Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | ImpB/MucB/SamB family protein | 0.0046 | 0.0143 | 0.0139 |
Leishmania major | hypothetical protein, conserved | 0.0133 | 0.1045 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0622 | 0.6135 | 1 |
Schistosoma mansoni | hypothetical protein | 0.006 | 0.0283 | 0.0455 |
Onchocerca volvulus | Glutaminyl cyclase homolog | 0.0364 | 0.3451 | 0.3273 |
Brugia malayi | Peptidase family M28 containing protein | 0.0364 | 0.3451 | 0.3449 |
Loa Loa (eye worm) | hypothetical protein | 0.0133 | 0.1045 | 0.1042 |
Schistosoma mansoni | tar DNA-binding protein | 0.0069 | 0.0377 | 0.0608 |
Schistosoma mansoni | Fxna peptidase (M28 family) | 0.0058 | 0.0266 | 0.0427 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0069 | 0.0377 | 0.0373 |
Echinococcus multilocularis | Ataxin 2, N terminal,domain containing protein | 0.006 | 0.0283 | 0.0455 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0247 | 0.2235 | 0.2232 |
Mycobacterium ulcerans | lipoprotein aminopeptidase LpqL | 0.0058 | 0.0266 | 0.5 |
Echinococcus granulosus | glutaminyl peptide cyclotransferase | 0.0364 | 0.3451 | 0.5623 |
Echinococcus multilocularis | glutaminyl peptide cyclotransferase | 0.0364 | 0.3451 | 0.5623 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0247 | 0.2235 | 0.2232 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0133 | 0.1045 | 1 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0069 | 0.0377 | 0.0373 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0033 | 0.0004 | 0.0038 |
Onchocerca volvulus | 0.0993 | 1 | 1 | |
Schistosoma mansoni | hypothetical protein | 0.0247 | 0.2235 | 0.3639 |
Trypanosoma cruzi | isocitrate dehydrogenase, putative | 0.0033 | 0.0004 | 0.0038 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0781 | 0.7792 | 0.7791 |
Brugia malayi | nicalin | 0.0058 | 0.0266 | 0.0262 |
Schistosoma mansoni | tar DNA-binding protein | 0.0069 | 0.0377 | 0.0608 |
Brugia malayi | RNA binding protein | 0.0069 | 0.0377 | 0.0373 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0247 | 0.2235 | 0.2232 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.0266 | 0.0262 |
Loa Loa (eye worm) | RNA binding protein | 0.0069 | 0.0377 | 0.0373 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0622 | 0.6135 | 1 |
Echinococcus granulosus | Ataxin 2 N terminaldomain containing protein | 0.006 | 0.0283 | 0.0455 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0247 | 0.2235 | 0.3639 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0058 | 0.0266 | 0.5 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0622 | 0.6135 | 1 |
Toxoplasma gondii | peptidase, M28 family protein | 0.0058 | 0.0266 | 0.2543 |
Echinococcus multilocularis | n acetylated alpha linked acidic dipeptidase 2 | 0.0058 | 0.0266 | 0.0427 |
Leishmania major | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0033 | 0.0004 | 0.0038 |
Schistosoma mansoni | hypothetical protein | 0.0247 | 0.2235 | 0.3639 |
Echinococcus multilocularis | endoplasmic reticulum metallopeptidase 1 | 0.0058 | 0.0266 | 0.0427 |
Echinococcus multilocularis | tar DNA binding protein | 0.0069 | 0.0377 | 0.0608 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0247 | 0.2236 | 0.2233 |
Leishmania major | hypothetical protein, conserved | 0.0058 | 0.0266 | 0.2543 |
Echinococcus multilocularis | dna polymerase eta | 0.0046 | 0.0143 | 0.0226 |
Toxoplasma gondii | hypothetical protein | 0.0058 | 0.0266 | 0.2543 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0622 | 0.6135 | 0.6134 |
Echinococcus granulosus | endoplasmic reticulum metallopeptidase 1 | 0.0058 | 0.0266 | 0.0427 |
Loa Loa (eye worm) | hypothetical protein | 0.0247 | 0.2235 | 0.2232 |
Trypanosoma cruzi | glutaminyl cyclase, putative | 0.0058 | 0.0266 | 0.2543 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0033 | 0.0004 | 0.0038 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0058 | 0.0266 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.0266 | 0.0262 |
Echinococcus granulosus | tar DNA binding protein | 0.0069 | 0.0377 | 0.0608 |
Mycobacterium tuberculosis | Conserved protein | 0.0058 | 0.0266 | 1 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0133 | 0.1045 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0069 | 0.0377 | 0.0608 |
Echinococcus granulosus | GPCR family 2 | 0.0247 | 0.2235 | 0.3639 |
Trypanosoma brucei | DNA polymerase eta, putative | 0.0046 | 0.0143 | 0.1331 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0133 | 0.1045 | 1 |
Echinococcus granulosus | endoplasmic reticulum metallopeptidase 1 | 0.0058 | 0.0266 | 0.0427 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0247 | 0.2235 | 0.3639 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0781 | 0.7792 | 0.7791 |
Schistosoma mansoni | nicalin (M28 family) | 0.0058 | 0.0266 | 0.0427 |
Schistosoma mansoni | glutaminyl-peptide cyclotransferase-related | 0.0058 | 0.0266 | 0.0427 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0247 | 0.2235 | 0.3639 |
Schistosoma mansoni | glutaminyl cyclase (M28 family) | 0.0364 | 0.3451 | 0.5623 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0781 | 0.7792 | 0.7791 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.0143 | 0.0139 |
Brugia malayi | hypothetical protein | 0.0133 | 0.1045 | 0.1042 |
Leishmania major | glutaminyl cyclase, putative | 0.0058 | 0.0266 | 0.2543 |
Brugia malayi | TAR-binding protein | 0.0069 | 0.0377 | 0.0373 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.0266 | 0.0262 |
Brugia malayi | leucyl aminopeptidase | 0.0058 | 0.0266 | 0.0262 |
Schistosoma mansoni | hypothetical protein | 0.0247 | 0.2235 | 0.3639 |
Trypanosoma cruzi | glutaminyl cyclase, putative | 0.0058 | 0.0266 | 0.2543 |
Loa Loa (eye worm) | pax transcription factor protein 2 | 0.0993 | 1 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.0069 | 0.0377 | 0.0373 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0622 | 0.6135 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0781 | 0.7792 | 0.7791 |
Schistosoma mansoni | tar DNA-binding protein | 0.0069 | 0.0377 | 0.0608 |
Leishmania major | DNA polymerase eta, putative | 0.0046 | 0.0143 | 0.1364 |
Schistosoma mansoni | hypothetical protein | 0.0534 | 0.522 | 0.8507 |
Schistosoma mansoni | hypothetical protein | 0.0247 | 0.2235 | 0.3639 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0622 | 0.6135 | 1 |
Schistosoma mansoni | DNA polymerase eta | 0.0046 | 0.0143 | 0.0226 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0622 | 0.6135 | 0.6134 |
Trypanosoma cruzi | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0033 | 0.0004 | 0.0038 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0133 | 0.1045 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.0266 | 0.0262 |
Brugia malayi | hypothetical protein | 0.0086 | 0.0555 | 0.0552 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0058 | 0.0266 | 0.5 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0534 | 0.522 | 0.5218 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0133 | 0.1045 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0622 | 0.6135 | 1 |
Trichomonas vaginalis | Clan MH, family M28, aminopeptidase S-like metallopeptidase | 0.0058 | 0.0266 | 0.5 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0247 | 0.2235 | 0.3639 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0133 | 0.1045 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0069 | 0.0377 | 0.0608 |
Echinococcus multilocularis | endoplasmic reticulum metallopeptidase 1 | 0.0058 | 0.0266 | 0.0427 |
Mycobacterium ulcerans | hypothetical protein | 0.0058 | 0.0266 | 0.5 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0247 | 0.2236 | 0.2233 |
Echinococcus granulosus | dna polymerase eta | 0.0046 | 0.0143 | 0.0226 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0133 | 0.1045 | 1 |
Trypanosoma brucei | glutaminyl cyclase, putative | 0.0058 | 0.0266 | 0.2514 |
Loa Loa (eye worm) | hypothetical protein | 0.0364 | 0.3451 | 0.3449 |
Mycobacterium tuberculosis | Probable lipoprotein aminopeptidase LpqL | 0.0058 | 0.0266 | 1 |
Brugia malayi | FXNA | 0.0058 | 0.0266 | 0.0262 |
Brugia malayi | MH2 domain containing protein | 0.0247 | 0.2236 | 0.2233 |
Loa Loa (eye worm) | leucyl aminopeptidase | 0.0058 | 0.0266 | 0.0262 |
Loa Loa (eye worm) | hypothetical protein | 0.0534 | 0.522 | 0.5218 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0046 | 0.0143 | 0.1364 |
Schistosoma mansoni | NAALADASE L peptidase (M28 family) | 0.0058 | 0.0266 | 0.0427 |
Echinococcus multilocularis | GPCR, family 2 | 0.0247 | 0.2235 | 0.3639 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0622 | 0.6135 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.