Detailed information for compound 1473443

Basic information

Technical information
  • TDR Targets ID: 1473443
  • Name: 1-(5-chloro-2-methylphenyl)-4-[1-[1-(furan-2- ylmethyl)tetrazol-5-yl]butyl]piperazine
  • MW: 414.932 | Formula: C21H27ClN6O
  • H donors: 0 H acceptors: 3 LogP: 4 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCC(c1nnnn1Cc1ccco1)N1CCN(CC1)c1cc(Cl)ccc1C
  • InChi: 1S/C21H27ClN6O/c1-3-5-19(21-23-24-25-28(21)15-18-6-4-13-29-18)26-9-11-27(12-10-26)20-14-17(22)8-7-16(20)2/h4,6-8,13-14,19H,3,5,9-12,15H2,1-2H3
  • InChiKey: IWNVURXZAIYEGZ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1-(5-chloro-2-methyl-phenyl)-4-[1-[1-(2-furylmethyl)tetrazol-5-yl]butyl]piperazine
  • 1-(5-chloro-2-methylphenyl)-4-[1-[1-(2-furylmethyl)-5-tetrazolyl]butyl]piperazine
  • 1-(5-chloro-2-methyl-phenyl)-4-[1-[1-(furan-2-ylmethyl)-1,2,3,4-tetrazol-5-yl]butyl]piperazine
  • ASN 05557300

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0028 0.0313 0.0351
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0029 0.003
Loa Loa (eye worm) hypothetical protein 0.0024 0.026 0.0291
Giardia lamblia Glycerol-3-phosphate dehydrogenase 0.0052 0.0667 1
Schistosoma mansoni cpg binding protein 0.0037 0.0445 0.0499
Mycobacterium leprae PROBABLE D-AMINO ACID OXIDASE AAO 0.0623 0.893 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.0786 0.1299
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 20 0.0052 0.0667 1
Loa Loa (eye worm) hypothetical protein 0.0028 0.0313 0.0351
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0028 0.0313 0.0313
Brugia malayi pyruvate dehydrogenase phosphatase regulatory subunit precursor 0.0052 0.0667 0.1102
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0028 0.0313 0.0351
Loa Loa (eye worm) hypothetical protein 0.0028 0.0313 0.0351
Onchocerca volvulus 0.0028 0.0313 0.4696
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0028 0.0313 0.0313
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0045 0.0561 0.8415
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.051 0.0844
Echinococcus multilocularis ubiquitin specific protease 41 0.0045 0.0561 0.07
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0045 0.0561 0.0561
Loa Loa (eye worm) hypothetical protein 0.0623 0.893 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0029 0.003
Loa Loa (eye worm) hypothetical protein 0.0041 0.051 0.0571
Onchocerca volvulus 0.0028 0.0313 0.4696
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0029 0.003
Loa Loa (eye worm) doublecortin family protein 0.0024 0.026 0.0291
Loa Loa (eye worm) hypothetical protein 0.0028 0.0313 0.0351
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0067 0.0879 0.1097
Schistosoma mansoni ATP:guanidino kinase (Smc74) 0.0052 0.0667 0.0747
Echinococcus multilocularis cpg binding protein 0.0037 0.0445 0.0555
Loa Loa (eye worm) hypothetical protein 0.0052 0.0667 0.0747
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0028 0.0313 0.0518
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0028 0.0313 0.0518
Loa Loa (eye worm) protein-tyrosine-phosphatase 0.0028 0.0313 0.0351
Onchocerca volvulus 0.0028 0.0313 0.4696
Loa Loa (eye worm) protein-tyrosine phosphatase 1 0.0028 0.0313 0.0351
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0028 0.0313 0.0351
Brugia malayi protein-tyrosine phosphatase Lar-like precursor, putative 0.0028 0.0313 0.0518
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0158 0.2199 0.2199
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0019 0.0191 0.0238
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0029 0.003
Brugia malayi follicle stimulating hormone receptor 0.0283 0.4002 0.6615
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0045 0.0561 0.0581
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0028 0.0313 0.0518
Loa Loa (eye worm) hypothetical protein 0.0052 0.0667 0.0747
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0029 0.003
Loa Loa (eye worm) hypothetical protein 0.0028 0.0313 0.0351
Schistosoma mansoni cpg binding protein 0.0035 0.0417 0.0467
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0028 0.0313 0.0518
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0009 0.004 0.0045
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0029 0.003
Trypanosoma cruzi L-2-hydroxyglutarate dehydrogenase, mitochondrial, putative 0.0052 0.0667 1
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0045 0.0561 0.0927
Onchocerca volvulus 0.0028 0.0313 0.4696
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0019 0.0191 0.0238
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0028 0.0313 0.0351
Echinococcus multilocularis receptor type tyrosine protein phosphatase zeta 0.0028 0.0313 0.039
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0028 0.0313 0.0313
Trypanosoma cruzi glycerol-3-phosphate dehydrogenase, putative 0.0052 0.0667 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.0786 0.1299
Loa Loa (eye worm) dual specificity protein phosphatase CDC14B 0.0028 0.0313 0.0351
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0045 0.0561 0.07
Echinococcus multilocularis dnaJ subfamily B 0.0494 0.7058 0.8802
Echinococcus granulosus Receptor type tyrosine protein phosphatase O 0.0028 0.0313 0.0313
Loa Loa (eye worm) hypothetical protein 0.0019 0.0191 0.0214
Loa Loa (eye worm) hypothetical protein 0.0028 0.0313 0.0351
Trypanosoma brucei FAD dependent oxidoreductase, putative 0.0052 0.0667 1
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0029 0.003
Loa Loa (eye worm) glycerol-3-phosphate dehydrogenase 0.0052 0.0667 0.0747
Schistosoma mansoni hypothetical protein 0.0024 0.026 0.0291
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0028 0.0313 0.0351
Schistosoma mansoni hypothetical protein 0.0494 0.7058 0.7904
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0028 0.0313 0.0351
Brugia malayi CXXC zinc finger family protein 0.0035 0.0417 0.0689
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0028 0.0313 0.0351
Trichomonas vaginalis conserved hypothetical protein 0.0208 0.2928 0.3034
Entamoeba histolytica anaerobic glycerol-3-phosphate dehydrogenase subunit A, putative 0.0052 0.0667 0.0379
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0158 0.2199 0.2742
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0028 0.0313 0.0518
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0158 0.2199 0.2199
Loa Loa (eye worm) hypothetical protein 0.0028 0.0313 0.0351
Brugia malayi hypothetical protein 0.0028 0.0313 0.0518
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0028 0.0313 0.0518
Trichomonas vaginalis pten, drome, putative 0.0028 0.0313 0.0324
Loa Loa (eye worm) hypothetical protein 0.0028 0.0313 0.0351
Loa Loa (eye worm) fibronectin type III domain-containing protein 0.0028 0.0313 0.0351
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0028 0.0313 0.0518
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0028 0.0313 0.039
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0028 0.0313 0.039
Echinococcus multilocularis 0.0028 0.0313 0.039
Onchocerca volvulus 0.0028 0.0313 0.4696
Schistosoma mansoni fad oxidoreductase 0.0052 0.0667 0.0747
Loa Loa (eye worm) hypothetical protein 0.0028 0.0313 0.0351
Trypanosoma brucei glycerol-3-phosphate dehydrogenase (FAD-dependent), putative 0.0052 0.0667 1
Echinococcus granulosus lipoxygenase domain containing protein 0.0024 0.026 0.026
Schistosoma mansoni receptor protein tyrosine phosphatase n (ia2) 0.0028 0.0313 0.0351
Echinococcus multilocularis RUN 0.0024 0.026 0.0324
Schistosoma mansoni hypothetical protein 0.0019 0.0191 0.0214
Toxoplasma gondii histone lysine methyltransferase SET1 0.0066 0.0865 1
Onchocerca volvulus 0.0028 0.0313 0.4696
Onchocerca volvulus 4.1 G protein, putative homolog 0.0028 0.0313 0.4696
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0028 0.0313 0.0518
Echinococcus multilocularis hypothetical protein 0.0028 0.0313 0.039
Schistosoma mansoni rab6-interacting 0.0024 0.026 0.0291
Trypanosoma cruzi tyrosine specific protein phosphatase, putative 0.0028 0.0313 0.4696
Brugia malayi hypothetical protein 0.0024 0.026 0.0429
Onchocerca volvulus 0.0028 0.0313 0.4696
Echinococcus multilocularis lipoxygenase domain containing protein 0.0024 0.026 0.0324
Loa Loa (eye worm) hypothetical protein 0.0214 0.3013 0.3374
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0011 0.007 0.0088
Onchocerca volvulus 0.0028 0.0313 0.4696
Onchocerca volvulus 0.0028 0.0313 0.4696
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0028 0.0313 0.039
Schistosoma mansoni pcd6 interacting protein-related 0.0028 0.0313 0.0351
Loa Loa (eye worm) hypothetical protein 0.0028 0.0313 0.0351
Schistosoma mansoni fad oxidoreductase 0.0052 0.0667 0.0747
Loa Loa (eye worm) hypothetical protein 0.0028 0.0313 0.0351
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0158 0.2199 0.2742
Echinococcus granulosus receptor type tyrosine protein phosphatase zeta 0.0028 0.0313 0.0313
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0028 0.0313 0.0351
Trichomonas vaginalis pps1 dual specificty phosphatase, putative 0.0673 0.965 1
Echinococcus granulosus Polycystic kidney disease protein 0.0024 0.026 0.026
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0028 0.0313 0.0351
Echinococcus granulosus neuropeptide receptor A26 0.056 0.8019 0.8019
Loa Loa (eye worm) hypothetical protein 0.0028 0.0313 0.0351
Echinococcus granulosus receptor type tyrosine protein phosphatase zeta 0.0028 0.0313 0.0313
Onchocerca volvulus 0.0028 0.0313 0.4696
Onchocerca volvulus 0.0028 0.0313 0.4696
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0028 0.0313 0.0518
Echinococcus multilocularis lipoxygenase domain containing protein 0.0024 0.026 0.0324
Echinococcus multilocularis neuropeptide receptor A26 0.056 0.8019 1
Schistosoma mansoni protein tyrosine phosphatase 0.0028 0.0313 0.0351
Loa Loa (eye worm) hypothetical protein 0.0028 0.0313 0.0351
Echinococcus granulosus FAD dependent oxidoreductase domain containing protein 0.0052 0.0667 0.0667
Leishmania major protein-tyrosine phosphatase 1-like protein 0.0028 0.0313 0.4696
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0019 0.0191 0.0191
Schistosoma mansoni glycerol-3-phosphate dehydrogenase 0.0052 0.0667 0.0747
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0028 0.0313 0.039
Onchocerca volvulus 0.0028 0.0313 0.4696
Trypanosoma brucei electron transfer flavoprotein-ubiquinone oxidoreductase, putative 0.0052 0.0667 1
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.0028 0.0313 0.039
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.0028 0.0313 0.039
Loa Loa (eye worm) hypothetical protein 0.0028 0.0313 0.0351
Echinococcus multilocularis receptor type tyrosine protein phosphatase zeta 0.0028 0.0313 0.039
Onchocerca volvulus 0.0028 0.0313 0.4696
Toxoplasma gondii FAD-dependent glycerol-3-phosphate dehydrogenase 0.0052 0.0667 0.7704
Echinococcus granulosus GPCR family 2 0.0019 0.0191 0.0191
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0424 0.6049 1
Echinococcus granulosus cpg binding protein 0.0037 0.0445 0.0445
Leishmania major hypothetical protein, conserved 0.0052 0.0667 1
Loa Loa (eye worm) hypothetical protein 0.0028 0.0313 0.0351
Echinococcus multilocularis receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type 0.0028 0.0313 0.039
Loa Loa (eye worm) hypothetical protein 0.0028 0.0313 0.0351
Echinococcus multilocularis Polycystic kidney disease protein 0.0024 0.026 0.0324
Echinococcus multilocularis neuropeptide s receptor 0.056 0.8019 1
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0158 0.2199 0.3635
Loa Loa (eye worm) hypothetical protein 0.0028 0.0313 0.0351
Schistosoma mansoni hypothetical protein 0.0019 0.0191 0.0214
Brugia malayi Protein-tyrosine phosphatase 0.0028 0.0313 0.0518
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0067 0.0879 0.0879
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0028 0.0313 0.0313
Onchocerca volvulus 0.0028 0.0313 0.4696
Loa Loa (eye worm) hypothetical protein 0.0028 0.0313 0.0351
Echinococcus granulosus dnaJ subfamily B 0.0494 0.7058 0.7058
Schistosoma mansoni protein tyrosine phosphatase 0.0028 0.0313 0.0351
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0045 0.0561 0.0266
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0028 0.0313 0.0351
Loa Loa (eye worm) hypothetical protein 0.0028 0.0313 0.0351
Brugia malayi cDNA sequence BC016226 0.0052 0.0667 0.1102
Leishmania major glycerol-3-phosphate dehydrogenase-like protein 0.0052 0.0667 1
Trypanosoma cruzi tyrosine specific protein phosphatase, putative 0.0028 0.0313 0.4696
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.004 0.004
Onchocerca volvulus 0.0028 0.0313 0.4696
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0008 0.0029 0.003
Loa Loa (eye worm) hypothetical protein 0.0024 0.026 0.0291
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0028 0.0313 0.0313
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0028 0.0313 0.0518
Schistosoma mansoni protein-tyrosine phosphatase n9 0.0028 0.0313 0.0351
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0028 0.0313 0.0351
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0019 0.0191 0.0191
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.0028 0.0313 0.039
Loa Loa (eye worm) hypothetical protein 0.0028 0.0313 0.0351
Onchocerca volvulus 0.0024 0.026 0.3893
Schistosoma mansoni lipoxygenase 0.0024 0.026 0.0291
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0028 0.0313 0.0313
Toxoplasma gondii hypothetical protein 0.0052 0.0667 0.7704
Schistosoma mansoni protein tyrosine phosphatase n11 (shp2) 0.0158 0.2199 0.2462
Onchocerca volvulus 0.0028 0.0313 0.4696
Schistosoma mansoni protein tyrosine phosphatase 0.0028 0.0313 0.0351
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0028 0.0313 0.0351
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0045 0.0561 0.7012
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0028 0.0313 0.0313
Chlamydia trachomatis D-amino acid dehydrogenase 0.0052 0.0667 0.5
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0045 0.0561 0.8415
Echinococcus multilocularis receptor type tyrosine protein phosphatase F 0.0028 0.0313 0.039
Echinococcus granulosus mixed lineage leukemia protein mll 0.0009 0.004 0.004
Onchocerca volvulus 0.0028 0.0313 0.4696
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.0786 0.088
Schistosoma mansoni lipoxygenase 0.0067 0.0879 0.0985
Brugia malayi Doublecortin family protein 0.0024 0.026 0.0429
Onchocerca volvulus 0.0028 0.0313 0.4696
Loa Loa (eye worm) hypothetical protein 0.0028 0.0313 0.0351
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0028 0.0313 0.0518
Plasmodium vivax FAD-dependent glycerol-3-phosphate dehydrogenase, putative 0.0052 0.0667 1
Loa Loa (eye worm) hypothetical protein 0.0028 0.0313 0.0351
Brugia malayi F/Y-rich N-terminus family protein 0.0011 0.0068 0.0113
Brugia malayi Latrophilin receptor protein 2 0.0019 0.0191 0.0315
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0028 0.0313 0.0351
Brugia malayi dimethylglycine dehydrogenase, mitochondrial precursor, putative 0.0052 0.0667 0.1102
Onchocerca volvulus 0.0028 0.0313 0.4696
Brugia malayi RE18450p 0.0052 0.0667 0.1102
Brugia malayi Protein-tyrosine phosphatase 0.0028 0.0313 0.0518
Echinococcus multilocularis FAD dependent oxidoreductase domain containing protein 0.0052 0.0667 0.0831
Brugia malayi Dual specificity protein phosphatase CDC14B 0.0028 0.0313 0.0518
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0029 0.003
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0029 0.003
Brugia malayi hypothetical protein 0.0028 0.0313 0.0518
Schistosoma mansoni protein tyrosine phosphatase non-receptor type nt1 0.0424 0.6049 0.6773
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0028 0.0313 0.0518
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0028 0.0313 0.0313
Echinococcus granulosus lipoxygenase domain containing protein 0.0024 0.026 0.026
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.0028 0.0313 0.039
Loa Loa (eye worm) hypothetical protein 0.0028 0.0313 0.0351
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0028 0.0313 0.039
Schistosoma mansoni receptor protein tyrosine phosphatase n (ia2) 0.0028 0.0313 0.0351
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0424 0.6049 0.6049
Onchocerca volvulus 0.0028 0.0313 0.4696
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0028 0.0313 0.0313
Schistosoma mansoni receptor protein tyrosine phosphatase 0.0028 0.0313 0.0351
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0029 0.003
Trypanosoma cruzi glycerol-3-phosphate dehydrogenase (FAD-dependent), putative 0.0052 0.0667 1
Trypanosoma brucei L-2-hydroxyglutarate dehydrogenase, mitochondrial, putative 0.0052 0.0667 1
Onchocerca volvulus Putative fad oxidoreductase 0.0052 0.0667 1
Onchocerca volvulus 0.0028 0.0313 0.4696
Schistosoma mansoni protein-tyrosine phosphatase non-receptor type nt5 0.0028 0.0313 0.0351
Brugia malayi Protein-tyrosine phosphatase 1 0.0028 0.0313 0.0518
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0028 0.0313 0.0518
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0074 0.0979 0.1096
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0028 0.0313 0.0518
Schistosoma mansoni loxhd1 0.0024 0.026 0.0291
Entamoeba histolytica dual specificity protein phosphatase, putative 0.0673 0.965 1
Onchocerca volvulus 0.0028 0.0313 0.4696
Echinococcus granulosus ubiquitin specific protease 41 0.0045 0.0561 0.0561
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0028 0.0313 0.0518
Trypanosoma cruzi glycerol-3-phosphate dehydrogenase (FAD-dependent), putative 0.0052 0.0667 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0029 0.003
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0045 0.0561 0.0628
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0028 0.0313 0.0518
Onchocerca volvulus Pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial homolog 0.0052 0.0667 1
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0028 0.0313 0.039
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0045 0.0561 0.0561
Echinococcus granulosus protein tyrosine phosphatase n9 0.0028 0.0313 0.0313
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0028 0.0313 0.0351
Loa Loa (eye worm) hypothetical protein 0.0028 0.0313 0.0351
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0028 0.0313 0.0313
Mycobacterium ulcerans D-amino acid oxidase Aao 0.0623 0.893 1
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0028 0.0313 0.0518
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0158 0.2199 0.2462
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0045 0.0561 0.0581
Trypanosoma cruzi tyrosine specific protein phosphatase, putative 0.0028 0.0313 0.4696
Schistosoma mansoni cpg binding protein 0.0037 0.0445 0.0499
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0283 0.4002 0.4481
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0045 0.0561 0.0628
Schistosoma mansoni rab6-interacting 0.0024 0.026 0.0291
Trypanosoma brucei protein tyrosine phosphatase 1 0.0028 0.0313 0.4696
Echinococcus multilocularis receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type 0.0028 0.0313 0.039
Brugia malayi hypothetical protein 0.0028 0.0313 0.0518
Loa Loa (eye worm) hypothetical protein 0.006 0.0786 0.088
Echinococcus multilocularis glycerol 3 phosphate dehydrogenase 0.0052 0.0667 0.0831
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0029 0.003
Schistosoma mansoni non-receptor protein-tyrosine phosphatase 0.0028 0.0313 0.0351
Echinococcus multilocularis protein tyrosine phosphatase n9 0.0028 0.0313 0.039
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0029 0.003
Loa Loa (eye worm) protein tyrosine phosphatase 0.0028 0.0313 0.0351
Plasmodium falciparum FAD-dependent glycerol-3-phosphate dehydrogenase, putative 0.0052 0.0667 1
Schistosoma mansoni hypothetical protein 0.0019 0.0191 0.0214
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0028 0.0313 0.0351
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0028 0.0313 0.0351
Echinococcus multilocularis receptor type tyrosine protein phosphatase H 0.0028 0.0313 0.039
Echinococcus granulosus RUN 0.0024 0.026 0.026
Schistosoma mansoni rgs-gaip interacting protein gipc 0.0028 0.0313 0.0351
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.0561 0.0581
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0029 0.003
Echinococcus multilocularis GPCR, family 2 0.0019 0.0191 0.0238
Brugia malayi hypothetical protein 0.0024 0.026 0.0429
Leishmania major hypothetical protein, conserved 0.0052 0.0667 1
Schistosoma mansoni d-amino acid oxidase 0.0623 0.893 1
Loa Loa (eye worm) histone methyltransferase 0.0011 0.007 0.0079
Brugia malayi Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog 0.0214 0.3013 0.4981
Schistosoma mansoni receptor protein tyrosine phosphatase r (pcptp1) 0.0028 0.0313 0.0351
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0028 0.0313 0.0518
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0028 0.0313 0.039
Brugia malayi hypothetical protein 0.0028 0.0313 0.0518
Loa Loa (eye worm) hypothetical protein 0.0028 0.0313 0.0351
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.004 0.005
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0028 0.0313 0.0351
Onchocerca volvulus 0.0028 0.0313 0.4696
Schistosoma mansoni NAD dehydrogenase 0.0052 0.0667 0.0747
Loa Loa (eye worm) hypothetical protein 0.0045 0.0561 0.0628
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0028 0.0313 0.039
Mycobacterium tuberculosis Probable D-amino acid oxidase Aao 0.0571 0.8179 1
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0028 0.0313 0.0351
Trypanosoma cruzi L-2-hydroxyglutarate dehydrogenase, mitochondrial, putative 0.0052 0.0667 1
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0424 0.6049 0.7544
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0045 0.0561 0.8415
Schistosoma mansoni polycystin 1-related 0.0024 0.026 0.0291
Loa Loa (eye worm) latrophilin receptor protein 2 0.0019 0.0191 0.0214
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0045 0.0561 0.07
Trypanosoma cruzi FAD dependent oxidoreductase, putative 0.0052 0.0667 1
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0045 0.0561 0.8415
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0019 0.0191 0.0315
Loa Loa (eye worm) CXXC zinc finger family protein 0.0035 0.0417 0.0467
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0011 0.007 0.007
Trypanosoma brucei glycerol-3-phosphate dehydrogenase (FAD-dependent), mitochondrial 0.0052 0.0667 1
Onchocerca volvulus 0.0024 0.026 0.3893
Onchocerca volvulus 0.0035 0.0417 0.6251
Leishmania major tyrosine specific protein phosphatase, putative 0.0028 0.0313 0.4696
Loa Loa (eye worm) hypothetical protein 0.0028 0.0313 0.0351
Schistosoma mansoni hypothetical protein 0.0041 0.051 0.0571
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0028 0.0313 0.0518
Loa Loa (eye worm) hypothetical protein 0.0052 0.0667 0.0747
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0009 0.004 0.005
Loa Loa (eye worm) hypothetical protein 0.0028 0.0313 0.0351
Brugia malayi hypothetical protein 0.0028 0.0313 0.0518
Echinococcus granulosus neuropeptide s receptor 0.056 0.8019 0.8019
Trichomonas vaginalis helicase, putative 0.0008 0.0029 0.003
Entamoeba histolytica NAD(FAD)-dependent dehydrogenase, putative 0.0052 0.0667 0.0379
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0028 0.0313 0.0518
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0424 0.6049 0.6773
Onchocerca volvulus Dimethylglycine dehydrogenase, mitochondrial homolog 0.0052 0.0667 1
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0029 0.003
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0028 0.0313 0.0313
Echinococcus granulosus glycerol 3 phosphate dehydrogenase 0.0052 0.0667 0.0667
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0008 0.0029 0.003
Schistosoma mansoni hypothetical protein 0.0019 0.0191 0.0214
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0028 0.0313 0.0518

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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