayi nuclear receptor RXR 0.0101 0.2239 0.2069
Loa Loa (eye worm) hypothetical protein 0.019 0.5376 0.5368
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0115 0.2752 0.512
Brugia malayi Heterochromatin protein 1 0.0084 0.1664 0.1481
Plasmodium vivax ataxin-2 like protein, putative 0.0081 0.1566 0.5
Loa Loa (eye worm) carboxylesterase 0.008 0.1521 0.1506
Brugia malayi hypothetical protein 0.009 0.1863 0.1685
Loa Loa (eye worm) nuclear hormone receptor 0.009 0.1863 0.1849
Trichomonas vaginalis chromobox protein, putative 0.0084 0.1664 0.1548
Echinococcus granulosus Nuclear hormone receptor HR96 0.009 0.1863 0.3466
Brugia malayi hypothetical protein 0.0101 0.2239 0.2069
Brugia malayi orphan nuclear receptor NR2E1 0.009 0.1863 0.1685
Loa Loa (eye worm) hypothetical protein 0.0047 0.0373 0.0356
Plasmodium falciparum ataxin-2 like protein, putative 0.0081 0.1566 0.5
Schistosoma mansoni nuclear hormone receptor 0.009 0.1863 0.2896
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0101 0.2239 0.2226
Brugia malayi latrophilin 2 splice variant baaae 0.0221 0.6433 0.6355
Echinococcus granulosus FTZ F1 alpha 0.019 0.5376 1
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0101 0.2239 0.4165
Loa Loa (eye worm) hypothetical protein 0.0101 0.2239 0.2226
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.005 0.0466 0.0724
Brugia malayi Nuclear hormone receptor family member nhr-49 0.019 0.5376 0.5275
Echinococcus granulosus retinoic acid receptor rxr beta a 0.019 0.5376 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.009 0.1863 0.3466
Trichomonas vaginalis chromobox protein, putative 0.0051 0.0498 0.015
Trypanosoma brucei PAB1-binding protein , putative 0.0081 0.1566 0.5
Schistosoma mansoni retinoic acid receptor RXR 0.019 0.5376 0.8357
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.019 0.5376 0.5368
Echinococcus granulosus thyroid hormone receptor alpha 0.009 0.1863 0.3466
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0115 0.2752 0.512
Schistosoma mansoni jumonji/arid domain-containing protein 0.0043 0.0214 0.0333
Schistosoma mansoni chromobox protein 0.0084 0.1664 0.2586
Loa Loa (eye worm) hypothetical protein 0.009 0.1863 0.1849
Schistosoma mansoni nuclear hormone receptor 0.009 0.1863 0.2896
Echinococcus granulosus Nuclear hormone receptor HR96 0.009 0.1863 0.3466
Loa Loa (eye worm) hypothetical protein 0.019 0.5376 0.5368
Loa Loa (eye worm) steroid hormone receptor 0.019 0.5376 0.5368
Schistosoma mansoni steroid hormone receptor ad4bp 0.019 0.5376 0.8357
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.009 0.1863 0.2123
Loa Loa (eye worm) hypothetical protein 0.0101 0.2239 0.2226
Schistosoma mansoni nuclear receptor 0.009 0.1863 0.2896
Schistosoma mansoni nuclear receptor 0.009 0.1863 0.2896
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0101 0.2239 0.4165
Loa Loa (eye worm) hypothetical protein 0.019 0.5376 0.5368
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.019 0.5376 1
Echinococcus granulosus jumonji domain containing protein 0.0049 0.0437 0.0813

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.2512 uM PubChem BioAssay. Inhibitors of USP1/UAF1: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 3.1623 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 11.2202 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) 14.1254 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference
Potency (functional) 19.9526 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] ChEMBL. No reference
Potency (functional) 20.5962 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) 28.1838 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference
Potency (functional) 31.6228 uM PubChem BioAssay. qHTS of Trypanosoma Brucei Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 50.1187 uM PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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