TDR Targets

Basic information

Technical information

TDR Targets ID: 1482291
Name: 2-(4-bromophenyl)-5-[2-(4-chlorophenyl)sulfon ylethyl]-1,3,4-oxadiazole
MW: 427.7 | Formula: C16H12BrClN2O3S
H donors: 0 H acceptors: 4 LogP: 3.96 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: Clc1ccc(cc1)S(=O)(=O)CCc1nnc(o1)c1ccc(cc1)Br
InChi: 1S/C16H12BrClN2O3S/c17-12-3-1-11(2-4-12)16-20-19-15(23-16)9-10-24(21,22)14-7-5-13(18)6-8-14/h1-8H,9-10H2
InChiKey: QQEUIXRUOCPMJI-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

2-(4-bromophenyl)-5-{2-[(4-chlorophenyl)sulfonyl]ethyl}-1,3,4-oxadiazole
MLS000533491
SMR000140928
ZINC00990878

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	ataxin 2	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	hypothetical protein	0.0272	0.0227	0.0227
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0807	0.261	0.5946
Onchocerca volvulus		0.1171	0.4234	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1171	0.4234	1
Brugia malayi	Cathepsin L-like precursor	0.0807	0.261	0.261
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1171	0.4234	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1171	0.4234	1
Onchocerca volvulus		0.0807	0.261	0.5946
Echinococcus multilocularis	cathepsin b	0.2466	1	1
Entamoeba histolytica	cysteine proteinase, putative	0.1171	0.4234	1
Plasmodium falciparum	serine repeat antigen 9	0.0272	0.0227	0.0537
Entamoeba histolytica	cysteine protease, putative	0.0636	0.1852	0.4054
Toxoplasma gondii	cathepsin CPL	0.1171	0.4234	1
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0807	0.261	0.261
Brugia malayi	Cathepsin L-like precursor	0.0807	0.261	0.261
Entamoeba histolytica	cysteine proteinase 2	0.0636	0.1852	0.4054
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1171	0.4234	1
Onchocerca volvulus	Cathepsin L homolog	0.1171	0.4234	1
Leishmania major	cathepsin L-like protease	0.1171	0.4234	1
Echinococcus multilocularis	cysteine protease	0.1171	0.4234	0.4234
Onchocerca volvulus		0.1171	0.4234	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.1171	0.4234	1
Leishmania major	cathepsin L-like protease	0.1171	0.4234	1
Plasmodium vivax	dipeptidyl aminopeptidase 3, putative	0.0272	0.0227	0.0537
Trypanosoma cruzi	cysteine peptidase, putative	0.1171	0.4234	0.4234
Giardia lamblia	Cathepsin B precursor	0.095	0.325	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0636	0.1852	0.4054
Leishmania major	cathepsin L-like protease	0.1171	0.4234	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1171	0.4234	1
Brugia malayi	Cathepsin L-like precursor	0.1171	0.4234	0.4234
Trypanosoma cruzi	cysteine peptidase, putative	0.1171	0.4234	0.4234
Trypanosoma cruzi	cysteine peptidase, putative	0.0636	0.1852	0.1852
Plasmodium falciparum	dipeptidyl aminopeptidase 3	0.0272	0.0227	0.0537
Brugia malayi	Papain family cysteine protease containing protein	0.0636	0.1852	0.1852
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.1171	0.4234	1
Entamoeba histolytica	cysteine protease, putative	0.0636	0.1852	0.4054
Plasmodium falciparum	serine repeat antigen 6	0.0272	0.0227	0.0537
Plasmodium vivax	serine-repeat antigen 3 (SERA)	0.0272	0.0227	0.0537
Echinococcus multilocularis	cathepsin L	0.0272	0.0227	0.0227
Loa Loa (eye worm)	cysteine protease	0.1171	0.4234	0.4234
Echinococcus granulosus	cysteine protease	0.0636	0.1852	0.1852
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.2466	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1171	0.4234	1
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.0636	0.1852	0.1852
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1171	0.4234	1
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0636	0.1852	0.1852
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1171	0.4234	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.2466	1	1
Loa Loa (eye worm)	ctsf protein	0.1171	0.4234	0.4234
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1171	0.4234	1
Brugia malayi	cathepsin L precursor	0.0272	0.0227	0.0227
Echinococcus granulosus	cathepsin l1	0.0807	0.261	0.261
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0636	0.1852	0.4373
Trypanosoma cruzi	cysteine peptidase, putative	0.0365	0.0643	0.0643
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.2466	1	1
Trypanosoma cruzi	major cysteine proteinase, putative	0.0272	0.0227	0.0227
Entamoeba histolytica	cysteine protease, putative	0.0636	0.1852	0.4054
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1171	0.4234	1
Leishmania major	cathepsin L-like protease	0.1171	0.4234	1
Echinococcus multilocularis	cathepsin L	0.0636	0.1852	0.1852
Entamoeba histolytica	cysteine protease, putative	0.0636	0.1852	0.4054
Onchocerca volvulus		0.1171	0.4234	1
Brugia malayi	cathepsin L-like cysteine proteinase, identical	0.0365	0.0643	0.0643
Plasmodium falciparum	serine repeat antigen 4	0.0272	0.0227	0.0537
Trypanosoma brucei	cysteine peptidase C (CPC)	0.095	0.325	0.7675
Plasmodium vivax	serine-repeat antigen 5 (SERA)	0.0272	0.0227	0.0537
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1171	0.4234	1
Plasmodium vivax	unspecified product	0.0365	0.0643	0.1518
Entamoeba histolytica	cysteine proteinase, putative	0.1171	0.4234	1
Entamoeba histolytica	cysteine protease, putative	0.0636	0.1852	0.4054
Schistosoma mansoni	cathepsin S (C01 family)	0.0272	0.0227	0.0227
Onchocerca volvulus	Cathepsin F homolog	0.1171	0.4234	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0272	0.0227	0.0227
Entamoeba histolytica	cysteine proteinase, putative	0.0636	0.1852	0.4054
Plasmodium vivax	serine-repeat antigen 4 (SERA)	0.0272	0.0227	0.0537
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1171	0.4234	1
Plasmodium vivax	serine-repeat antigen (SERA), putative	0.0272	0.0227	0.0537
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1171	0.4234	1
Echinococcus granulosus	cathepsin l cysteine peptidase	0.1171	0.4234	0.4234
Echinococcus granulosus	cathepsin b	0.2466	1	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.1171	0.4234	1
Entamoeba histolytica	cysteine protease, putative	0.0636	0.1852	0.4054
Plasmodium vivax	serine-repeat antigen (SERA)	0.0272	0.0227	0.0537
Entamoeba histolytica	cysteine protease, putative	0.0636	0.1852	0.4054
Brugia malayi	Papain family cysteine protease containing protein	0.0272	0.0227	0.0227
Onchocerca volvulus		0.1171	0.4234	1
Plasmodium vivax	serine-repeat antigen 4 (SERA), putative	0.0272	0.0227	0.0537
Entamoeba histolytica	cysteine protease, putative	0.0636	0.1852	0.4054
Entamoeba histolytica	cysteine proteinase, putative	0.0636	0.1852	0.4054
Loa Loa (eye worm)	hypothetical protein	0.0807	0.261	0.261
Plasmodium falciparum	dipeptidyl aminopeptidase 2	0.0272	0.0227	0.0537
Brugia malayi	Cathepsin L-like precursor	0.1171	0.4234	0.4234
Plasmodium falciparum	dipeptidyl aminopeptidase 1	0.0272	0.0227	0.0537
Brugia malayi	Cathepsin L-like precursor	0.1171	0.4234	0.4234
Trypanosoma cruzi	cruzipain precursor, putative	0.0365	0.0643	0.0643
Echinococcus multilocularis	cathepsin L cysteine protease	0.1171	0.4234	0.4234
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1171	0.4234	1
Onchocerca volvulus		0.1171	0.4234	1
Echinococcus granulosus	cathepsin b	0.2466	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1171	0.4234	1
Plasmodium vivax	unspecified product	0.0272	0.0227	0.0537
Loa Loa (eye worm)	hypothetical protein	0.0365	0.0643	0.0643
Loa Loa (eye worm)	hypothetical protein	0.1171	0.4234	0.4234
Plasmodium vivax	vivapain-2	0.1171	0.4234	1
Loa Loa (eye worm)	hypothetical protein	0.0807	0.261	0.261
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0365	0.0643	0.0643
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.1171	0.4234	0.4234
Plasmodium vivax	unspecified product	0.0636	0.1852	0.4373
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.095	0.325	0.325
Brugia malayi	cathepsin F-like cysteine proteinase	0.0272	0.0227	0.0227
Schistosoma mansoni	subfamily C1A non-peptidase homologue (C01 family)	0.0272	0.0227	0.0227
Leishmania major	cathepsin L-like protease	0.1171	0.4234	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.2466	1	1
Entamoeba histolytica	cysteine protease, putative	0.0636	0.1852	0.4054
Giardia lamblia	Cathepsin B precursor	0.095	0.325	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1171	0.4234	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.1171	0.4234	1
Loa Loa (eye worm)	hypothetical protein	0.0272	0.0227	0.0227
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0272	0.0227	0.0227
Brugia malayi	cathepsin F-like cysteine proteinase	0.0365	0.0643	0.0643
Plasmodium falciparum	serine repeat antigen 1	0.0272	0.0227	0.0537
Echinococcus multilocularis	cathepsin L cysteine protease	0.1171	0.4234	0.4234
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.1171	0.4234	1
Toxoplasma gondii	cathepsin CPC2	0.0272	0.0227	0.0537
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0272	0.0227	0.0227
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1171	0.4234	1
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.1171	0.4234	0.4234
Loa Loa (eye worm)	hypothetical protein	0.0272	0.0227	0.0227
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1171	0.4234	1
Entamoeba histolytica	cysteine protease, putative	0.0636	0.1852	0.4054
Echinococcus granulosus	cathepsin L cysteine protease	0.0636	0.1852	0.1852
Plasmodium vivax	dipeptidyl aminopeptidase 1, putative	0.0272	0.0227	0.0537
Plasmodium falciparum	cysteine proteinase falcipain 1	0.0636	0.1852	0.4373
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0272	0.0227	0.0227
Trypanosoma cruzi	cysteine protease, putative	0.0636	0.1852	0.1852
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1171	0.4234	1
Entamoeba histolytica	cysteine protease, putative	0.0636	0.1852	0.4054
Onchocerca volvulus		0.1171	0.4234	1
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0272	0.0227	0.0227
Plasmodium vivax	vivapain-3	0.0636	0.1852	0.4373
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0272	0.0227	0.0227
Loa Loa (eye worm)	hypothetical protein	0.0272	0.0227	0.0227
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.2466	1	1
Trypanosoma cruzi	cysteine proteinase, putative	0.0636	0.1852	0.1852
Echinococcus granulosus	cathepsin L cysteine proteinase	0.1171	0.4234	0.4234
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	0.095	0.325	0.7675
Brugia malayi	Cathepsin L-like precursor	0.1171	0.4234	0.4234
Entamoeba histolytica	cysteine proteinase, putative	0.0636	0.1852	0.4054
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.1171	0.4234	1
Loa Loa (eye worm)	hypothetical protein	0.0365	0.0643	0.0643
Brugia malayi	cathepsin L-like cysteine proteinase	0.0272	0.0227	0.0227
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0636	0.1852	0.1852
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.1171	0.4234	1
Entamoeba histolytica	cysteine proteinase, putative	0.0807	0.261	0.5946
Schistosoma mansoni	cathepsin B (C01 family)	0.0272	0.0227	0.0227
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.1171	0.4234	1
Brugia malayi	Cathepsin L-like precursor	0.1171	0.4234	0.4234
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.1171	0.4234	1
Trypanosoma cruzi	major cysteine proteinase, putative	0.0272	0.0227	0.0227
Echinococcus multilocularis	cysteine protease	0.1171	0.4234	0.4234
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0272	0.0227	0.0227
Loa Loa (eye worm)	fibroinase	0.1171	0.4234	0.4234
Leishmania major	cathepsin L-like protease	0.1171	0.4234	1
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.1171	0.4234	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1171	0.4234	1
Entamoeba histolytica	cysteine proteinase 1, putative	0.0636	0.1852	0.4054
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0807	0.261	0.5946
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.1171	0.4234	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.1171	0.4234	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1171	0.4234	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.095	0.325	0.325
Schistosoma mansoni	dipeptidyl-peptidase I (C01 family)	0.0272	0.0227	0.0227
Trypanosoma cruzi	cysteine peptidase, putative	0.1171	0.4234	0.4234
Onchocerca volvulus		0.1171	0.4234	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1171	0.4234	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1171	0.4234	1
Toxoplasma gondii	cathepsin CPC1	0.0272	0.0227	0.0537
Plasmodium falciparum	serine repeat antigen 5	0.0272	0.0227	0.0537
Entamoeba histolytica	cysteine proteinase, putative	0.0636	0.1852	0.4054
Plasmodium vivax	serine-repeat antigen (SERA), putative	0.0272	0.0227	0.0537
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0636	0.1852	0.4054
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.1171	0.4234	0.4234
Brugia malayi	Cathepsin L-like precursor	0.1171	0.4234	0.4234
Schistosoma mansoni	cathepsin F (C01 family)	0.1171	0.4234	0.4234
Brugia malayi	Cathepsin L-like precursor	0.0365	0.0643	0.0643
Toxoplasma gondii	cathepsin B	0.095	0.325	0.7675
Brugia malayi	Papain family cysteine protease containing protein	0.1171	0.4234	0.4234
Plasmodium falciparum	serine repeat antigen 2	0.0272	0.0227	0.0537
Brugia malayi	Papain family cysteine protease containing protein	0.0636	0.1852	0.1852
Entamoeba histolytica	cysteine protease, putative	0.0636	0.1852	0.4054
Plasmodium vivax	serine-repeat antigen (SERA)	0.0272	0.0227	0.0537
Brugia malayi	fibroinase precursor	0.0272	0.0227	0.0227
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.1171	0.4234	0.4234
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.1171	0.4234	1
Loa Loa (eye worm)	hypothetical protein	0.2466	1	1
Trypanosoma cruzi	cruzipain precursor, putative	0.1171	0.4234	0.4234
Schistosoma mansoni	cathepsin F (C01 family)	0.1171	0.4234	0.4234
Entamoeba histolytica	cysteine protease, putative	0.0636	0.1852	0.4054
Toxoplasma gondii	preprocathepsin c precursor, putative	0.0272	0.0227	0.0537
Entamoeba histolytica	cysteine protease, putative	0.1171	0.4234	1
Brugia malayi	cahepsin L-like non-peptiedase homolog	0.0272	0.0227	0.0227
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1171	0.4234	1
Loa Loa (eye worm)	cathepsin B	0.095	0.325	0.325
Loa Loa (eye worm)	hypothetical protein	0.0807	0.261	0.261
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.095	0.325	0.7543
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1171	0.4234	1
Plasmodium vivax	vivapain-1	0.0636	0.1852	0.4373
Leishmania major	cysteine peptidase A (CPA)	0.1171	0.4234	1
Plasmodium vivax	dipeptidyl aminopeptidase 2, putative	0.0272	0.0227	0.0537
Plasmodium vivax	serine-repeat antigen 2 (SERA)	0.0272	0.0227	0.0537
Onchocerca volvulus	Cathepsin L homolog	0.1171	0.4234	1
Brugia malayi	Papain family cysteine protease containing protein	0.0272	0.0227	0.0227
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0807	0.261	0.261
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0272	0.0227	0.0227
Giardia lamblia	Cathepsin B precursor	0.095	0.325	1
Schistosoma mansoni	cathepsin F (C01 family)	0.0807	0.261	0.261
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0272	0.0227	0.0227
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0636	0.1852	0.1852
Schistosoma mansoni	cathepsin s	0.0365	0.0643	0.0643
Echinococcus granulosus	cathepsin L	0.0272	0.0227	0.0227
Loa Loa (eye worm)	hypothetical protein	0.0272	0.0227	0.0227
Echinococcus granulosus	cathepsin L	0.0636	0.1852	0.1852
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0272	0.0227	0.0227
Loa Loa (eye worm)	hypothetical protein	0.0365	0.0643	0.0643
Brugia malayi	Papain family cysteine protease containing protein	0.0272	0.0227	0.0227
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0272	0.0227	0.0227
Loa Loa (eye worm)	cysteine proteinase cathepsin Z	0.0272	0.0227	0.0227
Trypanosoma cruzi	cysteine proteinase, putative	0.0636	0.1852	0.1852
Brugia malayi	cathepsin L-like precursor	0.0807	0.261	0.261
Leishmania major	cathepsin L-like protease	0.1171	0.4234	1
Echinococcus granulosus	cathepsin l1	0.1171	0.4234	0.4234
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0636	0.1852	0.4373
Leishmania major	cathepsin L-like protease	0.1171	0.4234	1
Plasmodium falciparum	cysteine proteinase falcipain 3	0.1171	0.4234	1
Echinococcus multilocularis	cathepsin b	0.2466	1	1
Plasmodium vivax	vivapain-2	0.1171	0.4234	1
Plasmodium falciparum	serine repeat antigen 8	0.0272	0.0227	0.0537
Plasmodium falciparum	serine repeat antigen 3	0.0272	0.0227	0.0537
Trypanosoma cruzi	cysteine peptidase, putative	0.1171	0.4234	0.4234
Schistosoma mansoni	cathepsin C	0.0272	0.0227	0.0227
Loa Loa (eye worm)	hypothetical protein	0.0272	0.0227	0.0227
Plasmodium falciparum	serine repeat antigen 7	0.0272	0.0227	0.0537

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	10.6213 uM	PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	29.0929 uM	PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125]	ChEMBL.	No reference
Potency (functional)	89.1251 uM	PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962]	ChEMBL.	No reference
Potency (functional)	89.1251 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Eta. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588636]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1713131

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1482291