Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Saccharomyces cerevisiae | Rce1p | Starlite/ChEMBL | No references |
Homo sapiens | SMAD family member 2 | Starlite/ChEMBL | No references |
Homo sapiens | Ras converting CAAX endopeptidase 1 | Starlite/ChEMBL | No references |
Sus scrofa | Trypsin | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | hypothetical protein | Ras converting CAAX endopeptidase 1 | 225 aa | 181 aa | 21.6 % |
Schistosoma japonicum | Cercarial protease precursor (EC 3.4.21.-) (Cercarial elastase), putative | Trypsin | 231 aa | 204 aa | 25.0 % |
Drosophila melanogaster | CG13744 gene product from transcript CG13744-RA | Trypsin | 231 aa | 249 aa | 31.3 % |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | Trypsin | 231 aa | 247 aa | 35.2 % |
Drosophila melanogaster | CG17239 gene product from transcript CG17239-RB | Trypsin | 231 aa | 227 aa | 33.5 % |
Loa Loa (eye worm) | hypothetical protein | Trypsin | 231 aa | 238 aa | 21.4 % |
Drosophila melanogaster | CG32277 gene product from transcript CG32277-RA | Trypsin | 231 aa | 221 aa | 33.5 % |
Drosophila melanogaster | CG10405 gene product from transcript CG10405-RB | Trypsin | 231 aa | 242 aa | 31.8 % |
Drosophila melanogaster | CG11313 gene product from transcript CG11313-RC | Trypsin | 231 aa | 255 aa | 31.8 % |
Drosophila melanogaster | CG30323 gene product from transcript CG30323-RB | Trypsin | 231 aa | 210 aa | 23.3 % |
Neospora caninum | ELMO/CED-12 family domain-containing protein, putative | Trypsin | 231 aa | 193 aa | 22.8 % |
Echinococcus multilocularis | subfamily S1A unassigned peptidase (S01 family) | Trypsin | 231 aa | 286 aa | 25.2 % |
Schistosoma japonicum | Enteropeptidase, putative | Trypsin | 231 aa | 262 aa | 25.6 % |
Echinococcus multilocularis | Mastin | Trypsin | 231 aa | 306 aa | 24.2 % |
Drosophila melanogaster | CG6582 gene product from transcript CG6582-RA | Trypsin | 231 aa | 187 aa | 23.5 % |
Echinococcus multilocularis | glycoprotein Antigen 5 | Trypsin | 231 aa | 301 aa | 22.3 % |
Echinococcus multilocularis | transmembrane protease serine 3 | Trypsin | 231 aa | 233 aa | 33.0 % |
Drosophila melanogaster | CG4815 gene product from transcript CG4815-RA | Trypsin | 231 aa | 212 aa | 27.4 % |
Drosophila melanogaster | Jonah 65Aiii | Trypsin | 231 aa | 241 aa | 34.0 % |
Drosophila melanogaster | CG30083 gene product from transcript CG30083-RB | Trypsin | 231 aa | 209 aa | 29.7 % |
Schistosoma japonicum | Transmembrane protease, serine 9, putative | Trypsin | 231 aa | 246 aa | 21.1 % |
Drosophila melanogaster | CG14990 gene product from transcript CG14990-RA | Trypsin | 231 aa | 238 aa | 29.4 % |
Drosophila melanogaster | CG30287 gene product from transcript CG30287-RA | Trypsin | 231 aa | 249 aa | 27.7 % |
Schistosoma mansoni | cercarial elastase (S01 family) | Trypsin | 231 aa | 235 aa | 25.5 % |
Drosophila melanogaster | CG9997 gene product from transcript CG9997-RB | Trypsin | 231 aa | 194 aa | 23.2 % |
Onchocerca volvulus | Trypsin | 231 aa | 212 aa | 21.2 % | |
Brugia malayi | MH2 domain containing protein | SMAD family member 2 | 467 aa | 405 aa | 31.6 % |
Drosophila melanogaster | CG3505 gene product from transcript CG3505-RA | Trypsin | 231 aa | 232 aa | 30.6 % |
Echinococcus granulosus | Mastin | Trypsin | 231 aa | 306 aa | 23.9 % |
Schistosoma japonicum | IPR001254,Peptidase S1 and S6, chymotrypsin/Hap;IPR009003,Peptidase, trypsin-like serine and cysteine,domain-containing | Trypsin | 231 aa | 225 aa | 23.1 % |
Drosophila melanogaster | Jonah 99Ci | Trypsin | 231 aa | 235 aa | 31.9 % |
Echinococcus granulosus | enteropeptidase | Trypsin | 231 aa | 230 aa | 28.3 % |
Drosophila melanogaster | CG4914 gene product from transcript CG4914-RA | Trypsin | 231 aa | 245 aa | 38.8 % |
Echinococcus multilocularis | enteropeptidase | Trypsin | 231 aa | 230 aa | 27.8 % |
Drosophila melanogaster | CG5909 gene product from transcript CG5909-RA | Trypsin | 231 aa | 256 aa | 28.9 % |
Schistosoma japonicum | ko:K01346 pancreatic elastase II [EC3.4.21.71], putative | Trypsin | 231 aa | 303 aa | 24.1 % |
Schistosoma mansoni | aminopeptidase PILS (M01 family) | Trypsin | 231 aa | 300 aa | 22.3 % |
Drosophila melanogaster | Jonah 65Aii | Trypsin | 231 aa | 235 aa | 35.3 % |
Echinococcus granulosus | glycoprotein Antigen 5 | Trypsin | 231 aa | 301 aa | 23.9 % |
Drosophila melanogaster | Jonah 66Ci | Trypsin | 231 aa | 234 aa | 32.9 % |
Drosophila melanogaster | CG33458 gene product from transcript CG33458-RA | Trypsin | 231 aa | 254 aa | 28.4 % |
Drosophila melanogaster | CG31326 gene product from transcript CG31326-RA | Trypsin | 231 aa | 249 aa | 24.1 % |
Schistosoma mansoni | cercarial elastase (S01 family) | Trypsin | 231 aa | 237 aa | 24.1 % |
Drosophila melanogaster | CG30288 gene product from transcript CG30288-RC | Trypsin | 231 aa | 245 aa | 29.0 % |
Drosophila melanogaster | Spatzle-Processing Enzyme | Trypsin | 231 aa | 271 aa | 29.1 % |
Schistosoma japonicum | ko:K09637 transmembrane protease, serine 6, putative | Trypsin | 231 aa | 242 aa | 28.9 % |
Echinococcus granulosus | subfamily S1A unassigned peptidase S01 family | Trypsin | 231 aa | 286 aa | 24.8 % |
Trypanosoma cruzi | hypothetical protein, conserved | Trypsin | 231 aa | 188 aa | 23.9 % |
Drosophila melanogaster | CG34436 gene product from transcript CG34436-RA | Trypsin | 231 aa | 214 aa | 22.0 % |
Drosophila melanogaster | CG3916 gene product from transcript CG3916-RA | Trypsin | 231 aa | 245 aa | 31.4 % |
Drosophila melanogaster | CG18180 gene product from transcript CG18180-RA | Trypsin | 231 aa | 233 aa | 27.9 % |
Echinococcus granulosus | transmembrane protease serine 3 | Trypsin | 231 aa | 234 aa | 33.8 % |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | Trypsin | 231 aa | 302 aa | 24.8 % |
Drosophila melanogaster | CG9673 gene product from transcript CG9673-RB | Trypsin | 231 aa | 239 aa | 27.6 % |
Drosophila melanogaster | CG31267 gene product from transcript CG31267-RA | Trypsin | 231 aa | 233 aa | 32.2 % |
Onchocerca volvulus | Trypsin | 231 aa | 251 aa | 22.7 % | |
Drosophila melanogaster | CG31220 gene product from transcript CG31220-RB | Trypsin | 231 aa | 263 aa | 27.8 % |
Drosophila melanogaster | CG9733 gene product from transcript CG9733-RB | Trypsin | 231 aa | 262 aa | 31.3 % |
Schistosoma mansoni | cercarial elastase (S01 family) | Trypsin | 231 aa | 201 aa | 22.9 % |
Schistosoma mansoni | cercarial elastase (S01 family) | Trypsin | 231 aa | 235 aa | 25.5 % |
Drosophila melanogaster | CG18420 gene product from transcript CG18420-RA | Trypsin | 231 aa | 239 aa | 28.4 % |
Drosophila melanogaster | CG33465 gene product from transcript CG33465-RC | Trypsin | 231 aa | 225 aa | 21.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | CAAX amino terminal protease, putative | 0.0221 | 1 | 0.5 |
Schistosoma mansoni | family U48 unassigned peptidase (U48 family) | 0.0221 | 1 | 1 |
Trypanosoma cruzi | CAAX prenyl protease 2, putative | 0.0221 | 1 | 0.5 |
Entamoeba histolytica | CAAX prenyl protease family | 0.0221 | 1 | 1 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0144 | 0.6353 | 0.6353 |
Brugia malayi | MH2 domain containing protein | 0.0144 | 0.6353 | 0.6353 |
Giardia lamblia | Hypothetical protein | 0.0221 | 1 | 0.5 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0114 | 0.4917 | 0.4917 |
Mycobacterium tuberculosis | Probable conserved integral membrane protein | 0.0046 | 0.1695 | 0.5 |
Trypanosoma cruzi | peptidase with unknown catalytic mechanism (family U48) | 0.0221 | 1 | 0.5 |
Trichomonas vaginalis | Clan U, family U48, CaaX prenyl peptidase 2-like | 0.0221 | 1 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.0046 | 0.1695 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0114 | 0.4917 | 0.4917 |
Toxoplasma gondii | CAAX amino terminal protease family protein | 0.0046 | 0.1695 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0221 | 1 | 1 |
Echinococcus granulosus | CAAX prenyl protease 2 | 0.0221 | 1 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0046 | 0.1695 | 0.5 |
Plasmodium falciparum | protease, putative | 0.0046 | 0.1695 | 0.5 |
Mycobacterium ulcerans | integral membrane protein | 0.0046 | 0.1695 | 0.5 |
Onchocerca volvulus | 0.0114 | 0.4917 | 1 | |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0046 | 0.1695 | 0.5 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0114 | 0.4917 | 0.4917 |
Toxoplasma gondii | hypothetical protein | 0.0046 | 0.1695 | 0.5 |
Mycobacterium tuberculosis | Probable integral membrane protein | 0.0046 | 0.1695 | 0.5 |
Echinococcus multilocularis | CAAX prenyl protease 2 | 0.0221 | 1 | 1 |
Brugia malayi | Trypsin family protein | 0.0114 | 0.4917 | 0.4917 |
Loa Loa (eye worm) | hypothetical protein | 0.0114 | 0.4917 | 0.4917 |
Toxoplasma gondii | hypothetical protein | 0.0046 | 0.1695 | 0.5 |
Mycobacterium tuberculosis | Probable conserved integral membrane protein | 0.0046 | 0.1695 | 0.5 |
Leishmania major | CAAX prenyl protease 2, putative,peptidase with unknown catalytic mechanism (family U48) | 0.0221 | 1 | 0.5 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0144 | 0.6353 | 0.6353 |
Chlamydia trachomatis | hypothetical protein | 0.0046 | 0.1695 | 0.5 |
Plasmodium vivax | protease, putative | 0.0046 | 0.1695 | 0.5 |
Schistosoma mansoni | family U48 unassigned peptidase (U48 family) | 0.0221 | 1 | 1 |
Treponema pallidum | hypothetical protein | 0.0046 | 0.1695 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
AC50 (binding) | = 9.639 uM | PUBCHEM_BIOASSAY: Trypsin Inhibition Assay Measured in Biochemical System Using Plate Reader - 2034-02_Inhibitor_Dose_CherryPick_Activity. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2618] | ChEMBL. | No reference |
AC50 (binding) | = 10.34 uM | PUBCHEM_BIOASSAY: Human Ras-Converting Enzyme Inhibition Assay Measured in Biochemical System Using Plate Reader - 2034-04_Inhibitor_Dose_CherryPick_Activity. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2618] | ChEMBL. | No reference |
AC50 (binding) | = 11.01 uM | PUBCHEM_BIOASSAY: Ras-converting Enzyme/Cell Proliferation Pathway Measured in Biochemical System Using Plate Reader - 2034-01_Inhibitor_Dose_CherryPick. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2618] | ChEMBL. | No reference |
Potency (functional) | 3.6964 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 4.4668 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] | ChEMBL. | No reference |
Potency (functional) | = 28.1838 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase). (Class of assay: confirmatory) [Related pubchem assays: 2429 (Confirmation qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2407 (Probe Development Summary for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2427 (Thermal Shift Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase))] | ChEMBL. | No reference |
Potency (functional) | 28.1838 uM | PubChem BioAssay. qHTS Assay for Activators of ClpP. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 28.1838 uM | PubChem BioAssay. qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 31.6228 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HSD17B4, hydroxysteroid (17-beta) dehydrogenase 4. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 31.6228 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 31.6228 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] | ChEMBL. | No reference |
Potency (functional) | = 31.6228 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HADH2 (Hydroxyacyl-Coenzyme A Dehydrogenase, Type II). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 50.1187 uM | PUBCHEM_BIOASSAY: qHTS Assay for Substrates of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] | ChEMBL. | No reference |
Potency (functional) | 50.1187 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 89.1251 um | PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.